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1. 发明授权

US07211278B2 Treating method for suppressing hair growth 有权
标题翻译：抑制毛发生长的处理方法
公开(公告)号：US07211278B2
公开(公告)日：2007-05-01
申请号：US10777976
申请日：2004-02-13
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
IPC分类号： A01N65/00 , A61K38/46 , A61K38/48 , A61K38/54
CPC分类号： A61Q7/02 , A61K8/046 , A61K8/14 , A61K8/66 , A61K8/97 , A61K36/15 , A61K36/8998 , A61K38/4826 , A61K38/4873 , A61K2800/782 , A61K2300/00
摘要： treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.
摘要翻译：治疗毛发生长抑制的方法，其包括施用（A）桧属a属植物的提取物或麦芽。另外，本发明涉及外用皮肤病学组合物，其包含（B）弹性蛋白酶抑制剂或中性肽链内切酶抑制剂，以及上述成分（A）和/或（C）至少一种选自以下的蛋白水解酶由木瓜蛋白酶，胰蛋白酶，糜蛋白酶，胃蛋白酶，菠萝蛋白酶，蓖麻毒素和胰酶组成的组。

2. 发明授权

US07056499B2 Treating method for suppressing hair growth 有权
公开(公告)号：US07056499B2
公开(公告)日：2006-06-06
申请号：US10067941
申请日：2002-02-08
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
IPC分类号： A61K7/06 , A61K38/54 , A61K38/48 , A61K38/46 , A01N57/00
CPC分类号： A61Q7/02 , A61K8/046 , A61K8/14 , A61K8/66 , A61K8/97 , A61K36/15 , A61K36/8998 , A61K38/4826 , A61K38/4873 , A61K2800/782 , A61K2300/00
摘要： The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.

3. 发明授权

US06747017B2 Method of inhibiting hair growth 有权
标题翻译：抑制毛发生长的方法
公开(公告)号：US06747017B2
公开(公告)日：2004-06-08
申请号：US09220691
申请日：1998-12-28
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
IPC分类号： A01N5726
CPC分类号： A61K8/46 , A61K8/447 , A61K8/55 , A61K2800/782 , A61Q7/02
摘要： Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.
摘要翻译：本文公开了一种抑制毛发生长的方法，其包括施用弹性蛋白酶样酶或中性内肽酶抑制剂的抑制剂，以及使用弹性蛋白酶样酶抑制剂或中性肽链内切酶抑制剂来制备毛发生长抑制剂。

4. 发明授权

US07041658B2 Method of inhibiting hair growth 失效
标题翻译：抑制毛发生长的方法
公开(公告)号：US07041658B2
公开(公告)日：2006-05-09
申请号：US10800668
申请日：2004-03-16
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
IPC分类号： A61K31/66
CPC分类号： A61K8/46 , A61K8/447 , A61K8/55 , A61K2800/782 , A61Q7/02
摘要： Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.
摘要翻译：本文公开了一种抑制毛发生长的方法，其包括施用弹性蛋白酶样酶或中性内肽酶抑制剂的抑制剂，以及使用弹性蛋白酶样酶抑制剂或中性肽链内切酶抑制剂来制备毛发生长抑制剂。

5. 发明授权

US06375948B1 Treating method for suppressing hair growth 有权
标题翻译：抑制毛发生长的处理方法
公开(公告)号：US06375948B1
公开(公告)日：2002-04-23
申请号：US09614166
申请日：2000-07-11
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yasuto Suzuki
IPC分类号： A61K3848
CPC分类号： A61Q7/02 , A61K8/046 , A61K8/14 , A61K8/66 , A61K8/97 , A61K36/15 , A61K36/8998 , A61K38/4826 , A61K38/4873 , A61K2800/782 , A61K2300/00
摘要： The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibitor or neutral endopeptidase inhibitor, and the above-described component (A) and/or (C) at least one proteolytic enzyme selected from the group consisting of papain, trypsin, chymotrypsin, pepsin, bromelain, ficin and pancreatin.
摘要翻译：本发明涉及一种用于毛发生长抑制的处理方法，其包括给予（A）桧属家a或麦芽的植物提取物。另外本发明涉及外用皮肤病学组合物，其包含（B）弹性蛋白酶抑制剂或中性肽链内切酶抑制剂，以及上述成分（A）和/或（C）至少一种选自以下的蛋白水解酶由木瓜蛋白酶，胰蛋白酶，糜蛋白酶，胃蛋白酶，菠萝蛋白酶，蓖麻毒素和胰酶组成的组。

