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1. 发明授权

US08153156B2 Hydrogel nanocompsites for ophthalmic applications 有权
标题翻译：用于眼科应用的水凝胶纳米复合体
公开(公告)号：US08153156B2
公开(公告)日：2012-04-10
申请号：US10574667
申请日：2004-09-03
申请人： Nathan Ravi
发明人： Nathan Ravi
IPC分类号： A61K9/14
CPC分类号： A61L27/00 , A61F2/16 , A61F2/1624 , A61K9/0048 , A61K9/5138 , A61K9/5192 , A61K31/785 , A61L27/50 , A61L27/52 , Y10S977/773
摘要： The present invention relates to reversible hydrogel systems. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidize state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. Reversible nanogels can also be formed from a dilute solution of the copolymers. The hydrogel is formed with nanoparticles embedded therein to form a nanocomposite whose refractive index and modulus can be controlled by varying the amounts of nanoparticles and the polymer concentration of the hydrogel, respectively.
摘要翻译：本发明涉及可逆水凝胶体系。特别地，本发明的水凝胶由在氧化状态下可以是水凝胶的共聚物构成，在还原状态时可以是溶液。共聚物的溶液可以被氧化形成水凝胶; 并且可以还原水凝胶以形成共聚物的溶液。可逆的纳米凝胶也可以由共聚物的稀溶液形成。水凝胶由嵌入其中的纳米颗粒形成以形成纳米复合材料，其纳米复合材料的折射率和模量可分别通过改变纳米颗粒的量和水凝胶的聚合物浓度来控制。

2. 发明申请

US20110144228A1 HYDROGEL NANOCOMPOSITES FOR INTRAOCULAR LENS APPLICATONS 有权
标题翻译：用于镜下镜片的水凝胶纳米复合材料
公开(公告)号：US20110144228A1
公开(公告)日：2011-06-16
申请号：US13019412
申请日：2011-02-02
申请人： Nathan Ravi
发明人： Nathan Ravi
IPC分类号： G02B1/04 , B82B1/00
CPC分类号： A61L27/00 , A61F2/16 , A61F2/1624 , A61K9/0048 , A61K9/5138 , A61K9/5192 , A61K31/785 , A61L27/50 , A61L27/52 , Y10S977/773
摘要： The present invention relates to reversible hydrogel systems. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. Reversible nanogels can also be formed from a dilute solution of the copolymers. The hydrogel is formed with nanoparticles embedded therein to form a nanocomposite whose refractive index and modulus can be controlled by varying the amounts of nanoparticles and the polymer concentration of the hydrogel, respectively.
摘要翻译：本发明涉及可逆水凝胶体系。特别地，本发明的水凝胶由共聚物构成，该共聚物在处于氧化状态时可以是水凝胶，并且当处于还原状态时可以是溶液。共聚物的溶液可以被氧化形成水凝胶; 并且可以还原水凝胶以形成共聚物的溶液。可逆的纳米凝胶也可以由共聚物的稀溶液形成。水凝胶由嵌入其中的纳米颗粒形成以形成纳米复合材料，其纳米复合材料的折射率和模量可分别通过改变纳米颗粒的量和水凝胶的聚合物浓度来控制。

3. 发明申请

US20070178062A1 Treatment of presbyopia with picolinic acid and its analogs 审中-公开
标题翻译：用吡啶甲酸及其类似物治疗老花眼
公开(公告)号：US20070178062A1
公开(公告)日：2007-08-02
申请号：US11544647
申请日：2006-10-10
申请人： Nathan Ravi , Paul Hamilton
发明人： Nathan Ravi , Paul Hamilton
IPC分类号： A61K31/785 , A61K31/58 , A61K31/455 , A61K31/335
CPC分类号： A61K31/335 , A61K9/0048 , A61K31/455 , A61K31/58 , A61K31/785
摘要： Compositions and methods for inhibiting the growth of lens epithelial cells are provided. The compositions provided include a chelating agent in an amount sufficient for inhibiting the growth of lens epithelial cells. The compositions and methods provided may also be used for the treatment of disorders of the eye, especially in the treatment of presbyopia.
摘要翻译：提供了抑制晶状体上皮细胞生长的组合物和方法。提供的组合物包括足以抑制晶状体上皮细胞生长的量的螯合剂。所提供的组合物和方法也可用于治疗眼睛疾病，特别是在治疗老花眼中。

