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1. 发明申请

US20190389904A2 MALT1 INHIBITORS AND USES THEREOF 审中-公开
公开(公告)号：US20190389904A2
公开(公告)日：2019-12-26
申请号：US15755951
申请日：2016-08-26
申请人： Nathanael S. Gray , David A. Scott , John Hatcher , Spandan Chennamadhavuni , Ari M. Melnick , Lorena Fontan Gabas , Hao Wu , Qi Qiao , Guangyan Du
发明人： Nathanael S. Gray , David A. Scott , John Hatcher , Spandan Chennamadhavuni , Ari M. Melnick , Lorena Fontan Gabas , Hao Wu , Qi Qiao , Guangyan Du
IPC分类号： C07K5/11 , A61K38/07
摘要： Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).

2. 发明授权

US09562242B2 Method for reusing water in fermented butanedioic acid separation process 有权
标题翻译：在发酵丁二酸分离过程中重复使用水的方法
公开(公告)号：US09562242B2
公开(公告)日：2017-02-07
申请号：US14344608
申请日：2012-09-13
申请人： Min Jiang , Min Zhang , Jiangfeng Ma , Hao Wu , Liya Liang , Rongming Liu , Guangming Wang , Ping Wei
发明人： Min Jiang , Min Zhang , Jiangfeng Ma , Hao Wu , Liya Liang , Rongming Liu , Guangming Wang , Ping Wei
IPC分类号： C12P7/46 , C07C51/41 , C07C51/43 , C07C51/44
CPC分类号： C12P7/46 , C07C51/412 , C07C51/43 , C07C51/44 , C07C55/10
摘要： This invention belongs to the field of biochemical engineering and relates to a method of cyclic utilization of water during separation of succinic acid made by fermentation. This invention uses water from separation process for aerobic growth of E. coli AFP111 and production of succinic acid by anaerobic fermentation, obtaining final succinic acid concentration of 55 g/L and yield of 91.6%. Compared with results of fermentation using culture medium prepared from tap water, succinic acid concentration and productivity increased by 8.5% and 8.46%, respectively. An outstanding advantage of this invention is recovery and utilization of evaporated water during separation of succinic acid, realizing cyclic use of water during industrial production of succinic acid, which is an environment-friendly process. Also, as evaporated water generated during separation of succinic acid contains small amount of organic acids such as acetic acid and formic acid, if this water is used for aerobic growth of thalli, the small amount of organic acids contained therein can be used as gluconeogenesis carbon source, improving activity of some key enzymes in cell and favoring succinic acid production by anaerobic fermentation of thalli.
摘要翻译：本发明属于生物化学工程领域，涉及通过发酵制备的琥珀酸分离期间循环利用水的方法。本发明利用分离过程中的水分进行大肠杆菌AFP111的有氧生长，通过厌氧发酵生产琥珀酸，得到最终琥珀酸浓度为55g / L，产率为91.6％。与使用自来水制备的培养基的发酵结果相比，琥珀酸浓度和产率分别提高了8.5％和8.46％。本发明的突出优点是分离琥珀酸期间蒸发水的回收利用，在工业生产琥珀酸期间循环使用水，这是一个环保的工艺。另外，由于琥珀酸分离过程中产生的蒸发水含有少量的有机酸如乙酸和甲酸，所以如果这种水用于铊的有氧生长，其中所含的少量有机酸可用作糖异生碳来源，改善细胞中一些关键酶的活性，并通过thalli的厌氧发酵有利于琥珀酸生产。

