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1. 发明申请

US20090202631A1 METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE AND RISPERIDONE 审中-公开
标题翻译：用于控制输送PALIPERIDONE和RISPERIDONE的方法和剂型
公开(公告)号：US20090202631A1
公开(公告)日：2009-08-13
申请号：US12428422
申请日：2009-04-22
申请人： Nyomi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff , Suneel K. Gupta , Gayatri Sathyan
发明人： Nyomi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff , Suneel K. Gupta , Gayatri Sathyan
IPC分类号： A61K31/519 , A61K9/20
CPC分类号： A61K9/0004 , A61K9/0053 , A61K9/2086 , A61K9/209 , A61K31/506 , A61K31/519
摘要： Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.
摘要翻译：提供了用于提供帕培酮或利培酮的基本上升释放速率的剂型和方法。当每天施用一次时，持续释放剂型提供治疗有效的平均稳态血浆普利培酮或利培酮浓度。这种每天一次的给药方案导致每24小时内出现一次峰值血浆普利培酮或利培酮浓度。此外，剂量给药后的较晚时间，峰值血浆普利培酮或利培酮浓度发生在比立即释放剂型给药帕立哌酮或利培酮后出现的峰值血浆普利培酮或利培酮浓度更小的程度。

2. 发明授权

US09393192B2 Methods and dosage forms for controlled delivery of paliperidone and risperidone 有权
标题翻译：受控输送帕培培酮和利培酮的方法和剂型
公开(公告)号：US09393192B2
公开(公告)日：2016-07-19
申请号：US12428422
申请日：2009-04-22
申请人： Nyomi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff , Suneel K. Gupta , Gayatri Sathyan
发明人： Nyomi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff , Suneel K. Gupta , Gayatri Sathyan
IPC分类号： A61K9/22 , A61K9/00 , A61K31/506 , A61K31/519
CPC分类号： A61K9/0004 , A61K9/0053 , A61K9/2086 , A61K9/209 , A61K31/506 , A61K31/519
摘要： Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.
摘要翻译：提供了用于提供帕培酮或利培酮的基本上升释放速率的剂型和方法。当每天施用一次时，持续释放剂型提供治疗有效的平均稳态血浆普利培酮或利培酮浓度。这种每天一次的给药方案导致每24小时内出现一次峰值血浆普利培酮或利培酮浓度。此外，剂量给药后的较晚时间，峰值血浆普利培酮或利培酮浓度发生在比立即释放剂型给药帕立哌酮或利培酮后出现的峰值血浆普利培酮或利培酮浓度更小的程度。

3. 发明申请

US20120283275A1 METHODS AND DOSAGE FORMS FOR REDUCING SIDE EFFECTS OF BENZISOZAZOLE DERIVATIVES 审中-公开
标题翻译：减少苯并唑唑衍生物副作用的方法和剂型
公开(公告)号：US20120283275A1
公开(公告)日：2012-11-08
申请号：US13467761
申请日：2012-05-09
申请人： Gayatri Sathyan , Suneel Gupta , Noymi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff
发明人： Gayatri Sathyan , Suneel Gupta , Noymi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff
IPC分类号： A61K31/519 , A61P25/18
CPC分类号： A61K9/0004 , A61K31/519
摘要： Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that substantially reduce or substantially eliminate certain side effects of the benzisoxazole derivatives when dosed to a patient.
摘要翻译：公开了包含苯并异恶唑衍生物的剂型和方法。更具体地，公开了苯甲异恶唑衍生物的剂型，方法和新用途，其显着降低或基本上消除了当给予患者时苯并异恶唑衍生物的某些副作用。

4. 发明申请

US20110195981A1 METHODS AND DOSAGE FORMS FOR REDUCING SIDE EFFECTS OF BENZISOZAZOLE DERIVATIVES 审中-公开
标题翻译：减少苯并唑唑衍生物副作用的方法和剂型
公开(公告)号：US20110195981A1
公开(公告)日：2011-08-11
申请号：US13012490
申请日：2011-01-24
申请人： Gayatri Sathyan , Suneel Gupta , Noymi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff
发明人： Gayatri Sathyan , Suneel Gupta , Noymi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff
IPC分类号： A61K31/519 , A61P25/18
CPC分类号： A61K9/0004 , A61K31/519
摘要： Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that substantially reduce or substantially eliminate certain side effects of the benzisoxazole derivatives when dosed to a patient.
摘要翻译：公开了包含苯并异恶唑衍生物的剂型和方法。更具体地，公开了苯甲异恶唑衍生物的剂型，方法和新用途，其显着降低或基本上消除了当给予患者时苯并异恶唑衍生物的某些副作用。

