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1. 发明授权

US09861442B2 Laser filler 有权
公开(公告)号：US09861442B2
公开(公告)日：2018-01-09
申请号：US14215057
申请日：2014-03-16
申请人： Nikolai Tankovich , Alexei Lukashev
发明人： Nikolai Tankovich , Alexei Lukashev
IPC分类号： A61B18/20 , A45D26/00 , A45D34/04 , A61M35/00 , A61B18/18 , A61B17/00 , A61B18/00 , A61N5/06 , A61N5/067
CPC分类号： A61B18/203 , A45D26/00 , A45D34/04 , A45D2026/009 , A61B18/1815 , A61B2017/00756 , A61B2018/00017 , A61B2018/0047 , A61B2018/00476 , A61B2018/202 , A61M35/00 , A61N2005/0644 , A61N2005/0659 , A61N2005/067
摘要： The present invention provides a laser system and laser handpiece and process for skin treatment. The system includes components for producing a continuous or pulse laser beam, and components for delivering a substance to the damaged region of skin. The system is designed to control and utilize the laser beam for damaging small volume of skin tissue and using a disposable tip to deliver a substance which is applied simultaneously or with some delay producing a combination of laser action with the action of named substance at the same time.

2. 发明申请

US20180147012A1 Dermatological Handpiece with Applicator Tip 审中-公开
公开(公告)号：US20180147012A1
公开(公告)日：2018-05-31
申请号：US15825102
申请日：2017-11-29
申请人： Nikolai Tankovich , Alexei Lukashev
发明人： Nikolai Tankovich , Alexei Lukashev
IPC分类号： A61B18/20 , A45D34/04 , A45D26/00 , A61N5/06 , A61M35/00 , A61B18/00 , A61B17/00 , A61B18/18 , A61N5/067
CPC分类号： A61B18/203 , A45D26/00 , A45D34/04 , A45D2026/009 , A61B18/1815 , A61B2017/00756 , A61B2018/00017 , A61B2018/0047 , A61B2018/00476 , A61B2018/202 , A61M35/00 , A61N2005/0644 , A61N2005/0659 , A61N2005/067
摘要： The present invention provides a laser system and laser handpiece and process for skin treatment. The system includes components for producing a continuous or pulse laser beam, and components for delivering a substance to the damaged region of skin. The system is designed to control and utilize the laser beam for damaging small volume of skin tissue and using a disposable tip to deliver a substance which is applied simultaneously or with some delay producing a combination of laser action with the action of a named substance at the same time.

3. 发明申请

US20150257828A1 LASER FILLER 审中-公开
标题翻译：激光灌装机
公开(公告)号：US20150257828A1
公开(公告)日：2015-09-17
申请号：US14215057
申请日：2014-03-16
申请人： NIKOLAI TANKOVICH , Alexei Lukashev
发明人： NIKOLAI TANKOVICH , Alexei Lukashev
IPC分类号： A61B18/20 , A61M35/00 , A45D40/18
CPC分类号： A61B18/203 , A45D26/00 , A45D34/04 , A45D2026/009 , A61B18/1815 , A61B2017/00756 , A61B2018/00017 , A61B2018/0047 , A61B2018/00476 , A61B2018/202 , A61M35/00 , A61N2005/0644 , A61N2005/0659 , A61N2005/067
摘要： The present invention provides a laser system and laser handpiece and process for skin treatment. The system includes components for producing a continuous or pulse laser beam, and components for delivering a substance to the damaged region of skin. The system is designed to control and utilize the laser beam for damaging small volume of skin tissue and using a disposable tip to deliver a substance which is applied simultaneously or with some delay producing a combination of laser action with the action of named substance at the same time.
摘要翻译：本发明提供了一种激光系统和激光手机以及用于皮肤治疗的方法。该系统包括用于产生连续或脉冲激光束的部件，以及用于将物质输送到皮肤受损区域的部件。该系统被设计为控制和利用激光束来损伤小体积的皮肤组织，并使用一次性尖端来递送同时施用或延迟产生激光作用与命名物质的作用相结合的物质时间。