3. 发明申请

US20160171401A1 LAYOUT OPTIMIZATION FOR INTERACTIONAL OBJECTS IN A CONSTRAINED GEOGRAPHICAL AREA 审中-公开
标题翻译：限制性地理区域互动对象的布局优化
公开(公告)号：US20160171401A1
公开(公告)日：2016-06-16
申请号：US14567458
申请日：2014-12-11
申请人： Hao Wu , Yu Cheng , Wen-Syan Li
发明人： Hao Wu , Yu Cheng , Wen-Syan Li
IPC分类号： G06Q10/06
CPC分类号： G06Q10/06312 , G06Q10/06315
摘要： The present disclosure describes methods, systems, and computer program products for finding a best location scheme for a set of interactional objects in a constrained geographical area. A geographic region representing a wind farm is partitioned into a plurality of lattices. Initial chromosomes are generated, where a particular chromosome is a binary series used to represent the presence of a wind turbine in a layout of the plurality of lattices. A cost associated with each wind turbine associated with the initial chromosomes is evaluated. Parent chromosomes are selected for a genetic operation, and following the genetic operation, a cost associated with each wind turbine if evaluated. The parent chromosomes are updated using a fitness value.
摘要翻译：本公开描述了用于在受限地理区域中为一组交互对象找到最佳位置方案的方法，系统和计算机程序产品。代表风电场的地理区域被划分成多个格子。产生初始染色体，其中特定染色体是用于表示多个晶格的布局中的风力涡轮机的存在的二进制序列。评估与与初始染色体相关联的每个风力涡轮机相关联的成本。选择亲本染色体用于遗传操作，并且在遗传操作之后，如果评估，则与每个风力涡轮机相关联的成本。使用适应度值更新父染色体。

4. 发明授权

US09170462B2 Array substrate and liquid crystal display panel 有权
标题翻译：阵列基板和液晶显示面板
公开(公告)号：US09170462B2
公开(公告)日：2015-10-27
申请号：US13270866
申请日：2011-10-11
申请人： Jian Guo , Weifeng Zhou , Xing Ming , Hao Wu
发明人： Jian Guo , Weifeng Zhou , Xing Ming , Hao Wu
IPC分类号： G02F1/1362
CPC分类号： G02F1/136259 , G02F2001/136263
摘要： An array substrate comprises a first metal layer in which first signal lines are disposed; a second metal layer in which second signal lines are disposed; an insulation layer provided between the first and second metal layers. A repairing line is provided in edge regions of the second metal layer and insulated from the second signal lines, and the repairing line comprises a first longitudinal portion, a second longitudinal portion and a transverse portion, the first longitudinal portion is electrically connected to the second longitudinal portion by the transverse portion. A projection of the first longitudinal portion in a plane of the first metal layer intersects with one end of each of the first signal lines, and a projection of the second longitudinal portion in the plane of the first metal layer intersects with the other end of each of the first signal lines.
摘要翻译：阵列基板包括其中设置有第一信号线的第一金属层; 设置第二信号线的第二金属层; 设置在第一和第二金属层之间的绝缘层。修理线设置在第二金属层的边缘区域并与第二信号线绝缘，并且修理线包括第一纵向部分，第二纵向部分和横向部分，第一纵向部分电连接到第二纵向部分纵向部分由横向部分。第一纵向部分在第一金属层的平面中的突起与第一信号线的一端相交，并且第一纵向部分在第一金属层的平面中的突起与每个第一金属层的另一端相交的第一条信号线。

5. 发明授权

US09147745B2 Semiconductor devices formed using a sacrificial layer and methods for manufacturing the same 有权
标题翻译：使用牺牲层形成的半导体器件及其制造方法
公开(公告)号：US09147745B2
公开(公告)日：2015-09-29
申请号：US13981808
申请日：2012-07-24
申请人： Huilong Zhu , Qingqing Liang , Huicai Zhong , Hao Wu
发明人： Huilong Zhu , Qingqing Liang , Huicai Zhong , Hao Wu
IPC分类号： H01L29/66 , H01L29/78 , H01L29/786 , H01L21/28 , H01L29/51
CPC分类号： H01L29/66477 , H01L21/2815 , H01L29/517 , H01L29/66545 , H01L29/66628 , H01L29/66636 , H01L29/66772 , H01L29/7848 , H01L29/78618 , H01L29/78639 , H01L29/78654
摘要： Semiconductor devices and methods for manufacturing the same are disclosed. In one embodiment, the method comprises: sequentially forming a sacrificial layer and a semiconductor layer on a substrate; forming a first cover layer on the semiconductor layer; forming an opening extending into the substrate with the first cover layer as a mask; selectively removing at least a portion of the sacrificial layer through the opening, and filling an insulating material in a gap due to removal of the sacrificial layer; forming one of source and drain regions in the opening; forming a second cover layer on the substrate; forming the other of the source and drain regions with the second cover layer as a mask; removing a portion of the second cover layer; and forming a gate dielectric layer, and forming a gate conductor in the form of spacer on a sidewall of a remaining portion of the second cover layer.
摘要翻译：公开了半导体装置及其制造方法。在一个实施例中，该方法包括：在衬底上顺序形成牺牲层和半导体层; 在所述半导体层上形成第一覆盖层; 形成以第一覆盖层为掩模延伸到基板的开口; 通过所述开口选择性地去除所述牺牲层的至少一部分，并且由于去除所述牺牲层而在绝缘材料中填充绝缘材料; 在开口中形成源极和漏极区域之一; 在所述基板上形成第二覆盖层; 以第二覆盖层为掩模形成源区和漏区中的另一个; 去除所述第二覆盖层的一部分; 以及形成栅极电介质层，并且在所述第二覆盖层的剩余部分的侧壁上形成隔板形式的栅极导体。

