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1. 发明授权

US09915667B2 Methods and means for diagnosing vasculitis 有权
公开(公告)号：US09915667B2
公开(公告)日：2018-03-13
申请号：US13981956
申请日：2012-01-27
申请人： Torsten Witte , Niklas Thomas Baerlecken
发明人： Torsten Witte , Niklas Thomas Baerlecken
IPC分类号： G01N33/564 , G01N33/68 , A61K39/00 , C07K16/44
CPC分类号： G01N33/6893 , A61K39/0008 , C07K16/44 , G01N33/564 , G01N2800/101 , G01N2800/328 , G01N2800/50 , G01N2800/52
摘要： Provided herein are methods for diagnosing the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like giant-cell arteritis (GCA), polymyalgia rheumatica (PMR), and Takayasu's arteritis, in a subject analyzing for the presence of antibodies against ferritin, in particular heavy chain ferritin or immunoreactive peptides thereof or ferritin analog protein, preferably bacterial ferritin analog protein, or immunoreactive peptides thereof, in a subject. In addition, test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject are also provided.

2. 发明授权

US09915664B2 Methods and means for diagnosing spondylarthritis using autoantibody markers 有权
公开(公告)号：US09915664B2
公开(公告)日：2018-03-13
申请号：US13816962
申请日：2011-08-16
申请人： Niklas Thomas Baerlecken , Torsten Witte
发明人： Niklas Thomas Baerlecken , Torsten Witte
IPC分类号： G01N33/68 , C12Q1/48 , G01N33/564 , A61K38/45
CPC分类号： G01N33/6854 , A61K38/45 , C12Q1/485 , C12Y207/1101 , G01N33/564 , G01N2333/70596 , G01N2800/102 , G01N2800/105 , G01N2800/50
摘要： The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject analysing for the presence of autoantibodies against CD74 and/or IKBKB in a subject. The presence of autoantibodies against CD74 and/or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and/or IKBKB allows early diagnosis of Spa, in particular, AS and undifferentiated spondyloarthritis.

3. 发明申请

US20130203088A1 METHODS AND MEANS FOR DIAGNOSING SPONDYLARTHRITIS USING AUTOANTIBODY MARKERS 有权
标题翻译：使用自动识别标记诊断心律失常的方法和手段
公开(公告)号：US20130203088A1
公开(公告)日：2013-08-08
申请号：US13816962
申请日：2011-08-16
申请人： Niklas Thomas Baerlecken , Torsten Witte
发明人： Niklas Thomas Baerlecken , Torsten Witte
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , A61K38/45 , C12Q1/485 , C12Y207/1101 , G01N33/564 , G01N2333/70596 , G01N2800/102 , G01N2800/105 , G01N2800/50
摘要： The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject analysing for the presence of autoantibodies against CD74 and/or IKBKB in a subject. The presence of autoantibodies against CD74 and/or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and/or IKBKB allows early diagnosis of Spa, in particular, AS and undifferentiated spondyloarthritis.
摘要翻译：本发明一般涉及用于诊断受试者，特别是哺乳动物的脊柱关节炎（Spa），特别是强直性脊柱炎（AS）和未分化脊椎关节炎的发展的存在或风险或治疗控制的方法。此外，本发明涉及用于诊断受试者中存在或发展风险的治疗试剂盒，或用于SPA的治疗控制，如AS和未分化的脊椎关节炎。特别地，本发明涉及一种用于分析在针对CD74和/或IKBKB的自身抗体存在的受试者中用于诊断发展的存在或风险或用于SPA的治疗控制（如AS和未分化脊柱关节炎）的方法课程。针对CD74和/或IKBKB的自身抗体的存在表明存在或发展的风险，或用于SPA的治疗控制，如AS和未分化的脊柱关节炎。特别地，检测针对CD74和/或IKBKB的自身抗体的存在允许Spa的早期诊断，特别是AS和未分化的脊柱关节炎。

