专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060018961A1 Compression formed preparation and method for manufacturing same 审中-公开
标题翻译：压缩成型制备及其制造方法
公开(公告)号：US20060018961A1
公开(公告)日：2006-01-26
申请号：US11236640
申请日：2005-09-28
申请人： Naoko Nakamura , Naoki Kameyama , Akihito Iwasa , Yukinari Iwata
发明人： Naoko Nakamura , Naoki Kameyama , Akihito Iwasa , Yukinari Iwata
IPC分类号： A61K9/20 , A61K31/366
CPC分类号： A61K9/2018 , A61K9/0056 , A61K9/2013 , A61K9/2027 , A61K31/366 , A61K45/06 , A61K2300/00
摘要： A compression formed preparation that rapidly disintegrates in the mouth or in an aqueous solvent, which imparts an excellent feeling during administration, and maintains a suitable hardness required for handling such as distribution and the like, and a method for manufacturing the compression formed preparation. The present invention provides a rapidly disintegrating compression formed preparation comprising one or more compounds selected from gluconolactones and pullulans added to the pharmaceutical base. The pharmaceutical base is preferably a saccharide and particularly preferably a sugar alcohol and starch syrup. The compression formed preparation is prepared by compressing granules obtained by granulation of particles comprising preparation assistants in addition to the pharmaceutical base in a solution of gluconolactone or pullulan dissolved in an aqueous solvent or together with gluconolactone or pullulan in an aqueous solvent.
摘要翻译：一种在口腔或水性溶剂中快速崩解的压制成型制剂，其在给药期间赋予优异的感觉，并保持诸如分布等的处理所需的合适的硬度，以及压缩成型制剂的制造方法。本发明提供了包含一种或多种选自加入到药物基质中的葡糖酸内酯和支链淀粉的化合物的快速崩解的压制成形制剂。药物基质优选为糖类，特别优选糖醇和淀粉糖浆。通过将溶解在水性溶剂中的葡萄糖酸内酯或支链淀粉的溶液中的制剂助剂以外的制剂助剂颗粒压制成颗粒而得到的压缩成型制剂，或者与葡萄糖酸内酯或支链淀粉一起在水性溶剂中。

2. 发明申请

US20090035750A1 METHOD OF DETECTING HUMAN PAPILLOMA VIRUS BY USING NUCLEIC ACID AMPLIFICATION METHOD AND NUCLEIC ACID CHAIN-IMMOBILIZED CARRIER 有权
标题翻译：通过使用核酸扩增方法和核酸链固定载体检测人乳头瘤病毒的方法
公开(公告)号：US20090035750A1
公开(公告)日：2009-02-05
申请号：US12134420
申请日：2008-06-06
申请人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
发明人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
IPC分类号： C12Q1/70 , C07H21/00
CPC分类号： C12Q1/708
摘要： Provided is a nucleic acid primer for LAMP amplification for use in the detection of human papilloma virus and identification of its genotype. The present invention also provides a method of detecting human papilloma virus and identifying its genotype, includes a step of amplifying the nucleic acid chains in a sample in LAMP reaction by using multiple primers including at least one primer selected from the nucleic acid primers according to the present invention and a step of detecting presence of amplified products after the amplification reaction and identifying their genotypes.
摘要翻译：提供了用于LAMP扩增的核酸引物，用于检测人乳头瘤病毒并鉴定其基因型。本发明还提供了一种检测人乳头状瘤病毒并鉴定其基因型的方法，包括通过使用包含至少一种引物的多个引物来扩增LAMP反应中的核酸链的步骤，该引物选自根据本发明的核酸引物本发明和扩增反应后检测扩增产物的存在并鉴定其基因型的步骤。

