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1. 发明授权

US06358218B1 Fluid-recovery system with integrally molded components 失效
标题翻译：具有整体模制部件的流体回收系统
公开(公告)号：US06358218B1
公开(公告)日：2002-03-19
申请号：US09358944
申请日：1999-07-22
申请人： Nicholas Want , Theodore Karwoski , Steve A. Herweck , Thomas S. Cochran , Scott E. Corbeil , David R. Autote , Ralph L. Gillis
发明人： Nicholas Want , Theodore Karwoski , Steve A. Herweck , Thomas S. Cochran , Scott E. Corbeil , David R. Autote , Ralph L. Gillis
IPC分类号： A61B500
CPC分类号： A61M1/0013
摘要： The present invention relates to fluid recovery systems for collecting fluid from a patient. A fluid recovery system according to the teachings of the invention includes a housing having a collection chamber for collecting fluid from a patient, and further includes a plurality of components and/or structures that are integrally formed with the housing. Such integrally molded components can include valves for controlling fluid flow within the fluid recovery system and a tamper resistant disposal system.
摘要翻译：本发明涉及用于从患者收集流体的流体回收系统。根据本发明的教导的流体回收系统包括具有用于从患者收集流体的收集室的壳体，并且还包括与壳体一体形成的多个部件和/或结构。这种整体模制的部件可以包括用于控制流体回收系统内的流体流动的阀和防篡改处理系统。

2. 发明授权

US06210383B1 Fluid recovery system 失效
标题翻译：流体回收系统
公开(公告)号：US06210383B1
公开(公告)日：2001-04-03
申请号：US09240127
申请日：1999-01-29
申请人： Nicholas Want , Theodore Karwoski , Steve A. Herweck , Ralph L. Gillis , Craig J. Weimer
发明人： Nicholas Want , Theodore Karwoski , Steve A. Herweck , Ralph L. Gillis , Craig J. Weimer
IPC分类号： A61M100
CPC分类号： A61M1/0013 , A61M2209/084
摘要： A fluid recovery system, such as a chest or thoracic cavity drain, having a collection chamber for collecting fluid from a patient includes a base and a front face having a translucent portion for viewing the collected fluid and monitoring operation of the system. The front face is coupled to the base at an acute angle to facilitate viewing of the collected fluid, and measurement of the fluid volume, from a position substantially above the fluid recovery system. Additionally, a column insert can be positioned within the collection chamber to collect an initial volume of the fluid and to allow precise determination of its volume.
摘要翻译：具有用于从患者收集流体的收集室的液体回收系统（例如胸部或胸腔排出物）包括基部和具有用于观察收集的流体的透光部分和监视系统的操作的前表面。前表面以锐角联接到基部，以便于从基本上在流体回收系统上方的位置观察所收集的流体和测量流体体积。此外，柱插入件可以定位在收集室内以收集初始体积的流体并允许精确确定其体积。

3. 发明授权

US09000040B2 Cross-linked fatty acid-based biomaterials 有权
标题翻译：交联脂肪酸基生物材料
公开(公告)号：US09000040B2
公开(公告)日：2015-04-07
申请号：US12364763
申请日：2009-02-03
申请人： Keith M. Faucher , Hui Tang , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Allison Sullivan , Greg Melville , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Allison Sullivan , Greg Melville , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/4353 , A61L31/16 , A61F2/82
CPC分类号： A61L31/08 , A61F2/82 , A61F2250/0067 , A61K31/4353 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/606 , A61L2420/06 , A61L2430/00
摘要： Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译：描述了基于脂肪酸的预固化衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。

4. 发明授权

US08312836B2 Method and apparatus for application of a fresh coating on a medical device 有权
标题翻译：用于在医疗装置上施加新鲜涂层的方法和装置
公开(公告)号：US08312836B2
公开(公告)日：2012-11-20
申请号：US12182261
申请日：2008-07-30
申请人： Scott E. Corbeil , Roger Labrecque , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Edward Bromander , Georgette Henrich
发明人： Scott E. Corbeil , Roger Labrecque , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Suzanne Conroy , Brian Sunter , Edward Bromander , Georgette Henrich
IPC分类号： B05C3/00 , A61F2/06 , A61F2/00
CPC分类号： A61M25/0009 , A61F2/86 , A61F2240/001 , A61F2250/0067 , A61M25/0045
摘要： A method, a kit, and an apparatus provide a coating on an implantable medical device. The apparatus includes housing, a sealed reservoir chamber disposed in the housing, a reducing template, and a reservoir access port. The sealed reservoir contains the coating material. The reducing template is sized to receive a medical device therethrough for application of the coating material. A seal breaching mechanism can be provided and adapted to breach the sealed reservoir upon activation of the apparatus. The reservoir access port, which is disposed in the housing, is adapted to fluidly couple the reducing template with the reservoir chamber upon activation of the apparatus for coating the medical device.
摘要翻译：方法，试剂盒和装置在可植入医疗装置上提供涂层。该装置包括壳体，设置在壳体中的密封储存室，还原模板和储存器进入端口。密封的容器包含涂料。还原模板的尺寸适于接收穿过其中的医疗装置以施加涂层材料。可以提供密封破裂机构并适于在启动装置时破坏密封储存器。设置在壳体中的储存器进入端口适于在激活用于涂覆医疗装置的装置时将还原模板与储存室流体联接。

