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1. 发明申请

US20070027167A1 Use of c-Src inhibitors alone or in combinaton with STI571 for the treatment of leukaemia 审中-公开
标题翻译：单独使用c-Src抑制剂或与STI571组合用于治疗白血病
公开(公告)号：US20070027167A1
公开(公告)日：2007-02-01
申请号：US11515981
申请日：2006-09-05
申请人： Nicholas Donato , Doriano Fabbro , Paul Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
发明人： Nicholas Donato , Doriano Fabbro , Paul Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
IPC分类号： A61K31/519
CPC分类号： A61K35/02 , A61K31/506 , A61K31/519
摘要： The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamdio]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.
摘要翻译：本发明涉及一种组合，其包含（a）至少一种降低c-Src活性的化合物和（b）N- {5- [4-（4-甲基 - 哌嗪基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺或其单甲磺酸盐; 包含所述组合的药物组合物; 以及治疗具有白血病，特别是慢性骨髓性白血病的温血动物的方法，包括向所述动物施用至少一种抑制Src激酶家族成员，Tec激酶家族或Raf激酶抑制剂的活性的化合物，特别是抑制c-Src蛋白酪氨酸激酶活性或同时抑制c-Src蛋白酪氨酸激酶活性和Bcr-Abl酪氨酸激酶活性，单独或与Bcr-Abl抑制剂组合，特别是N- {5- [ 4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺。

2. 发明申请

US20070149539A1 USE OF C-SRC INHIBITORS ALONE OR IN COMBINATION WITH STI571 FOR THE TREATMENT OF LEUKAEMIA 审中-公开
标题翻译：使用C-SRC抑制剂或与STI571组合用于治疗白血病
公开(公告)号：US20070149539A1
公开(公告)日：2007-06-28
申请号：US11679901
申请日：2007-02-28
申请人： Nicholas Donato , Doriano Fabbro , Paul Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
发明人： Nicholas Donato , Doriano Fabbro , Paul Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
IPC分类号： A61K31/506 , A61K31/497 , A61K31/519
CPC分类号： A61K35/02 , A61K31/506 , A61K31/519
摘要： The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamdio]-2-methylphenyl }-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N- {5- [4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl }-4-(3-pyridyl)-2-pyrimidine-amine.
摘要翻译：本发明涉及一种组合，其包含（a）至少一种降低c-Src活性的化合物和（b）N- {5- [4-（4-甲基 - 哌嗪基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺或其单甲磺酸盐; 包含所述组合的药物组合物; 以及治疗具有白血病，特别是慢性骨髓性白血病的温血动物的方法，包括向动物施用至少一种抑制Src激酶家族成员，Tec激酶家族或Raf激酶抑制剂的活性的化合物，特别是抑制c-Src蛋白酪氨酸激酶活性或同时抑制c-Src蛋白酪氨酸激酶活性和Bcr-Abl酪氨酸激酶活性，单独或与Bcr-Abl抑制剂组合，特别是N- {5- [ 4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺。

3. 发明申请

US20060074094A1 Use of c-Src inhibitors alone or in combination with STI571 for the treatment of leukaemia 失效
标题翻译：单独或与STI571组合使用c-Src抑制剂治疗白血病
公开(公告)号：US20060074094A1
公开(公告)日：2006-04-06
申请号：US11285664
申请日：2005-11-22
申请人： Nicholas Donato , Doriano Fabbro , Paul Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
发明人： Nicholas Donato , Doriano Fabbro , Paul Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
IPC分类号： A61K31/519
CPC分类号： A61K35/02 , A61K31/506 , A61K31/519
摘要： The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.
摘要翻译：本发明涉及一种组合，其包含（a）至少一种降低c-Src活性的化合物和（b）N- {5- [4-（4-甲基 - 哌嗪基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺或其单甲磺酸盐; 包含所述组合的药物组合物; 以及治疗具有白血病，特别是慢性骨髓性白血病的温血动物的方法，包括向所述动物施用至少一种抑制Src激酶家族成员，Btk激酶家族，Tec激酶家族的活性的化合物或 Raf激酶抑制剂，特别是抑制c-Src蛋白酪氨酸激酶活性或同时抑制c-Src蛋白酪氨酸激酶活性和Bcr-Abl酪氨酸激酶活性，单独或与Bcr-Abl抑制剂组合，特别是N - {5- [4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺。

4. 发明授权

US08119649B2 Use of c-Src inhibitors alone or in combination with STI571 for the treatment of leukaemia 失效
公开(公告)号：US08119649B2
公开(公告)日：2012-02-21
申请号：US12466186
申请日：2009-05-14
申请人： Nicholas J Donato , Doriano Fabbro , Paul W Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
发明人： Nicholas J Donato , Doriano Fabbro , Paul W Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
IPC分类号： A61K31/519
CPC分类号： A61K35/02 , A61K31/506 , A61K31/519
摘要： The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.

