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1. 发明授权

US10709449B2 Systems and methods for variable stiffness tethers 有权
公开(公告)号：US10709449B2
公开(公告)日：2020-07-14
申请号：US14000177
申请日：2012-02-17
申请人： Niel F. Starksen , Joe Eder
发明人： Niel F. Starksen , Joe Eder
IPC分类号： A61B5/00 , A61B17/08 , A61M25/00 , A61M25/09
摘要： Described herein are devices and methods for guide elements configured with variable stiffness, with one or more flexible portions and one or more stiff portions. The flexible portion is be used as a tensioning element of a cinchable implant to tighten or compress tissues while the stiff portion is used to facilitate the insertion or withdrawal of portions of the implant or instruments acting on the implant. The guide element is further configured to be separated or severed between the flexible and stiff portions so that a flexible portion is left within the body as part of the implant, while the stiff portion is withdrawn from the body after implantation is completed.

2. 发明申请

US20140155783A1 SYSTEMS AND METHODS FOR VARIABLE STIFFNESS TETHERS 审中-公开
标题翻译：系统和方法适用于变形刚度
公开(公告)号：US20140155783A1
公开(公告)日：2014-06-05
申请号：US14000177
申请日：2012-02-17
申请人： Niel F. Starksen , Joe Eder
发明人： Niel F. Starksen , Joe Eder
IPC分类号： A61B17/08 , A61M25/09
摘要： Described herein are devices and methods for guide elements configured with variable stiffness, with one or more flexible portions and one or more stiff portions. The flexible portion is be used as a tensioning element of a cinchable implant to tighten or compress tissues while the stiff portion is used to facilitate the insertion or withdrawal of portions of the implant or instruments acting on the implant. The guide element is further configured to be separated or severed between the flexible and stiff portions so that a flexible portion is left within the body as part of the implant, while the stiff portion is withdrawn from the body after implantation is completed.
摘要翻译：这里描述的是用于具有可变刚度的导向元件的装置和方法，具有一个或多个柔性部分和一个或多个刚性部分。柔性部分可用作可固定植入物的张紧元件，以紧固或压缩组织，而刚性部分用于促进植入物或作用在植入物上的器械的部分的插入或取出。引导元件进一步构造成在柔性部分和刚性部分之间被分离或切断，使得柔性部分作为植入物的一部分留在身体内部，而在植入完成之后刚性部分从身体中撤出。

3. 发明授权

US09125632B2 Systems and methods for cardiac remodeling 有权
标题翻译：心脏重塑的系统和方法
公开(公告)号：US09125632B2
公开(公告)日：2015-09-08
申请号：US12253792
申请日：2008-10-17
申请人： Didier Loulmet , Niel F. Starksen , Mariel Fabro , Eugene Serina
发明人： Didier Loulmet , Niel F. Starksen , Mariel Fabro , Eugene Serina
IPC分类号： A61F2/24 , A61B17/00 , A61B17/04 , A61B17/064
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B2017/00243 , A61B2017/00783 , A61B2017/0414 , A61B2017/0496 , A61F2/2445 , A61F2/2481 , A61F2/2487
摘要： Described herein are devices and methods for improving the hemodynamic function of a patient. In particular, a first device adapted to reshape an atrio-ventricular valve is used in combination with a second device configured to further alter the blood flow through the valve. The first device is typically an implant positioned in the subvalvular space of a ventricle. The second device may be an annuloplasty implant, a non-annulus valve apparatus implant, a ventriculoplasty implant, or a cardiac rhythm management device.
摘要翻译：本文描述了用于改善患者的血液动力学功能的装置和方法。特别地，适于重新形成心室瓣膜的第一装置与被配置为进一步改变通过所述瓣膜的血液流动的第二装置组合使用。第一装置通常是定位在心室的瓣膜下空间的植入物。第二装置可以是瓣环成形植入物，非环形瓣膜装置植入物，心室成形术植入物或心律管理装置。

4. 发明授权

US07753922B2 Devices and methods for cardiac annulus stabilization and treatment 有权
标题翻译：用于心脏瓣环稳定和治疗的装置和方法
公开(公告)号：US07753922B2
公开(公告)日：2010-07-13
申请号：US10656797
申请日：2003-09-04
申请人： Niel F. Starksen
发明人： Niel F. Starksen
IPC分类号： A61B17/04
CPC分类号： A61F2/2445 , A61F2/2451 , A61F2/2466
摘要： Devices and methods generally provide enhanced stabilization, exposure and/or treatment of a cardiac valve annulus. Methods generally involve introducing a stabilizing member beneath one or more leaflets of a heart valve to engage the annulus at an intersection between the leaflets and the interior ventricular wall of the heart. Force is then applied to the stabilizing member to stabilize and/or expose the valve annulus. In some embodiments, the stabilizing member may include a series of hydraulically driven tethered anchors, such as hooks or clips, for engaging and cinching valve annulus tissue to decrease the diameter of a regurgitant valve. Alternatively, other treatments may be delivered by a stabilizing member, such as radiofrequency energy, drugs, bulking agents or shape memory stents. A second stabilizing member may also be introduced above the leaflets for further stabilization.
摘要翻译：装置和方法通常提供增强的心脏瓣膜环的稳定，暴露和/或治疗。方法通常包括在心脏瓣膜的一个或多个小叶下方引入稳定构件，以在瓣膜和心脏的室内心室壁之间的交叉处接合环状物。然后将力施加到稳定构件以使阀环稳定和/或暴露。在一些实施例中，稳定构件可以包括一系列液压驱动的栓系锚，例如钩或夹子，用于接合和收紧瓣膜环组织以减小反流阀的直径。或者，其他治疗可以由稳定构件例如射频能量，药物，填充剂或形状记忆支架递送。还可以在传单上方引入第二稳定构件以进一步稳定。