4. 发明授权

US11199549B2 MEl'hods and means for diagnosing spondylarthritis using autoantibody markers 有权
公开(公告)号：US11199549B2
公开(公告)日：2021-12-14
申请号：US15883126
申请日：2018-01-30
申请人： Niklas Thomas Baerlecken , Torsten Witte
发明人： Niklas Thomas Baerlecken , Torsten Witte
IPC分类号： G01N33/564 , G01N33/68 , C12Q1/48 , A61K38/45
摘要： The present invention relates generally to methods for diagnosing the presence or the risk of development or the therapy control of spondyloarthritis (Spa), in particular, of ankylosing spondylitis (AS) and undifferentiated spondyloarthritis in a subject, in particular in mammals. In addition, the present invention relates to test kits for use in the diaposis of the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis, it a subject analysing for the presence of autoantibodies against CD74 and/or IKBKB in a subject. The presence of autoantibodies against CD74 and/or IKBKB is indicative for the presence or the risk of development, or for the therapy control of Spa, like AS and undifferentiated spondyloarthritis. In particular, detection of the presence of autoantibodies against CD74 and/or IKBKB allows early diagnostic of Spa, in particular, AS and undifferentiated spondyloarthritis.

5. 发明申请

US20130310273A1 Methods and Means for Diagnosing Vasculitis 有权
标题翻译：诊断血管炎的方法和手段
公开(公告)号：US20130310273A1
公开(公告)日：2013-11-21
申请号：US13981956
申请日：2012-01-27
申请人： Torsten Witte , Niklas Thomas Baerlecken
发明人： Torsten Witte , Niklas Thomas Baerlecken
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , A61K39/0008 , C07K16/44 , G01N33/564 , G01N2800/101 , G01N2800/328 , G01N2800/50 , G01N2800/52
摘要： The present inventions relates generally to methods for diagnosing the presence or the risk of development or the therapy control of vasculitis, in particular, of large vessel vasculitis, like giant-cell arteritis (GCA), polymyalgia rheumatica (PMR) and Takayasu's arteritis in a subject, in particular, in mammals. In addition, the present invention relates to test kits for use in the diagnosis of the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject. In particular, the present invention relates to a method for diagnosing the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis, in a subject analyzing for the presence of antibodies against ferritin, in particular heavy chain ferritin or immunoreactive peptides thereof or ferritin analog protein, preferably bacterial ferritin analog protein, or immunoreactive peptides thereof, in a subject. The presence of antibodies against ferritin or immunoreactive peptides thereof is indicative for the presence or the risk of development, or for the therapy control of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis. In particular, detection of the presence of antibodies against ferritin or immunoreactive peptides thereof, allows early diagnosis of vasculitis, in particular of large vessel vasculitis, like GCA, PMR and Takayasu's arteritis.
摘要翻译：本发明一般涉及用于诊断血管炎的存在或风险或治疗控制的方法，特别是大血管血管炎，如巨细胞动脉炎（GCA），风湿综合征（PMR）和Takayasu的动脉炎主题，特别是哺乳动物。此外，本发明涉及用于诊断存在或发展风险的检测试剂盒，或用于在受试者中诊断血管炎，特别是大血管血管炎（如GCA，PMR和Takayasu的动脉炎）的治疗控制。特别地，本发明涉及用于诊断存在或风险的方法，或用于治疗血管炎，特别是大血管血管炎，如GCA，PMR和Takayasu的动脉炎的治疗控制方法，抗体，特别是重链铁蛋白或其免疫反应性肽或铁蛋白类似蛋白，优选细菌铁蛋白类似物蛋白或其免疫反应性肽。针对铁蛋白或其免疫反应性肽的抗体的存在指示存在或发展的风险，或用于治疗血管炎，特别是大血管血管炎如GCA，PMR和Takayasu的动脉炎的治疗控制。特别地，检测抗铁蛋白或其免疫反应性肽的抗体的存在允许血管炎，特别是大血管血管炎如GCA，PMR和Takayasu的动脉炎的早期诊断。

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