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1. 发明授权

US5527919A Process for the preparation of 1-[(1,1'-biphenyl]-4-YL]-methyl-1H-imidazole-5-carboxylic acids 失效
标题翻译：制备1 - [（1,1'-联苯] -4-YL] - 甲基-1H-咪唑-5-羧酸的方法
公开(公告)号：US5527919A
公开(公告)日：1996-06-18
申请号：US177153
申请日：1994-01-04
申请人： Neerja Bhatnagar , Jean Buendia , Christine Griffoul , Holger Heitsch , Adalbert Wagner
发明人： Neerja Bhatnagar , Jean Buendia , Christine Griffoul , Holger Heitsch , Adalbert Wagner
IPC分类号： C07D233/66 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/505 , A61P1/00 , A61P9/00 , A61P9/04 , A61P9/12 , A61P13/02 , A61P13/12 , A61P15/00 , A61P15/04 , A61P43/00 , C07C311/08 , C07C311/18 , C07C311/37 , C07C311/51 , C07C311/58 , C07C311/60 , C07C327/58 , C07D233/84 , C07D233/90 , C07D233/92 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/12 , C07D417/12
CPC分类号： C07D403/10 , C07C311/18 , C07C311/37 , C07C311/51 , C07C311/58 , C07C327/58 , C07D233/84 , C07D233/90
摘要： A novel process for the preparation of a compound of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the text.
摘要翻译：用于制备式（I）的化合物的新方法，其中R 1，R 2，R 3和R 4在文中定义。

2. 发明授权

US5618975A Process for the preparation of biphenyl derivatives 失效
标题翻译：联苯衍生物的制备方法
公开(公告)号：US5618975A
公开(公告)日：1997-04-08
申请号：US449396
申请日：1995-05-24
申请人： Adalbert Wagner , Neerja Bhatnagar , Jean Buendia , Christine Griffoul
发明人： Adalbert Wagner , Neerja Bhatnagar , Jean Buendia , Christine Griffoul
IPC分类号： B01J23/44 , A61K31/235 , A61K31/41 , C07B37/04 , C07B61/00 , C07C41/48 , C07C45/61 , C07C45/71 , C07C47/546 , C07C67/30 , C07C67/343 , C07C69/76 , C07C69/767 , C07C253/30 , C07C255/37 , C07C255/40 , C07C255/56 , C07C303/40 , C07C311/09 , C07C311/48 , C07C311/51 , C07C311/52 , C07C311/53 , C07C311/54 , C07C311/57 , C07C311/58 , C07D257/04 , C07C311/21
CPC分类号： C07D257/04 , C07B37/04 , C07C253/30 , C07C303/40 , C07C311/09 , C07C311/51 , C07C311/58 , C07C67/343
摘要： Biphenyl derivatives and processes for the preparation of biphenyl derivatives are described. A compound of formula (I) is disclosed ##STR1## in which the substituent X is --CHO or --CH(OR.sup.1)OR.sup.2, where R.sup.1 and R.sup.2 independently of one another are (C.sub.1 -C.sub.6)-alkyl or R.sup.1 and R.sup.2 together are an alkylene group (--CH.sub.2).sub.n --, where n is 2, 3 4 or 5 and R is --F, --Cl, --NO.sub.2, --(CH.sub.2).sub.m --COOR.sup.3, --(CH.sub.2).sub.m --CONHR.sup.3, --(CH.sub.2).sub.m --CN, --SO.sub.2 NH--COOR.sup.3, --SO.sub.2 NH--CO--NHR.sup.3, --SO.sub.2 NH--SO.sub.2 --R.sup.3, --NHSO.sub.2 R.sup.3, ##STR2## --PO.sub.3 R.sup.3, --NH--SO.sub.2 --CF.sub.3, --SO.sub.2 NR.sup.4 where R.sup.3 is hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.6)cycloalkyl, or (C.sub.1 -C.sub.6)-alkyl-(C.sub.3 -C.sub.6)cycloalkyl and R.sup.4 is a group .dbd.C--N(CH.sub.3).sub.2, and m is 0, 1, 2, 3, or 4. The invention also relates to a process for the preparation of a compound of the formula (I) in which X is an optionally protected formyl group and R is a group which is itself inert to the reaction conditions of the synthesis, which comprises reacting a compound of the formula (II) ##STR3## with a substituted phenyl-halogen compound of the formula (III) ##STR4## wherein the substituent Hal is a halogen group.
摘要翻译：描述了联苯衍生物和制备联苯衍生物的方法。公开了式（I）化合物，其中取代基X为-CHO或-CH（OR 1）OR 2，其中R 1和R 2彼此独立地为（C 1 -C 6） - 烷基或R 1和 R2一起是亚烷基（-CH 2）n - ，其中n是2,3,4或5，R是-F，-Cl，-NO 2， - （CH 2）m -COOR 3， - （CH 2）m -CONHR 3， - （CH2）m-CN，-SO2NH-COOR3，-SO2NH-CO-NHR3，-SO2NH-SO2-R3，-NHSO2R3，-PO3R3，-NH-SO2-CF3，-SO2NR4，其中R3是氢，（C 1 -C 6） - 烷基，（C 3 -C 6）环烷基或（C 1 -C 6） - 烷基 - （C 3 -C 6）环烷基，R 4是基团= CN（CH 3）2，m是0,1,2 ，3或4.本发明还涉及一种制备式（I）化合物的方法，其中X是任选保护的甲酰基，R是本身对于合成的反应条件是惰性的基团其包括使式（II）化合物（II）与式（III）取代的苯基 - 卤素化合物（III）反应，其中取代基Hal为卤素基团。