6. 发明申请

US20060093567A1 Method of inhibiting hair growth 审中-公开
标题翻译：抑制毛发生长的方法
公开(公告)号：US20060093567A1
公开(公告)日：2006-05-04
申请号：US11311170
申请日：2005-12-20
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
IPC分类号： A61K8/65
CPC分类号： A61K8/46 , A61K8/447 , A61K8/55 , A61K2800/782 , A61Q7/02
摘要： Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and-use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.
摘要翻译：本文公开了抑制毛发生长的方法，其包括施用弹性蛋白酶样酶抑制剂或中性肽链内切酶抑制剂，以及使用弹性蛋白酶样酶抑制剂或中性内肽酶抑制剂来制备毛发生长抑制剂。

7. 发明授权

US07189708B2 Topical composition for skin 有权
标题翻译：皮肤专题组成
公开(公告)号：US07189708B2
公开(公告)日：2007-03-13
申请号：US10252057
申请日：2002-09-23
申请人： Yasuto Suzuki , Mikako Watanabe , Naoko Tsuji , Shigeru Moriwaki , Shinya Amano
发明人： Yasuto Suzuki , Mikako Watanabe , Naoko Tsuji , Shigeru Moriwaki , Shinya Amano
IPC分类号： A61K31/545
CPC分类号： C07C237/20 , A61K38/05
摘要： A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.
摘要翻译：含有由式（1）表示的二肽化合物或二肽盐的局部皮肤组合物：其中R 1表示氢原子，烷基，烷酰基或-CH（R' 其中R 6表示氢原子或低级烷基，R 7表示氢原子或低级烷基，氢原子，低级烷基，低级烯基或芳烷基）。 R 2表示氢原子或可以具有取代基的烷基; R 3表示低级烷基或苯基; R 4表示氢原子或低级烷基，并且可以与R 5和相邻的氮原子一起形成杂环; R 5表示氢原子，可以具有取代基的烷基或可具有取代基的芳烷基，并且可以与R 4一起形成杂环， ; X表示-COOR 8（其中R 8表示氢原子，低级烷基，低级烯基或芳烷基）或-SO 3 H; 并且n是0-4的整数; 和其药学上可接受的载体。

8. 发明授权

US06171595B2 Skin external preparation 有权
标题翻译：皮肤外用制剂
公开(公告)号：US06171595B2
公开(公告)日：2001-01-09
申请号：US09480794
申请日：2000-01-11
申请人： Yasuto Suzuki , Naoko Tsuji , Shigeru Moriwaki , Yoshinori Nishizawa , Yoshinori Takema , Satoshi Kanazawa , Genji Imokawa , Yukihiro Ohashi , Mikako Watanabe
发明人： Yasuto Suzuki , Naoko Tsuji , Shigeru Moriwaki , Yoshinori Nishizawa , Yoshinori Takema , Satoshi Kanazawa , Genji Imokawa , Yukihiro Ohashi , Mikako Watanabe
IPC分类号： A61K39385
CPC分类号： A61K8/97 , A61K8/44 , A61K8/442 , A61K8/55 , A61Q7/00 , A61Q19/08
摘要： The present invention provides a skin external preparation comprising a compound of the formula (1), (2), (3) or (4). wherein X represents COOH, etc., Z represents CONH2, etc. and R1 and R7 individually represent a hydrogen atom, etc. The above-described compound has excellent effects, for example, for preventing or alleviating skin aging or inhibiting hair growth.
摘要翻译：本发明提供包含式（1），（2），（3）或（4）的化合物的皮肤外用制剂，其中X表示COOH等，Z表示CONHH等，R 1和R 7各自表示氢原子等。上述化合物具有优异的效果，例如用于预防或缓解皮肤老化或抑制毛发生长。