3. 发明申请

US20080215272A1 Fluorescence Microscope and Fluorescence Microscope Method 有权
标题翻译：荧光显微镜和荧光显微镜法
公开(公告)号：US20080215272A1
公开(公告)日：2008-09-04
申请号：US11792304
申请日：2005-10-14
申请人： Katsumasa Fujita , Satoshi Kawata , Naoko Nakamura , Osamu Nakamura , Minoru Kobayashi
发明人： Katsumasa Fujita , Satoshi Kawata , Naoko Nakamura , Osamu Nakamura , Minoru Kobayashi
IPC分类号： G06F15/00
CPC分类号： G01N21/6458 , G01N21/6408 , G01N21/6428 , G01N2201/0697 , G02B21/16
摘要： To increase spatial resolution by observing a sample based on saturated fluorescence components. A fluorescence microscope according to the present invention includes: a laser light source 10 emitting laser light as excitation light; an objective lens 13 focusing the laser light and applying the focused laser light to a sample 14; a detector 22 detecting fluorescence generated in the sample 14 with the laser light; and a stage 15 scanning the sample 14 while moving the sample 14 relative to the laser light, wherein the laser light is applied to the sample with varying intensities such that saturation of fluorescence occurs at the maximum intensity of the laser light, and fluorescence is detected with the detector in accordance with intensity of the laser light, and the sample is observed based on the saturation components of fluorescence.
摘要翻译：通过观察基于饱和荧光成分的样品来增加空间分辨率。根据本发明的荧光显微镜包括：发射激光作为激发光的激光光源10; 聚焦激光并将聚焦的激光施加到样品14的物镜13; 用激光检测样品14中产生的荧光的检测器22; 以及在样品14相对于激光移动的同时扫描样品14的阶段15，其中激光以不同的强度施加到样品，使得在激光的最大强度下发生荧光饱和，并且检测到荧光与检测器根据激光的强度，并且基于荧光的饱和分量观察样品。

4. 发明授权

US07951541B2 Assay kit for use in method of detecting a target nucleic acid 有权
标题翻译：用于检测靶核酸的方法的测定试剂盒
公开(公告)号：US07951541B2
公开(公告)日：2011-05-31
申请号：US12851675
申请日：2010-08-06
申请人： Naoko Nakamura , Keiko Ito
发明人： Naoko Nakamura , Keiko Ito
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6844 , C12Q2525/161 , C12Q2525/301 , C12Q2531/101
摘要： Kits for use in a method of detecting an amplification product by hybridizing it with a probe, the amplification product is amplified from a target nucleic acid with the primers, including placing F3, F2 and F1 regions in this order from a 5′ terminal side and B3c, B2c and B1c regions in this order from a 3′ terminal side, and additionally an FP region in the region from the F2 to F1 regions and/or a BPc region in the region from the B2c to B1c regions in the target nucleic acid, determining the respective regions in such a manner that the FP and F2 regions and/or the BPc and B2c regions have an unoverlapping region of at least 10 bases or more and overlapping regions of 10 bases or less, and designing the primers according to the regions.
摘要翻译：用于通过与探针杂交来检测扩增产物的方法的试剂盒，使用引物从靶核酸扩增扩增产物，包括从5'末端侧依次放置F3，F2和F1区， B3c，B2c和B1c区域，另外在靶核酸中的从B2c到B1c区域的F2到F1区和/或BPc区的区域中的FP区域以这样的方式确定各个区域，使得FP和F2区域和/或BPc和B2c区域具有至少10个碱基以上的重叠区域和10个碱基以下的重叠区域，并且根据地区。

5. 发明授权

US07919252B2 Method for detecting a target nucleic acid sequence 有权
标题翻译：检测靶核酸序列的方法
公开(公告)号：US07919252B2
公开(公告)日：2011-04-05
申请号：US12341295
申请日：2008-12-22
申请人： Naoko Nakamura , Koji Hashimoto
发明人： Naoko Nakamura , Koji Hashimoto
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6813
摘要： A method of detecting a target nucleic acid sequence comprising providing a stem-and-loop structured nucleic acid for measurement wherein the nucleic acid comprises complementary sequence portions located at both terminals and a target sequence portion therebetween as well as a double-stranded portion formed by hybridization of the complementary sequence portions located at both terminals and a remaining looped single-stranded portion, providing a probe nucleic acid having a sequence complementary to the target sequence portion wherein one end of the probe nucleic acid being immobilized to a solid substrate surface, reacting the nucleic acid for measurement with the probe nucleic acid to specifically hybridize the target sequence portion of the nucleic acid for measurement to the probe nucleic acid, and detecting presence or absence of the nucleic acid for measurement hybridized to the probe nucleic acid.
摘要翻译：一种检测靶核酸序列的方法，包括提供用于测量的茎 - 环结构化核酸，其中所述核酸包含位于两端的互补序列部分和其间的靶序列部分以及由双链部分形成的双链部分位于两个末端的互补序列部分和剩余的环状单链部分的杂交，提供具有与靶序列部分互补的序列的探针核酸，其中探针核酸的一端被固定在固体基质表面上，使用于与探针核酸进行测量的核酸以将用于测量的核酸的靶序列部分特异性杂交到探针核酸，并检测与探针核酸杂交的用于测量的核酸的存在或不存在。

