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1. 发明授权

US07378492B2 CD40-related receptor that binds CD40L 失效
标题翻译：结合CD40L的CD40相关受体
公开(公告)号：US07378492B2
公开(公告)日：2008-05-27
申请号：US10504973
申请日：2003-02-18
申请人： Narinder K. Chawla , Henry Yue , Thomas W. Richardson , Joseph P. Marquis , Patricia M. Lehr-Mason , Ann E. Gorvad , Shanya D. Becha , Amy E. Kable , Anita Swarnakar , Pei Jin , Phillip R. Hawkins , David Chien , Jayalaxmi Ramkumar , Uyen K. Tran , April J. A. Hafalia , Mariah R. Baughn , Soo Yeun Lee , Xin Jiang , Alan A. Jackson , Reena Khare , Sean A. Bulloch
发明人： Narinder K. Chawla , Henry Yue , Thomas W. Richardson , Joseph P. Marquis , Patricia M. Lehr-Mason , Ann E. Gorvad , Shanya D. Becha , Amy E. Kable , Anita Swarnakar , Pei Jin , Phillip R. Hawkins , David Chien , Jayalaxmi Ramkumar , Uyen K. Tran , April J. A. Hafalia , Mariah R. Baughn , Soo Yeun Lee , Xin Jiang , Alan A. Jackson , Reena Khare , Sean A. Bulloch
IPC分类号： C07K14/705 , C07K19/00
CPC分类号： C07K14/705 , C07K16/28
摘要： Various embodiments of the invention provide human receptors and membrane-associated proteins (REMAP) and Q polynucleotides which identify and encode REMAP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REMAP.
摘要翻译：本发明的各种实施方案提供鉴定和编码REMAP的人受体和膜相关蛋白（REMAP）和Q多核苷酸。本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。其他实施方案提供用于诊断，治疗或预防与REMAP异常表达相关的紊乱的方法。

2. 发明授权

US06379913B1 Human serine carboxypeptidase 失效
标题翻译：人丝氨酸羧肽酶
公开(公告)号：US06379913B1
公开(公告)日：2002-04-30
申请号：US09299689
申请日：1999-04-26
申请人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
发明人： Olga Bandman , Phillip R. Hawkins , Jennifer L. Hillman , Preeti Lal , Surya K. Goli
IPC分类号： C12N948
CPC分类号： C12N9/48 , A61K38/00
摘要： The present invention provides a human serine carboxypeptidase (CPEPT) and polynucleotides which identify and encode CPEPT. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of CPEPT.
摘要翻译：本发明提供了人丝氨酸羧肽酶（CPEPT）和识别和编码CPEPT的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与CPEPT表达相关的疾病的方法。

3. 发明授权

US06312895B1 Human selenium-binding protein 失效
标题翻译：人硒结合蛋白
公开(公告)号：US06312895B1
公开(公告)日：2001-11-06
申请号：US09088641
申请日：1998-06-02
申请人： Olga Bandman , Phillip R. Hawkins
发明人： Olga Bandman , Phillip R. Hawkins
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human selenium-binding protein (HSEBP) and polynucleotides which identify and encode HSEBP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSEBP and a method for producing HSEBP. The invention also provides for agonists and antibodies specifically binding HSEBP, and their use in the prevention and treatment of diseases associated with expression of HSEBP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSEBP for the treatment of diseases associated with the expression of HSEBP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSEBP.
摘要翻译：本发明提供了人类硒结合蛋白（HSEBP）和识别和编码HSEBP的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HSEBP的核酸序列和生产HSEBP的方法。本发明还提供了特异性结合HSEBP的激动剂和抗体，以及它们在预防和治疗与HSEBP表达相关的疾病中的用途。另外，本发明提供了将反义分子用于编码HSEBP的多核苷酸用于治疗与HSEBP表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合HSEBP的抗体的诊断测定法。

4. 发明授权

US6015883A Rantes homolog from prostate 失效
标题翻译：来自前列腺的Rantes同系物
公开(公告)号：US6015883A
公开(公告)日：2000-01-18
申请号：US936772
申请日：1997-09-24
申请人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
发明人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61K48/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A61K38/19
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供从前列腺cDNA文库分离的多核苷酸（PTEC），其鉴定并编码新的人类群同系物PTEC（前列腺表达的趋化因子）。本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途，以及用于治疗与PTEC表达相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

5. 发明授权

US5948626A Method of detecting human phospholipase inhibitor 失效
标题翻译：检测人磷脂酶抑制剂的方法
公开(公告)号：US5948626A
公开(公告)日：1999-09-07
申请号：US153751
申请日：1998-09-15
申请人： Phillip R. Hawkins , Lynn E. Murry
发明人： Phillip R. Hawkins , Lynn E. Murry
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P25/28 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6876 , C07K14/4703 , A61K38/00 , C12Q2600/158
摘要： The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase inhibitor (GIPL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding GIPL. The invention also provides for the use of purified GIPL and its agonists in pharmaceutical compositions for the treatment of diseases associated with the abnormal or excess phospholipase activity. Additionally, the invention provides for the use of antisense molecules to gipl or inhibitors of GIPL in pharmaceutical compositions for the prevention of pregnancy or treatment of Alzheimer's disease. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of gipl, or anti-GIPL antibodies which specifically bind to the polypeptide, GIPL.
摘要翻译：本发明提供了一种多核苷酸（gipl），其部分序列最初从THP-1 cDNA文库中分离，并鉴定并编码新的人磷脂酶抑制剂（GIPL）。本发明提供了包含编码GIPL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化GIPL及其激动剂在药物组合物中用于治疗与异常或过量磷脂酶活性相关的疾病的用途。另外，本发明提供了用于预防妊娠或治疗阿尔茨海默病的药物组合物中的GIP1或GIPL抑制剂的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与gipl的基因组序列或转录物或特异性结合多肽GIPL的抗GIPL抗体杂交。

