专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060058370A1 Methods for producing cyclic benzamidine derivatives 失效
标题翻译：环苯甲脒衍生物的制备方法
公开(公告)号：US20060058370A1
公开(公告)日：2006-03-16
申请号：US11208289
申请日：2005-08-18
申请人： Naoyuki Shimomura , Manabu Sasho , Akio Kayano , Kazuhiro Yoshizawa , Masahiko Tsujii , Hiroshi Kuroda , Ken Furukawa
发明人： Naoyuki Shimomura , Manabu Sasho , Akio Kayano , Kazuhiro Yoshizawa , Masahiko Tsujii , Hiroshi Kuroda , Ken Furukawa
IPC分类号： C07D209/44 , A61K31/4035
CPC分类号： C07D295/096 , C07C43/225 , C07C43/315 , C07C255/54 , C07C255/56 , C07C303/28 , C07D209/44 , C07D209/48 , C07C309/66
摘要： In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide. The methods of this invention for producing a morpholine-substituted phenacyl derivative (B), or a salt thereof, comprise reaction of a specific novel compound with morpholine, reaction of the product with a halogenating reagent, and deketalization of the product. The methods of this invention for a producing cyclic benzamidine derivative (C), or a salt thereof, comprise the step of coupling compound (A), or a salt thereof, with compound (B), or a salt thereof, in the presence of an ether or a hydrocarbon. The methods of this invention for recrystallizing a cyclic benzamidine derivative (C), or a salt thereof, comprise the steps of dissolving compound (C), or the salt thereof, in a mixed solvent comprising an alcohol and water, or a mixed solvent comprising an ether and water, and after dissolution, adding additional water to precipitate crystals of compound (C), or the salt thereof.
摘要翻译：在本发明中，制备氟化环状苯甲脒衍生物（A）或其盐的方法包括使特定的新化合物与氨或酰亚胺反应的步骤。本发明用于生产吗啉取代的苯甲酰甲基衍生物（B）或其盐的方法包括特异性新化合物与吗啉的反应，产物与卤化试剂的反应和产物的脱缩合作用。本发明的制备环状苯甲脒衍生物（C）或其盐的方法包括将化合物（A）或其盐与化合物（B）或其盐偶联的步骤在醚或烃。本发明用于环状苄脒衍生物（C）或其盐的重结晶的方法包括将化合物（C）或其盐溶解在包含醇和水的混合溶剂中的步骤或包含醚和水，溶解后加入另外的水，使化合物（C）的结晶或其盐析出。

2. 发明授权

US07375236B2 Methods for producing cyclic benzamidine derivatives 失效
标题翻译：环苯甲脒衍生物的制备方法
公开(公告)号：US07375236B2
公开(公告)日：2008-05-20
申请号：US11208289
申请日：2005-08-18
申请人： Naoyuki Shimomura , Manabu Sasho , Akio Kayano , Kazuhiro Yoshizawa , Masahiko Tsujii , Hiroshi Kuroda , Ken Furukawa
发明人： Naoyuki Shimomura , Manabu Sasho , Akio Kayano , Kazuhiro Yoshizawa , Masahiko Tsujii , Hiroshi Kuroda , Ken Furukawa
IPC分类号： C07D265/30 , C07D209/44 , C07C43/307
CPC分类号： C07D295/096 , C07C43/225 , C07C43/315 , C07C255/54 , C07C255/56 , C07C303/28 , C07D209/44 , C07D209/48 , C07C309/66
摘要： In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide.The methods of this invention for producing a morpholine-substituted phenacyl derivative (B), or a salt thereof, comprise reaction of a specific novel compound with morpholine, reaction of the product with a halogenating reagent, and deketalization of the product.The methods of this invention for a producing cyclic benzamidine derivative (C), or a salt thereof, comprise the step of coupling compound (A), or a salt thereof, with compound (B), or a salt thereof, in the presence of an ether or a hydrocarbon.The methods of this invention for recrystallizing a cyclic benzamidine derivative (C), or a salt thereof, comprise the steps of dissolving compound (C), or the salt thereof, in a mixed solvent comprising an alcohol and water, or a mixed solvent comprising an ether and water, and after dissolution, adding additional water to precipitate crystals of compound (C), or the salt thereof.
摘要翻译：在本发明中，制备氟化环状苯甲脒衍生物（A）或其盐的方法包括使特定的新化合物与氨或酰亚胺反应的步骤。本发明用于生产吗啉取代的苯甲酰甲基衍生物（B）或其盐的方法包括特异性新化合物与吗啉的反应，产物与卤化试剂的反应和产物的脱缩合作用。本发明的制备环状苯甲脒衍生物（C）或其盐的方法包括将化合物（A）或其盐与化合物（B）或其盐偶联的步骤在醚或烃。本发明用于环状苄脒衍生物（C）或其盐的重结晶的方法包括将化合物（C）或其盐溶解在包含醇和水的混合溶剂中的步骤或包含醚和水，溶解后加入另外的水，使化合物（C）的结晶或其盐析出。