6. 发明申请

US20090117544A1 METHOD OF DESIGNING PRIMERS FOR USE IN METHOD OF DETECTING TARGET NUCLEIC ACID AND ASSAY KIT 有权
标题翻译：设计用于检测目标核酸和测定试剂盒的方法中使用的方法
公开(公告)号：US20090117544A1
公开(公告)日：2009-05-07
申请号：US11624814
申请日：2007-01-19
申请人： Naoko Nakamura , Keiko Ito
发明人： Naoko Nakamura , Keiko Ito
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6844 , C12Q2525/161 , C12Q2525/301 , C12Q2531/101
摘要： A method of designing primers for use in a method of detecting an amplification product by hybridizing it with a probe, the amplification product is amplified from a target nucleic acid with the primers, including placing F3, F2 and F1 regions in this order from a 5′ terminal side and Bc, B2c and B1c regions in this order from a 3′ terminal side, and additionally an FP region in the region from the F2 to F1 regions and/or a BPc region in the region from the B2c to B1c regions in the target nucleic acid, determining the respective regions in such a manner that the FP and F2 regions and/or the BPc and B2c regions have an unoverlapping region of at least 10 bases or more and overlapping regions of 10 bases or less, and designing the primers according to the regions.
摘要翻译：一种设计引物用于通过与探针杂交来检测扩增产物的方法的引物的方法，用引物从靶核酸扩增扩增产物，其中包括将F3，F2和F1区域从5 '端子侧和Bc，B2c和B1c区域，另外在从F2到F1区域的区域中的FP区域和/或从B2c到B1c区域的区域中的BPc区域靶核酸，以使得FP和F2区域和/或BPc和B2c区域具有至少10个碱基以上的不重叠区域和10个碱基以下的重叠区域的方式来确定各个区域，并且设计引物根据区域。

7. 发明授权

US5714382A Synthetic plasmids and transformants comprising a feline interferon cDNA 失效
标题翻译：包含猫干扰素cDNA的合成质粒和转化体
公开(公告)号：US5714382A
公开(公告)日：1998-02-03
申请号：US463242
申请日：1995-06-05
申请人： Akira Yanai , Naoko Nakamura , Susumu Matsuda
发明人： Akira Yanai , Naoko Nakamura , Susumu Matsuda
IPC分类号： C12N1/21 , A61K38/21 , A61P37/00 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C12N5/10 , C12N15/09 , C12N15/21 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C07K14/555
摘要： A synthetic plasmid in which DNA encoding protein of a feline interferon is integrated, a transformant obtainable by the transformation of a host cell by the use of the synthetic plasmid and a feline interferon having a biological activity given by a protein carrying a specific amino acid sequence, a feline interferon gene encoding the feline interferon, a feline interferon precursor comprised of a cleavable peptide or a signal peptide being linked to the N terminal of the feline interferon, a feline interferon precursor gene encoding the feline interferon precursor and a method for producing the feline interferon, which are applied to the mass production of a feline interferon to be used as a remedy for feline viral disease and tumor.
摘要翻译：将编码猫干扰素的蛋白质的DNA整合的合成质粒，通过使用合成质粒转化宿主细胞而获得的转化体和具有由具有特定氨基酸序列的蛋白质赋予的生物活性的猫干扰素，编码猫干扰素的猫干扰素基因，由可切割肽或与猫干扰素的N末端连接的信号肽构成的猫干扰素前体，编码猫干扰素前体的猫干扰素前体基因，以及制备猫干扰素，其被用于大量生产猫干扰素，用作猫病毒性疾病和肿瘤的补救剂。