6. 发明申请

US20150246902A1 SUBSTITUED BENZOFURAN COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权
标题翻译：替代苯并呋喃化合物及其用于治疗病毒性疾病的方法
公开(公告)号：US20150246902A1
公开(公告)日：2015-09-03
申请号：US14343462
申请日：2012-08-16
申请人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Qun Dang
发明人： Casey C. McComas , Nigel J. Liverton , Joerg Habermann , Uwe Koch , Frank Narjes , Peng Li , Xuanjia Peng , Richard Soll , Hao Wu , Anandan Palani , Xing Dai , Hong Liu , Shuwen He , Qun Dang
IPC分类号： C07D405/04 , C07D473/00 , A61K31/52 , A61K45/06 , A61K31/437 , C07D487/04 , A61K31/4985 , A61K31/5025 , A61K31/4184 , C07D471/04
CPC分类号： C07D405/04 , A61K31/4045 , A61K31/416 , A61K31/4184 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/4985 , A61K31/5025 , A61K31/52 , A61K45/06 , C07D405/14 , C07D471/04 , C07D473/00 , C07D487/04 , C07D498/04 , Y02A50/387 , Y02A50/389 , Y02A50/395 , A61K2300/00
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译：本发明涉及可用作丙型肝炎病毒（HCV）NS5B聚合酶抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5B聚合酶活性用于治疗或预防HCV感染的式（I）化合物并用于在基于细胞的系统中抑制HCV病毒复制和/或病毒生产。

7. 发明授权

US08929923B2 Method and device for locating terminal by using base station 有权
标题翻译：使用基站定位终端的方法和装置
公开(公告)号：US08929923B2
公开(公告)日：2015-01-06
申请号：US13257125
申请日：2010-05-26
申请人： Yin Gao , Hao Wu
发明人： Yin Gao , Hao Wu
IPC分类号： H04M3/00 , H04W24/00 , H04W4/00 , H04W64/00 , G01S5/00 , G01S5/02 , G01S5/14
CPC分类号： H04W64/00 , G01S5/00 , G01S5/0205 , G01S5/14 , Y02D70/1222 , Y02D70/1242 , Y02D70/1262 , Y02D70/1264
摘要： The present invention provides a method for locating a terminal by using a base station, and the method includes steps as follows: constructing a locating message by expanding a location report message or via an independent message; sending the locating message to a locating judgment center; and locating the terminal by using the locating message. The present invention is helpful to reduce the power consumption of the User Equipment (UE).
摘要翻译：本发明提供了一种通过使用基站来定位终端的方法，该方法包括以下步骤：通过扩展位置报告消息或经由独立消息来构建定位消息; 将定位消息发送到定位判断中心; 并使用定位信息定位终端。本发明有助于降低用户设备（UE）的功耗。

