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1. 发明申请

US20050197328A1 Imidazopyridine derivatives as kinase inhibitors 失效
标题翻译：咪唑并吡啶衍生物作为激酶抑制剂
公开(公告)号：US20050197328A1
公开(公告)日：2005-09-08
申请号：US10508760
申请日：2003-03-21
申请人： Nicholas Bailey , Mark Bamford , Haifeng Cui , Stephen Garland , Krista Goodman , Mark Hilfiker , Dennis Lee , Terence Panchal , Robert Stavenger , David Wilson , Jason Witherington
发明人： Nicholas Bailey , Mark Bamford , Haifeng Cui , Stephen Garland , Krista Goodman , Mark Hilfiker , Dennis Lee , Terence Panchal , Robert Stavenger , David Wilson , Jason Witherington
IPC分类号： C07D473/36 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/52 , A61K31/5377 , A61P1/04 , A61P11/06 , A61P19/10 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07D471/04 , A61K31/551 , A61K31/498 , A61K31/503 , C07D473/14 , C07D487/02
CPC分类号： C07D471/04
摘要： A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.
摘要翻译：下式的化合物及其生理上可接受的盐和/或其N-氧化物，其中X 1是N或CR 3; X 2是N或CR 4; X 3是N或CR 5; X 4是N或CR 6。条件是X 1，X 2，X 3和X 4中的至少一个但不多于两个， SUB>表示N. R 1是选自a，b，c或d的5-或6-元杂环基，其中X 5是选自 N或CR 7和X 6是选自O，S或NR 8的基团; 可以相同或不同的是选自N或CR 9的基团;其中X 1和X 3可以相同或不同。 X 9是选自O，S或NR 8和X 10的基团是N或CR 10; X 11，X 12和X 13可以相同或不同，选自基团N或CR 13， 11 其制备方法，含有它们的药物组合物及其在医药中的用途。

2. 发明申请

US20070123561A1 Preparation of 1,7-disubstituted azabensimidazoles as kinase inhibitors 审中-公开
标题翻译：制备1,7-二取代的氮杂双环咪唑作为激酶抑制剂
公开(公告)号：US20070123561A1
公开(公告)日：2007-05-31
申请号：US10574675
申请日：2004-10-06
申请人： Dennis Lee , Robert Stavenger , Krista Goodman , Mark Hilfiker , Haifeng Cui , Joseph Marino
发明人： Dennis Lee , Robert Stavenger , Krista Goodman , Mark Hilfiker , Haifeng Cui , Joseph Marino
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Novel inhibitors of Rho-kinases are disclosed.
摘要翻译：公开了Rho激酶的新型抑制剂。

3. 发明授权

US07348339B2 Imidazopyridine derivatives as kinase inhibitors 失效
标题翻译：咪唑并吡啶衍生物作为激酶抑制剂
公开(公告)号：US07348339B2
公开(公告)日：2008-03-25
申请号：US10508760
申请日：2003-03-21
申请人： Nicholas Bailey , Mark James Bamford , Haifeng Cui , Stephen Garland , Krista B Goodman , Mark A Hilfiker , Dennis Lee , Terence Aaron Panchal , Robert A Stavenger , David Matthew Wilson , Jason Witherington
发明人： Nicholas Bailey , Mark James Bamford , Haifeng Cui , Stephen Garland , Krista B Goodman , Mark A Hilfiker , Dennis Lee , Terence Aaron Panchal , Robert A Stavenger , David Matthew Wilson , Jason Witherington
IPC分类号： A61K31/44 , A01N43/42 , C07D265/30 , C07D295/00 , C07D498/02
CPC分类号： C07D471/04
摘要： A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR3; X2 is N or CR4; X3 is N or CR5; X4 is N or CR6. with the proviso that at least one but not more than two of X1, X2, X3 and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X5 is a group selected from N or CR7 and X6 is a group selected from O, S or NR8; X7 and X8 which may be the same or different is a group selected from N or CR9; X9 is a group selected from O, S or NR8 and X10 is N or CR10; X11, X12 and X13 may be the same or different and selected from a group N or CR11; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.
摘要翻译：下式的化合物及其生理上可接受的盐和/或其N-氧化物，其中X 1是N或CR 3; X 2是N或CR 4; X 3是N或CR 5; X 4是N或CR 6。条件是X 1，X 2，X 3和X 4中的至少一个但不多于两个， SUB>表示N. R 1是选自a，b，c或d的5-或6-元杂环基，其中X 5是选自 N或CR 7和X 6是选自O，S或NR 8的基团; X 7和X 8可以相同或不同，是选自N或CR 9的基团。 X 9是选自O，S或NR 8和X 10的基团是N或CR 10; X 11，X 12和X 13可以相同或不同，并且选自N或C 11 ; 其制备方法，含有它们的药物组合物及其在医药中的用途。