9. 发明授权

US06489291B1 Topical composition for skin 有权
标题翻译：皮肤专题组成
公开(公告)号：US06489291B1
公开(公告)日：2002-12-03
申请号：US09678615
申请日：2000-10-04
申请人： Yasuto Suzuki , Mikako Watanabe , Naoko Tsuji , Shigeru Moriwaki , Shinya Amano
发明人： Yasuto Suzuki , Mikako Watanabe , Naoko Tsuji , Shigeru Moriwaki , Shinya Amano
IPC分类号： A01N3718
CPC分类号： C07C237/20 , A61K38/05
摘要： A topical skin composition containing a dipeptide compound represented by, formula (1) or a salt of the dipeptide: wherein R1 represents a, hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R6)COOR7 (wherein R6 represents a hydrogen atom or a lower alkyl group, and R7 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group); R2 represents a hydrogen atom or an alkyl group which may have a substituent; R3 represents a lower alkyl group or a phenyl group; R4 represents a hydrogen atom or a lower alkyl group, and may form a heterocyclic ring together with R5 and an adjacent nitrogen atom; R5 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, and may form the heterocyclic ring together with R4; X represents —COOR8 (wherein R8 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, or an aralkyl group) or —SO3H; and n is an integer of 0-4; and a pharmaceutically acceptable carrier therefor.
摘要翻译：含有由式（1）表示的二肽化合物或二肽盐的局部皮肤组合物：其中R1表示氢原子，烷基，烷酰基或-CH（R6）COOR7（其中R6表示氢原子或低级烷基，R7表示氢原子，低级烷基，低级烯基或芳烷基）; R2表示氢原子或可具有取代基的烷基; R3表示低级烷基或苯基; R 4表示氢原子或低级烷基，并且可以与R 5和相邻的氮原子一起形成杂环; R 5表示氢原子，可以具有取代基的烷基或可以具有取代基的芳烷基，也可以与R4形成杂环; X表示-COOR8（其中R8表示氢原子，低级烷基，低级烯基或芳烷基）或-SO3H; andn是0-4的整数; 和其药学上可接受的载体。

10. 发明授权

US6075052A Skin external preparation 有权
标题翻译：皮肤外用制剂
公开(公告)号：US6075052A
公开(公告)日：2000-06-13
申请号：US276504
申请日：1999-03-25
申请人： Yasuto Suzuki , Naoko Tsuji , Shigeru Moriwaki , Yoshinori Nishizawa , Yoshinori Takema , Satoshi Kanazawa , Genji Imokawa , Yukihiro Ohashi , Mikako Watanabe
发明人： Yasuto Suzuki , Naoko Tsuji , Shigeru Moriwaki , Yoshinori Nishizawa , Yoshinori Takema , Satoshi Kanazawa , Genji Imokawa , Yukihiro Ohashi , Mikako Watanabe
IPC分类号： C07D207/16 , A61K8/00 , A61K8/02 , A61K8/30 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61K8/58 , A61K8/97 , A61K31/185 , A61K31/195 , A61K31/22 , A61K31/27 , A61K31/40 , A61K31/66 , A61P17/00 , A61Q5/00 , A61Q7/00 , A61Q9/04 , A61Q19/00 , A61Q19/08 , A01N37/12 , A01N37/02 , A01N37/10 , C07C51/16 , C07C229/00
CPC分类号： A61K8/97 , A61K8/44 , A61K8/442 , A61K8/55 , A61Q19/08 , A61Q7/00
摘要： The present invention provides a skin external preparation comprising a compound of the formula (1), (2), (3) or (4). ##STR1## wherein X represents COOH, etc., Z represents CONH.sub.2, etc. and R.sup.1 and R.sup.7 individually represent a hydrogen atom, etc.The above-described compound has excellent effects, for example, for preventing or alleviating skin aging or inhibiting hair growth.
摘要翻译：本发明提供包含式（1），（2），（3）或（4）的化合物的皮肤外用制剂。其中X表示COOH等，Z表示CONH 2等，R 1和R 7各自表示氢原子等。上述化合物具有优异的效果，例如用于预防或缓解皮肤老化或抑制毛发生长。

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