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1. 发明申请

US20090270623A1 PROCESS FOR PRODUCTION OF CINNAMIDE DERIVATIVE 审中-公开
标题翻译：生产氰化氢衍生物的方法
公开(公告)号：US20090270623A1
公开(公告)日：2009-10-29
申请号：US12093287
申请日：2006-11-17
申请人： Naoyuki Shimomura , Nobuaki Sato , Toshihiko Kaneko , Mamoru Takaishi , Kazunori Wakasugi , Seiji Yoshikawa , Yoshihiro Nishikawa , Taiju Nakamura , Tohru Fukuyama
发明人： Naoyuki Shimomura , Nobuaki Sato , Toshihiko Kaneko , Mamoru Takaishi , Kazunori Wakasugi , Seiji Yoshikawa , Yoshihiro Nishikawa , Taiju Nakamura , Tohru Fukuyama
IPC分类号： C07F9/59 , C07D401/10 , C07D211/76
CPC分类号： C07D401/10
摘要： A compound (8) represented by the formula: (8) wherein R1 represents a 6- to 14-membered aromatic hydrocarbon ring group which may have a substituent; and n represents 0 to 2, can be produced with good efficiency by reacting a compound (3) represented by the formula: (3) wherein R1 and n are as defined above; and Q represents a single bond or —CH(Y)— where Y represents a hydrogen atom or a C1-6 alkyl group] with 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the presence of a base.
摘要翻译：由式（8）表示的化合物（8）：其中R1表示可具有取代基的6至14元芳族烃环基团; n表示0〜2，可以通过使式（3）表示的化合物（3）（其中R 1和n如上所定义）反应而得到良好的效率。和Q表示单键或-CH（Y） - ，其中Y表示氢原子或C 1-6烷基]与3-甲氧基-4-（4-甲基-1H-咪唑-1-基）苯甲醛在存在基地

2. 发明申请

US20100280243A1 PROCESS FOR PRODUCTION OF 4- (SUBSTITUTED PHENYL) HEXAHYDROPYRIDO [2,1-C] [1,4] OXAZIN-6-ONE 审中-公开
标题翻译：制备4-（取代苯基）十六氢化二[2,1-C] [1,4]氧杂-6-酮的方法
公开(公告)号：US20100280243A1
公开(公告)日：2010-11-04
申请号：US12810783
申请日：2008-12-25
申请人： Akio Kayano , Mitsuo Nagai , Yorihisa Hoshino , Kazunori Wakasugi , Masaaki Matsuda , Atsushi Kamada , Minetaka Isomura , Yoshihiro Nishikawa , Seiji Yoshikawa , Daisuke Shimmyo
发明人： Akio Kayano , Mitsuo Nagai , Yorihisa Hoshino , Kazunori Wakasugi , Masaaki Matsuda , Atsushi Kamada , Minetaka Isomura , Yoshihiro Nishikawa , Seiji Yoshikawa , Daisuke Shimmyo
IPC分类号： C07D498/04 , C07D265/30
CPC分类号： C07D265/30 , C07D498/04
摘要： 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one represented by formula (I) or a salt thereof is useful as an intermediate for the production of a bicyclic cinnamide compound which is an Aβ production inhibitor. 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one or the salt thereof can be produced in an industrially advantageous manner by subjecting a compound represented by formula (II) or a salt thereof to an intramolecular condensation reaction.
摘要翻译：由式（I）表示的4-（取代的苯基）六氢吡啶并[2,1-c] [1,4]恶嗪-6-酮或其盐可用作生产二环肉桂酰胺化合物的中间体，其为 A＆bgr 生产抑制剂。 4-（取代的苯基）六氢吡啶并[2,1-c] [1,4]恶嗪-6-酮或其盐可以工业上有利的方式通过使由式（II）表示的化合物或其盐进行分子内缩合反应。

