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1. 发明申请

US20100124586A1 STABLE, DURABLE GRANULES WITH ACTIVE AGENTS 审中-公开
标题翻译：稳定的，具有活性剂的耐用颗粒
公开(公告)号：US20100124586A1
公开(公告)日：2010-05-20
申请号：US12083387
申请日：2006-10-12
申请人： Nathaniel T. Becker , Kathleen A. Clarkson , Douglas A. Dale , Beth Fryksdale , Mark S. Gebert , Michael Partsuf , Troels N. Gravesen
发明人： Nathaniel T. Becker , Kathleen A. Clarkson , Douglas A. Dale , Beth Fryksdale , Mark S. Gebert , Michael Partsuf , Troels N. Gravesen
IPC分类号： A23L1/03
CPC分类号： A61K9/14 , A23K20/189 , A23K40/30 , A23K50/75 , A61K9/16 , A61K9/5073 , A61K38/465 , A61K38/47 , A61K47/02 , C12N9/96 , C12N9/98
摘要： A stable, durable granule for feed compositions has a core, at least one active agent; and at least one coating. The active agent of the granule retains at least 50% activity, at least 60% activity, at least 70% activity, at least 80% activity after conditions selected from one or more of a) a feed pelleting process, b) a steam-heated feed pretreatment process, c) storage, d) storage as an ingredient in an unpelleted mixture, and e) storage as an ingredient in a feed base mix or a feed premix comprising at least one compound selected from trace minerals, organic acids, reducing sugars, vitamins, choline chloride, and compounds which result in an acidic or a basic feed base mix or feed premix.
摘要翻译：用于饲料组合物的稳定，耐用的颗粒具有核心，至少一种活性剂; 和至少一个涂层。颗粒的活性剂在选自a）进料造粒方法中的一种或多种的条件之后保留至少50％的活性，至少60％的活性，至少70％的活性，至少80％的活性，b）加热进料预处理方法，c）储存，d）作为未混和的混合物中的成分进行储存，以及e）作为原料的混合物或原料预混物中的成分储存，所述进料预混物包含至少一种选自微量矿物质，有机酸，还原剂糖，维生素，氯化胆碱和导致酸性或碱性饲料基料混合物或饲料预混物的化合物。

2. 发明申请

US20120309664A1 Spray Drying Process 审中-公开
标题翻译：喷雾干燥过程
公开(公告)号：US20120309664A1
公开(公告)日：2012-12-06
申请号：US13491106
申请日：2012-06-07
申请人： Herbert B. Scher , Deborah S. Winetzky , Nathaniel T. Becker , Kathleen A. Clarkson , Mark S. Gebert , Troels N. Gravesen , Michael Partsuf
发明人： Herbert B. Scher , Deborah S. Winetzky , Nathaniel T. Becker , Kathleen A. Clarkson , Mark S. Gebert , Troels N. Gravesen , Michael Partsuf
IPC分类号： B29B9/00 , C11D3/386
CPC分类号： C11D3/38672 , C11D3/225 , C11D3/3707
摘要： The present invention generally relates to particulate compositions and methods for making the compositions. It specifically relates to improved spray drying methods that substantially reduce the production of small particles that pose industrial hygiene concerns for factory workers and product consumers. In a composition aspect, the present invention provides an atomized aqueous composition. The composition is formed using a spray-drying apparatus. It includes 0.001 to 0.10 weight percent of a polymer, which is selected from a group consisting of a cellulose-based polymer, a gum, and a synthetic polymer. It further includes at least one polypeptide, which is present in the aqueous composition at a concentration greater than 0.01 weight percent.
摘要翻译：本发明一般涉及制备组合物的颗粒组合物和方法。它具体涉及改进的喷雾干燥方法，其显着降低了造成工厂工人和产品消费者的工业卫生问题的小颗粒的生产。在组合物方面，本发明提供雾化的水性组合物。使用喷雾干燥装置形成组合物。它包括0.001至0.10重量％的聚合物，其选自纤维素基聚合物，胶和合成聚合物。它还包括至少一种多肽，其以大于0.01重量％的浓度存在于水性组合物中。

