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1. 发明申请

US20120122891A1 GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO 有权
标题翻译：促性腺激素释放激素受体拮抗剂及其相关方法
公开(公告)号：US20120122891A1
公开(公告)日：2012-05-17
申请号：US13293943
申请日：2011-11-10
申请人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Richard Lowe , Willy Moree , Nicole Smith , Warren Wade , Liren Zhao , Yun-Fei Zhu , Martin Rowbottom , Neil Ashweek
发明人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Richard Lowe , Willy Moree , Nicole Smith , Warren Wade , Liren Zhao , Yun-Fei Zhu , Martin Rowbottom , Neil Ashweek
IPC分类号： A61K31/519 , C07D471/04 , C07D495/04 , A61K31/513 , A61K31/4375 , A61P13/02 , A61P5/08 , A61P17/00 , A61P15/08 , A61P1/00 , A61P35/00 , C07D239/36 , A61P15/00
CPC分类号： C07D495/04 , C07C233/88 , C07C235/42 , C07C255/57 , C07D213/56 , C07D213/58 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/14 , C07D215/54 , C07D239/36 , C07D401/04 , C07D401/12 , C07D413/12 , C07D417/12
摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
摘要翻译：公开了GnRH受体拮抗剂，其可用于治疗男性和女性中各种性激素相关病症。本发明的化合物具有以下结构：其中R1a，R1b，R1c，R1d，R2，R2a和A如本文所定义，包括其立体异构体，酯，溶剂化物和药学上可接受的盐。还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中拮抗促性腺激素释放激素的方法。

2. 发明授权

US08084614B2 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto 有权
标题翻译：促性腺激素释放激素受体拮抗剂及其相关方法
公开(公告)号：US08084614B2
公开(公告)日：2011-12-27
申请号：US12594809
申请日：2008-04-04
申请人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Richard Lowe , Willy Moree , Nicole Smith , Warren Wade , Liren Zhao , Yun-fei Zhu , Martin Rowbottom , Neil Ashweek
发明人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Richard Lowe , Willy Moree , Nicole Smith , Warren Wade , Liren Zhao , Yun-fei Zhu , Martin Rowbottom , Neil Ashweek
IPC分类号： C07D213/00 , C07D211/70 , C07D233/00 , A61K31/44
CPC分类号： C07D495/04 , C07C233/88 , C07C235/42 , C07C255/57 , C07D213/56 , C07D213/58 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/14 , C07D215/54 , C07D239/36 , C07D401/04 , C07D401/12 , C07D413/12 , C07D417/12
摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
摘要翻译：公开了GnRH受体拮抗剂，其可用于治疗男性和女性中各种性激素相关病症。本发明的化合物具有以下结构，其中R1a，R1b，R1c，R1d，R2，R2a和A如本文所定义，包括其立体异构体，酯，溶剂合物及其药学上可接受的盐。还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中拮抗促性腺激素释放激素的方法。

3. 发明申请

US20070212965A1 SCRUB PAD WITH PRINTED RIGID PLATES AND ASSOCIATED METHODS 审中-公开
标题翻译：具有印刷刚性板的SCRUB PAD和相关方法
公开(公告)号：US20070212965A1
公开(公告)日：2007-09-13
申请号：US11748941
申请日：2007-05-15
申请人： Nicole Smith , Young Kim , Hong Ji , Young Kim
发明人： Nicole Smith , Young Kim , Hong Ji , Young Kim
IPC分类号： B32B5/18 , B32B5/22
CPC分类号： B32B5/26 , A41D31/245 , A45D2200/1018 , A45D2200/1054 , A45D2200/1063 , A47L13/16 , A47L23/266 , B32B3/08 , B32B2038/0076 , B32B2305/18 , B32B2307/554 , D06N3/183 , D06N3/186 , D06N7/0092 , D06N2201/02 , D06N2201/042 , D06N2203/041 , D06N2205/04 , D06N2205/20 , F41H5/0492 , Y10T442/3325 , Y10T442/3472 , Y10T442/3846
摘要： The invention relates to a flexible scrubbing material that combines at least two discrete components. One component is a continuous flexible substrate. A second component is a discontinuous abrasive layer affixed to the flexible substrate. The abrasive layer is a set of plates formed from a material different than the continuous flexible substrate. One or two flexible substrates with affixed plates can be combined with an intermediate layer such as sponge or terry cloth. The gaps between plates are relatively large and are generally larger than one-third the largest plate dimension. The flexible substrate can be tightly woven fabric that can be printed with visually attractive colors, patterns and images. The plate material is a printable material that subsequently solidifies, such as epoxy. The inventions include associated methods of use and manufacture.
摘要翻译：本发明涉及组合至少两个分立组件的柔性洗涤材料。一个组件是连续的柔性基板。第二组分是固定在柔性基底上的不连续磨料层。研磨层是由不同于连续柔性基底的材料形成的一组板。具有固定板的一个或两个柔性基底可以与诸如海绵或毛圈布之类的中间层组合。板之间的间隙相对较大并且通常大于最大板尺寸的三分之一。柔性基底可以是可以用视觉吸引人的颜色，图案和图像打印的紧密织物。板材是随后固化的可印刷材料，例如环氧树脂。本发明包括相关的使用和制造方法。