3. 发明授权

US06841549B1 Condensed imidazole compounds and a therapeutic agent for diabetes mellitus 失效
标题翻译：缩合咪唑化合物和糖尿病治疗剂
公开(公告)号：US06841549B1
公开(公告)日：2005-01-11
申请号：US10018688
申请日：2000-06-30
申请人： Osamu Asano , Hitoshi Harada , Seiji Yoshikawa , Nobuhisa Watanabe , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Hiroe Minami , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi , Isao Tanaka , Tsutomu Kawata , Naoyuki Shimomura , Hiroshi Akamatsu , Naoki Ozeki , Toshikazu Shimizu , Kenji Hayashi , Toyokazu Haga , Shigeto Negi , Toshihiko Naito
发明人： Osamu Asano , Hitoshi Harada , Seiji Yoshikawa , Nobuhisa Watanabe , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Hiroe Minami , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi , Isao Tanaka , Tsutomu Kawata , Naoyuki Shimomura , Hiroshi Akamatsu , Naoki Ozeki , Toshikazu Shimizu , Kenji Hayashi , Toyokazu Haga , Shigeto Negi , Toshihiko Naito
IPC分类号： A61P3/10 , A61P43/00 , C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40 , A16K31/33 , C07D239/70 , C07D471/00 , C07D487/00 , A16K31/52
CPC分类号： C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40
摘要： The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action.That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I); (wherein R1 represents e.g. an amino group which may be substituted with an alkyl group; R2 represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R3 represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.
摘要翻译：本发明提供了一种基于腺苷A2受体拮抗剂作用的新型糖尿病和糖尿病并发症的预防或治疗剂。即提供了具有腺苷A2受体拮抗剂作用的新颖的缩合咪唑化合物，是有效预防或治疗糖尿病和糖尿病并发症，并由式（I）表示;（其中R 1表示例如可被烷基取代的氨基; R 2表示例如氢原子，可以被羟基取代的烷基，环烷基或烷基，烯基或炔基; R 3表示例如任选取代的烷基，烯基，炔基，芳基，杂芳基，吡啶酮基，嘧啶酮基或哌嗪酮基; Ar表示例如任选取代的芳基或杂芳基; Q和W彼此相同或不同，每个代表 N或CH），其药理学上可接受的盐或其水合物。

4. 发明申请

US20080306272A1 ONE-POT METHODS FOR PREPARING CINNAMIDE DERIVATIVES 审中-公开
标题翻译：用于制备氰化物衍生物的一种方法
公开(公告)号：US20080306272A1
公开(公告)日：2008-12-11
申请号：US12121454
申请日：2008-05-15
申请人： Naoyuki Shimomura , Seiji Yoshikawa , Yoshihiko Hisatake , Akio Imai
发明人： Naoyuki Shimomura , Seiji Yoshikawa , Yoshihiko Hisatake , Akio Imai
IPC分类号： C07D401/02
CPC分类号： C07D401/10 , Y02P20/55
摘要： A compound represented by the following formula (1): wherein R represents a 4-fluorophenyl group and the like; Q represents —CH(CH3)— and the like; and n represents 1 and the like and a pharmaceutically acceptable salt thereof can be prepared in one-pot by reacting a compound represented by the following formula (2): wherein R1 represents a 4-fluorophenyl group and the like; and Q and n have the same meaning as described above, with 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in the presence of a base and, if necessary, removing a protecting group.
摘要翻译：由下式（1）表示的化合物：其中R表示4-氟苯基等; Q表示-CH（CH 3） - 等; 和n表示1等的化合物及其药学上可接受的盐可以通过使由下式（2）表示的化合物反应而制备：其中R1表示4-氟苯基等; 和Q和n具有与上述相同的含义，与3-甲氧基-4-（4-甲基-1H-咪唑-1-基）苯甲醛在碱存在下反应，如果需要，除去保护基。

5. 发明授权

US07772226B2 Condensed imidazole derivatives 失效
标题翻译：缩合咪唑衍生物
公开(公告)号：US07772226B2
公开(公告)日：2010-08-10
申请号：US12199982
申请日：2008-08-28
申请人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
发明人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Kazunobu Kira , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki
IPC分类号： A61K31/437 , A61K31/496 , C07D487/04 , C07D471/04 , C07D473/06 , C07D473/18 , C07D473/22 , C07D473/30 , C07D473/40 , C07D498/14 , A61K31/5025 , A61K31/522
CPC分类号： C07D473/30 , C07D471/04 , C07D473/04 , C07D473/06 , C07D473/18 , C07D473/36 , C07D473/40 , C07D487/04 , C07D491/14
摘要： The present invention is related to compounds represented by the following formula, or salts or hydrates thereof wherein, T1 represents a 4- to 12-membered heterocyclic group containing one or two nitrogen atoms in the ring, which is a monocyclic or bicyclic structure that may have one or more substituents; X represents a C1-6 alkyl group which may have one or more substituents, or such; Z1 and Z2 each independently represent a nitrogen atom or a group represented by the formula —CR2—; R1 and R2 independently represent a hydrogen atom, a C1-6 alkyl group which may have one or more substituents, or a C1-6 alkoxy group which may have one or more substituents, or such. These are novel compounds that exhibit an excellent DPPIV-inhibiting activity.
摘要翻译：本发明涉及由下式表示的化合物或其盐或水合物，其中，T1表示在环中含有一个或两个氮原子的4至12元杂环基，其为单环或双环结构，其可以是具有一个或多个取代基; X表示可以具有一个或多个取代基的C 1-6烷基; Z 1和Z 2各自独立地表示氮原子或由式-CR 2表示的基团; R1和R2独立地表示氢原子，可以具有一个或多个取代基的C 1-6烷基或可以具有一个或多个取代基的C 1-6烷氧基等。这些是表现出优异的DPPIV抑制活性的新型化合物。