4. 发明授权

US07547779B2 Preparation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors 有权
标题翻译：制备1,6-二取代的氮杂苯并咪唑作为激酶抑制剂
公开(公告)号：US07547779B2
公开(公告)日：2009-06-16
申请号：US10574676
申请日：2004-10-06
申请人： Dennis Lee , Robert A. Stavenger , Krista B. Goodman , Mark A. Hilfiker , Haifeng Cui , Andrew Q. Viet , Joseph P. Marino
发明人： Dennis Lee , Robert A. Stavenger , Krista B. Goodman , Mark A. Hilfiker , Haifeng Cui , Andrew Q. Viet , Joseph P. Marino
IPC分类号： C07D413/00 , C07D401/00 , C07D471/02 , C07D491/02
CPC分类号： C07D471/04
摘要： Novel inhibitors of Rho-kinases are disclosed.
摘要翻译：公开了Rho激酶的新型抑制剂。

5. 发明申请

US20080234261A1 Preparation of 1,6-Disubstituted Azabenzimidazoles as Kinase Inhibitors 有权
标题翻译： 1,6-二取代偶氮苯并咪唑作为激酶抑制剂的制备
公开(公告)号：US20080234261A1
公开(公告)日：2008-09-25
申请号：US10574676
申请日：2004-10-06
申请人： Dennis Lee , Robert A. Stavenger , Krista A. Goodman , Mark A. Hilfiker , Haifeng Cui , Andrew Q. Viet , Joseph P. Marino
发明人： Dennis Lee , Robert A. Stavenger , Krista A. Goodman , Mark A. Hilfiker , Haifeng Cui , Andrew Q. Viet , Joseph P. Marino
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , A61P9/00 , A61K31/496
CPC分类号： C07D471/04
摘要： Novel inhibitors of Rho-kinases are disclosed.
摘要翻译：公开了Rho激酶的新型抑制剂。

6. 发明授权

US08568659B2 Fiber optic device 有权
标题翻译：光纤设备
公开(公告)号：US08568659B2
公开(公告)日：2013-10-29
申请号：US12208669
申请日：2008-09-11
申请人： Dennis Lee
发明人： Dennis Lee
IPC分类号： C12Q1/68
CPC分类号： C40B60/12 , B01J13/02 , B01J2219/005 , B01J2219/00524 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00702 , B01J2219/0072 , B01J2219/00725 , B01J2219/0074 , C09B67/0097 , Y10T428/2991
摘要： The present invention is directed to a fiber optic device consisting of a fiber bundle having multiple legs of silica fibers, using a plurality of microspheres construct to attach target cells, for the assay of cytotoxic compounds. Each leg of silica fibers consists of twenty-five or more silica fibers treated with biotin and streptavidin treated microspheres which chemically bind the microspheres to the silica fibers. Further, the present invention is directed to the unique microspheres. The microspheres have a core, preferably alginate, with an outer surface of chitosan.The present invention is further directed to the use of the described fiber optic device to isolate, research and develop biological medicaments and diagnostic cytotoxic compounds. The fiber optic device utilizes thousands of fibers and the unique microspheres to provide a high-throughput screening device.
摘要翻译：本发明涉及由具有多个二氧化硅纤维腿的纤维束组成的光纤装置，其使用多个微球构造来附着靶细胞，用于细胞毒性化合物的测定。二氧化硅纤维的每条腿由二十五个或更多的用生物素和链霉亲和素处理的微球处理的二氧化硅纤维组成，其将微球化学结合到二氧化硅纤维上。此外，本发明涉及独特的微球。微球具有芯，优选藻酸盐，壳聚糖的外表面。本发明还涉及所述光纤装置分离，研究和开发生物药物和诊断性细胞毒性化合物的用途。光纤设备利用成千上万的光纤和独特的微球体来提供高通量的筛选装置。

