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1. 发明授权

US06872696B2 Particle with substituted polyvinyl alcohol coating 有权
标题翻译：具有取代聚乙烯醇涂层的颗粒
公开(公告)号：US06872696B2
公开(公告)日：2005-03-29
申请号：US09954386
申请日：2001-09-12
申请人： Nathaniel T. Becker , Matthew J. Flynn , Mark S. Gebert
发明人： Nathaniel T. Becker , Matthew J. Flynn , Mark S. Gebert
IPC分类号： C08F8/00 , C11D3/04 , C11D3/16 , C11D3/37 , C11D3/386 , C11D3/39 , C11D17/00 , C11D3/00
CPC分类号： C11D3/38672 , C11D3/166 , C11D3/3753 , C11D3/386 , C11D3/3942 , C11D17/0039
摘要： The present invention provides an improved coating material for use with particles, such as enzyme granules, and the like. In particular, the present invention provides a modified PVA, as well as particles or granules that include such coating. The PVA is modified by substituting hydrophilic moieties for the hydroxyl or alcohol groups of the PVA. Substitution may be achieved with hydrophilic acids, amines, thiols, or combinations thereof.
摘要翻译：本发明提供一种用于颗粒如酶颗粒等的改进的涂料。特别地，本发明提供了改性PVA，以及包括这种涂层的颗粒或颗粒。通过用亲水部分代替PVA的羟基或醇基来修饰PVA。用亲水酸，胺，硫醇或其组合可以进行取代。

2. 发明申请

US20090238887A1 Highly Impact-Resistant Granules 有权
标题翻译：高抗冲击颗粒
公开(公告)号：US20090238887A1
公开(公告)日：2009-09-24
申请号：US12342398
申请日：2008-12-23
申请人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
发明人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
IPC分类号： A61K9/16 , A61K38/43 , A61K38/48 , A61K38/47 , A61K38/46 , A61K47/30
CPC分类号： C11D3/38 , C11D3/222 , C11D3/3753 , C11D3/38672 , C11D17/0039
摘要： The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.
摘要翻译：本发明提供包含活性成分的高抗冲击性，水溶性或水分散性低粉尘颗粒及其获得方法。

3. 发明申请

US20100124586A1 STABLE, DURABLE GRANULES WITH ACTIVE AGENTS 审中-公开
标题翻译：稳定的，具有活性剂的耐用颗粒
公开(公告)号：US20100124586A1
公开(公告)日：2010-05-20
申请号：US12083387
申请日：2006-10-12
申请人： Nathaniel T. Becker , Kathleen A. Clarkson , Douglas A. Dale , Beth Fryksdale , Mark S. Gebert , Michael Partsuf , Troels N. Gravesen
发明人： Nathaniel T. Becker , Kathleen A. Clarkson , Douglas A. Dale , Beth Fryksdale , Mark S. Gebert , Michael Partsuf , Troels N. Gravesen
IPC分类号： A23L1/03
CPC分类号： A61K9/14 , A23K20/189 , A23K40/30 , A23K50/75 , A61K9/16 , A61K9/5073 , A61K38/465 , A61K38/47 , A61K47/02 , C12N9/96 , C12N9/98
摘要： A stable, durable granule for feed compositions has a core, at least one active agent; and at least one coating. The active agent of the granule retains at least 50% activity, at least 60% activity, at least 70% activity, at least 80% activity after conditions selected from one or more of a) a feed pelleting process, b) a steam-heated feed pretreatment process, c) storage, d) storage as an ingredient in an unpelleted mixture, and e) storage as an ingredient in a feed base mix or a feed premix comprising at least one compound selected from trace minerals, organic acids, reducing sugars, vitamins, choline chloride, and compounds which result in an acidic or a basic feed base mix or feed premix.
摘要翻译：用于饲料组合物的稳定，耐用的颗粒具有核心，至少一种活性剂; 和至少一个涂层。颗粒的活性剂在选自a）进料造粒方法中的一种或多种的条件之后保留至少50％的活性，至少60％的活性，至少70％的活性，至少80％的活性，b）加热进料预处理方法，c）储存，d）作为未混和的混合物中的成分进行储存，以及e）作为原料的混合物或原料预混物中的成分储存，所述进料预混物包含至少一种选自微量矿物质，有机酸，还原剂糖，维生素，氯化胆碱和导致酸性或碱性饲料基料混合物或饲料预混物的化合物。