3. 发明授权

US06872696B2 Particle with substituted polyvinyl alcohol coating 有权
标题翻译：具有取代聚乙烯醇涂层的颗粒
公开(公告)号：US06872696B2
公开(公告)日：2005-03-29
申请号：US09954386
申请日：2001-09-12
申请人： Nathaniel T. Becker , Matthew J. Flynn , Mark S. Gebert
发明人： Nathaniel T. Becker , Matthew J. Flynn , Mark S. Gebert
IPC分类号： C08F8/00 , C11D3/04 , C11D3/16 , C11D3/37 , C11D3/386 , C11D3/39 , C11D17/00 , C11D3/00
CPC分类号： C11D3/38672 , C11D3/166 , C11D3/3753 , C11D3/386 , C11D3/3942 , C11D17/0039
摘要： The present invention provides an improved coating material for use with particles, such as enzyme granules, and the like. In particular, the present invention provides a modified PVA, as well as particles or granules that include such coating. The PVA is modified by substituting hydrophilic moieties for the hydroxyl or alcohol groups of the PVA. Substitution may be achieved with hydrophilic acids, amines, thiols, or combinations thereof.
摘要翻译：本发明提供一种用于颗粒如酶颗粒等的改进的涂料。特别地，本发明提供了改性PVA，以及包括这种涂层的颗粒或颗粒。通过用亲水部分代替PVA的羟基或醇基来修饰PVA。用亲水酸，胺，硫醇或其组合可以进行取代。

4. 发明申请

US20090238887A1 Highly Impact-Resistant Granules 有权
标题翻译：高抗冲击颗粒
公开(公告)号：US20090238887A1
公开(公告)日：2009-09-24
申请号：US12342398
申请日：2008-12-23
申请人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
发明人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
IPC分类号： A61K9/16 , A61K38/43 , A61K38/48 , A61K38/47 , A61K38/46 , A61K47/30
CPC分类号： C11D3/38 , C11D3/222 , C11D3/3753 , C11D3/38672 , C11D17/0039
摘要： The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.
摘要翻译：本发明提供包含活性成分的高抗冲击性，水溶性或水分散性低粉尘颗粒及其获得方法。

5. 发明授权

US08309334B2 Method for producing highly impact-resistant granules 有权
标题翻译：高抗冲击颗粒的制造方法
公开(公告)号：US08309334B2
公开(公告)日：2012-11-13
申请号：US12342398
申请日：2008-12-23
申请人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
发明人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
IPC分类号： C12N9/98 , C12N11/14 , C12N11/10 , C12N11/08 , C07K17/14 , C07K17/10 , C07K17/08
CPC分类号： C11D3/38 , C11D3/222 , C11D3/3753 , C11D3/38672 , C11D17/0039
摘要： The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.
摘要翻译：本发明提供包含活性成分的高抗冲击性，水溶性或水分散性低粉尘颗粒及其获得方法。

6. 发明授权

US07018821B2 Highly impact-resistant granules 有权
公开(公告)号：US07018821B2
公开(公告)日：2006-03-28
申请号：US10176342
申请日：2002-06-20
申请人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
发明人： Nathaniel T. Becker , Mark S. Gebert , Isabelle Mazeaud
IPC分类号： C12N9/98 , C12N11/14 , C12N11/10 , C12N11/08
CPC分类号： C11D3/38 , C11D3/222 , C11D3/3753 , C11D3/38672 , C11D17/0039
摘要： The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.

7. 发明申请

US20120214727A1 Granule With Hydrated Barrier Material 审中-公开
标题翻译：颗粒与水合屏障材料
公开(公告)号：US20120214727A1
公开(公告)日：2012-08-23
申请号：US13361860
申请日：2012-01-30
申请人： Nathaniel T. Becker , Robert I. Christensen, JR. , Alfred L. Gaertner , Mahmood M. Ghani , Douglas A. Dale
发明人： Nathaniel T. Becker , Robert I. Christensen, JR. , Alfred L. Gaertner , Mahmood M. Ghani , Douglas A. Dale
IPC分类号： C11D3/386 , B05D7/00
CPC分类号： C12N9/48 , C11D3/38672 , C11D11/0088
摘要： A granule having high stability and low dust is described. The granule includes a hydrated barrier material having moderate or high water activity. Also described are methods of producing the granules.
摘要翻译：描述了具有高稳定性和低灰尘的颗粒。颗粒包括具有中等或高水分活性的水合阻隔材料。还描述了生产颗粒的方法。

8. 发明申请

US20080206830A1 GRANULE WITH HYDRATED BARRIER MATERIAL 审中-公开
标题翻译：具有水力障碍物的颗粒
公开(公告)号：US20080206830A1
公开(公告)日：2008-08-28
申请号：US12113422
申请日：2008-05-01
申请人： Nathaniel T. Becker , Robert I. Christensen , Alfred L. Gaertner , Mahmood M. Ghani , Douglas A. Dale
发明人： Nathaniel T. Becker , Robert I. Christensen , Alfred L. Gaertner , Mahmood M. Ghani , Douglas A. Dale
IPC分类号： C12N9/00
CPC分类号： C12N9/48 , C11D3/38672 , C11D11/0088
摘要： A granule having high stability and low dust is described. The granule includes a hydrated barrier material having moderate or high water activity. Also described are methods of producing the granules.
摘要翻译：描述了具有高稳定性和低灰尘的颗粒。颗粒包括具有中等或高水分活性的水合阻隔材料。还描述了生产颗粒的方法。

