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1. 发明授权

US08496944B2 Process for the manufacture of powders of inhalable medicaments 有权
标题翻译：制造可吸入药物粉末的方法
公开(公告)号：US08496944B2
公开(公告)日：2013-07-30
申请号：US12263818
申请日：2008-11-03
申请人： Nathalie Jongen , Jacques Lemaître , Paul Bowen , Marcel Donnet , Joerg Schiewe , Bernd Zierenberg , Cristina Lucica Soare
发明人： Nathalie Jongen , Jacques Lemaître , Paul Bowen , Marcel Donnet , Joerg Schiewe , Bernd Zierenberg , Cristina Lucica Soare
IPC分类号： A61K9/14
CPC分类号： B01F13/0071 , A61K9/0075 , A61K9/1688 , B01D9/0013 , B01D9/005 , B01D9/0054 , B01D9/0081 , B01F2215/0431 , B01J2/18 , B01J19/0093 , B01J2219/00788 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00932 , B01J2219/00984
摘要： The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor (a) a segmented flow of that fluid comprised of discrete volumes; or (b) a fluid mixture being separated by discrete volumes of a separating fluid which is substantially immiscible with said fluid, characterized in that the crystallization is initiated by application of ultrasound.
摘要翻译：本发明涉及通过从含有所述药物的过饱和流体结晶生产可吸入药物的粉末的改进方法，所述方法包括沿着管状反应器（a）将由该离散体构成的流体的分段流动; 或（b）流体混合物被离散体积分离的分离液体分离，所述分离流体与所述流体基本上不混溶，其特征在于通过施加超声波来引发结晶。

2. 发明授权

US06458335B1 Production of powders 失效
标题翻译：生产粉末
公开(公告)号：US06458335B1
公开(公告)日：2002-10-01
申请号：US09230026
申请日：1999-09-07
申请人： Jacques Lemaitre , Nathalie Jongen , Robert Vacassy , Paul Bowen
发明人： Jacques Lemaitre , Nathalie Jongen , Robert Vacassy , Paul Bowen
IPC分类号： C01B3124
CPC分类号： B01J19/2415 , B01J2/00 , B01J2219/00166 , C07C51/418 , Y10S977/775 , C07C55/07
摘要： A process for the production of powders by precipitation from a liquid reaction mixture comprises passing along a tubular reactor a segmented reaction flow comprised of discrete volumes of the reaction mixture separated by discrete volumes of a separating fluid which is substantially immiscible with said reaction mixture, the residence time of said discrete volumes of reaction mixture in the reactor being sufficient for the precipitation reaction to be effected.
摘要翻译：用于通过液体反应混合物沉淀生产粉末的方法包括沿管式反应器通过分段的反应流程，该反应流由离散体积的反应混合物分离，分离体积与基本上与所述反应混合物不混溶，在反应器中所述离散体积的反应混合物的停留时间足以进行沉淀反应。

3. 发明申请

US20070202036A1 Production Of Barium Titanate Compounds 审中-公开
标题翻译：钛酸钡化合物的生产
公开(公告)号：US20070202036A1
公开(公告)日：2007-08-30
申请号：US10599668
申请日：2005-04-07
申请人： Nathalie Jongen , Andrea Testino
发明人： Nathalie Jongen , Andrea Testino
IPC分类号： C01B13/14
CPC分类号： C04B35/4682 , B82Y30/00 , C01G23/006 , C01P2002/72 , C01P2004/03 , C01P2004/62 , C01P2004/64 , C01P2006/10 , C01P2006/12 , C04B2235/528 , C04B2235/5409 , C04B2235/5445 , C04B2235/5454 , C04B2235/5481 , C04B2235/604 , C04B2235/6582 , C04B2235/6588 , C04B2235/761 , C04B2235/762 , C04B2235/765 , C04B2235/94
摘要： An ultrafine powder of barium titanate including solid solutions and doped compounds that meets up to specific characteristics is produced by method comprising two main steps. The first step is a reaction, typically in a Segmented Flow Tubular Reactor, between reactants to produce cubic-structure barium titanate composed of non-agglomerated ultrafine particles having a shape of given aspect ratio, usually a generally spherical shape, of low density corresponding at most to 90% of the intrinsic density, all particles being smaller than 1 micron and having a narrow particle size distribution and wherein the ratio of Ba:Ti including substitutents and dopants is very close to the ideal stoichiometry. This is followed by subjecting the powder produced in the first step to a second stage solvothermal post treatment typically in an autoclave at temperature less than 400° C. to convert the cubic-structure particles of low density to ultrafine tetragonal particles of increased density corresponding to at least 90% of the intrinsic density while maintaining the same aspect ratio, and maintaining the size of all particles below 1 micron, the narrow particle size distribution span, and the given ideal stoichiometry. The produced particles can have a non-spherical facetted shape such as cube-like.
摘要翻译：通过包括两个主要步骤的方法产生包括满足特定特征的固溶体和掺杂化合物的钛酸钡超细粉末。第一步是通常在分段流动管式反应器中的反应物之间产生立方结构的钛酸钡的反应，所述立方结构钛酸钡由具有给定纵横比（通常为大致球形）的非附聚超细颗粒组成，低密度对应于大约90％的固有密度，所有颗粒小于1微米，具有窄的粒度分布，并且其中包括取代基和掺杂剂的Ba：Ti的比率非常接近理想的化学计量。然后将第一步产生的粉末在低于400℃的高压釜中进行第二阶段溶剂热处理，以将低密度的立方结构颗粒转化成对应于至少90％的固有密度，同时保持相同的纵横比，并保持所有颗粒的尺寸低于1微米，窄的粒度分布范围以及给定的理想化学计量。产生的颗粒可以具有非球形的小面形状，例如立方体状。

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