4. 发明授权

US08481738B2 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto 有权
公开(公告)号：US08481738B2
公开(公告)日：2013-07-09
申请号：US13293943
申请日：2011-11-10
申请人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Richard Lowe , Willy Moree , Nicole Smith , Warren Wade , Liren Zhao , Yun-fei Zhu , Martin Rowbottom , Neil Ashweek
发明人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Richard Lowe , Willy Moree , Nicole Smith , Warren Wade , Liren Zhao , Yun-fei Zhu , Martin Rowbottom , Neil Ashweek
IPC分类号： C07D513/02 , C07D401/00
CPC分类号： C07D495/04 , C07C233/88 , C07C235/42 , C07C255/57 , C07D213/56 , C07D213/58 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/14 , C07D215/54 , C07D239/36 , C07D401/04 , C07D401/12 , C07D413/12 , C07D417/12
摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

5. 发明申请

US20090007313A1 CUT, ABRASION AND/OR PUNCTURE RESISTANT KNITTED GLOVES 审中-公开
标题翻译：切割，磨损和/或抗针刺针织手套
公开(公告)号：US20090007313A1
公开(公告)日：2009-01-08
申请号：US12134862
申请日：2008-06-06
申请人： Jim Boorsma , Nicole Smith
发明人： Jim Boorsma , Nicole Smith
IPC分类号： A41D19/00 , A41D19/015 , A41D19/02 , D04B7/34
CPC分类号： A41D19/01505 , A41D19/04 , A41D2500/10
摘要： An improved protective knitted glove assembly includes a knitted glove and two or more non-coplanar arrays of printed guard plates. The guard plates are small, regularly-spaced, generally uniform thickness, non-overlapping, hard polymer material members arranged in a predetermined pattern having an area parallel to a surface of the glove with major and minor dimensions. The major dimension to minor dimension aspect ratio of the guard plates is between about 3 and 1. The overall abrasion resistance of the glove assembly is substantially greater than an abrasion resistance of the knitted glove without the guard plates.
摘要翻译：一种改进的防护针织手套组件包括编织手套和两个或更多个非共面阵列的印刷防护板。保护板是具有平行于具有主要和次要尺寸的手套的表面的面积的预定图案布置的小的，规则间隔的，大致均匀的厚度，非重叠的硬质聚合物材料构件。防护板的小尺寸纵横比的主要尺寸在约3和1之间。手套组件的总体耐磨性显着大于没有防护板的针织手套的耐磨性。

6. 发明授权

US07018692B2 Penetration resistant fabric with multiple layer guard plate assemblies and method of making the same 有权
公开(公告)号：US07018692B2
公开(公告)日：2006-03-28
申请号：US10036740
申请日：2001-12-31
申请人： Young-Hwa Kim , Nicole Smith , Hong Ji
发明人： Young-Hwa Kim , Nicole Smith , Hong Ji
IPC分类号： B32B3/14 , B32B3/16 , B32B3/06 , B32B9/00 , B32B5/12 , B32B3/00 , B32B27/04 , B32B27/12 , B32B5/02
CPC分类号： F41H5/0492 , A41D31/0061 , B32B3/08 , B32B3/16 , B32B2037/243 , B32B2038/0076 , B32B2305/18 , B32B2307/554 , B32B2307/581 , D06N3/183 , D06N2209/1685 , Y10S428/911 , Y10T428/168 , Y10T428/24041 , Y10T428/24752 , Y10T428/2476 , Y10T442/2057 , Y10T442/2098 , Y10T442/2615 , Y10T442/2623 , Y10T442/273
摘要： A fabric includes a fabric substrate and a plurality guard plate assemblies affixed to the fabric substrate in a spaced relationship to each other. Each guard plate assembly includes a first layer of material affixed to the fabric substrate and a second layer of material joined to the first layer of material on a surface opposite the fabric substrate. The second layer of material has characteristics different than the first layer of material and are chosen commonly to meet the demands of the application to which the fabric is designed.