4. 发明授权

US08932278B2 Skin treatment system with time modulated laser pulses 有权
标题翻译：具有时间调制激光脉冲的皮肤处理系统
公开(公告)号：US08932278B2
公开(公告)日：2015-01-13
申请号：US13199415
申请日：2011-08-29
申请人： Nikolai Tankovich , Alexei Lukashev
发明人： Nikolai Tankovich , Alexei Lukashev
IPC分类号： A61B18/20 , H01S3/113 , H01S3/067 , H01S3/16 , A61B18/00 , A61B18/22
CPC分类号： A61B18/203 , A61B18/20 , A61B18/22 , A61B2018/00029 , A61B2018/00452 , A61B2018/00458 , A61B2018/2035 , A61B2018/208 , H01S3/0675 , H01S3/113 , H01S3/1608
摘要： A laser skin treatment process and system. The system includes features for producing a first laser beam of long pulse duration and a second laser beam of short pulse duration and a skin cooler for cooling the surface of a region of skin. The system is designed to utilize the first laser beam for heating a volume of skin tissue below the cooled surface region to a temperature to produce skin tissue modification but below skin tissue damage threshold. This volume of skin tissue is called a “thermal cavity”. The second laser beam is divided into a plurality of separate laser beams that are directed through separate optical fibers and via separate paths through skin tissue to a single tiny volume of skin tissue within the thermal cavity to produce in that tiny volume mechanical damage. This tiny volume is called an energy droplet. Thus tiny regions of tissue are damaged while minimizing or preventing any significant damage to adjacent tissue.
摘要翻译：激光皮肤治疗过程和系统。该系统包括用于产生长脉冲持续时间的第一激光束和短脉冲持续时间的第二激光束以及用于冷却皮肤区域的表面的皮肤冷却器的特征。该系统被设计为利用第一激光束将一定体积的冷却表面区域下方的皮肤组织加热至产生皮肤组织修饰但低于皮肤组织损伤阈值的温度。这个体积的皮肤组织被称为“热腔”。第二激光束被分成多个单独的激光束，其被引导通过分开的光纤并且经由穿过皮肤组织的单独路径到达热腔内的单个微小体积的皮肤组织以产生微小体积的机械损伤。这个微小的体积被称为能量液滴。因此，在最小化或防止对相邻组织的任何显着损伤的同时损坏组织的微小区域。

5. 发明申请

US20140286910A1 STEM CELLS AND METHODS INCORPORATING ENVIRONMENTAL FACTORS AS A MEANS FOR ENHANCING STEM CELL PROLIFERATION AND PLASTICITY 审中-公开
标题翻译：包含环境因子的干细胞和方法作为增强干细胞增殖和塑性的手段
公开(公告)号：US20140286910A1
公开(公告)日：2014-09-25
申请号：US13847471
申请日：2013-03-19
申请人： NIKOLAI TANKOVICH , Alexandar Kharazi , Alexei Lukashev
发明人： NIKOLAI TANKOVICH , Alexandar Kharazi , Alexei Lukashev
IPC分类号： C12N5/0797
CPC分类号： C12N5/0623 , A61K35/28 , A61K35/34 , A61K35/36 , A61K35/51
摘要： Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension. The environmental factors and culture conditions of the invention produce stem cells having an enhanced therapeutic ability and enhanced proliferation in culture. Stem cells of the invention retain their plasticity through a higher number of cell passages relative to know methods of stem cell culture. The invention also contemplates the use of such stem cells in the treatment of neurodegenerative disorders including Alzheimer's disease and stroke.
摘要翻译：治疗干细胞及其使用和制造方法。干细胞在其中干细胞暴露于至少一种环境因素（包括氧压下降）的条件下产生。本发明的环境因素和培养条件产生具有增强的治疗能力和增强培养物增殖的干细胞。相对于已知的干细胞培养方法，本发明的干细胞通过更多数量的细胞通路保持其可塑性。本发明还考虑使用这种干细胞来治疗包括阿尔茨海默病和中风的神经变性疾病。