3. 发明授权

US06642377B1 Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates 失效
标题翻译：碱性抗生素无机酸加成盐和草酸盐中间体的制备方法
公开(公告)号：US06642377B1
公开(公告)日：2003-11-04
申请号：US10030909
申请日：2002-01-14
申请人： Akio Kayano , Hiroyuki Chiba , Taiju Nakamura , Shin Sakurai , Hiroyuki Ishizuka , Hiroyuki Saito , Yuuki Komatsu , Manabu Sasho , Nobuaki Sato , Shigeto Negi
发明人： Akio Kayano , Hiroyuki Chiba , Taiju Nakamura , Shin Sakurai , Hiroyuki Ishizuka , Hiroyuki Saito , Yuuki Komatsu , Manabu Sasho , Nobuaki Sato , Shigeto Negi
IPC分类号： C07D47720
CPC分类号： C07D477/20 , C07D477/02 , C07D477/08 , Y02P20/55
摘要： A production process which comprises subjecting a basic antibiotic.oxalate (II) to salt-exchange with an alkali earth metal salt (III) of an inorganic acid: wherein the ring A means the basic antibiotic; R10 means a protected functional group used in organic synthesis; Ak—E means the alkali earth metal; and B means the inorganic acid, respectively.
摘要翻译：一种制备方法，其包括使碱性抗生素 - 草酸盐（II）与无机酸的碱土金属盐（III）进行盐交换：其中环A表示碱性抗生素; R 10表示有机合成中使用的被保护的官能团; Ak-E表示碱土金属; B分别表示无机酸。

4. 发明申请

US20060040916A1 Carbapenem compound crystals and injection preparations 审中-公开
标题翻译：碳青霉烯复合晶体和注射剂
公开(公告)号：US20060040916A1
公开(公告)日：2006-02-23
申请号：US11259509
申请日：2005-10-26
申请人： Hiroyuki Chiba , Masahiko Tsujii , Astsushi Koiwa , Shin Sakurai , Akio Kayano , Hiroyuki Ishizuka , Hiroyuki Saito , Taiju Nakamura , Ikuo Kushida , Yasuyuki Suzuki , Takako Yoshiba , Kazuhide Ashizawa , Masahiro Sakurai , Eiichi Yamamoto
发明人： Hiroyuki Chiba , Masahiko Tsujii , Astsushi Koiwa , Shin Sakurai , Akio Kayano , Hiroyuki Ishizuka , Hiroyuki Saito , Taiju Nakamura , Ikuo Kushida , Yasuyuki Suzuki , Takako Yoshiba , Kazuhide Ashizawa , Masahiro Sakurai , Eiichi Yamamoto
IPC分类号： C07D487/04 , A61K31/407
CPC分类号： C07D477/20 , A61K31/407
摘要： The present invention provides carbapenem hydrochloride trihydrate crystals, which are chemically stable, easily purified and useful as antimicrobial agents, a process for producing them, and a powdery charged preparation for injection containing them. That is, it provides carbapenem hydrochloride trihydrate crystals having a powdery X-ray diffraction pattern containing lattice distances (d) of 9.0, 4.1 and 2.8 Å, a process for producing them, and a powdery charged preparation for injection containing them.
摘要翻译：本发明提供化学稳定，易于纯化和用作抗微生物剂的盐酸碳青霉烯盐酸盐三水合物晶体，其制备方法和含有它们的注射用粉末状药物制剂。也就是说，它提供了具有包含晶格距离（d）为9.0,4.1和2.8的粉末X射线衍射图的碳青霉烯盐酸盐三水合物晶体，其制备方法和含有它们的注射用粉末状药物制剂。

