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1. 发明申请

US20110285979A1 PROJECTION OBJECTIVE WITH DIAPHRAGMS 有权
标题翻译：投影目标与石墨片
公开(公告)号：US20110285979A1
公开(公告)日：2011-11-24
申请号：US13107011
申请日：2011-05-13
申请人： Nils Dieckmann , Alexander Wolf , Christian Holland , Ulrich Loering , Franz Sorg
发明人： Nils Dieckmann , Alexander Wolf , Christian Holland , Ulrich Loering , Franz Sorg
IPC分类号： G03B27/72 , G02B17/08 , G02B27/18
CPC分类号： G03F7/70941 , G02B27/0043
摘要： A projection objective for imaging an object arranged in an object plane of the projection objective into an image of the object lying in an image plane of the projection objective has a multiplicity of transparent optical elements and holding devices for holding the optical elements at prescribable positions along an imaging beam path of the projection objective. Each of the optical elements has an optical useful region lying in the imaging beam path and an edge region lying outside the optical useful region. At least one holding element of the holding device assigned to the optical element acts at the edge region in the region of a contact zone. At least one of the optical elements is assigned a diaphragm arrangement with a false light diaphragm arranged directly upstream of the optical element and a second false light diaphragm arranged directly downstream of the optical element. Each of the false light diaphragms is fashioned in such a way that the false light diaphragm screens at least a part of the edge region against radiation running outside the imaging beam path.
摘要翻译：用于将布置在投影物镜的物平面中的物体成像为位于投影物镜的像平面中的物体的图像的投影物镜具有多个透明光学元件和用于将光学元件保持在规定位置的保持装置投影物镜的成像光束路径。每个光学元件具有位于成像光束路径中的光学有用区域和位于光学有用区域外部的边缘区域。分配给光学元件的保持装置的至少一个保持元件作用在接触区域的边缘区域。至少一个光学元件被分配有具有布置在光学元件的正上游的假光膜的膜片装置和直接布置在光学元件的下游的第二假光膜。每个假光隔膜以这样的方式形成，使得假光隔膜将至少一部分边缘区域屏蔽到抵抗在成像光束路径外部运行的辐射。

2. 发明授权

US08488104B2 Projection objective with diaphragms 有权
标题翻译：投影目的与隔膜
公开(公告)号：US08488104B2
公开(公告)日：2013-07-16
申请号：US13107011
申请日：2011-05-13
申请人： Nils Dieckmann , Alexander Wolf , Christian Holland , Ulrich Loering , Franz Sorg
发明人： Nils Dieckmann , Alexander Wolf , Christian Holland , Ulrich Loering , Franz Sorg
IPC分类号： G03B27/72 , G03B27/54
CPC分类号： G03F7/70941 , G02B27/0043
摘要： A projection objective for imaging an object arranged in an object plane of the projection objective into an image of the object lying in an image plane of the projection objective has a multiplicity of transparent optical elements and holding devices for holding the optical elements at prescribable positions along an imaging beam path of the projection objective. Each of the optical elements has an optical useful region lying in the imaging beam path and an edge region lying outside the optical useful region. At least one holding element of the holding device assigned to the optical element acts at the edge region in the region of a contact zone. At least one of the optical elements is assigned a diaphragm arrangement with a false light diaphragm arranged directly upstream of the optical element and a second false light diaphragm arranged directly downstream of the optical element. Each of the false light diaphragms is fashioned in such a way that the false light diaphragm screens at least a part of the edge region against radiation running outside the imaging beam path.
摘要翻译：用于将布置在投影物镜的物平面中的物体成像为位于投影物镜的像平面中的物体的图像的投影物镜具有多个透明光学元件和用于将光学元件保持在规定位置的保持装置投影物镜的成像光束路径。每个光学元件具有位于成像光束路径中的光学有用区域和位于光学有用区域外部的边缘区域。分配给光学元件的保持装置的至少一个保持元件作用在接触区域的边缘区域。至少一个光学元件被分配有具有布置在光学元件的正上游的假光膜的膜片装置和直接布置在光学元件的下游的第二假光膜。每个假光隔膜以这样的方式形成，使得假光隔膜将至少一部分边缘区域屏蔽到抵抗在成像光束路径外部运行的辐射。