5. 发明申请

US20090227608A1 USE OF C-SRC INHIBITORS ALONE OR IN COMBINATION WITH STI571 FOR THE TREATMENT OF LEUKAEMIA 失效
标题翻译：使用C-SRC抑制剂或与STI571组合用于治疗白血病
公开(公告)号：US20090227608A1
公开(公告)日：2009-09-10
申请号：US12466186
申请日：2009-05-14
申请人： Nicholas J. Donato , Doriano Fabbro , Paul William Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
发明人： Nicholas J. Donato , Doriano Fabbro , Paul William Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
IPC分类号： A61K31/519 , A61P35/00
CPC分类号： A61K35/02 , A61K31/506 , A61K31/519
摘要： The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.
摘要翻译：本发明涉及一种组合，其包含（a）至少一种降低c-Src活性的化合物和（b）N- {5- [4-（4-甲基 - 哌嗪基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺或其单甲磺酸盐; 包含所述组合的药物组合物; 以及治疗具有白血病，特别是慢性骨髓性白血病的温血动物的方法，包括向所述动物施用至少一种抑制Src激酶家族成员，Btk激酶家族，Tec激酶家族的活性的化合物或 Raf激酶抑制剂，特别是抑制c-Src蛋白酪氨酸激酶活性或同时抑制c-Src蛋白酪氨酸激酶活性和Bcr-Abl酪氨酸激酶活性，单独或与Bcr-Abl抑制剂组合，特别是N - {5- [4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺。

6. 发明授权

US08268837B2 Use of c-Src inhibitors alone or in combination with STI571 for the treatment of leukaemia 失效
标题翻译：单独或与STI571组合使用c-Src抑制剂治疗白血病
公开(公告)号：US08268837B2
公开(公告)日：2012-09-18
申请号：US11285664
申请日：2005-11-22
申请人： Nicholas J Donato , Doriano Fabbro , Paul W Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
发明人： Nicholas J Donato , Doriano Fabbro , Paul W Manley , Jurgen Mestan , Markus Warmuth , Michael Hallek , Moshe Talpaz , Ji Wu
IPC分类号： A61K31/519
CPC分类号： A61K35/02 , A61K31/506 , A61K31/519
摘要： The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.
摘要翻译：本发明涉及一种组合，其包含（a）至少一种降低c-Src活性的化合物和（b）N- {5- [4-（4-甲基 - 哌嗪基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺或其单甲磺酸盐; 包含所述组合的药物组合物; 以及治疗具有白血病，特别是慢性骨髓性白血病的温血动物的方法，包括向所述动物施用至少一种抑制Src激酶家族成员，Btk激酶家族，Tec激酶家族的活性的化合物或 Raf激酶抑制剂，特别是抑制c-Src蛋白酪氨酸激酶活性或同时抑制c-Src蛋白酪氨酸激酶活性和Bcr-Abl酪氨酸激酶活性，单独或与Bcr-Abl抑制剂组合，特别是N - {5- [4-（4-甲基 - 哌嗪子基 - 甲基） - 苯甲酰氨基] -2-甲基苯基} -4-（3-吡啶基）-2-嘧啶胺。

7. 发明授权

US09804227B2 Electric machine fast transient condition detection 有权
公开(公告)号：US09804227B2
公开(公告)日：2017-10-31
申请号：US12889482
申请日：2010-09-24
申请人： Ji Wu , Joe Youqing Xiang
发明人： Ji Wu , Joe Youqing Xiang
IPC分类号： G01R31/34 , G01R31/02
CPC分类号： G01R31/343 , G01R31/025
摘要： During a transient operating condition in an electric machine, a diagnostic routine associated with the electric machine may erroneously indicate a fault. According to the disclosure, a flag is set when a transient condition is detected. The flag is communicated to the diagnostic routine. The output of the diagnostic routine may be altered when the flag is set, i.e., when a transient is detected.