5. 发明申请

US20100082098A1 DELIVERY DEVICES AND METHODS FOR HEART VALVE REPAIR 审中-公开
标题翻译：输送装置和心脏瓣膜修复方法
公开(公告)号：US20100082098A1
公开(公告)日：2010-04-01
申请号：US12581040
申请日：2009-10-16
申请人： Niel F. Starksen , John To , Mariel Fabro , Michael F. Wei , Rodolfo A. Morales
发明人： Niel F. Starksen , John To , Mariel Fabro , Michael F. Wei , Rodolfo A. Morales
IPC分类号： A61F2/24
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B17/072 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0437 , A61B2017/0464 , A61B2017/0496 , A61B2017/07221 , A61B2017/2905 , A61F2/2445 , A61M2025/0096
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.
摘要翻译：装置，系统和方法便于心脏瓣膜环空处理装置的定位，从而增强环空处理。方法通常包括将锚定器输送装置通过患者的脉管系统推进到心脏中的一个位置处理瓣膜环，使锚定器输送装置与一段长度的瓣膜环接触，将多个耦合的锚固件从锚定器输送装置输送到将锚固件固定到环形空间，并将锚固件拉紧在一起以周向地紧固阀环。装置通常包括具有至少一个张紧构件和至少一个张紧致动器的细长导管，用于使导管的远端部分变形以帮助其符合瓣膜环。导管装置可用于导航二尖瓣下方的子宫下空间，以便锚定器输送装置的定位。

6. 发明申请

US20080243150A1 DELIVERY DEVICES AND METHODS FOR HEART VALVE REPAIR 审中-公开
公开(公告)号：US20080243150A1
公开(公告)日：2008-10-02
申请号：US12133306
申请日：2008-06-04
申请人： Niel F. Starksen , John To , Mariel Fabro , Michael F. Wei , Rodolfo A. Morales
发明人： Niel F. Starksen , John To , Mariel Fabro , Michael F. Wei , Rodolfo A. Morales
IPC分类号： A61B17/08
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.

7. 发明申请

US20080234704A1 DELIVERY DEVICES AND METHODS FOR HEART VALVE REPAIR 有权
标题翻译：输送装置和心脏瓣膜修复方法
公开(公告)号：US20080234704A1
公开(公告)日：2008-09-25
申请号：US12133319
申请日：2008-06-04
申请人： Niel F. Starksen , John To , Mariel Fabro , Michael F. Wei , Rodolfo A. Morales
发明人： Niel F. Starksen , John To , Mariel Fabro , Michael F. Wei , Rodolfo A. Morales
IPC分类号： A61B17/08
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.
摘要翻译：装置，系统和方法便于心脏瓣膜环空处理装置的定位，从而增强环空处理。方法通常包括将锚定器输送装置通过患者的脉管系统推进到心脏中的一个位置处理瓣膜环，使锚定器输送装置与一段长度的瓣膜环接触，将多个耦合的锚固件从锚定器输送装置输送到将锚固件固定到环形空间，并将锚固件拉紧在一起以周向地紧固阀环。装置通常包括具有至少一个张紧构件和至少一个张紧致动器的细长导管，用于使导管的远端部分变形以帮助其符合瓣膜环。导管装置可用于导航二尖瓣下方的子宫下空间，以便锚定器输送装置的定位。

8. 发明授权

US09226825B2 Delivery devices and methods for heart valve repair 有权
公开(公告)号：US09226825B2
公开(公告)日：2016-01-05
申请号：US10901554
申请日：2004-07-27
申请人： Niel F. Starksen , John To , Mariel Fabro , Michael F. Wei , Rodolfo A. Morales
发明人： Niel F. Starksen , John To , Mariel Fabro , Michael F. Wei , Rodolfo A. Morales
IPC分类号： A61F2/24 , A61B17/00 , A61B17/04 , A61B17/064 , A61B17/068 , A61B17/29
CPC分类号： A61F2/2436 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0496 , A61B2017/2905 , A61F2/2427 , A61F2/2442 , A61F2/2445 , A61F2/2454 , A61F2/2466
摘要： Devices, systems and methods facilitate positioning of a cardiac valve annulus treatment device, thus enhancing treatment of the annulus. Methods generally involve advancing an anchor delivery device through vasculature of the patient to a location in the heart for treating the valve annulus, contacting the anchor delivery device with a length of the valve annulus, delivering a plurality of coupled anchors from the anchor delivery device to secure the anchors to the annulus, and drawing the anchors together to circumferentially tighten the valve annulus. Devices generally include an elongate catheter having at least one tensioning member and at least one tensioning actuator for deforming a distal portion of the catheter to help it conform to a valve annulus. The catheter device may be used to navigate a subannular space below a mitral valve to facilitate positioning of an anchor delivery device.