4. 发明授权

US08877227B2 Hydrogel nanocomposites for intraocular lens applicatons 有权
标题翻译：水凝胶纳米复合材料用于眼内透镜应用
公开(公告)号：US08877227B2
公开(公告)日：2014-11-04
申请号：US13019412
申请日：2011-02-02
申请人： Nathan Ravi
发明人： Nathan Ravi
IPC分类号： A61F2/16 , A61L27/50 , A61K9/51 , A61L27/52 , A61K31/785 , A61K9/00
CPC分类号： A61L27/00 , A61F2/16 , A61F2/1624 , A61K9/0048 , A61K9/5138 , A61K9/5192 , A61K31/785 , A61L27/50 , A61L27/52 , Y10S977/773
摘要： The present invention relates to reversible hydrogel systems. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. Reversible nanogels can also be formed from a dilute solution of the copolymers. The hydrogel is formed with nanoparticles embedded therein to form a nanocomposite whose refractive index and modulus can be controlled by varying the amounts of nanoparticles and the polymer concentration of the hydrogel, respectively.
摘要翻译：本发明涉及可逆水凝胶体系。特别地，本发明的水凝胶由共聚物构成，该共聚物在处于氧化状态时可以是水凝胶，并且当处于还原状态时可以是溶液。共聚物的溶液可以被氧化形成水凝胶; 并且可以将水凝胶还原形成共聚物的溶液。可逆的纳米凝胶也可以由共聚物的稀溶液形成。水凝胶由嵌入其中的纳米颗粒形成以形成纳米复合材料，其纳米复合材料的折射率和模量可分别通过改变纳米颗粒的量和水凝胶的聚合物浓度来控制。

5. 发明申请

US20070110707A1 Method of treating diseases involving non-enzymatic glycation 审中-公开
标题翻译：治疗涉及非酶促糖化的疾病的方法
公开(公告)号：US20070110707A1
公开(公告)日：2007-05-17
申请号：US11555320
申请日：2006-11-01
申请人： Nathan Ravi
发明人： Nathan Ravi
IPC分类号： A61K31/785 , A61K33/10 , A61K33/24 , A61K31/433 , A61K31/34
CPC分类号： A61K33/24 , A61K31/34 , A61K31/433 , A61K31/785 , A61K33/06 , A61K33/08 , A61K45/06
摘要： Methods for preventing or diminishing non-enzymatic glycation as well as methods for treating diseases involving non-enzymatic glycation are disclosed. The methods involve administering to a patient an agent that decreases serum inorganic phosphate levels. The agent can be a carbonic anhydrase inhibitor diuretic agent or an agent that binds phosphate in the gastrointestinal tract.
摘要翻译：公开了用于预防或减少非酶促糖化的方法以及用于治疗涉及非酶促糖化的疾病的方法。所述方法包括向患者施用降低血清无机磷酸盐水平的试剂。该试剂可以是碳酸酐酶抑制剂利尿剂或在胃肠道中结合磷酸盐的试剂。

6. 发明授权

US08192485B2 Reversible hydrogel systems and methods therefor 有权
标题翻译：可逆水凝胶体系及其方法
公开(公告)号：US08192485B2
公开(公告)日：2012-06-05
申请号：US10706081
申请日：2003-11-13
申请人： Nathan Ravi
发明人： Nathan Ravi
IPC分类号： A61F2/16 , A61F2/14
CPC分类号： A61L27/52 , A61F2/16 , A61L27/50 , Y10S977/773
摘要： The present invention relates to reversible hydrogel systems for medical applications. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. The solution can be dehydrated to produce the dry copolymer for storage. Furthermore, the present invention also relates to methods of making and using the reversible hydrogel systems.
摘要翻译：本发明涉及用于医疗应用的可逆水凝胶体系。特别地，本发明的水凝胶由共聚物构成，该共聚物在处于氧化状态时可以是水凝胶，并且当处于还原状态时可以是溶液。共聚物的溶液可以被氧化形成水凝胶; 并且可以还原水凝胶以形成共聚物的溶液。可以将溶液脱水以制备用于储存的干燥共聚物。此外，本发明还涉及制备和使用可逆水凝胶体系的方法。