4. 发明申请

US20120309664A1 Spray Drying Process 审中-公开
标题翻译：喷雾干燥过程
公开(公告)号：US20120309664A1
公开(公告)日：2012-12-06
申请号：US13491106
申请日：2012-06-07
申请人： Herbert B. Scher , Deborah S. Winetzky , Nathaniel T. Becker , Kathleen A. Clarkson , Mark S. Gebert , Troels N. Gravesen , Michael Partsuf
发明人： Herbert B. Scher , Deborah S. Winetzky , Nathaniel T. Becker , Kathleen A. Clarkson , Mark S. Gebert , Troels N. Gravesen , Michael Partsuf
IPC分类号： B29B9/00 , C11D3/386
CPC分类号： C11D3/38672 , C11D3/225 , C11D3/3707
摘要： The present invention generally relates to particulate compositions and methods for making the compositions. It specifically relates to improved spray drying methods that substantially reduce the production of small particles that pose industrial hygiene concerns for factory workers and product consumers. In a composition aspect, the present invention provides an atomized aqueous composition. The composition is formed using a spray-drying apparatus. It includes 0.001 to 0.10 weight percent of a polymer, which is selected from a group consisting of a cellulose-based polymer, a gum, and a synthetic polymer. It further includes at least one polypeptide, which is present in the aqueous composition at a concentration greater than 0.01 weight percent.
摘要翻译：本发明一般涉及制备组合物的颗粒组合物和方法。它具体涉及改进的喷雾干燥方法，其显着降低了造成工厂工人和产品消费者的工业卫生问题的小颗粒的生产。在组合物方面，本发明提供雾化的水性组合物。使用喷雾干燥装置形成组合物。它包括0.001至0.10重量％的聚合物，其选自纤维素基聚合物，胶和合成聚合物。它还包括至少一种多肽，其以大于0.01重量％的浓度存在于水性组合物中。

5. 发明授权

US08309334B2 Method for producing highly impact-resistant granules 有权
标题翻译：高抗冲击颗粒的制造方法
公开(公告)号：US08309334B2
公开(公告)日：2012-11-13
申请号：US12342398
申请日：2008-12-23
申请人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
发明人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
IPC分类号： C12N9/98 , C12N11/14 , C12N11/10 , C12N11/08 , C07K17/14 , C07K17/10 , C07K17/08
CPC分类号： C11D3/38 , C11D3/222 , C11D3/3753 , C11D3/38672 , C11D17/0039
摘要： The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.
摘要翻译：本发明提供包含活性成分的高抗冲击性，水溶性或水分散性低粉尘颗粒及其获得方法。

6. 发明授权

US07018821B2 Highly impact-resistant granules 有权
公开(公告)号：US07018821B2
公开(公告)日：2006-03-28
申请号：US10176342
申请日：2002-06-20
申请人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
发明人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
IPC分类号： C12N9/98 , C12N11/14 , C12N11/10 , C12N11/08
CPC分类号： C11D3/38 , C11D3/222 , C11D3/3753 , C11D3/38672 , C11D17/0039
摘要： The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.

7. 发明授权

US07223386B2 Preparations for topical skin use and treatment 有权
标题翻译：局部皮肤使用和治疗的准备
公开(公告)号：US07223386B2
公开(公告)日：2007-05-29
申请号：US10660101
申请日：2003-09-10
申请人： Richard R. Bott , Mark S. Gebert , Paal Christian Klykken , Isabelle Mazeaud , Xavier Jean-Paul Thomas
发明人： Richard R. Bott , Mark S. Gebert , Paal Christian Klykken , Isabelle Mazeaud , Xavier Jean-Paul Thomas
IPC分类号： A61K31/74 , A61K38/46 , A61K9/107 , C12N9/00
CPC分类号： A61K9/7069 , A61K9/0014 , A61K9/7007 , A61K38/465 , A61K38/482 , A61K47/02 , A61K47/24 , A61K47/34 , A61L26/0019 , A61L26/0066 , A61L2300/254 , A61L2300/602 , A61L2300/622 , C08L83/04
摘要： Topical preparations for release of an active agent and to methods of making and using the topical preparations are provided. The preparations may have an internal phase dispersed within an external phase. The internal phase may be a hydrophilic carrier and an active agent. The external phase may be a silicone matrix.
摘要翻译：提供了用于释放活性剂的局部制剂以及制备和使用局部制剂的方法。制剂可能具有分散在外部相中的内相。内相可以是亲水载体和活性剂。外部相可以是硅树脂基质。