5. 发明授权

US07084268B1 Carbapenem compound crystals and interjection preparations 失效
标题翻译：碳青霉烯复合晶体和注射剂
公开(公告)号：US07084268B1
公开(公告)日：2006-08-01
申请号：US09979679
申请日：2000-06-05
申请人： Hiroyuki Chiba , Masahiko Tsujii , Astsushi Koiwa , Shin Sakurai , Akio Kayano , Hiroyuki Ishizuka , Hiroyuki Saito , Taiju Nakamura , Ikuo Kushida , Yasuyuki Suzuki , Takako Yoshiba , Kazuhide Ashizawa , Masahiro Sakurai , Eiichi Yamamoto
发明人： Hiroyuki Chiba , Masahiko Tsujii , Astsushi Koiwa , Shin Sakurai , Akio Kayano , Hiroyuki Ishizuka , Hiroyuki Saito , Taiju Nakamura , Ikuo Kushida , Yasuyuki Suzuki , Takako Yoshiba , Kazuhide Ashizawa , Masahiro Sakurai , Eiichi Yamamoto
IPC分类号： C07D477/20 , A61K31/407 , A61P31/04
CPC分类号： C07D477/20 , A61K31/407
摘要： The present invention provides carbapenem hydrochloride trihydrate crystals, which are chemically stable, easily purified and useful as antimicrobial agents, a process for producing them, and a powdery charged preparation for injection containing them. That is, it provides carbapenem hydrochloride trihydrate crystals having a powdery X-ray diffraction pattern containing lattice distances (d) of 9.0, 4.1 and 2.8 Å, a process for producing them, and a powdery charged preparation for injection containing them.
摘要翻译：本发明提供化学稳定，易于纯化和用作抗微生物剂的盐酸碳青霉烯盐酸盐三水合物晶体，其制备方法和含有它们的注射用粉末状药物制剂。也就是说，它提供了具有包含晶格距离（d）为9.0,4.1和2.8的粉末X射线衍射图的碳青霉烯盐酸盐三水合物晶体，其制备方法和含有它们的注射用粉末状药物制剂。

6. 发明授权

US08772497B2 Method for producing 1, 2-dihydropyridine-2-one compound 有权
标题翻译： 1,2-二氢吡啶-2-酮化合物的制备方法
公开(公告)号：US08772497B2
公开(公告)日：2014-07-08
申请号：US12870507
申请日：2010-08-27
申请人： Itaru Arimoto , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Kayano , Katsutoshi Nishiura
发明人： Itaru Arimoto , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Kayano , Katsutoshi Nishiura
IPC分类号： C07D401/04
CPC分类号： C07D213/64
摘要： The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one and production processes therefore.
摘要翻译：本发明提供了一种商业生产下式（III-a）表示的1,2-二氢吡啶-2-酮化合物的方法，其中环A表示任选取代的2-吡啶基，环B表示任选取代的苯基，环C表示任选取代的苯基。此外，本发明提供3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮的晶体及其制备方法。

7. 发明授权

US08304548B2 Method for producing 1, 2-dihydropyridine-2-one compound 有权
标题翻译： 1,2-二氢吡啶-2-酮化合物的制备方法
公开(公告)号：US08304548B2
公开(公告)日：2012-11-06
申请号：US11649299
申请日：2007-01-04
申请人： Akio Kayano , Katsutoshi Nishiura
发明人： Akio Kayano , Katsutoshi Nishiura
IPC分类号： C07D401/02
CPC分类号： C07D213/64
摘要： The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one and production processes therefor.
摘要翻译：本发明提供了一种商业生产下式（III-a）表示的1,2-二氢吡啶-2-酮化合物的方法，其中环A表示任选取代的2-吡啶基，环B表示任选取代的苯基，环C表示任选取代的苯基。此外，本发明提供3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮的晶体及其制备方法。