3. 发明授权

US08999982B2 Pharmaceutically active compounds as Axl inhibitors 有权
标题翻译：作为Axl抑制剂的药物活性化合物
公开(公告)号：US08999982B2
公开(公告)日：2015-04-07
申请号：US13819560
申请日：2011-08-26
申请人： Carsten Schultz-Fademrecht , Bert Klebl , Axel Choidas , Uwe Koch , Jan Eickhoff , Alexander Wolf , Axel Ullrich
发明人： Carsten Schultz-Fademrecht , Bert Klebl , Axel Choidas , Uwe Koch , Jan Eickhoff , Alexander Wolf , Axel Ullrich
IPC分类号： A61K31/495 , A61K31/47 , C07D401/12 , C07D401/14 , C07D417/12 , C07D417/14 , C07D413/12 , C07D413/14 , C07D215/233
CPC分类号： C07D401/12 , A61K31/47 , A61K31/495 , C07D215/233 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to 1-nitrogen-heterocyclic-2-carboxamides and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the treatment and/or prevention of Axl receptor tyrosine kinase subfamily induced disorders, including cancer and primary tumor metastases, and pharmaceutical compositions containing at least one of said 1-nitrogen-heterocyclic-2-carboxamide derivatives and/or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及1-氮杂环-2-甲酰胺和/或其药学上可接受的盐，这些衍生物用作药物活性剂，特别是用于治疗和/或预防Axl受体酪氨酸激酶亚家族诱导的病症，包括癌症和原发性肿瘤转移，以及含有至少一种所述1-氮杂环-2-甲酰胺衍生物和/或其药学上可接受的盐的药物组合物。

4. 发明申请

US20140051106A1 METHOD FOR ASSAYING OGFOD1 ACTIVITY 有权
标题翻译：测定OGFOD1活性的方法
公开(公告)号：US20140051106A1
公开(公告)日：2014-02-20
申请号：US13985243
申请日：2012-02-10
申请人： Christopher Joseph Schofield , Alexander Wolf , Wei Ge , Armin Thalhammer , Christoph Loenarz , Peter John Ratcliffe , Matthew Edward Cockman
发明人： Christopher Joseph Schofield , Alexander Wolf , Wei Ge , Armin Thalhammer , Christoph Loenarz , Peter John Ratcliffe , Matthew Edward Cockman
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26 , G01N2333/90245
摘要： The present invention relates to assays for monitoring activity of OGFOD1 activity, in particular, to assays for identifying modulators of OGFOD1 activity. The invention also relates to assays to monitor the prolyl hydroxylase activity of OGFOD1 on its substrate, the human ribosomal protein RPS23. The invention also enables the introduction of 3-hydroxyprolyl residues into peptides and proteins.
摘要翻译：本发明涉及用于监测OGFOD1活性的活性的测定法，特别是用于鉴定OGFOD1活性调节剂的测定法。本发明还涉及监测OGFOD1在其底物，人核糖体蛋白RPS23上的脯氨酰羟化酶活性的测定。本发明还能够将3-羟基脯氨酸残基引入肽和蛋白质。

5. 发明申请

US20140018365A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS 有权
标题翻译：药物活性化合物作为AXL抑制剂
公开(公告)号：US20140018365A1
公开(公告)日：2014-01-16
申请号：US13819560
申请日：2011-08-26
申请人： Carsten Schultz-Fademrecht , Bert Klebl , Axel Choidas , Uwe Koch , Jan Eickhoff , Alexander Wolf , Axel Ullrich
发明人： Carsten Schultz-Fademrecht , Bert Klebl , Axel Choidas , Uwe Koch , Jan Eickhoff , Alexander Wolf , Axel Ullrich
IPC分类号： C07D401/12 , C07D215/233 , C07D417/12 , C07D413/14 , C07D417/14 , C07D401/14
CPC分类号： C07D401/12 , A61K31/47 , A61K31/495 , C07D215/233 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to 1-nitrogen-heterocyclic-2-carboxamides and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the treatment and/or prevention of Axl receptor tyrosine kinase subfamily induced disorders, including cancer and primary tumor metastases, and pharmaceutical compositions containing at least one of said 1-nitrogen-heterocyclic-2-carboxamide derivatives and/or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及1-氮杂环-2-甲酰胺和/或其药学上可接受的盐，这些衍生物用作药物活性剂，特别是用于治疗和/或预防Axl受体酪氨酸激酶亚家族诱导的病症，包括癌症和原发性肿瘤转移，以及含有至少一种所述1-氮杂环-2-甲酰胺衍生物和/或其药学上可接受的盐的药物组合物。