6. 发明申请

US20100045825A1 Image Apparatus and Image Processing Method 审中-公开
标题翻译：图像设备和图像处理方法
公开(公告)号：US20100045825A1
公开(公告)日：2010-02-25
申请号：US12090838
申请日：2006-09-15
申请人： Toshiki Hatori , Yuusuke Hayashi , Masayuki Satou , Seiji Yoshikawa
发明人： Toshiki Hatori , Yuusuke Hayashi , Masayuki Satou , Seiji Yoshikawa
IPC分类号： H04N5/217
CPC分类号： G02B7/36 , G02B13/0015 , G02B13/0055 , G02B13/009 , G02B13/18 , G02B15/177 , G06T5/002 , G06T5/50 , H04N5/23212
摘要： An imaging apparatus and an image processing method able to simplify an optical system, able to reduce costs, able to obtain an image blurred only in a background by a single imaging operation, and able to obtain a restored images with little influence of noise, wherein a signal processing portion formed by an image processing device 140 etc. has a generation function of generating a diffusion-free image signal from a diffused image signal of an object from an imaging element 120 and performing other predetermined signal processing on the diffused image signal and combining an image before the processing of this signal processing portion and an image after the processing to form a new image, and, in this generation function, generates a plurality of images in a background region by blurred image processing combines them with a focused image of an object region including a main object after the processing to generate a new image and records the image before the signal processing, the restoration image after the processing, and the combined new image in a memory buffer etc.
摘要翻译：一种成像设备和图像处理方法，其能够简化能够降低成本的光学系统，能够通过单个成像操作获得仅在背景中模糊的图像，并且能够获得几乎没有噪声影响的恢复图像，其中由图像处理装置140等形成的信号处理部具有从来自摄像元件120的物体的扩散图像信号产生无扩散图像信号的生成功能，并对扩散图像信号进行其他规定的信号处理，将该信号处理部分的处理之前的图像与处理之后的图像组合以形成新图像，并且在该生成函数中，通过模糊图像处理在背景区域中生成多个图像，将它们与聚焦图像在产生新图像的处理之后包括主要对象的对象区域，并且在信号处理之前记录图像处理后的存储图像，以及在存储器缓冲器等中组合的新图像

7. 发明授权

US07074798B2 Xanthine derivative and DPPIV inhibitor 失效
标题翻译：黄嘌呤衍生物和DPPIV抑制剂
公开(公告)号：US07074798B2
公开(公告)日：2006-07-11
申请号：US10374918
申请日：2003-02-24
申请人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki , Mika Aoki
发明人： Seiji Yoshikawa , Eita Emori , Fumiyoshi Matsuura , Richard Clark , Hironori Ikuta , Nobuyuki Yasuda , Tadashi Nagakura , Kazuto Yamazaki , Mika Aoki
IPC分类号： C07D473/06 , C07D473/08 , C07D473/04 , A61K31/522 , A61P3/10
CPC分类号： C07D473/06 , C07D473/08
摘要： The present invention provides novel compounds exhibiting an excellent DPPIV inhibition effect.The compounds are represented by the formula: wherein, m is 0 or 1; n is 0; R31, R32, R33, R34, R35, R36, R37, R38, R39, R40, R41, and R42 each represent a hydrogen atom; X represents an alkynyl group, an aryl group, and such, which group may be substituted; and, R1 and R2 each independently represents a hydrogen atom, an alkyl group, an alkoxyl group, or such, or salts or hydrates thereof.
摘要翻译：本发明提供具有优异DPPIV抑制作用的新化合物。化合物由下式表示：其中，m为0或1; n为0; R 32，R 32，R 34，R 34，R 35，R 32， R＆lt; 36＆gt;，R＆lt; 37＆gt;，＆lt; 38＆gt;，R 39，R 40， R 41和R 42各自表示氢原子; X表示可以被取代的炔基，芳基等; R 1和R 2各自独立地表示氢原子，烷基，烷氧基等，或其盐或水合物。