8. 发明授权

US06313303B1 Process for the preparation of pyridine derivatives 失效
标题翻译：吡啶衍生物的制备方法
公开(公告)号：US06313303B1
公开(公告)日：2001-11-06
申请号：US09462180
申请日：2000-01-03
申请人： Katsuya Tagami , Nobuo Niikawa , Akio Kayano , Hirofumi Kuroda
发明人： Katsuya Tagami , Nobuo Niikawa , Akio Kayano , Hirofumi Kuroda
IPC分类号： C07D40100
CPC分类号： C07D401/12
摘要： Processes for preparing sulfoxides useful as drugs such as acid secretion inhibitors or antiulcer drugs or intermediates for the preparation of drugs in high yields, at high purities, and with safety. Specifically, a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with a peroxoborate salt in the presence of an acid anhydride or a metal catalyst; and a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with an N-halosuccinimide, 1,3-dihalo-5,5-dimethyl-hydantoin or dichloroisocyanuric acid salt in the presence of a base. In said formulae R1 is hydrogen, methoxy or difluoromethoxy; R2 is methyl or methoxy; R3 is 3-methoxypropoxy, methoxy or 2,2,2-trifluoroethoxy; and R4 is hydrogen or methyl
摘要翻译：用于制备用作药物的亚砜的方法，例如酸分泌抑制剂或抗溃疡药物或用于以高产率，高纯度和安全性制备药物的中间体。具体地说，在酸酐或金属催化剂存在下，用过氧硼酸盐氧化硫醚（I），制备亚砜（Ⅱ）的方法; 和通过在碱存在下用N-卤代琥珀酰亚胺，1,3-二卤代-5,5-二甲基 - 乙内酰脲或二氯异氰脲酸盐氧化硫醚（I）来制备亚砜（II）的方法。在所述式中，R 1是氢，甲氧基或二氟甲氧基; R2是甲基或甲氧基; R3是3-甲氧基丙氧基，甲氧基或2,2,2-三氟乙氧基; R4为氢或甲基

9. 发明申请

US20100280243A1 PROCESS FOR PRODUCTION OF 4- (SUBSTITUTED PHENYL) HEXAHYDROPYRIDO [2,1-C] [1,4] OXAZIN-6-ONE 审中-公开
标题翻译：制备4-（取代苯基）十六氢化二[2,1-C] [1,4]氧杂-6-酮的方法
公开(公告)号：US20100280243A1
公开(公告)日：2010-11-04
申请号：US12810783
申请日：2008-12-25
申请人： Akio Kayano , Mitsuo Nagai , Yorihisa Hoshino , Kazunori Wakasugi , Masaaki Matsuda , Atsushi Kamada , Minetaka Isomura , Yoshihiro Nishikawa , Seiji Yoshikawa , Daisuke Shimmyo
发明人： Akio Kayano , Mitsuo Nagai , Yorihisa Hoshino , Kazunori Wakasugi , Masaaki Matsuda , Atsushi Kamada , Minetaka Isomura , Yoshihiro Nishikawa , Seiji Yoshikawa , Daisuke Shimmyo
IPC分类号： C07D498/04 , C07D265/30
CPC分类号： C07D265/30 , C07D498/04
摘要： 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one represented by formula (I) or a salt thereof is useful as an intermediate for the production of a bicyclic cinnamide compound which is an Aβ production inhibitor. 4-(Substituted phenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one or the salt thereof can be produced in an industrially advantageous manner by subjecting a compound represented by formula (II) or a salt thereof to an intramolecular condensation reaction.
摘要翻译：由式（I）表示的4-（取代的苯基）六氢吡啶并[2,1-c] [1,4]恶嗪-6-酮或其盐可用作生产二环肉桂酰胺化合物的中间体，其为 A＆bgr 生产抑制剂。 4-（取代的苯基）六氢吡啶并[2,1-c] [1,4]恶嗪-6-酮或其盐可以工业上有利的方式通过使由式（II）表示的化合物或其盐进行分子内缩合反应。

10. 发明申请

US20070142640A1 Method for producing 1, 2-dihydropyridine-2-one compound 有权
标题翻译： 1,2-二氢吡啶-2-酮化合物的制备方法
公开(公告)号：US20070142640A1
公开(公告)日：2007-06-21
申请号：US11649299
申请日：2007-01-04
申请人： Itaru Arimoto , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Kayano , Katsutoshi Nishiura
发明人： Itaru Arimoto , Satoshi Nagato , Yukiko Sugaya , Yoshio Urawa , Koichi Ito , Hiroyuki Naka , Takao Omae , Akio Kayano , Katsutoshi Nishiura
IPC分类号： A61K31/444 , C07D401/02
CPC分类号： C07D213/64
摘要： The present inventions provide a method for commercially producing a 1,2-dihydropyridine-2-one compound represented by the following formula (III-a) wherein the ring A represents an optionally substituted 2-pyridyl group, the ring B represents an optionally substituted phenyl group, and the ring C represents an optionally substituted phenyl group. Further, the invention provides crystals of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one and production processes therefor.
摘要翻译：本发明提供了一种商业生产下式（III-a）表示的1,2-二氢吡啶-2-酮化合物的方法，其中环A表示任选取代的2-吡啶基，环B表示任选取代的苯基，环C表示任选取代的苯基。此外，本发明提供3-（2-氰基苯基）-5-（2-吡啶基）-1-苯基-1,2-二氢吡啶-2-酮的晶体及其制备方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式