6. 发明申请

US20050179218A1 Sealing strip 失效
标题翻译：密封条
公开(公告)号：US20050179218A1
公开(公告)日：2005-08-18
申请号：US10808862
申请日：2004-03-24
申请人： Alexander Wolf
发明人： Alexander Wolf
IPC分类号： B60J10/00 , F16J15/06 , F16J15/10 , F16J15/08
CPC分类号： F16J15/061 , B60J10/16 , B60J10/34 , B60J10/45 , F16J15/104 , Y10T428/14 , Y10T428/1452 , Y10T428/1462 , Y10T428/1471 , Y10T428/1476 , Y10T428/1486 , Y10T428/149 , Y10T428/22 , Y10T428/24132 , Y10T428/249982 , Y10T428/249991
摘要： A sealing strip is intended to seal a gap between two parts which are movable relative to each other. The sealing strip has a surface which is intended to adhere to one of the two parts and which has an adhesive layer. Before it is adhered to the one part, the adhesive layer is covered with a cover sheet. In order to make it easier to remove the cover sheet from the adhesive layer a tear-thread is provided which passes through the cover sheet and has at least one free end that protrudes from the sealing strip.
摘要翻译：密封条旨在密封可相对于彼此移动的两个部件之间的间隙。密封条具有旨在粘附到两个部分之一并且具有粘合剂层的表面。在粘合到一个部分之前，粘合剂层被覆盖片覆盖。为了使粘合剂层更容易去除覆盖片，提供穿过覆盖片的撕裂线，并且具有从密封条突出的至少一个自由端。

7. 发明授权

US4646871A Gas-gun for acoustic well sounding 失效
标题翻译：气枪声音测井
公开(公告)号：US4646871A
公开(公告)日：1987-03-03
申请号：US646860
申请日：1984-09-04
申请人： Alexander Wolf
发明人： Alexander Wolf
IPC分类号： G01V1/137 , G01V1/52 , G01V1/04 , G01V1/133
CPC分类号： G01V1/52 , G01V1/137
摘要： In the art of acoustic well sounding a gas-gun for the sudden discharge of a measured quantity of compressed gas, comprised of two chambers, viz. a discharge chamber closed at one end by a poppet, and on the opposite end by a power-head, the latter a cylinder including a sealed piston, with the poppet connected by sealed piston rod penetrating the cylinder head, and terminated at the piston. The entire assembly to be so proportioned that regardless of the position of the piston a gap remains between the piston and the cylinder-head penetrated by the piston rod. Means for connecting this gap to the inside of the discharge chamber through a check valve permits gas flow from the discharge chamber to the gap, but not in the reverse direction, and means for venting the gap to the atmosphere. A passage from the opposite side of the piston to the axial outlet of the discharge chamber, a spring or a positive locking device for pressing the poppet against the valve seat. The entire construction is limited by the requirement that the piston rod be smaller in diameter than the seat diameter of the poppet, and the latter to be smaller than the diameter of the piston.
摘要翻译：在声学井的技术领域，用于突然排出由两个室组成的测量量的压缩气体的气枪，排气室一端由提升阀封闭，而在另一端由动力头封闭，后者是一个包括一个密封活塞的气缸，该提升阀由密封的活塞杆连接，穿过气缸盖，并终止于活塞。整个组件如此成比例，无论活塞的位置如何，活塞和活塞杆所穿透的气缸盖之间保留有间隙。通过止回阀将该间隙连接到排出室内部的装置允许气体从排出室流到间隙而不是相反方向，以及用于将间隙排放到大气中的装置。从活塞的相对侧到排放室的轴向出口的通道，用于将提升阀压靠在阀座上的弹簧或正锁定装置。整个结构受到活塞杆直径小于提升阀座直径的要求的限制，后者要小于活塞的直径。