8. 发明授权

US06457345B1 Repeated impact apparatus and method for characterizing granule strength 有权
标题翻译：用于表征颗粒强度的重复冲击装置和方法
公开(公告)号：US06457345B1
公开(公告)日：2002-10-01
申请号：US09611631
申请日：2000-07-07
申请人： Mark S. Gebert , Ramanan Pitchumani , Willem J. Beekman , Gabriel M. H. Meesters , Brian Scarlett
发明人： Mark S. Gebert , Ramanan Pitchumani , Willem J. Beekman , Gabriel M. H. Meesters , Brian Scarlett
IPC分类号： G01N356
CPC分类号： G01N3/56 , G01N3/565 , G01N15/0272 , G01N2015/0261 , G01N2015/0288 , G01N2033/0091 , G01N2203/0005 , G01N2203/0037
摘要： The present invention provides methods and devices for measuring granule impact strength and granule attrition rates by vibrating a small container of granules at a well-controlled amplitude in order to inflict reproducible damage to the granules. Damage to the granules is measured as a function of time and amplitude and attrition rates are measured in terms of dust generate per number of collisions versus mass of the granules. The measurements obtained yield a highly reproducible means for characterizing granule attrition, attrition rates, and fragmentation.
摘要翻译：本发明提供了通过以良好控制的振幅振动小容器的颗粒来测量颗粒冲击强度和颗粒磨损率的方法和装置，以便对颗粒造成可重复的损害。根据时间和幅度来测量颗粒的损害，并且根据每次碰撞产生的粉尘相对于颗粒的质量来测量磨损率。所获得的测量结果表现出用于表征颗粒磨损，磨损率和碎裂的高度可重复性的手段。

9. 发明授权

US6063402A Purified galactomannan as an improved pharmaceutical excipient 失效
标题翻译：纯化的半乳甘露聚糖作为改进的药物赋形剂
公开(公告)号：US6063402A
公开(公告)日：2000-05-16
申请号：US487605
申请日：1995-06-07
申请人： Mark S. Gebert , David R. Friend , David Wong , Jagdish Parasrampuria
发明人： Mark S. Gebert , David R. Friend , David Wong , Jagdish Parasrampuria
IPC分类号： A61K47/36 , A61K9/20 , C08B37/00 , C08L5/14 , C07M1/00
CPC分类号： A61K9/205 , C08B37/0087 , C08L5/14
摘要： Disclosed is a substantially anhydrous, powdered, galactomannan composition consisting essentially of a galactomannan hydrocolloid exhibiting about 50% to about 90% by weight of anhydromannose residues and about 10% to about 50% by weight anhydrogalactose residues; less than about 1% by weight of protein material and less than about 3% of other nonaqueous impurities. This material is useful for preparing pharmaceutical compositions both in the substantially anhydrous form but preferably in an anhydrated form which includes about 5-15% by weight water. The pharmaceutical compositions comprise a therapeutically effective amount of a drug, the hydrated powered gallactomannan composition and optionally other pharmaceutically-acceptable excipients. When the hydrated powdered purified glactomannan of the invention is used to form a tablet, one sees improved hardness in the tablet formed. The pharmaceutical composition of the invention is particularly valuable for delivering a therapeutically effective drug to the colon without significant release of the drug in the upper GI tract after oral administration of the composition. Unique means to prepare the purified galactomannan in large quantities is provided.
摘要翻译：公开了基本上无水的，粉状的半乳甘露聚糖组合物，其基本上由显示约50重量％至约90重量％的脱水甘露糖残基和约10重量％至约50重量％的半脱水半乳糖残基的半乳甘露聚糖水胶体组成; 小于约1重量％的蛋白质材料和小于约3％的其它非水性杂质。该材料可用于制备基本上无水形式的药物组合物，但优选以包含约5-15重量％水的脱水形式。药物组合物包含治疗有效量的药物，水合动力的甘蔗聚糖组合物和任选的其它药学上可接受的赋形剂。当使用本发明的水合粉末状纯化甘蓝聚糖来形成片剂时，可以看出形成的片剂的硬度提高。本发明的药物组合物对于在口服给药组合物之后将治疗有效的药物递送至结肠而不会在上GI道中显着释放药物是特别有价值的。提供了大量制备纯化的半乳甘露聚糖的独特手段。

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