9. 发明授权

US06602841B1 Granule with hydrated barrier material 有权
标题翻译：颗粒与水合屏障材料
公开(公告)号：US06602841B1
公开(公告)日：2003-08-05
申请号：US09581717
申请日：2000-06-16
申请人： Nathaniel T. Becker , Robert I. Christensen, Jr. , Alfred L. Gaertner , Mahmood M. Ghani , Douglas A. Dale
发明人： Nathaniel T. Becker , Robert I. Christensen, Jr. , Alfred L. Gaertner , Mahmood M. Ghani , Douglas A. Dale
IPC分类号： C11D742
CPC分类号： C12N9/48 , C11D3/38672 , C11D11/0088
摘要： A granule having high stability and low dust is described. The granule includes a hydrated barrier material having moderate or high water activity. Also described are methods of producing the granules.
摘要翻译：描述了具有高稳定性和低灰尘的颗粒。颗粒包括具有中等或高水分活性的水合阻隔材料。还描述了生产颗粒的方法。

10. 发明授权

US5879920A Coated enzyme-containing granule 失效
标题翻译：包被的含酶颗粒
公开(公告)号：US5879920A
公开(公告)日：1999-03-09
申请号：US577894
申请日：1995-12-22
申请人： Douglas A. Dale , Alfred L. Gaertner , Gene Park , Nathaniel T. Becker
发明人： Douglas A. Dale , Alfred L. Gaertner , Gene Park , Nathaniel T. Becker
IPC分类号： C11D1/29 , C11D1/72 , C11D3/37 , C11D3/386 , C11D17/00 , C12N11/02 , C12N11/04 , C12N11/14 , C12N9/98 , C11D10/00 , C12N11/08 , D06M16/00
CPC分类号： C11D3/3707 , C11D17/0039 , C11D3/3753 , C11D3/3776 , C11D3/38672 , C12N11/02 , C12N11/04 , C12N11/14 , C11D1/29 , C11D1/72
摘要： A granular enzyme composition is produced having reduced tendency to form dust and leave a residue, and improved stability and delayed release characteristics. The composition has a core, optionally coated with a vinyl polymer, a layer containing an enzyme and a vinyl polymer and optionally a plasticizer or anti-agglomeration agent, and an outer coating containing a polymer and optionally a low residue pigment and/or lubricant. Preferably, the core is a salt or sugar nonpareil, the vinyl polymer coating the core is polyvinyl alcohol and most preferably partially hydrolyzed polyvinyl alcohol, the vinyl polymer in the enzyme layer is polyvinyl pyrrolidone, and the polymer of the outer coating is polyvinyl pyrrolidone, polyvinyl alcohol which may be partially hydrolyzed, polyethylene glycol or mixtures thereof such as a mixture of polyvinyl pyrrolidone and polyvinyl alcohol or a mixture of polyvinyl pyrrolidone and polyethylene glycol. Preferably, the pigment is titanium dioxide and the lubricant is a nonionic or anionic surfactant such as a linear primary alcohol of a 9-15 carbon atom chain length alkane or alkene or an ethoxylate or ethoxysulfate derivative thereof. The enzyme can be a protease, amylase, lipase, cellulase, xylanase, oxidase, peroxidase or mixtures thereof. The composition may be produced by spray coating in a fluidized bed a solution of the enzyme and vinyl polymer onto the core to form the enzyme layer, and then spray coating in a fluidized bed a solution of polymer on the enzyme layer to form the outer coating.
摘要翻译：产生颗粒状酶组合物，其具有降低形成粉尘并留下残留物的倾向，以及改进的稳定性和延迟释放特性。该组合物具有核心，任选地涂覆有乙烯基聚合物，含有酶和乙烯基聚合物的层以及任选的增塑剂或抗附聚剂，以及含有聚合物和任选的低残留颜料和/或润滑剂的外涂层。优选地，核心是盐或糖不分散体，涂覆核心的乙烯基聚合物是聚乙烯醇，最优选部分水解的聚乙烯醇，酶层中的乙烯基聚合物是聚乙烯吡咯烷酮，外涂层的聚合物是聚乙烯吡咯烷酮，可以部分水解的聚乙烯醇，聚乙二醇或其混合物，例如聚乙烯吡咯烷酮和聚乙烯醇的混合物，或聚乙烯吡咯烷酮和聚乙二醇的混合物。优选地，颜料是二氧化钛，润滑剂是非离子或阴离子表面活性剂，例如9-15碳原子的链烷烃或链烯烃的直链伯醇或其乙氧基化物或乙氧基硫酸盐衍生物。酶可以是蛋白酶，淀粉酶，脂肪酶，纤维素酶，木聚糖酶，氧化酶，过氧化物酶或其混合物。组合物可以通过在流化床中将酶和乙烯基聚合物的溶液喷雾到芯上以形成酶层，然后在流化床中将聚合物溶液在酶层上喷涂以形成外涂层。

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