5. 发明申请

US20050232995A1 Methods and dosage forms for controlled delivery of paliperidone and risperidone 审中-公开
标题翻译：受控输送帕培培酮和利培酮的方法和剂型
公开(公告)号：US20050232995A1
公开(公告)日：2005-10-20
申请号：US11051165
申请日：2005-02-04
申请人： Nyomi Yam , Iran Reyes , Nipun Davar , Atul Ayer , Julie Lee , Sonya Seroff , Suneel Gupta , Gayatri Sathyan
发明人： Nyomi Yam , Iran Reyes , Nipun Davar , Atul Ayer , Julie Lee , Sonya Seroff , Suneel Gupta , Gayatri Sathyan
IPC分类号： A61K31/506 , A61K31/519 , A61K9/24
CPC分类号： A61K9/0004 , A61K9/0053 , A61K9/2086 , A61K9/209 , A61K31/506 , A61K31/519
摘要： Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.
摘要翻译：提供了用于提供帕培酮或利培酮的基本上升释放速率的剂型和方法。当每天施用一次时，持续释放剂型提供治疗有效的平均稳态血浆普利培酮或利培酮浓度。这种每天一次的给药方案导致每24小时内出现一次峰值血浆普利培酮或利培酮浓度。此外，剂量给药后的较晚时间，峰值血浆普利培酮或利培酮浓度发生在比立即释放剂型给药帕立哌酮或利培酮后出现的峰值血浆普利培酮或利培酮浓度更小的程度。

6. 发明申请

US20050208132A1 Methods and dosage forms for reducing side effects of benzisozazole derivatives 审中-公开
标题翻译：减少苯并异唑衍生物副作用的方法和剂型
公开(公告)号：US20050208132A1
公开(公告)日：2005-09-22
申请号：US11051060
申请日：2005-02-04
申请人： Gayatri Sathyan , Suneel Gupta , Noymi Yam , Iran Reyes , Nipun Davar , Atul Ayer , Julie Lee , Sonya Seroff
发明人： Gayatri Sathyan , Suneel Gupta , Noymi Yam , Iran Reyes , Nipun Davar , Atul Ayer , Julie Lee , Sonya Seroff
IPC分类号： A61K31/506 , A61K31/519 , A61K31/42 , A61K9/22
CPC分类号： A61K9/0004 , A61K31/519
摘要： Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that substantially reduce or substantially eliminate certain side effects of the benzisoxazole derivatives when dosed to a patient.
摘要翻译：公开了包含苯并异恶唑衍生物的剂型和方法。更具体地，公开了苯甲异恶唑衍生物的剂型，方法和新用途，其显着降低或基本上消除了当给予患者时苯并异恶唑衍生物的某些副作用。

7. 发明申请

US20070166381A1 OSMOTIC DOSAGE FORM WITH CONTROLLED RELEASE AND FAST RELEASE ASPECTS 审中-公开
标题翻译： OSMOTIC剂型与控制释放和快速释放方面
公开(公告)号：US20070166381A1
公开(公告)日：2007-07-19
申请号：US11619468
申请日：2007-01-03
申请人： Iran Reyes , Julie Lee , Brian Barclay , Iswadi Liejanto , Nipun Davar
发明人： Iran Reyes , Julie Lee , Brian Barclay , Iswadi Liejanto , Nipun Davar
IPC分类号： A61K9/24
CPC分类号： A61K9/0004 , A61K31/506
摘要： Disclosed are osmotic dosage forms and methods that provide for fast release of drugs together with controlled release of drugs. In an aspect, disclosed are osmotic dosage forms including: a semi-permeable membrane; a lubricating subcoat located within the semi-permeable membrane; an orifice in the semi-permeable membrane located at an end of the semi-permeable membrane; a drug layer located adjacent to the orifice and within the lubricating subcoat; a push layer located within the lubricating subcoat and on a side of the drug layer opposite from the orifice; wherein an area of the orifice is greater than or equal to about 1,600 mil2; and wherein the drug layer comprises from about 20 wt % to about 90 wt % microcrystalline cellulose, and less than or equal to about 10 wt % of a drug, based on the total weight of the drug layer. Also disclosed are methods of making osmotic dosage forms.
摘要翻译：公开了提供药物快速释放以及药物控制释放的渗透剂型和方法。一方面，所公开的是渗透剂型，包括：半透膜; 位于半透膜内的润滑底涂层; 位于半透膜端部的半透膜中的孔口; 邻近孔口并位于润滑底涂层内的药物层; 位于所述润滑底层内并且在所述药物层的与所述孔相对的一侧的推层; 其中所述孔口的面积大于或等于约1,600密耳2; 并且其中基于药物层的总重量，药物层包含约20重量％至约90重量％的微晶纤维素和小于或等于约10重量％的药物。还公开了制备渗透剂型的方法。

8. 发明申请

US20050058707A1 Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation 审中-公开
标题翻译：通过增强的分散配方，长时间均匀地输送托吡酯
公开(公告)号：US20050058707A1
公开(公告)日：2005-03-17
申请号：US10910040
申请日：2004-08-03
申请人： Iran Reyes , Noymi Yam , Padmaja Shivanand , Shaoling Li , Patrick Wong
发明人： Iran Reyes , Noymi Yam , Padmaja Shivanand , Shaoling Li , Patrick Wong
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/28 , A61K9/48 , A61K31/35
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/2027 , A61K9/2031 , A61K9/2086 , A61K9/209 , A61K9/4866 , A61K31/35
摘要： Compositions and dosage forms for enhanced dispersion of topiramate in a controlled release dosage form delivered as a dry or substantially dry erodible solid at a uniform rate over a prolonged period of time are described.
摘要翻译：描述了用于增强托吡酯在控制释放剂型中的分散性的组合物和剂型，其作为干燥或基本上干燥的可侵蚀固体以均匀速率在延长的时间段内递送。

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