6. 发明申请

US20110313408A1 Skin treatement system with time modulated laser pulses 审中-公开
标题翻译：具有时间调制激光脉冲的皮肤处理系统
公开(公告)号：US20110313408A1
公开(公告)日：2011-12-22
申请号：US13199415
申请日：2011-08-29
申请人： Nikolai Tankovich , Alexei Lukashev
发明人： Nikolai Tankovich , Alexei Lukashev
IPC分类号： A61B18/22 , A61B18/20
CPC分类号： A61B18/203 , A61B18/20 , A61B18/22 , A61B2018/00029 , A61B2018/00452 , A61B2018/00458 , A61B2018/2035 , A61B2018/208 , H01S3/0675 , H01S3/113 , H01S3/1608
摘要： A laser skin treatment process and system. The system includes features for producing a first laser beam of long pulse duration and a second laser beam of short pulse duration and a skin cooler for cooling the surface of a region of skin. The system is designed to utilize the first laser beam for heating a volume of skin tissue below the cooled surface region to a temperature to produce skin tissue modification but below skin tissue damage threshold. This volume of skin tissue is called a “thermal cavity”. The second laser beam is divided into a plurality of separate laser beams that are directed through separate optical fibers and via separate paths through skin tissue to a single tiny volume of skin tissue within the thermal cavity to produce in that tiny volume mechanical damage. This tiny volume is called an energy droplet. Thus tiny regions of tissue are damaged while minimizing or preventing any significant damage to adjacent tissue.
摘要翻译：激光皮肤治疗过程和系统。该系统包括用于产生长脉冲持续时间的第一激光束和短脉冲持续时间的第二激光束以及用于冷却皮肤区域的表面的皮肤冷却器的特征。该系统被设计为利用第一激光束将一定体积的冷却表面区域下方的皮肤组织加热至产生皮肤组织修饰但低于皮肤组织损伤阈值的温度。这个体积的皮肤组织被称为“热腔”。第二激光束被分成多个单独的激光束，其被引导通过分开的光纤并且经由穿过皮肤组织的单独路径到达热腔内的单个微小体积的皮肤组织以产生微小体积的机械损伤。这个微小的体积被称为能量液滴。因此，在最小化或防止对相邻组织的任何显着损伤的同时损坏组织的微小区域。

7. 发明申请

US20060007965A1 Passive Q-switch modulated fiber laser 审中-公开
标题翻译：被动Q开关调制光纤激光器
公开(公告)号：US20060007965A1
公开(公告)日：2006-01-12
申请号：US10890076
申请日：2004-07-12
申请人： Nikolai Tankovich , Alexei Lukashev , Alexander Kirhanov , Valery Filippov , Andrei Staroovmov
发明人： Nikolai Tankovich , Alexei Lukashev , Alexander Kirhanov , Valery Filippov , Andrei Staroovmov
IPC分类号： H01S3/11 , H01S3/30
CPC分类号： H01S3/113 , A61B18/20 , H01S3/0675
摘要： An all-fiber erbium laser oscillating in a passive Q switched mode. The laser includes a crystal saturable absorber that may be Co2+:ZnSe or Cr2+:ZnSe. In preferred embodiments continuous pumping or short pulse pumping may be utilized. The laser is characterized by low threshold high-power, short-pulse generation. In preferred embodiments the threshold is only about 20 mW. The crystals are bleached at extremely low intensity, of about 0.8 kW/cm2 and provide moderate relaxation time of the excited state (290 μs) within a spectral range of about 1400-1800 nm. The simplicity of the design and low cost of that laser 2000).
摘要翻译：全光纤铒激光器以无源Q切换模式振荡。激光器包括可以是Co 2+，ZnSe或Cr 2+ 2+ ZnSe的晶体可饱和吸收体。在优选实施例中，可以使用连续泵送或短脉冲泵送。激光器的特点是低阈值大功率，短脉冲发生。在优选实施例中，阈值仅为约20mW。晶体以非常低的强度漂白，约0.8kW / cm 2，并且在约1400-1800nm的光谱范围内提供激发态（290μs）的适度弛豫时间。该设计的简单性和低成本的激光2000）。