9. 发明授权

US08066766B2 Methods and devices for termination 有权
标题翻译：终止方法和设备
公开(公告)号：US08066766B2
公开(公告)日：2011-11-29
申请号：US11894530
申请日：2007-08-20
申请人： John To , Niel F. Starksen , Tenny C. Calhoun , Brian Tang
发明人： John To , Niel F. Starksen , Tenny C. Calhoun , Brian Tang
IPC分类号： A61F2/24
CPC分类号： A61B17/0487 , A61B17/00234 , A61B17/0401 , A61B17/0467 , A61B17/0469 , A61B17/0485 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B17/1285 , A61B2017/00243 , A61B2017/00783 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0443 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0462 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , A61B2017/06176 , A61F2/2445
摘要： Devices and methods used in termination of a tissue tightening procedure are described. Termination includes the cinching of a tether to tighten the tissue, locking the tether to maintain tension, and cutting excess tether. In procedures involving anchors secured to the tissue, the tether is coupled to the anchors and the tissue is tightened via tension applied to the anchors by cinching the tether. In general, the devices and methods can be used in minimally invasive surgical procedures, and can be applied through small incisions or intravascularly. A method for tightening tissue by fixedly coupling a first anchor to a tether and slidably coupling a second anchor to the tether, securing both anchors to the tissue, applying tension to the tether intravascularly, fixedly coupling the tether to the second anchor, and cutting the tether is described. The tissue to be tightened can comprise heart tissue, in particular heart valve annulus tissue. Various devices and methods for locking the tether in place and cutting excess tether are described.
摘要翻译：描述用于终止组织紧固程序的装置和方法。终止包括收紧系绳以收紧组织，锁定系绳以保持张力，并切割多余的系绳。在涉及固定到组织上的锚固件的过程中，系绳联接到锚固件上，并且组织通过紧固锚固件而被施加到锚固件上的张紧而被紧固。通常，这些装置和方法可用于微创外科手术，并可通过小切口或血管内应用。一种通过将第一锚定器固定地连接到系绳并将第二锚固件可滑动地联接到系绳来紧固组织的方法，将两个锚固件固定到组织上，将血管内的系绳施加张力，将系绳固定地连接到第二锚定器，并切割系绳被描述。待紧固的组织可以包括心脏组织，特别是心脏瓣膜环形组织。描述了将系绳锁定就位并切割多余系绳的各种装置和方法。

10. 发明申请

US20110160528A1 DEVICES AND METHODS FOR CARDIAC ANNULUS STABILIZATION AND TREATMENT 审中-公开
标题翻译：心脏稳定和治疗的装置和方法
公开(公告)号：US20110160528A1
公开(公告)日：2011-06-30
申请号：US13042369
申请日：2011-03-07
申请人： Niel F. Starksen
发明人： Niel F. Starksen
IPC分类号： A61B17/00
CPC分类号： A61F2/2445 , A61F2/2451 , A61F2/2466
摘要： Devices and methods generally provide enhanced stabilization, exposure and/or treatment of a cardiac valve annulus. Methods generally involve introducing a stabilizing member beneath one or more leaflets of a heart valve to engage the annulus at an intersection between the leaflets and the interior ventricular wall of the heart. Force is then applied to the stabilizing member to stabilize and/or expose the valve annulus. In some embodiments, the stabilizing member may include a series of hydraulically driven tethered anchors, such as hooks or clips, for engaging and cinching valve annulus tissue to decrease the diameter of a regurgitant valve. Alternatively, other treatments may be delivered by a stabilizing member, such as radiofrequency energy, drugs, bulking agents or shape memory stents. A second stabilizing member may also be introduced above the leaflets for further stabilization.
摘要翻译：装置和方法通常提供增强的心脏瓣膜环的稳定，暴露和/或治疗。方法通常包括在心脏瓣膜的一个或多个小叶下方引入稳定构件，以在瓣膜和心脏的室内心室壁之间的交叉处接合环状物。然后将力施加到稳定构件以使阀环稳定和/或暴露。在一些实施例中，稳定构件可以包括一系列液压驱动的栓系锚，例如钩或夹子，用于接合和收紧瓣膜环组织以减小反流阀的直径。或者，其他治疗可以由稳定构件例如射频能量，药物，填充剂或形状记忆支架递送。还可以在传单上方引入第二稳定构件以进一步稳定。

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