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1. 发明申请

US20120235016A1 System, Method, and Product for Scanning of Biological Materials 有权
标题翻译：生物材料扫描的系统，方法和产品
公开(公告)号：US20120235016A1
公开(公告)日：2012-09-20
申请号：US13480888
申请日：2012-05-25
申请人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleinik-Ovod
发明人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleinik-Ovod
IPC分类号： H01L27/146
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
摘要翻译：描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联一个或多个位置校正值。

2. 发明申请

US20100142850A1 System, method, and product for scanning of biological materials 有权
标题翻译：用于生物材料扫描的系统，方法和产品
公开(公告)号：US20100142850A1
公开(公告)日：2010-06-10
申请号：US12704350
申请日：2010-02-11
申请人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleink-Ovod
发明人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleink-Ovod
IPC分类号： G06K9/40
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
摘要翻译：描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联一个或多个位置校正值。

3. 发明授权

US07983467B2 System, method, and product for scanning of biological materials 有权
公开(公告)号：US07983467B2
公开(公告)日：2011-07-19
申请号：US12704350
申请日：2010-02-11
申请人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
发明人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

4. 发明授权

US07689022B2 System, method, and product for scanning of biological materials 有权
公开(公告)号：US07689022B2
公开(公告)日：2010-03-30
申请号：US10389194
申请日：2003-03-14
申请人： Nathan K. Weiner , Patrick J. Odoy , Erik Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleink-Ovod
发明人： Nathan K. Weiner , Patrick J. Odoy , Erik Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel Katz , Ksenia Oleink-Ovod
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

5. 发明授权

US07871812B2 System, method, and product for scanning of biological materials 有权
标题翻译：用于生物材料扫描的系统，方法和产品
公开(公告)号：US07871812B2
公开(公告)日：2011-01-18
申请号：US10975788
申请日：2004-10-27
申请人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
发明人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman Deweerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
摘要翻译：描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联一个或多个位置校正值。

6. 发明申请

US20110243411A1 System, method, and product for scanning of biological materials 有权
公开(公告)号：US20110243411A1
公开(公告)日：2011-10-06
申请号：US13156928
申请日：2011-06-09
申请人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman DeWeerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
发明人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James Overbeck , Herman DeWeerd , David A. Stura , Albert Bukys , Tim Woolaver , Thomas P. Regan , David Bradbury , Eric Earl McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleink-Ovod
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.

7. 发明授权

US08208710B2 System, method, and product for scanning of biological materials 有权
标题翻译：用于生物材料扫描的系统，方法和产品
公开(公告)号：US08208710B2
公开(公告)日：2012-06-26
申请号：US13156928
申请日：2011-06-09
申请人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleinik-Ovod
发明人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Ksenia Oleinik-Ovod
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
摘要翻译：描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联一个或多个位置校正值。

8. 发明授权

US08391582B2 System and method for scanning of probe arrays 有权
标题翻译：用于扫描探针阵列的系统和方法
公开(公告)号：US08391582B2
公开(公告)日：2013-03-05
申请号：US13480888
申请日：2012-05-25
申请人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Oleinik-Ovod Ksenia
发明人： Nathan K. Weiner , Patrick J. Odoy , Eric Schultz , Mark Jones , James T. Overbeck , Herman DeWeerd , David A. Stura , Albert K. Bukys , Tim J. Woolaver , Thomas P. Regan , David Bradbury , Eric E. McKenzie , Roger DiPaolo , Christopher Miles , Joel M. Katz , Oleinik-Ovod Ksenia
IPC分类号： G06K9/00
CPC分类号： G01N21/6428 , G01N21/253 , G01N21/6452 , G01N2021/6471
摘要： An embodiment of a scanning system is described including optical elements that direct an excitation beam at a probe array, detectors that receive reflected intensity data responsive to the excitation beam, where the reflected intensity data is responsive to a focusing distance between an optical element and the probe array, a transport frame that adjusts the focusing distance in a direction with respect to the probe array, an auto-focuser that determines a best plane of focus based upon characteristics of the reflected intensity data of at least two focusing distances where the detectors further receive pixel intensity values based upon detected emissions from a plurality of probe features disposed on the probe array at the best plane of focus, and an image generator that associates each of the pixel intensity values with at least one image pixel position of a probe array based upon one or more position correction values.
摘要翻译：描述了扫描系统的实施例，其包括将激发光束引导到探针阵列的光学元件，响应于激发光束接收反射光强数据的检测器，其中反射光强度数据响应于光学元件和探针阵列，调整相对于探针阵列的方向上的聚焦距离的传输框架，基于至少两个聚焦距离的反射强度数据的特性确定最佳聚焦距离的自动对焦器，其中检测器进一步基于在最佳焦点平面上设置在探针阵列上的多个探针特征的检测到的发射来接收像素强度值，以及图像生成器，其将每个像素强度值与探针阵列的至少一个图像像素位置相关联一个或多个位置校正值。