8. 发明授权

US09228224B2 Method for assaying OGFOD1 activity 有权
标题翻译： OGFOD1活性测定方法
公开(公告)号：US09228224B2
公开(公告)日：2016-01-05
申请号：US13985243
申请日：2012-02-10
申请人： Christopher Joseph Schofield , Alexander Wolf , Wei Ge , Armin Thalhammer , Christoph Loenarz , Peter John Ratcliffe , Matthew Edward Cockman
发明人： Christopher Joseph Schofield , Alexander Wolf , Wei Ge , Armin Thalhammer , Christoph Loenarz , Peter John Ratcliffe , Matthew Edward Cockman
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26 , G01N2333/90245
摘要： The present invention relates to assays for monitoring activity of OGFOD1 activity, in particular, to assays for identifying modulators of OGFOD1 activity. The invention also relates to assays to monitor the prolyl hydroxylase activity of OGFOD1 on its substrate, the human ribosomal protein RPS23. The invention also enables the introduction of 3-hydroxyprolyl residues into peptides and proteins.
摘要翻译：本发明涉及用于监测OGFOD1活性的活性的测定法，特别是用于鉴定OGFOD1活性调节剂的测定法。本发明还涉及监测OGFOD1在其底物，人核糖体蛋白RPS23上的脯氨酰羟化酶活性的测定。本发明还能够将3-羟基脯氨酸残基引入肽和蛋白质。

9. 发明申请

US20140045930A1 ASSAY FOR ARGINYL HYDROXYLASE ACTIVITY 审中-公开
标题翻译：测定ARGINYL羟化酶活性
公开(公告)号：US20140045930A1
公开(公告)日：2014-02-13
申请号：US13982639
申请日：2012-01-30
申请人： Christopher Joseph Schofield , Chia-Hua Ho , Alexander Wolf , Wei Ge
发明人： Christopher Joseph Schofield , Chia-Hua Ho , Alexander Wolf , Wei Ge
IPC分类号： C12Q1/26 , C12P21/00 , A61K45/00
CPC分类号： C12Q1/26 , A61K45/00 , C12P21/00 , G01N2333/90245
摘要： The present invention relates to assays for monitoring activity of YcfD activity, in particular, to assays for identifying modulators of YcfD activity. The present invention also relates to the use of YcfD inhibitors as antibiotics. The invention also relates to methods for introducing hydroxyarginine residues into proteins.
摘要翻译：本发明涉及用于监测YcfD活性的活性的测定法，特别是用于鉴定YcfD活性调节剂的测定法。本发明还涉及YcfD抑制剂作为抗生素的用途。本发明还涉及将精氨酸残基引入蛋白质的方法。

10. 发明授权

US07320819B2 Sealing strip 失效
标题翻译：密封条
公开(公告)号：US07320819B2
公开(公告)日：2008-01-22
申请号：US10808862
申请日：2004-03-24
申请人： Alexander Wolf
发明人： Alexander Wolf
IPC分类号： B32B33/00
CPC分类号： F16J15/061 , B60J10/16 , B60J10/34 , B60J10/45 , F16J15/104 , Y10T428/14 , Y10T428/1452 , Y10T428/1462 , Y10T428/1471 , Y10T428/1476 , Y10T428/1486 , Y10T428/149 , Y10T428/22 , Y10T428/24132 , Y10T428/249982 , Y10T428/249991
摘要： A sealing strip is intended to seal a gap between two parts which are movable relative to each other. The sealing strip has a surface which is intended to adhere to one of the two parts and which has an adhesive layer. Before it is adhered to the one part, the adhesive layer is covered with a cover sheet. In order to make it easier to remove the cover sheet from the adhesive layer a pull-thread is provided which passes through the cover sheet and has at least one free end that protrudes from the sealing strip.
摘要翻译：密封条旨在密封可相对于彼此移动的两个部件之间的间隙。密封条具有旨在粘附到两个部分之一并且具有粘合剂层的表面。在粘合到一个部分之前，粘合剂层被覆盖片覆盖。为了使粘合剂层更容易去除覆盖片，提供穿过覆盖片的拉线，并且具有从密封条突出的至少一个自由端。

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