6. 发明授权

US5936068A Liver expressed chemokine-1 失效
标题翻译：肝表达趋化因子-1
公开(公告)号：US5936068A
公开(公告)日：1999-08-10
申请号：US798143
申请日：1997-02-10
申请人： Craig G. Wilde , Phillip R. Hawkins , Olga Bandman , Jeffrey J. Seilhamer
发明人： Craig G. Wilde , Phillip R. Hawkins , Olga Bandman , Jeffrey J. Seilhamer
IPC分类号： G01N33/566 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/715 , C07K14/523 , C07K16/24 , C12Q1/6876 , C07K2319/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also provides for antisense molecules to the nucleotide sequences which encode ECs, expression vectors for the production of purified ECs, antibodies capable of binding specifically to ECs, hybridization probes or oligonucleotides for the detection of EC-encoding nucleotide sequences, genetically engineered host cells for the expression of ECs, diagnostic tests for inflammation or disease based on on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs, pharmaceutical compositions to treat inflammation or disease based on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs.
摘要翻译：本发明提供鉴定和编码来自肝脏和垂体腺组织的新型表达趋化因子（EC）的核苷酸和氨基酸序列。本发明还提供编码EC的核苷酸序列的反义分子，用于产生纯化的EC的表达载体，能够特异性结合EC的抗体，用于检测编码EC编码的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主基于编码EC的编码核酸分子或能够特异性结合EC的抗体的ECs表达的细胞，炎症或疾病的诊断性测试，基于编码EC编码的核酸分子的治疗炎症或疾病的药物组合物或能够特异性地结合EC。

7. 发明授权

US5854046A Human hyaluronidase 失效
公开(公告)号：US5854046A
公开(公告)日：1998-12-29
申请号：US8962
申请日：1998-01-20
申请人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
发明人： Janice Au-Young , Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61K38/00 , C12N1/21 , C12N9/26 , C12N15/56
CPC分类号： C12N9/2408 , A61K38/00
摘要： The present invention provides a polynucleotide (hhp) which identifies and encodes a novel human hyaluronidase (HHP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HHP. The invention also provides for the use of substantially purified HHP and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of HHP. Additionally, the invention provides for the use of antisense molecules to hhp in pharmaceutical compositions for treatment of diseases associated with the expression of HHP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of hhp. The present invention also relates to anti-HHP antibodies which specifically bind to HHP.

8. 发明授权

US5846778A Human map kinase homolog 失效
标题翻译：人地图激酶同源物
公开(公告)号：US5846778A
公开(公告)日：1998-12-08
申请号：US920296
申请日：1997-08-28
申请人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
发明人： Phillip R. Hawkins , Janice Au-Young , Karl J. Guegler , Craig G. Wilde
IPC分类号： A61K38/00 , C12N9/12 , C12N15/00 , C07H21/04 , C07K14/435
CPC分类号： C12N9/1205 , C12N9/12 , A61K38/00 , Y10S530/827
摘要： The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
摘要翻译：本发明提供了鉴定和编码在人胃细胞中表达的新的人映射激酶同源物（SMAP）的核酸和氨基酸序列。本发明还提供用于检测编码SMAP或SMAP样分子的核苷酸序列的PCR寡聚体或杂交探针，编码SMAP的核苷酸序列的反义分子，基于SMAP编码核酸分子的诊断测试，基因工程表达载体和用于产生纯化SMAP的宿主细胞，能够特异性结合SMAP的抗体，以及对多肽SMAP具有特异性结合活性的激动剂和抑制剂。

9. 发明授权

US5844084A Chemokine expressed in inflamed adenoid 失效
标题翻译：趋化因子在发炎的腺样体中表达
公开(公告)号：US5844084A
公开(公告)日：1998-12-01
申请号：US862607
申请日：1997-05-23
申请人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
发明人： Karl J. Guegler , Phillip R. Hawkins , Craig G. Wilde , Jeffrey J. Seilhamer
IPC分类号： C12N15/09 , A61K38/00 , A61P9/00 , A61P43/00 , C07K14/52 , C07K14/54 , C07K16/24 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/19
CPC分类号： C07K14/522 , C12Q1/6883 , A61K38/00 , C12Q2600/158 , Y10S514/885 , Y10S930/14
摘要： The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically engineered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.
摘要翻译：本发明提供鉴定和编码来自发炎腺样体组织的新型表达趋化因子（ADEC）的核苷酸和氨基酸序列。本发明还提供编码ADEC的核苷酸序列的反义分子，用于产生纯化的ADEC的表达载体，能够特异性结合ADEC的抗体，用于检测编码ADEC的核苷酸序列的杂交探针或寡核苷酸的遗传工程宿主用于表达ADEC的细胞，基于编码ADEC的核酸分子或能够特异性结合ADEC的抗体的炎症或疾病的诊断测试。

10. 发明授权

US5817482A Disease related nucleotide kinases 失效
标题翻译：疾病相关的核苷酸激酶
公开(公告)号：US5817482A
公开(公告)日：1998-10-06
申请号：US879561
申请日：1997-06-20
申请人： Olga Bandman , Jennifer L. Hillman , Phillip R. Hawkins , Karl J. Guegler , Neil C. Corley
发明人： Olga Bandman , Jennifer L. Hillman , Phillip R. Hawkins , Karl J. Guegler , Neil C. Corley
IPC分类号： A61K38/00 , C12N9/12 , C12N15/00
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides human nucleotide kinases and polynucleotides which identify and encode DRNK. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of DRNK.
摘要翻译：本发明提供鉴定和编码DRNK的人核苷酸激酶和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与DRNK表达相关的疾病的方法。

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