8. 发明授权

US07978252B2 Imaging apparatus, imaging system, and imaging method 有权
标题翻译：成像设备，成像系统和成像方法
公开(公告)号：US07978252B2
公开(公告)日：2011-07-12
申请号：US11909789
申请日：2006-03-29
申请人： Seiji Yoshikawa
发明人： Seiji Yoshikawa
IPC分类号： H04N5/232 , H04N5/225 , G01J4/00
CPC分类号： H04N5/3572 , G02B27/0075 , G03B7/28 , H04N5/23209 , H04N5/23296
摘要： An imaging apparatus, imaging system, and imaging method enabling restoration of image according to a plurality of optical systems by one apparatus, having a plurality of imaging apparatuses 100A to 100C each having an optical system 110, phase plate (optical wavefront modulation element) 120, imaging element 130 able to capture an object aberration image passing through the optical system 110 and phase plate 120, imaging apparatus side storage portion 140 storing coefficient specifying information for specifying a convolution coefficient, and transmission device 150 transmitting object aberration image data obtained from the imaging element 130 and the coefficient specifying information stored in the storage portion 140; and a processing device 200 acquiring one coefficient from among a plurality of convolution coefficients stored in advance based on coefficient specifying information in accordance with a zoom position or zoom amount transmitted from the imaging apparatus 100, and generating dispersion-free object image data from a dispersed image signal from the imaging element 130.
摘要翻译：一种成像装置，成像系统和成像方法，能够通过一个装置根据多个光学系统恢复图像，具有多个成像装置100A至100C，每个成像装置具有光学系统110，相位板（光学波前调制元件）120 能够捕获通过光学系统110和相位板120的物体像差图像的成像元件130，存储用于指定卷积系数的系数指定信息的成像装置侧存储部分140，以及传送装置150，传送从成像元件130和存储在存储部分140中的系数指定信息; 以及处理装置200，根据从成像装置100发送的变焦位置或变焦量，基于系数指定信息从预先存储的多个卷积系数中获取一个系数，并从分散的图像数据生成无色物体图像数据来自成像元件130的图像信号。

9. 发明申请

US20050190274A1 Imaging device and image generation method of imaging device 审中-公开
标题翻译：成像装置的成像装置和图像生成方法
公开(公告)号：US20050190274A1
公开(公告)日：2005-09-01
申请号：US11069896
申请日：2005-02-28
申请人： Seiji Yoshikawa , Ryuichi Sawada
发明人： Seiji Yoshikawa , Ryuichi Sawada
IPC分类号： H04N3/14 , H04N5/225 , H04N5/232 , H04N5/235 , H04N5/335 , H04N5/76 , H04N5/77 , H04N5/91 , H04N5/917 , H04N7/26 , H04N7/50 , H04N9/04 , H04N9/083 , H04N9/79 , H04N9/804
CPC分类号： H04N5/2353 , H04N5/232 , H04N5/23245 , H04N5/343 , H04N5/3456 , H04N5/772 , H04N9/045 , H04N9/7921 , H04N9/8045 , H04N9/8047 , H04N19/102 , H04N19/159 , H04N19/162 , H04N19/172 , H04N19/46 , H04N19/61
摘要： An imaging device having nonconventional and a completely new imaging method and an image generation method of the imaging device, wherein the imaging device has an image processing section generating a first compressed image compressed high image data with intra-frame compression in capturing single moving image data and a second compressed image compressed low image data with inter-frame compression in a front period and/or in a rear period of a period generating the first compressed image as one stream, where the imaging device generates still image data having high-resolution indicating one screen designated by decompression and decoding by the second compressed image and the other compressed image including the first compressed image when one screen of a second compressed image is designated.
摘要翻译：一种具有非常规和全新的成像方法和成像装置的图像生成方法的成像装置，其中成像装置具有图像处理部，该图像处理部在捕获单个运动图像数据的同时，生成具有帧内压缩的压缩高图像数据的第一压缩图像以及第二压缩图像，其在前期和/或在产生作为一个流的第一压缩图像的周期的后期周期中压缩了低图像数据，其中所述成像装置产生具有高分辨率的静止图像数据，通过第二压缩图像的解压缩和解码指定的一个画面，以及指定第二压缩图像的一个画面时包括第一压缩图像的其他压缩图像。

10. 发明授权

US07956222B2 Methods for producing dibromofluorobenzene derivatives 失效
标题翻译：二溴氟苯衍生物的制备方法
公开(公告)号：US07956222B2
公开(公告)日：2011-06-07
申请号：US11573882
申请日：2005-07-27
申请人： Seiji Yoshikawa
发明人： Seiji Yoshikawa
IPC分类号： C07C41/22
CPC分类号： C07C41/16 , C07C37/56 , C07C39/245 , C07C41/22 , C07C43/225 , C07C45/562 , C07C47/565
摘要： Methods of the present invention for producing dibromofluorobenzene derivatives (compounds II) comprise Step 1, in which compounds (I) having the following general formula (I): (wherein, R1 and R2 each independently represent a C1-6 alkyl group) are reacted in a solvent with a brominating reagent.
摘要翻译：用于制备二溴氟苯衍生物（化合物II）的方法包括步骤1，其中具有以下通式（I）的化合物（I）：（其中，R 1和R 2各自独立地表示C 1-6烷基）反应在具有溴化试剂的溶剂中。

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