9. 发明授权

US08331196B2 System and method for controlling an acoustic transducer 有权
标题翻译：用于控制声换能器的系统和方法
公开(公告)号：US08331196B2
公开(公告)日：2012-12-11
申请号：US12755481
申请日：2010-04-07
申请人： Nathan K. Weiner
发明人： Nathan K. Weiner
IPC分类号： H04B1/02
CPC分类号： G10K15/043 , B01F11/0283 , B06B1/0238 , H01L41/042
摘要： A system and method for controlling operation of a transducer circuit, e.g., including an acoustic transducer arranged to cause mixing, cavitation or other movement in a liquid contained in a vessel located remote from the transducer. A load current of a transformer used to generate a drive signal for the transducer may be controlled to vary sinusoidally, to vary between negative and positive values and such that the load current flows in a closed loop when a zero voltage bias is applied across the primary transformer winding, to have a reduced or eliminated 3rd harmonic mode and/or to vary between three discrete modes including a forward current mode, a zero voltage loop current mode, and a freewheel current mode. An inverter circuit may be used to control the load current, e.g., so that the load current flows in a closed loop during portions of the control cycle.
摘要翻译：用于控制换能器电路的操作的系统和方法，例如包括声换能器，该声换能器布置成在容纳在远离换能器的容器中的液体中引起混合，气蚀或其它运动。可以控制用于产生用于换能器的驱动信号的变压器的负载电流，以正弦变化地变化，以在负值和正值之间变化，并且使得当零电压偏压施加在主电压上时，负载电流在闭环中流动变压器绕组，具有减小或消除的三次谐波模式和/或在三个离散模式之间变化，包括正向电流模式，零电压回路电流模式和续流电流模式。逆变器电路可以用于控制负载电流，例如，使得负载电流在控制周期的部分期间在闭环中流动。

10. 发明申请

US20100260012A1 SYSTEM AND METHOD FOR CONTROLLING AN ACOUSTIC TRANSDUCER 有权
标题翻译：用于控制声学传感器的系统和方法
公开(公告)号：US20100260012A1
公开(公告)日：2010-10-14
申请号：US12755481
申请日：2010-04-07
申请人： Nathan K. Weiner
发明人： Nathan K. Weiner
IPC分类号： H04B1/02
CPC分类号： G10K15/043 , B01F11/0283 , B06B1/0238 , H01L41/042
摘要： A system and method for controlling operation of a transducer circuit, e.g., including an acoustic transducer arranged to cause mixing, cavitation or other movement in a liquid contained in a vessel located remote from the transducer. A load current of a transformer used to generate a drive signal for the transducer may be controlled to vary sinusoidally, to vary between negative and positive values and such that the load current flows in a closed loop when a zero voltage bias is applied across the primary transformer winding, to have a reduced or eliminated 3rd harmonic mode and/or to vary between three discrete modes including a forward current mode, a zero voltage loop current mode, and a freewheel current mode. An inverter circuit may be used to control the load current, e.g., so that the load current flows in a closed loop during portions of the control cycle.
摘要翻译：用于控制换能器电路的操作的系统和方法，例如包括声换能器，该声换能器布置成在容纳在远离换能器的容器中的液体中引起混合，气蚀或其它运动。可以控制用于产生用于换能器的驱动信号的变压器的负载电流，以正弦变化地变化，以在负值和正值之间变化，并且使得当零电压偏压施加在主电压上时，负载电流在闭环中流动变压器绕组，具有减小或消除的三次谐波模式和/或在三个离散模式之间变化，包括正向电流模式，零电压回路电流模式和续流电流模式。逆变器电路可以用于控制负载电流，例如，使得负载电流在控制周期的部分期间在闭环中流动。

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