7. 发明授权

US08498947B1 Inserting stops into delivery routes 有权
标题翻译：插入送货路线
公开(公告)号：US08498947B1
公开(公告)日：2013-07-30
申请号：US12640516
申请日：2009-12-17
申请人： Paul N. Haake , Dennis Lee , Sarah T. Rowe , Steve R. Harman
发明人： Paul N. Haake , Dennis Lee , Sarah T. Rowe , Steve R. Harman
IPC分类号： G06Q30/00 , G06Q10/00
CPC分类号： G06Q10/047 , G06Q10/08 , G06Q50/30
摘要： Various systems and methods are described for insertion of optional stops in delivery routes. To this end, a plurality of delivery routes is provided in a computing device, where each delivery route has a plurality of stops. A determination is made in the computing devices as to whether an optional stop can be inserted between a pair of the stops in at least one of the delivery routes without violating a predefined set of criteria. The optional stop is ultimately inserted between a respective pair of stops in a selected one of the delivery routes.
摘要翻译：描述了各种系统和方法，用于在可选择的停靠点插入交付路线。为此，在计算设备中提供多个递送路径，其中每个递送路线具有多个停靠点。在计算设备中确定在不违反预定义的一组标准的情况下，是否可以在至少一个递送路由中的一对停靠点之间插入可选停止。可选停止件最终插入在所选择的一个输送路径中的相应的一对止动件之间。

8. 发明申请

US20100318190A1 Methods for Injecting a Curable Biomaterial into an Intervertebral Space 有权
标题翻译：将可固化生物材料注入椎间空间的方法
公开(公告)号：US20100318190A1
公开(公告)日：2010-12-16
申请号：US12861037
申请日：2010-08-23
申请人： Keith Collins , Thomas S. Wilson , Jared Walkenhorst , Dennis Lee , Andrew Carter , John Pafford , Mark D. LoGuidice , Lance Middleton , Lawrence Boyd
发明人： Keith Collins , Thomas S. Wilson , Jared Walkenhorst , Dennis Lee , Andrew Carter , John Pafford , Mark D. LoGuidice , Lance Middleton , Lawrence Boyd
IPC分类号： A61F2/44
CPC分类号： A61F2/4657 , A61B17/70 , A61B17/8811 , A61B17/8827 , A61B2017/0256 , A61B2017/564 , A61F2/4611 , A61F2/4684 , A61F2002/444 , A61F2002/4627 , A61F2002/4663 , A61M29/02
摘要： A method for treating a diseased or damaged spinal disc comprises the steps of: (a) providing access to the nucleus pulposus through the annulus; (b) removing at least a portion of the nucleus pulposus to create an intradiscal space; (c) determining the size of the intradiscal space; and (d) sealably introducing under pressure a curable biomaterial through the annulus directly into the intradiscal space. The step of determining the size of the intradiscal space may be accomplished by expanding a compliant balloon within the intradiscal space using a contrast medium capable of visualization under fluoroscopy. The curable material is sealably introduced through a vented needle inserted through the opening. The curable biomaterial is introduced until a quantity of the material flows into the vent.
摘要翻译：用于治疗患病或损伤的椎间盘的方法包括以下步骤：（a）通过所述环提供进入髓核的通路; （b）去除髓核的至少一部分以产生椎间盘内空间; （c）确定椎间盘内空间的大小; 和（d）在压力下可密封地将可固化生物材料通过环形物直接引入椎间盘内空间。确定椎间盘内空间大小的步骤可以通过使用能够在荧光透视下可视化的造影剂来扩展椎间盘内空间内的顺应气囊来实现。可固化材料通过穿过开口插入的通气针密封地引入。引入可固化的生物材料，直到一定量的材料流入通气口。

9. 发明授权

US07592357B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US07592357B2
公开(公告)日：2009-09-22
申请号：US10589995
申请日：2005-02-18
申请人： Dennis Lee , Krista B. Goodman
发明人： Dennis Lee , Krista B. Goodman
IPC分类号： A61K31/4709 , A61K31/4439 , C07D401/12 , C07D401/14
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： Novel Inhibitors of Rho-kinases are disclosed.
摘要翻译：公开了新型的Rho激酶抑制剂。

10. 发明申请

US20080041350A1 Pre-ignition fuel treatment system 失效
标题翻译：预燃燃油处理系统
公开(公告)号：US20080041350A1
公开(公告)日：2008-02-21
申请号：US11889226
申请日：2007-08-10
申请人： Dennis Lee
发明人： Dennis Lee
IPC分类号： F02M27/02
CPC分类号： F02M27/02 , F02M27/045 , F02M31/18 , Y02T10/126
摘要： A method and apparatus for reforming a hydrocarbon fuel increases its energy content, improves its combustibility and reduces combustion by-products. The hydrocarbon fuel is cracked and ionized in a reactor vessel by means of a feedback loop of electro-chemical interactions with a reactor rod composed of a magnetic and catalytic material.
摘要翻译：用于重整烃燃料的方法和装置增加其能量含量，提高其燃烧性并减少燃烧副产物。烃燃料通过与由磁性和催化材料组成的反应器的电化学相互作用的反馈回路在反应器容器中裂化和离子化。

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