7. 发明授权

US11898125B2 Composition for an organic cleaning product 有权
公开(公告)号：US11898125B2
公开(公告)日：2024-02-13
申请号：US17307775
申请日：2021-05-04
申请人： Nicole Smith
发明人： Nicole Smith
IPC分类号： C11D3/382 , C11D3/50 , C11D7/08 , C11D9/16 , C11D9/00 , C11D11/00 , C11D9/38 , C11D9/26
CPC分类号： C11D9/002 , C11D9/16 , C11D9/26 , C11D9/38 , C11D11/0023 , C11D11/0064
摘要： A natural cleaning product which does not contain any harsh chemicals or toxins. Specifically, the cleaning product is based on borax and yucca plant products. A composition for an organic cleaning product comprises distilled water; borax; distilled white vinegar; yucca root soap; and optionally, lavender essential oil, peppermint essential oil; and eucalyptus. Also disclosed is a process for the production of yucca root soap which is used in producing the organic cleaning product of the invention.

8. 发明申请

US20100152207A1 GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO 有权
标题翻译：促性腺激素释放激素受体拮抗剂及其相关方法
公开(公告)号：US20100152207A1
公开(公告)日：2010-06-17
申请号：US12594809
申请日：2008-04-04
申请人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Willy Moree , Martin Rowbottom , Warren Wade , Liren Zhao , Richard Lowe , Nicole Smith , Neil Ashweek , Yun-Fei Zhu
发明人： Graham Beaton , Mi Chen , Timothy Richard Coon , Todd Ewing , Wanlong Jiang , Willy Moree , Martin Rowbottom , Warren Wade , Liren Zhao , Richard Lowe , Nicole Smith , Neil Ashweek , Yun-Fei Zhu
IPC分类号： A61K31/519 , C07D213/56 , A61K31/4418 , C07D215/38 , A61K31/47 , C07D495/04 , C07C233/67 , A61K31/165 , C07D213/84 , A61K31/44 , C07D401/04 , A61K31/4439 , C07D213/62 , C07D239/02 , A61K31/505 , C07D401/12 , C07D413/12 , C07D403/02 , A61K31/444 , A61P15/00
CPC分类号： C07D495/04 , C07C233/88 , C07C235/42 , C07C255/57 , C07D213/56 , C07D213/58 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/14 , C07D215/54 , C07D239/36 , C07D401/04 , C07D401/12 , C07D413/12 , C07D417/12
摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
摘要翻译：公开了GnRH受体拮抗剂，其可用于治疗男性和女性中各种性激素相关病症。本发明的化合物具有以下结构，其中R1a，R1b，R1c，R1d，R2，R2a和A如本文所定义，包括其立体异构体，酯，溶剂合物及其药学上可接受的盐。还公开了含有本发明化合物与药学上可接受的载体组合的组合物，以及涉及其在有需要的受试者中拮抗促性腺激素释放激素的方法。

9. 发明申请

US20220033742A1 COMPOSITION FOR AN ORGANIC CLEANING PRODUCT 有权
公开(公告)号：US20220033742A1
公开(公告)日：2022-02-03
申请号：US17307775
申请日：2021-05-04
申请人： Nicole Smith
发明人： Nicole Smith
IPC分类号： C11D9/00 , C11D9/16 , C11D9/26 , C11D9/38 , C11D11/00
摘要： A natural cleaning product which does not contain any harsh chemicals or toxins. Specifically, the cleaning product is based on borax and yucca plant products. A composition for an organic cleaning product comprises distilled water; borax; distilled white vinegar; yucca root soap; and optionally, lavender essential oil, peppermint essential oil; and eucalyptus. Also disclosed is a process for the production of yucca root soap which is used in producing the organic cleaning product of the invention.

10. 发明授权

US07584116B2 Monitoring a demand forecasting process 失效
标题翻译：监测需求预测过程
公开(公告)号：US07584116B2
公开(公告)日：2009-09-01
申请号：US10287248
申请日：2002-11-04
申请人： Steve Kakouros , Dorothea Kuettner , Marguerita Sasser , Nicole Smith
发明人： Steve Kakouros , Dorothea Kuettner , Marguerita Sasser , Nicole Smith
IPC分类号： G06F17/30
CPC分类号： G06Q10/06 , G06Q10/06395 , G06Q30/0202
摘要： Systems and methods of monitoring a demand forecasting process are described. In accordance with a demand forecasting monitoring method, a measure of forecast error variability is computed at each period of a selected time frame, and an indicator of forecast bias is computed at a given period within the selected time frame based on forecast error consistency over periods of the selected time frame prior to the given period. A computer program for implementing the demand forecasting monitoring method is described. A system for monitoring a demand forecasting process that includes a graphical user interface configured to display a measure of standard deviation of percent forecast error at each period of a selected time frame also is described.
摘要翻译：描述了监测需求预测过程的系统和方法。根据需求预测监测方法，在选定时间段的每个周期计算出预测误差变异性的量度，并根据期间的预测误差一致性，在选定时间段内的给定时间段内计算预测偏差指标在给定期间之前的所选时间范围内。描述了用于实现需求预测监测方法的计算机程序。还描述了一种用于监视需求预测过程的系统，其包括配置成在所选择的时间帧的每个周期显示百分比预测误差的标准差的度量的图形用户界面。

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