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1. 发明授权

US06319724B1 Trace level detection of analytes using artificial olfactometry 有权
公开(公告)号：US06319724B1
公开(公告)日：2001-11-20
申请号：US09336428
申请日：1999-06-17
申请人： Nathan S. Lewis , Erik J. Severin , Bernard Wong , David M. Kelso , Beth C. Munoz
发明人： Nathan S. Lewis , Erik J. Severin , Bernard Wong , David M. Kelso , Beth C. Munoz
IPC分类号： G01N2518
CPC分类号： G01N33/497 , A61B5/00 , A61B5/082 , A61B5/4547 , G01N1/22 , G01N1/405 , G01N33/0031 , G01N33/0034 , G01N33/0044 , Y10S436/90 , Y10S977/879 , Y10T436/143333 , Y10T436/17 , Y10T436/200833 , Y10T436/212 , Y10T436/214 , Y10T436/216
摘要： The present invention provides methods for detecting the presence of an analyte indicative of various medical conditions, including halitosis, periodontal disease and other diseases are also disclosed.

2. 发明授权

US06841391B2 Medical applications of artificial olfactometry 失效
标题翻译：人工嗅觉的医学应用
公开(公告)号：US06841391B2
公开(公告)日：2005-01-11
申请号：US09855277
申请日：2001-05-14
申请人： Nathan S. Lewis , Erik J. Severin , Bernard Wong , David M. Kelso , Beth C. Munoz
发明人： Nathan S. Lewis , Erik J. Severin , Bernard Wong , David M. Kelso , Beth C. Munoz
IPC分类号： G01N27/12 , A61B5/00 , A61M15/00 , A61M15/08 , A61M16/00 , G01N1/02 , G01N1/22 , G01N1/34 , G01N1/40 , G01N21/01 , G01N21/05 , G01N21/75 , G01N21/76 , G01N27/00 , G01N27/02 , G01N27/04 , G01N27/416 , G01N29/02 , G01N30/96 , G01N33/00 , G01N33/497
CPC分类号： G01N33/497 , A61B5/00 , A61B5/082 , A61B5/4547 , G01N1/22 , G01N1/405 , G01N33/0031 , G01N33/0034 , G01N33/0044 , Y10S436/90 , Y10S977/879 , Y10T436/143333 , Y10T436/17 , Y10T436/200833 , Y10T436/212 , Y10T436/214 , Y10T436/216
摘要： The present invention provides methods for detecting the presence of an analyte indicative of various medical conditions, including halitosis, periodontal disease and other diseases are also disclosed.
摘要翻译：本发明提供了用于检测指示各种医学状况的分析物的存在的方法，包括口臭，牙周病和其它疾病。

3. 发明授权

US06244096B1 Trace level detection of analytes using artificial olfactometry 有权
标题翻译：使用人工嗅觉测定法分析物的痕量水平检测
公开(公告)号：US06244096B1
公开(公告)日：2001-06-12
申请号：US09335425
申请日：1999-06-17
申请人： Nathan S. Lewis , Erik J. Severin , Bernard Wong
发明人： Nathan S. Lewis , Erik J. Severin , Bernard Wong
IPC分类号： G01N33497
CPC分类号： G01N33/497 , A61B5/00 , A61B5/082 , A61B5/4547 , G01N1/22 , G01N1/405 , G01N33/0031 , G01N33/0034 , G01N33/0044 , Y10S436/90 , Y10S977/879 , Y10T436/143333 , Y10T436/17 , Y10T436/200833 , Y10T436/212 , Y10T436/214 , Y10T436/216
摘要： The present invention provides a device for detecting the presence of an analyte, wherein said analyte is a microorganism marker gas. The device comprises a sample chamber having a fluid inlet port for the influx of the microorganism marker gas; a fluid concentrator in flow communication with the sample chamber, wherein the fluid concentrator has an absorbent material capable of absorbing the microorganism marker gas and thereafter releasing a concentrated microorganism marker gas; and an array of sensors in fluid communication with the concentrated microorganism marker gas. The sensor array detects and identifies the marker gas upon its release from fluid concentrate.
摘要翻译：本发明提供了一种用于检测分析物的存在的装置，其中所述分析物是微生物标记气体。该装置包括具有用于微生物标记气体的流入的流体入口的样品室; 流体浓缩器，其与样品室流体连通，其中所述流体浓缩器具有能够吸收微生物标记气体并随后释放浓缩的微生物标记气体的吸收材料; 以及与浓缩的微生物标记气体流体连通的传感器阵列。传感器阵列在从流体浓缩物释放时检测并识别标记气体。