7. 发明授权

US07670794B2 Managing glycemia status in diabetic patients 有权
标题翻译：管理糖尿病患者的血糖状况
公开(公告)号：US07670794B2
公开(公告)日：2010-03-02
申请号：US11555330
申请日：2006-11-01
申请人： Nathan Ravi
发明人： Nathan Ravi
IPC分类号： C12Q1/54
CPC分类号： G01N33/723 , G01N33/66 , G01N2800/042
摘要： Methods for monitoring and managing glycemia status in a diabetic patient are disclosed. The methods comprise measuring in a diabetic patient, serum concentrations of HbA1c, glucose and inorganic phosphate and comparing the measured concentrations with reference concentrations. An equation representing the reference relationship of HbA1c, glucose and inorganic phosphate is also provided.
摘要翻译：公开了监测和控制糖尿病患者血糖状态的方法。该方法包括在糖尿病患者中测量血清HbA1c，葡萄糖和无机磷酸盐的浓度，并将测量的浓度与参考浓度进行比较。还提供了表示HbA1c，葡萄糖和无机磷酸盐的参考关系的方程式。

8. 发明申请

US20070269488A1 Hydrogel Nanocompsites for Ophthalmic Applications 有权
标题翻译：水凝胶纳米机械用于眼科应用
公开(公告)号：US20070269488A1
公开(公告)日：2007-11-22
申请号：US10574667
申请日：2004-09-03
申请人： Nathan Ravi
发明人： Nathan Ravi
IPC分类号： A61K31/785 , A61K9/00 , A61P27/12
CPC分类号： A61L27/00 , A61F2/16 , A61F2/1624 , A61K9/0048 , A61K9/5138 , A61K9/5192 , A61K31/785 , A61L27/50 , A61L27/52 , Y10S977/773
摘要： The present invention relates to reversible hydrogel systems. Particularly, the hydrogel of the present invention is made up of copolymers that can be a hydrogel when in an oxidized state and can be a solution when in a reduced state. A solution of the copolymer can be oxidized to form a hydrogel; and the hydrogel can be reduced to form a solution of the copolymer. Reversible nanogels can also be formed from a dilute solution of the copolymers. The hydrogel is formed with nanoparticles embedded therein to form a nanocomposite whose refractive index and modulus can be controlled by varying the amounts of nanoparticles and the polymer concentration of the hydrogel, respectively
摘要翻译：本发明涉及可逆水凝胶体系。特别地，本发明的水凝胶由共聚物构成，该共聚物在处于氧化状态时可以是水凝胶，并且当处于还原状态时可以是溶液。共聚物的溶液可以被氧化形成水凝胶; 并且可以还原水凝胶以形成共聚物的溶液。可逆的纳米凝胶也可以由共聚物的稀溶液形成。水凝胶由嵌入其中的纳米颗粒形成以形成纳米复合材料，其纳米复合材料的折射率和模量可分别通过改变纳米颗粒的量和水凝胶的聚合物浓度来控制

9. 发明申请

US20070111272A1 MANAGING GLYCEMIA STATUS IN DIABETIC PATIENTS RELATED APPLICATION 有权
标题翻译：糖尿病患者GLYCEMIA状态的管理相关应用
公开(公告)号：US20070111272A1
公开(公告)日：2007-05-17
申请号：US11555330
申请日：2006-11-01
申请人： Nathan Ravi
发明人： Nathan Ravi
IPC分类号： C12Q1/54 , C12Q1/48
CPC分类号： G01N33/723 , G01N33/66 , G01N2800/042
摘要： Methods for monitoring and managing glycemia status in a diabetic patient are disclosed. The methods comprise measuring in a diabetic patient, serum concentrations of HbA1c, glucose and inorganic phosphate and comparing the measured concentrations with reference concentrations. An equation representing the reference relationship of HbA1c, glucose and inorganic phosphate is also provided.
摘要翻译：公开了监测和控制糖尿病患者血糖状态的方法。该方法包括在糖尿病患者中测量血清HbA1c，葡萄糖和无机磷酸盐的浓度，并将测量的浓度与参考浓度进行比较。还提供了表示HbA1c，葡萄糖和无机磷酸盐的参考关系的方程式。

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