8. 发明授权

US09150108B2 High-frequency signal injection based high voltage interlock 有权
标题翻译：高频信号注入基于高压互锁
公开(公告)号：US09150108B2
公开(公告)日：2015-10-06
申请号：US13448343
申请日：2012-04-16
申请人： Chang-Jiang Wang , Michael W. Degner , Ji Wu
发明人： Chang-Jiang Wang , Michael W. Degner , Ji Wu
IPC分类号： F16P3/20 , B60L3/00 , G01R31/02 , B60L3/04 , B60L11/18 , B60L15/20
CPC分类号： B60L3/0069 , B60L3/04 , B60L11/1803 , B60L15/20 , B60L2220/14 , B60L2240/421 , B60L2240/423 , B60L2250/10 , B60L2270/142 , B60L2270/145 , G01R31/026 , Y02T10/642 , Y02T10/645 , Y02T10/7005 , Y02T10/72 , Y02T10/7275
摘要： Systems, methods and apparatus are presented to determine high voltage cable connectivity between an inverter module and a remote electric machine. A high frequency (HF) interlock module can be configured to inject a high frequency excitation signal that can be superimposed on inverter drive signals. High frequency current components can be determined and used to determine connectivity status. The sum and difference of positive and negative sequence component values can be compared to predetermined limitations to detect one or more open phases. An example method can include enabling a HF detection strategy under predetermined conditions. In response to an open phase detection a fault flag can be set.
摘要翻译：提出了系统，方法和装置，以确定逆变器模块和远程电机之间的高压电缆连接。高频（HF）互锁模块可配置为注入可叠加在变频器驱动信号上的高频激励信号。可以确定高频电流分量并用于确定连接状态。可以将正和负序列分量值的和差与预定的限制进行比较以检测一个或多个开放相位。示例性方法可以包括在预定条件下启用HF检测策略。响应于开路相位检测，可以设置故障标志。

9. 发明申请

US20130270974A1 High-Frequency Signal Injection Based High Voltage Interlock 有权
标题翻译：高频信号注入高压互锁
公开(公告)号：US20130270974A1
公开(公告)日：2013-10-17
申请号：US13448343
申请日：2012-04-16
申请人： Chang-Jiang Wang , Michael W. Degner , Ji Wu
发明人： Chang-Jiang Wang , Michael W. Degner , Ji Wu
IPC分类号： H02K11/00
CPC分类号： B60L3/0069 , B60L3/04 , B60L11/1803 , B60L15/20 , B60L2220/14 , B60L2240/421 , B60L2240/423 , B60L2250/10 , B60L2270/142 , B60L2270/145 , G01R31/026 , Y02T10/642 , Y02T10/645 , Y02T10/7005 , Y02T10/72 , Y02T10/7275
摘要： Systems, methods and apparatus are presented to determine high voltage cable connectivity between an inverter module and a remote electric machine. A high frequency (HF) interlock module can be configured to inject a high frequency excitation signal that can be superimposed on inverter drive signals. High frequency current components can be determined and used to determine connectivity status. The sum and difference of positive and negative sequence component values can be compared to predetermined limitations to detect one or more open phases. An example method can include enabling a HF detection strategy under predetermined conditions. In response to an open phase detection a fault flag can be set.
摘要翻译：提出了系统，方法和装置，以确定逆变器模块和远程电机之间的高压电缆连接。高频（HF）互锁模块可配置为注入可叠加在变频器驱动信号上的高频激励信号。可以确定高频电流分量并用于确定连接状态。可以将正和负序列分量值的和差与预定的限制进行比较以检测一个或多个开放相位。示例性方法可以包括在预定条件下启用HF检测策略。响应于开路相位检测，可以设置故障标志。

10. 发明授权

US07979171B2 Permanent magnet temperature estimation 有权
标题翻译：永磁体温度估算
公开(公告)号：US07979171B2
公开(公告)日：2011-07-12
申请号：US12887117
申请日：2010-09-21
申请人： Ji Wu , Franco Leonardi , Feng Liang , Michael W. Degner , Daniel Luedtke
发明人： Ji Wu , Franco Leonardi , Feng Liang , Michael W. Degner , Daniel Luedtke
IPC分类号： B60L15/00
CPC分类号： H02P23/14 , B60L15/025 , B60L2240/421 , B60L2240/425 , B60L2260/44 , H02P21/20 , H02P29/662 , Y02T10/643
摘要： A method of controlling a vehicle including a permanent magnet (PM) synchronous motor is provided. The motor is controlled based on direct-axis (d-axis) and quadrature-axis (q-axis) current commands. The method includes estimating permanent magnet flux linkage based on q-axis voltage and electrical angular speed, and estimating permanent magnet temperature based on permanent magnet flux linkage and the temperature coefficient of the permanent magnet. The vehicle is controlled based on the estimated permanent magnet temperature.
摘要翻译：提供了一种控制包括永磁（PM）同步电动机的车辆的方法。基于直轴（d轴）和正交轴（q轴）电流指令控制电机。该方法包括基于q轴电压和电角速度估计永磁体磁链，并根据永磁体磁链和永磁体的温度系数估计永磁体温度。基于估计的永磁体温度来控制车辆。

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