4. 发明授权

US06467333B2 Trace level detection of analytes using artificial olfactometry 失效
标题翻译：使用人工嗅觉测定法分析物的痕量水平检测
公开(公告)号：US06467333B2
公开(公告)日：2002-10-22
申请号：US09815618
申请日：2001-03-22
申请人： Nathan S. Lewis , Erik J. Severin , Bernard Wong
发明人： Nathan S. Lewis , Erik J. Severin , Bernard Wong
IPC分类号： A61B1900
CPC分类号： G01N33/497 , A61B5/00 , A61B5/082 , A61B5/4547 , G01N1/22 , G01N1/405 , G01N33/0031 , G01N33/0034 , G01N33/0044 , Y10S436/90 , Y10S977/879 , Y10T436/143333 , Y10T436/17 , Y10T436/200833 , Y10T436/212 , Y10T436/214 , Y10T436/216
摘要： The present invention provides a device for detecting the presence of an analyte, such as for example, a lightweight device, including: a sample chamber having a fluid inlet port for the influx of the analyte; a fluid concentrator in flow communication with the sample chamber wherein the fluid concentrator has an absorbent material capable of absorbing the analyte and capable of desorbing a concentrated analyte; and an array of sensors in fluid communication with the concentrated analyte to be released from the fluid concentrator.
摘要翻译：本发明提供了一种用于检测分析物（例如轻质装置）的存在的装置，包括：样品室，其具有用于分析物流入的流体入口; 与样品室流体连通的流体浓缩器，其中流体浓缩器具有能够吸收分析物并能够解吸浓缩分析物的吸收材料; 以及与浓缩分析物流体连通以从流体浓缩器释放的传感器阵列。

5. 发明授权

US06844197B1 Method for validating that the detection ability of a sensor array mimics a human nose detection ability 失效
标题翻译：用于验证传感器阵列的检测能力模拟人鼻检测能力的方法
公开(公告)号：US06844197B1
公开(公告)日：2005-01-18
申请号：US09293669
申请日：1999-04-16
申请人： Brett J. Doleman , Nathan S. Lewis , Erik J. Severin
发明人： Brett J. Doleman , Nathan S. Lewis , Erik J. Severin
IPC分类号： G01N33/00 , G01N27/416
CPC分类号： G01N33/0006 , Y10T436/10 , Y10T436/100833
摘要： The present invention relates to methods for matching and validating the response intensity of a sensor array to an odorant with the detection threshold of a human nose.
摘要翻译：本发明涉及用于将感测器阵列的响应强度与具有人鼻检测阈值的气味剂进行匹配和验证的方法。

6. 发明授权

US06759010B2 Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids 有权
公开(公告)号：US06759010B2
公开(公告)日：2004-07-06
申请号：US09910243
申请日：2001-07-20
申请人： Nathan S. Lewis , Erik J. Severin , Michael Freund , Adam J. Matzger
发明人： Nathan S. Lewis , Erik J. Severin , Michael Freund , Adam J. Matzger
IPC分类号： G01N2702
CPC分类号： G01N33/0031 , G01N15/0826 , G01N27/126 , G01N29/022 , G01N29/449 , G01N2291/0217 , G01N2291/0256 , G01N2291/02863 , G01N2291/0423 , G01N2291/0426
摘要： Chemical sensors for detecting the activity of a molecule or analyte of interest is provided. The chemical sensors comprise and array or plurality of sensors that are capable of interacting with a molecule of interest, wherein the interaction provides a response fingerprint. The fingerprint can be associated with a library of similar molecules of interest to determine the molecule's activity and diffusion coefficient.