8. 发明申请

US20110151554A1 METHOD FOR CULTURING AND SUBCULTURING PRIMATE EMBRYONIC STEM CELL, AS WELL AS METHOD FOR INDUCING DIFFERENTIATION THEREOF 审中-公开
标题翻译：用于培养和再培养原始胚胎干细胞的方法，作为诱导其差异的方法
公开(公告)号：US20110151554A1
公开(公告)日：2011-06-23
申请号：US12514207
申请日：2007-11-09
申请人： Akira Yuo , Kumiko Tobe , Koichi Saeki , Masako Nakahara , Naoko Nakamura , Yoshiko Yogisashi , Satoko Matsuyama , Asako Yoneda
发明人： Akira Yuo , Kumiko Tobe , Koichi Saeki , Masako Nakahara , Naoko Nakamura , Yoshiko Yogisashi , Satoko Matsuyama , Asako Yoneda
IPC分类号： C12N5/0735 , C12N5/078 , C12N5/071 , C12N5/0789
CPC分类号： C12N5/0606 , C12N5/0634 , C12N2500/84 , C12N2501/105 , C12N2501/115 , C12N2501/125 , C12N2501/155 , C12N2501/165 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2506/02 , C12N2509/00 , C12N2533/90
摘要： The present invention provides a method for subculturing primate embryonic stem cells, and a method for inducing differentiation of the same cell into a vascular endothelial cell and a blood cell. The present invention provides a method comprising culturing primate embryonic stem cells in a medium containing a protein component without using feeder cells and cytokines in a container coated with an extracellular matrix, detaching colonies of the resulting embryonic stem cells in the presence of a cytodetachment agent, and plating the colonies in the similar medium, and a method comprising culturing primate embryonic stem cells in a serum-containing or not containing medium in the presence of cytokine, adhesion-culturing the resulting embryoid body or embroyid body-analogous cellular aggregate in the presence of a cytokine to obtain specific precursor cells, and separating non-adherent cells and adherent cells from the specific precursor cells to obtain blood cells and vascular endothelial precursor cells.
摘要翻译：本发明提供了用于传代培养灵长类动物胚胎干细胞的方法，以及诱导将相同细胞分化成血管内皮细胞和血细胞的方法。本发明提供了一种方法，其包括在含有蛋白质组分的培养基中培养灵长类动物胚胎干细胞，而不在包被细胞外基质的容器中使用饲养细胞和细胞因子，在细胞分析剂存在下分离所得胚胎干细胞的集落，并将菌落电镀在相似的培养基中，以及包括在存在细胞因子的情况下在含有血清的或不含有培养基中培养灵长类动物胚胎干细胞的方法，在存在的情况下粘附培养所得到的类胚体或刺激体类似的细胞聚集体的细胞因子以获得特异性前体细胞，并从特异性前体细胞分离非贴壁细胞和贴壁细胞以获得血细胞和血管内皮前体细胞。

9. 发明授权

US07919611B2 Nucleotide primer set and nucleotide probe for detecting genotype of N-acetyltransferase-2 (NAT2) 失效
标题翻译：用于检测N-乙酰转移酶-2（NAT2）基因型的核苷酸引物组和核苷酸探针
公开(公告)号：US07919611B2
公开(公告)日：2011-04-05
申请号：US12014592
申请日：2008-01-15
申请人： Naoko Nakamura , Keiko Ito , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko Nakamura , Keiko Ito , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： There is provided a nucleotide primer set for LAMP amplification, used for detecting genotypes of single-nucleotide polymorphisms G590A, G857A and T341C of a NAT2 gene. There is also provided a nucleotide probe for detection of an amplification product amplified with the primer set according to the present invention. There is also provided a method of detecting the genotypes of NAT2 gene single-nucleotide polymorphisms G590A, G857A and T341C by using the primer set according to the present invention.
摘要翻译：提供了LAMP扩增的核苷酸引物组，用于检测NAT2基因的单核苷酸多态性G590A，G857A和T341C的基因型。还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。还提供了通过使用本发明的引物组来检测NAT2基因单核苷酸多态性G590A，G857A和T341C的基因型的方法。

10. 发明申请

US20100003671A1 NUCLEOTIDE PRIMER SET AND NUCLEOTIDE PROBE FOR DETECTING GENOTYPE OF N-ACETYLTRANSFERASE-2 (NAT2) 失效
标题翻译：用于检测N-乙酰基转移酶-2（NAT2）基因组的核酸酶基因组和核酸探针
公开(公告)号：US20100003671A1
公开(公告)日：2010-01-07
申请号：US12014592
申请日：2008-01-15
申请人： Naoko Nakamura , Keiko Ito , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko Nakamura , Keiko Ito , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： There is provided a nucleotide primer set for LAMP amplification, used for detecting genotypes of single-nucleotide polymorphisms G590A, G857A and T341C of a NAT2 gene. There is also provided a nucleotide probe for detection of an amplification product amplified with the primer set according to the present invention. There is also provided a method of detecting the genotypes of NAT2 gene single-nucleotide polymorphisms G590A, G857A and T341C by using the primer set according to the present invention.
摘要翻译：提供了LAMP扩增的核苷酸引物组，用于检测NAT2基因的单核苷酸多态性G590A，G857A和T341C的基因型。还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。还提供了通过使用本发明的引物组来检测NAT2基因单核苷酸多态性G590A，G857A和T341C的基因型的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式