3. 发明授权

US5633400A Process for the preparation of biphenyl derivatives 失效
标题翻译：联苯衍生物的制备方法
公开(公告)号：US5633400A
公开(公告)日：1997-05-27
申请号：US449389
申请日：1995-05-24
申请人： Adalbert Wagner , Neerja Bhatnagar , Jean Buendia , Christine Griffoul
发明人： Adalbert Wagner , Neerja Bhatnagar , Jean Buendia , Christine Griffoul
IPC分类号： B01J23/44 , A61K31/235 , A61K31/41 , C07B37/04 , C07B61/00 , C07C41/48 , C07C45/61 , C07C45/71 , C07C47/546 , C07C67/30 , C07C67/343 , C07C69/76 , C07C69/767 , C07C253/30 , C07C255/37 , C07C255/40 , C07C255/56 , C07C303/40 , C07C311/09 , C07C311/48 , C07C311/51 , C07C311/52 , C07C311/53 , C07C311/54 , C07C311/57 , C07C311/58 , C07D257/04 , C07C317/00 , C07C229/00 , C07C303/00
CPC分类号： C07D257/04 , C07B37/04 , C07C253/30 , C07C303/40 , C07C311/09 , C07C311/51 , C07C311/58 , C07C67/343
摘要： The invention relates to a process for the preparation of a compound of the formula (I) ##STR1## in which X is an optionally protected formyl group andR is a group which is itself inert to the reaction conditions of the synthesis,which comprises reacting a compound of the formula (II) ##STR2## where X is as defined above, with a substituted phenyl-halogen compound of the formula (III) ##STR3## where the substituent Hal is a halogen group and R is as defined above.
摘要翻译：本发明涉及一种制备式（I）化合物（I）的方法，其中X是任选保护的甲酰基，R是本身对合成的反应条件是惰性的基团，其包括使式（II）化合物（II）其中X如上定义，与式（III）取代的苯基 - 卤素化合物（III）反应，其中取代基Hal为卤素基团和R如上所定义。

4. 发明授权

US5493046A Process 失效
标题翻译：处理
公开(公告)号：US5493046A
公开(公告)日：1996-02-20
申请号：US330331
申请日：1994-10-27
申请人： Neerja Bhatnagar , Jean Buendia , Christine Griffoul
发明人： Neerja Bhatnagar , Jean Buendia , Christine Griffoul
IPC分类号： C07C311/16 , A61K31/00 , C07C311/19 , C07C317/14 , C07D233/66 , C07D233/84 , C07D233/90 , C07D233/92 , C07D403/10 , C07F5/02 , C07F9/6506 , C07D231/10
CPC分类号： C07D233/92 , C07D403/10
摘要： The novel process of the invention for the preparation of a compound of the formula ##STR1##
摘要翻译：本发明的制备式（Ⅰ）化合物的新方法

5. 发明授权

US5391732A Process for the preparation of biphenyl-imidazole derivatives 失效
标题翻译：联苯咪唑衍生物的制备方法
公开(公告)号：US5391732A
公开(公告)日：1995-02-21
申请号：US177158
申请日：1994-01-04
申请人： Neerja Bhatnagar , Jean Buendia , Christine Griffoul
发明人： Neerja Bhatnagar , Jean Buendia , Christine Griffoul
IPC分类号： C07C311/16 , A61K31/00 , C07C311/19 , C07C317/14 , C07D233/66 , C07D233/84 , C07D233/90 , C07D233/92 , C07D403/10 , C07F5/02 , C07F9/6506 , C07D403/04 , C07D211/08 , C07D233/58 , C07F9/28
CPC分类号： C07D233/92 , C07D403/10
摘要： A novel process for the preparation of a compound of the formula ##STR1##
摘要翻译：一种制备式（Ⅰ）化合物的新方法

