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    • 6. 发明授权
    • Use of c-Src inhibitors alone or in combination with STI571 for the treatment of leukaemia
    • 单独或与STI571组合使用c-Src抑制剂治疗白血病
    • US08268837B2
    • 2012-09-18
    • US11285664
    • 2005-11-22
    • Nicholas J DonatoDoriano FabbroPaul W ManleyJurgen MestanMarkus WarmuthMichael HallekMoshe TalpazJi Wu
    • Nicholas J DonatoDoriano FabbroPaul W ManleyJurgen MestanMarkus WarmuthMichael HallekMoshe TalpazJi Wu
    • A61K31/519
    • A61K35/02A61K31/506A61K31/519
    • The invention relates to a combination which comprises (a) at least one compound decreasing the c-Src activity and (b) N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine or the monomethanesulfonate salt thereof; to pharmaceutical compositions comprising said combinations; and to a method of treating a warm-blooded animal having leukaemia, especially chronic myelogenous leukaemia, comprising administering to the animal at least one compound inhibiting the activity of a member of the Src kinase family, the Btk kinase family, the Tec kinase family or a Raf kinase inhibitor, in particular inhibiting the c-Src protein tyrosine kinase activity or inhibiting simultaneously the c-Src protein tyrosine kinase activity and the Bcr-Abl tyrosine kinase activity, alone or in combination with a Bcr-Abl inhibitor, in particular N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine.
    • 本发明涉及一种组合,其包含(a)至少一种降低c-Src活性的化合物和(b)N- {5- [4-(4-甲基 - 哌嗪基 - 甲基) - 苯甲酰氨基] -2-甲基苯基} -4-(3-吡啶基)-2-嘧啶胺或其单甲磺酸盐; 包含所述组合的药物组合物; 以及治疗具有白血病,特别是慢性骨髓性白血病的温血动物的方法,包括向所述动物施用至少一种抑制Src激酶家族成员,Btk激酶家族,Tec激酶家族的活性的化合物或 Raf激酶抑制剂,特别是抑制c-Src蛋白酪氨酸激酶活性或同时抑制c-Src蛋白酪氨酸激酶活性和Bcr-Abl酪氨酸激酶活性,单独或与Bcr-Abl抑制剂组合,特别是N - {5- [4-(4-甲基 - 哌嗪子基 - 甲基) - 苯甲酰氨基] -2-甲基苯基} -4-(3-吡啶基)-2-嘧啶胺。
    • 9. 发明授权
    • Apparatus and method for detecting glass break
    • 玻璃破裂检测装置及方法
    • US06493687B1
    • 2002-12-10
    • US09465254
    • 1999-12-18
    • Ji WuWilliam S. DiPoala
    • Ji WuWilliam S. DiPoala
    • G06F9445
    • G08B13/04G08B13/1672G08B29/24
    • A glass break detector is disclosed that uses a neural network to determine if an audio signal is breaking glass. A characteristic extraction unit is used to extract a set of signal characteristics from a time domain signal based on the audio signal. The set of signal characteristics is the set of the magnitudes of the discrete Fourier transform coefficients of an acquired time domain signal, or the Fourier transform coefficients themselves. A classifier is connected to the characteristic extraction unit. It is a two-layer neural network that uses the set of signal characteristics to accurately determine whether the acquired time domain signal represents breaking glass.
    • 公开了一种玻璃破裂检测器,其使用神经网络来确定音频信号是否破碎玻璃。 特征提取单元用于从基于音频信号的时域信号中提取一组信号特征。 信号特征的集合是所获取的时域信号的离散傅里叶变换系数的幅度集合,或傅立叶变换系数本身。 分类器连接到特征提取单元。 它是一个双层神经网络,使用该组信号特征来准确地确定所获取的时域信号是否表示破碎玻璃。