8. 发明申请

US20140370923A1 METHOD AND SYSTEM FOR SENDING SHORT MESSAGE 有权
标题翻译：发送短消息的方法和系统
公开(公告)号：US20140370923A1
公开(公告)日：2014-12-18
申请号：US14376119
申请日：2012-04-24
申请人： Hao Wu
发明人： Hao Wu
IPC分类号： H04W4/14
CPC分类号： H04W4/14
摘要： The disclosure provides a method and system for sending a short message. The method includes: an SMS-SC sending a short message to an SMS-GMSC, and after the SMS-GMSC sends the short message to an MME, the MME sending a failure report to the SMS-GMSC when the MME detects that a terminal is unreachable (S202); the SMS-GMSC receiving the sent failure report and sending a short-message sending status message to an HSS, and the HSS setting waiting data according to the short-message sending status message (S204); upon detecting that the terminal switches from unreachable to reachable, the MME notifying the HSS that the terminal is reachable (S206); upon learning that the terminal is reachable, the HSS sending, according to the waiting data, a warning message to notify the SMS-SC that the terminal is reachable, and upon learning that the terminal is reachable again, the SMS-SC sending the short message again (S208). By means of the solution, a short message service can also be received in an area covered only by a packet switched network.
摘要翻译：本公开提供了发送短消息的方法和系统。该方法包括：SMS-SC向SMS-GMSC发送短消息，在SMS-GMSC向MME发送短消息之后，当MME检测到终端时，MME向SMS-GMSC发送故障报告是不可达的（S202）; SMS-GMSC接收发送的故障报告并向HSS发送短消息发送状态消息，并根据短消息发送状态消息发送HSS设置等待数据（S204）; 一旦检测到终端从不可达到达可切换，则MME通知HSS终端可达（S206）; 在学习终端可达时，HSS根据等待数据发送警告消息，通知SMS-SC终端可达，并且在学习到终端可再次到达后，SMS-SC发送短消息消息（S208）。通过解决方案，也可以在仅由分组交换网络覆盖的区域中接收短消息服务。

9. 发明申请

US20140206681A1 BTK INHIBITORS 审中-公开
标题翻译： BTK抑制剂
公开(公告)号：US20140206681A1
公开(公告)日：2014-07-24
申请号：US14160587
申请日：2014-01-22
申请人： RONALD M. KIM , Jian Liu , Xiaolei Gao , Sobhana Babu Boga , Deodialsingh Guiadeen , Joseph A. Kozlowski , Wensheng Yu , Rajan Anand , Younong Yu , Oleg B. Selyutin , Ying-Duo Gao , Hao Wu , Shilan Liu , Chundao Yang , Hongjian Wang
发明人： RONALD M. KIM , Jian Liu , Xiaolei Gao , Sobhana Babu Boga , Deodialsingh Guiadeen , Joseph A. Kozlowski , Wensheng Yu , Rajan Anand , Younong Yu , Oleg B. Selyutin , Ying-Duo Gao , Hao Wu , Shilan Liu , Chundao Yang , Hongjian Wang
IPC分类号： C07D471/04 , A61K31/4985 , A61K31/506 , C07D487/04 , A61K31/5383 , A61K31/519 , A61K31/5365 , A61K45/06 , C07D498/04 , C07D455/02
CPC分类号： C07D491/048 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , Y02A50/411 , Y02A50/463
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
摘要翻译：本发明提供了根据式I的Bruton's酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。特别地，本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。

10. 发明申请

US20140199264A1 TETRACYCLIC XANTHENE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权
标题翻译：四环素衍生物及其用于治疗病毒性疾病的方法
公开(公告)号：US20140199264A1
公开(公告)日：2014-07-17
申请号：US14005430
申请日：2012-03-16
申请人： Craig A. Coburn , Stuart B. Rosenblum , Joseph A. Kozlowski , Richard Soll , Hao Wu , Bin Hu , Bin Zhong , Dahai Wang , Changmao Shen , Fei Sun
发明人： Craig A. Coburn , Stuart B. Rosenblum , Joseph A. Kozlowski , Richard Soll , Hao Wu , Bin Hu , Bin Zhong , Dahai Wang , Changmao Shen , Fei Sun
IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4178 , C07D498/06 , C07D493/06
CPC分类号： A61K31/5383 , A61K31/4178 , A61K45/06 , C07D491/06 , C07D493/06 , C07D498/06
摘要： The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及式（I）的新型四环Xanthene衍生物及其药学上可接受的盐，其中A，Y1，Y2，Z，Ra，Rb，R1a，R1b和R2如本文所定义。本发明还涉及包含至少一种四环Xanthene衍生物的组合物，以及使用四环Xanthene衍生物治疗或预防患者HCV感染的方法。

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