6. 发明授权

US5594127A Intermediates for the preparation of .DELTA..sup.4,9(11),17(20) -pregnatriene-3-ones 失效
标题翻译：制备DELTA 4,9（11），17（20） - 三烯-3-酮的中间体
公开(公告)号：US5594127A
公开(公告)日：1997-01-14
申请号：US557594
申请日：1995-11-14
申请人： Francis Brion , Jean Buendia , Christian Diolez , Michel Vivat
发明人： Francis Brion , Jean Buendia , Christian Diolez , Michel Vivat
IPC分类号： C07J7/00 , C07J13/00 , C07J21/00 , C07J33/00 , C07J75/00
CPC分类号： C07J13/005 , C07J13/007 , C07J21/006 , C07J33/007 , Y02P20/55 , Y02P20/582
摘要： A compound having a formula ##STR1## in which K is defined as above, C--P being CH.sub.2 or --C.dbd.CH.sub.2 or ##STR2## and J is --SO.sub.2 R.sub.2, or C--P is C.dbd.O and J is --CH.sub.2 Hal.sub.2, or C--P is --CH SO.sub.2 R.sub.2 and J is CO.sub.2 R or Hal.sub.1, R.sub.2 is methyl, phenyl, tolyl or xylyl, R is alkyl of 1 to 6 carbon atoms, aralkyl of 7 to 15 is carbon atoms or a silylated remainder selected from the group consisting of trimethylsilyl, tert.-butyldimethylsilyl, triphenylsilyl and diphenyltert.-butylsilyl, Hal.sub.1 is halogen, Hal.sub.2 is chlorine, bromine or iodine and the wavy lines symbolize any one of the isomer forms or their mixtures which are intermediates.
摘要翻译：具有式“IMAGE”G的化合物，其中K如上所定义，CP是CH 2或-C = CH 2或者，而J是-SO 2 R 2，或CP是C = O，J是-CH 2 Hal 2，或CP是 -CH + Z SO 2 R 2，J为+ Z CO 2 R或Hal 1，R 2为甲基，苯基，甲苯基或二甲苯基，R为1至6个碳原子的烷基，7至15的芳烷基为碳原子或选自由三甲基甲硅烷基，叔丁基二甲基甲硅烷基，三苯基甲硅烷基和二苯基叔丁基甲硅烷基组成，Hal1是卤素，Hal2是氯，溴或碘，波浪线表示任何一种异构体形式或它们作为中间体的混合物。

7. 发明授权

US5585482A Preparation of 11-keto steroids 失效
标题翻译： 11-酮类固醇的制备
公开(公告)号：US5585482A
公开(公告)日：1996-12-17
申请号：US545518
申请日：1995-10-19
申请人： Francis Brion , Jean Buendia , Christian Diolez , Michel Vivat
发明人： Francis Brion , Jean Buendia , Christian Diolez , Michel Vivat
IPC分类号： C07J5/00 , C07J7/00 , C07J33/00 , C07J53/00 , C07J75/00
CPC分类号： C07J5/0053 , C07J7/0045
摘要： A process for the preparation of a compound of the formula ##STR1## wherein R and R' and the A and B are as defined in the specification. ##STR2## K is selected from the group consisting of ##STR3## n is 2 or 3 and the dotted lined is an optional bond.
摘要翻译：制备下式化合物的方法其中R和R'以及A和B如说明书中所定义。 K选自 n为2或3，虚线为可选键。

8. 发明授权

US5473087A Preparation process for 20-keto 21(S) hydroxy steroids compounds and intermediates 失效
标题翻译： 20-keto 21（S）羟基类固醇化合物和中间体的制备方法
公开(公告)号：US5473087A
公开(公告)日：1995-12-05
申请号：US307908
申请日：1994-09-16
申请人： Jean Buendia , Jean-Yves Godard , Philippe Mackiewicz , Christian Richard
发明人： Jean Buendia , Jean-Yves Godard , Philippe Mackiewicz , Christian Richard
IPC分类号： C07J9/00 , C07J31/00 , C07J75/00 , C12P41/00
CPC分类号： C07J31/006 , C07J9/00 , C12P41/004
摘要： Mixtures of compounds of ##STR1## or a mixture of the latter and a compound of the formula ##STR2## which are useful intermediates for the preparation 20-keto-21(S)-hydroxy steroids.
摘要翻译：＆lt; IMAGE＆gt; II1化合物的混合物或其后者与式（IV）化合物的混合物，其是制备20-酮-21（S） - 羟基类固醇的有用中间体。