7. 发明授权

US06571603B1 Method of resolving analytes in a fluid 有权
标题翻译：解决流体中分析物的方法
公开(公告)号：US06571603B1
公开(公告)日：2003-06-03
申请号：US09318900
申请日：1999-05-26
申请人： Brett J. Doleman , Erik J. Severin , Nathan S. Lewis
发明人： Brett J. Doleman , Erik J. Severin , Nathan S. Lewis
IPC分类号： G01N33497
CPC分类号： G06K9/6234 , G01N33/0031 , G01N33/0034
摘要： A statistical metric, based on the magnitude and standard deviations along linear projections of clustered array response data, is utilized to facilitate an evaluation of the performance of detector arrays in various vapor classification tasks. This approach allows quantification of the ability of arrays of different types including carbon black-insulating polymer composite chemiresistor sensors, tin oxide sensors and bulk conducting organic polymer sensors to distinguish between analytes. The evaluation of questions such as the optimal number of detectors required for a specific task, whether improved performance is obtained by increasing the number of detectors in a detector array, and how to assess statistically the diversity of a collection of detectors in order to understand more fully which properties are underrepresented in a particular set of array elements, are addressed.
摘要翻译：基于沿群集阵列响应数据的线性投影的幅度和标准偏差的统计度量被用来促进各种蒸汽分类任务中检测器阵列性能的评估。这种方法允许定量不同类型的阵列的能力，包括炭黑绝缘聚合物复合化学电阻传感器，氧化锡传感器和体导电有机聚合物传感器来区分分析物。对诸如特定任务所需的最佳检测数量的问题的评估，通过增加检测器阵列中的检测器的数量来获得改进的性能，以及如何统计地评估检测器集合的多样性，以便了解更多在特定的一组阵列元素中完全具有哪些属性不足。

8. 发明授权

US07955561B2 Colloidal particles used in sensing array 有权
标题翻译：用于传感阵列的胶体颗粒
公开(公告)号：US07955561B2
公开(公告)日：2011-06-07
申请号：US11108538
申请日：2005-04-18
申请人： Nathan S. Lewis , Brett J. Doleman , Shawn M. Briglin , Erik J. Severin
发明人： Nathan S. Lewis , Brett J. Doleman , Shawn M. Briglin , Erik J. Severin
IPC分类号： G01N27/04 , G01N27/06
CPC分类号： G01N27/126 , G01N27/127 , Y10S977/957
摘要： Chemical sensors for detecting analytes in fluids comprising a plurality of alternating nonconductive regions (comprising a nonconductive material) and conductive regions (comprising a conductive material). In preferred embodiments, the conducting region comprises a nanoparticle. Variability in chemical sensitivity from sensor to sensor is provided by qualitatively or quantitatively varying the composition of the conductive and/or nonconductive regions. An electronic nose for detecting an analyte in a fluid may be constructed by using such arrays in conjunction with an electrical measuring device electrically connected to the conductive elements of each sensor.
摘要翻译：用于检测包含多个交替非导电区域（包括非导电材料）和导电区域（包括导电材料）的流体中的分析物的化学传感器。在优选实施方案中，导电区域包含纳米颗粒。通过定性地或定量地改变导电和/或非导电区域的组成来提供从传感器到传感器的化学敏感性的变化。用于检测流体中的分析物的电子鼻可以通过使用这样的阵列结合电连接到每个传感器的导电元件的电测量装置来构造。

9. 发明授权

US06610367B2 Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids 有权
公开(公告)号：US06610367B2
公开(公告)日：2003-08-26
申请号：US09910242
申请日：2001-07-20
申请人： Nathan S. Lewis , Erik J. Severin , Michael Freund , Adam J. Matzger
发明人： Nathan S. Lewis , Erik J. Severin , Michael Freund , Adam J. Matzger
IPC分类号： B05D102
CPC分类号： G01N33/0031 , G01N15/0826 , G01N27/126 , G01N29/022 , G01N29/449 , G01N2291/0217 , G01N2291/0256 , G01N2291/02863 , G01N2291/0423 , G01N2291/0426
摘要： Chemical sensors for detecting the activity of a molecule or analyte of interest is provided. The chemical sensors comprise and array or plurality of sensors that are capable of interacting with a molecule of interest, wherein the interaction provides a response fingerprint. The fingerprint can be associated with a library of similar molecules of interest to determine the molecule's activity and diffusion coefficient.

10. 发明授权

US06387329B1 Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids 有权
公开(公告)号：US06387329B1
公开(公告)日：2002-05-14
申请号：US09442074
申请日：1999-11-16
申请人： Nathan S. Lewis , Erik J. Severin , Michael Freund , Adam J. Matzger
发明人： Nathan S. Lewis , Erik J. Severin , Michael Freund , Adam J. Matzger
IPC分类号： G01N2700
CPC分类号： G01N33/0031 , G01N15/0826 , G01N27/126 , G01N29/022 , G01N29/449 , G01N2291/0217 , G01N2291/0256 , G01N2291/02863 , G01N2291/0423 , G01N2291/0426
摘要： Chemical sensors for detecting the activity of a molecule or analyte of interest is provided. The chemical sensors comprise and array or plurality of sensors that are capable of interacting with a molecule of interest, wherein the interaction provides a response fingerprint. The fingerprint can be associated with a library of similar molecules of interest to determine the molecule's activity and diffusion coefficient.

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