8. 发明授权

US10624700B2 Acccessory for electromagnetic handpiece 有权
公开(公告)号：US10624700B2
公开(公告)日：2020-04-21
申请号：US16230961
申请日：2018-12-21
申请人： Nikolai Tankovich , Alexei Lukashev
发明人： Nikolai Tankovich , Alexei Lukashev
IPC分类号： A61B18/20 , A45D26/00 , A45D34/04 , A61M35/00 , A61B18/18 , A61B17/00 , A61B18/00 , A61N5/06 , A61N5/067
CPC分类号： A61B18/203 , A45D26/00 , A45D34/04 , A45D2026/009 , A61B18/1815 , A61B2017/00756 , A61B2018/00017 , A61B2018/0047 , A61B2018/00476 , A61B2018/2023 , A61B2018/2035 , A61M35/00 , A61N2005/067 , A61N2005/0644 , A61N2005/0659
摘要： The present invention provides a laser system and laser handpiece and process for skin treatment. The system includes components for producing a continuous or pulse laser beam, and components for delivering a substance to the damaged region of skin. The system is designed to control and utilize the laser beam for damaging small volume of skin tissue and using a disposable tip to deliver a substance which is applied simultaneously or with some delay producing a combination of laser action with the action of a named substance at the same time.

9. 发明授权

US10206743B2 Dermatological Handpiece with Applicator Tip 有权
公开(公告)号：US10206743B2
公开(公告)日：2019-02-19
申请号：US15825102
申请日：2017-11-29
申请人： Nikolai Tankovich , Alexei Lukashev
发明人： Nikolai Tankovich , Alexei Lukashev
IPC分类号： A61B18/20 , A45D26/00 , A45D34/04 , A61M35/00 , A61B18/18 , A61B17/00 , A61B18/00 , A61N5/06 , A61N5/067
摘要： The present invention provides a laser system and laser handpiece and process for skin treatment. The system includes components for producing a continuous or pulse laser beam, and components for delivering a substance to the damaged region of skin. The system is designed to control and utilize the laser beam for damaging small volume of skin tissue and using a disposable tip to deliver a substance which is applied simultaneously or with some delay producing a combination of laser action with the action of a named substance at the same time.

10. 发明申请

US20160143950A1 STEM CELLS AND STEM CELL FACTORS FOR INHIBITING THE PROGRESSION OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：干细胞和干细胞因子抑制阿尔茨海默病的进展
公开(公告)号：US20160143950A1
公开(公告)日：2016-05-26
申请号：US14138078
申请日：2013-12-22
申请人： NIKOLAI TANKOVICH , Alexander Kharazi , Alexei Lukashev , Yuri Kudinov
发明人： NIKOLAI TANKOVICH , Alexander Kharazi , Alexei Lukashev , Yuri Kudinov
IPC分类号： A61K35/28
CPC分类号： A61K35/28 , C12N5/0663 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , G01N33/68 , G01N2333/4709 , G01N2800/2821
摘要： Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension. The environmental factors and culture conditions of the invention produce stem cells having an enhanced therapeutic ability and enhanced proliferation in culture. Stem cells of the invention retain their plasticity through a higher number of cell passages relative to know methods of stem cell culture. The invention also contemplates the use of such stem cells in the treatment of neurodegenerative disorders including Alzheimer's disease and stroke.
摘要翻译：治疗干细胞及其使用和制造方法。干细胞在其中干细胞暴露于至少一种环境因素（包括氧压下降）的条件下产生。本发明的环境因素和培养条件产生具有增强的治疗能力和增强培养物增殖的干细胞。相对于已知的干细胞培养方法，本发明的干细胞通过更多数量的细胞通路保持其可塑性。本发明还考虑使用这种干细胞来治疗包括阿尔茨海默病和中风的神经变性疾病。

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