5. 发明授权

US09012506B2 Cross-linked fatty acid-based biomaterials 有权
标题翻译：交联脂肪酸基生物材料
公开(公告)号：US09012506B2
公开(公告)日：2015-04-21
申请号：US12325546
申请日：2008-12-01
申请人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16
CPC分类号： A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译：描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。

6. 发明申请

US20090181937A1 CROSS-LINKED FATTY ACID-BASED BIOMATERIALS 有权
标题翻译：交联的基于脂肪酸的生物材料
公开(公告)号：US20090181937A1
公开(公告)日：2009-07-16
申请号：US12325546
申请日：2008-12-01
申请人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
发明人： Keith M. Faucher , Hui Tang , Joseph Ferraro , Paul Martakos , Steve A. Herweck , Theodore Karwoski , Scott E. Corbeil
IPC分类号： A61K31/20 , A61K31/395 , A61P41/00
CPC分类号： A61L31/08 , A61K31/225 , A61K31/355 , A61L29/08 , A61L29/16 , A61L31/148 , A61L31/16 , A61L2300/22
摘要： Fatty acid-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
摘要翻译：描述了脂肪酸衍生的生物材料，制备生物材料的方法以及将其用作药物递送载体的方法。脂肪酸衍生的生物材料可以单独使用或与医疗装置组合使用以释放和局部递送一种或多种治疗剂。还提供了形成和调整所述生物材料的性质的方法以及使用所述生物材料治疗哺乳动物的损伤的方法。

7. 发明授权

US5722964A Filtered blood collection device 失效
标题翻译：过滤采血装置
公开(公告)号：US5722964A
公开(公告)日：1998-03-03
申请号：US487468
申请日：1995-06-07
申请人： Steve A. Herweck , Theodore Karwoski , Nicholas Want
发明人： Steve A. Herweck , Theodore Karwoski , Nicholas Want
IPC分类号： A61M1/00 , A61M1/36
CPC分类号： A61M1/0013 , A61M1/0031 , A61M1/0033 , A61M1/3627
摘要： A blood collection vessel includes a blood inlet, a pooling region in which blood from the inlet collects, and an outlet in the pooling region for reinfusion of the collected blood. A filter located in the blood path between inlet and outlet extends at least in part into the pooling region and impounds clots so they remain away from the outlet but suspended in the collected blood. Preferably, the filter is located to provide venting between both sides of the filter. In one embodiment the filter is a vertical wall, which defines a shielded outlet column or chimney extending above the outlet. Blood permeates to the outlet region over a broad area, and the column forms an open suction path that prevents suction differentials from arising across the filter, so clots cannot be sucked through the large-pore material. With the clots residing in the collected fluid, the total fluid loss is directly displayed in a single window at all times, and maximal use is made of the limited volume in the vessel. In another embodiment, the filter constitutes a false floor or basket in the pooling region. A preferred construction employs filter material on a support grid, to form a flexible and self-supporting filter sheet, which inserts like a plate to compartmentalize the collection vessel and form an impounding surface in the pooling region.
摘要翻译：血液采集容器包括血液入口，来自入口的血液收集的汇集区域以及汇集区域中用于回收血液回输的出口。位于入口和出口之间的血液路径中的过滤器至少部分地延伸到汇集区域中并扣留凝块，使得它们保持远离出口但悬浮在收集的血液中。优选地，过滤器被定位成在过滤器的两侧之间提供排气。在一个实施例中，过滤器是垂直壁，其限定在出口上方延伸的屏蔽出口塔或烟囱。血液在大面积上渗透到出口区域，柱形成一个开放的吸入路径，防止吸入差异跨越过滤器，因此凝块不能通过大孔材料吸入。在收集的液体中存在凝块的情况下，总的流体损失始终直接显示在单个窗口中，并且最大限度地利用了容器中有限的体积。在另一个实施例中，过滤器构成汇集区域中的假地板或篮子。优选的结构是在支撑格栅上使用过滤材料，以形成柔性和自支撑的过滤片，其将类似板的插入物分隔成收集容器并在汇集区域中形成蓄水表面。

8. 外观设计

USD517897S1 Handle for chest drain bag 失效
标题翻译：胸部排液袋手柄
公开(公告)号：USD517897S1
公开(公告)日：2006-03-28
申请号：US29192612
申请日：2003-10-27
申请人： Nicholas Want , Theodore Karwoski , Steve A. Herweck
设计人： Nicholas Want , Theodore Karwoski , Steve A. Herweck

9. 发明授权

US08962023B2 UV cured gel and method of making 有权
标题翻译：紫外线固化凝胶及其制备方法
公开(公告)号：US08962023B2
公开(公告)日：2015-02-24
申请号：US11236943
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
IPC分类号： A61K9/00 , A61L27/54 , A61F13/02 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/08 , A61L2/20 , A61L27/36 , A61L27/52 , A61L31/00 , A61L31/10 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译：提供UV固化方法和相应的所得非聚合交联凝胶。交联凝胶可以与医疗装置结构组合。除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。固化方法可以改变UV光在强度和持续时间上的应用，以实现形成凝胶的所需量的交联。

10. 发明授权

US08795703B2 Stand-alone film and methods for making the same 有权
标题翻译：独立电影和制作相同的方法
公开(公告)号：US08795703B2
公开(公告)日：2014-08-05
申请号：US11237264
申请日：2005-09-28
申请人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61F2/00 , A61K9/14 , A61K35/60
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：至少部分地从脂肪酸衍生独立的膜。独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。所得到的独立膜是生物可吸收的。

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