9. 发明授权

US4431576A Perfumant cyclopropane-carboxylic acid derivatives 失效
标题翻译：香料环丙烷 - 羧酸衍生物
公开(公告)号：US4431576A
公开(公告)日：1984-02-14
申请号：US343348
申请日：1982-01-27
申请人： Jacques Martel , Jean Buendia , Francois Nezot
发明人： Jacques Martel , Jean Buendia , Francois Nezot
IPC分类号： C07C69/747 , A01N53/06 , A01N53/10 , A61K8/37 , A61Q13/00 , C07D307/54 , C07D307/58 , C07D333/24 , C07D333/32 , C11B9/00 , A61K7/46
CPC分类号： C11B9/0092 , C07D307/54 , C07D333/24 , C11B9/003 , C11B9/0076
摘要： A compound in all its possible isomeric forms and mixtures thereof of the formula ##STR1## wherein R is selected from the group consisting of (a) alkyl of 1 to 12 carbon atoms optionally substituted with cycloalkyl or cycloalkenyl of 3 to 6 carbon atoms or a hydrocarbon chain of 2 to 8 carbon atoms optionally interrupted by an oxygen or ketone, (b) alkenyl and alkynyl of 3 to 8 carbon atoms, (c) cycloalkyl of 3 to 12 carbon atoms optionally containing at least one double bond and substituted with at least one alkyl and (d) aralkyl of 7 to 12 carbon atoms optionally substituted with at least one member of the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen and --CF.sub.3 and R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, --CHO, --COAlK.sub.1, --COOAlK.sub.2 and --CN, at least one being hydrogen, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 8 carbon atoms and R.sub.1 and R.sub.2 taken together with the carbon atom to which they are attached form the group ##STR2## and X is selected from the group consisting of sulfur, oxygen and imino joined to the 1-carbon atom with a double bond with the proviso that the double bond has the E geometry when R.sub.1 or R.sub.2 are --CHO, --COAlK.sub.1, --COOAlK.sub.2 or ##STR3## and their preparation and odorant compositions containing at least one compound of formula I as a perfume agent.
摘要翻译：化合物，其全部可能的异构形式及其混合物，其中R选自（a）任选被3至6个碳原子的环烷基或环烯基取代的1至12个碳原子的烷基或 2至8个碳原子的烃链任选被氧或酮中断，（b）3至8个碳原子的烯基和炔基，（c）3至12个碳原子的环烷基，任选地含有至少一个双键并被至少一个烷基和（d）7-12个碳原子的芳烷基，任选被至少一个1-4个碳原子的烷基，1-4个碳原子的烷氧基，卤素和-CF 3和R 1和 R2分别选自氢，-CHO，-COAlK1，-COOAlK2和-CN，至少一个为氢，AlK1和AlK2为1至8个碳原子的烷基，R1和R2与碳原子一起它们所连接的组由和X选自硫，氧和亚氨基与具有双键的1-碳原子连接，条件是当R1或R2为-CHO，-COAlK1， - COOAlK2或及其制备和加味剂组合物，其含有至少一种式I化合物作为预浸剂。

10. 发明授权

US4308209A .beta.-Lactones of 2-hydroxy-cyclopentane-carboxylic acids 失效
标题翻译： β-内酯2-羟基 - 环戊烷 - 羧酸的内酯
公开(公告)号：US4308209A
公开(公告)日：1981-12-29
申请号：US216124
申请日：1980-12-15
申请人： Jean Buendia , Michel Vivat , Laurent Taliani
发明人： Jean Buendia , Michel Vivat , Laurent Taliani
IPC分类号： A61K31/337 , A61K31/34 , A61K31/365 , A61K31/38 , A61P9/12 , C07D305/14 , C07D309/12 , C07D333/32 , C07D409/06 , C07D409/12
CPC分类号： C07D333/32 , C07D305/14 , C07D309/12
摘要： Novel .beta.-lactones of 2-hydroxy-cyclopentane-carboxylic acids of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and methyl and R.sub.2 is selected from the group consisting of --CH.sub.2 --O--CH.sub.2 --CH.sub.3 and --X--Ar, X is selected from the group consisting of --O-- and --CH.sub.2 --, Ar is an optionally substituted member selected from the group consisting of thienyl, thiazolyl, phenyl and thiadiazolyl, the optional substituents being at least one member selected from the group consisting of halogen and --CF.sub.3 and the wavy lines indicate that the groups may be in the .alpha.,.beta. or .beta.,.alpha.-positions or mixtures thereof having hypotensive activity and their preparation.
摘要翻译：式（I）的2-羟基 - 环戊烷 - 羧酸的新型β-内酯，其中R 1选自氢和甲基，R 2选自-CH 2 -O-CH 2 -CH 3和 -X-Ar，X选自-O-和-CH 2 - ，Ar是选自噻吩基，噻唑基，苯基和噻二唑基的任选取代的成员，任选的取代基是至少一个选自由卤素和-CF 3组成的组和波浪线表示这些基团可以是具有低血压活性的α，β或β，α-位或其混合物及其制备。

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