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1. 发明申请

US20090061433A1 NUCLEOTIDE PRIMER SET AND NUCLEOTIDE PROBE FOR DETECTING GENOTYPE OF SERUM AMYLOID A1(SAA1) 审中-公开
标题翻译：用于检测血清AMYLOID A1（SAA1）基因组的核酸酶基因组和核酸探针
公开(公告)号：US20090061433A1
公开(公告)日：2009-03-05
申请号：US12049475
申请日：2008-03-17
申请人： Naoko NAKAMURA , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko NAKAMURA , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6853 , C12Q2531/119 , C12Q2525/155
摘要： Provided is a LAMP-amplification nucleotide primer set for detection of the genotype of single nucleotide polymorphisms C-13T, C2995T and T3010C of the SAA1 gene. Also provided is a nucleotide probe for detection of the amplification product amplified with the primer set according to the present invention. Further provided is a method of detecting the genotype of the single nucleotide polymorphisms C-13T, C2995T and T3010C of the SAA1 gene by using the primer set according to the present invention.
摘要翻译：提供了用于检测SAA1基因的单核苷酸多态性C-13T，C2995T和T3010C的基因型的LAMP扩增核苷酸引物组。还提供了用于检测用根据本发明的引物组扩增的扩增产物的核苷酸探针。进一步提供了通过使用本发明的引物组检测SAA1基因的单核苷酸多态性C-13T，C2995T和T3010C的基因型的方法。

2. 发明申请

US20080242554A1 NUCLEOTIDE PRIMER SET AND NUCLEOTIDE PROBE FOR DETECTING GENOTYPE OF METHYLENE TETRAHYDROFOLATE REDUCTASE (MTHFR) 失效
标题翻译：用于检测甲基四氢叶酸还原酶（MTHFR）基因组的核酸酶和核苷酸探针
公开(公告)号：US20080242554A1
公开(公告)日：2008-10-02
申请号：US12015645
申请日：2008-01-17
申请人： Naoko NAKAMURA , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko NAKAMURA , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C12Q1/68 , C40B30/04 , C07H21/00 , C40B40/06
CPC分类号： C12Q1/6827 , C12Q2537/137 , C12Q2525/301
摘要： There is provided is a nucleotide primer set for LAMP amplification used for detecting genotypes of single-nucleotide polymorphisms C677T and A1298C of an MTHFR gene. There is also provided a nucleotide probe for detecting an amplification product amplified by the primer set according to the present invention. There is also provided a method of detecting the genotypes of the single-nucleotide polymorphisms C677T and A1298C in the MTHFR gene, by using the primer set according to the present invention.
摘要翻译：提供了用于检测MTHFR基因的单核苷酸多态性C677T和A1298C的基因型的LAMP扩增的核苷酸引物组。还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。还提供了通过使用根据本发明的引物组来检测MTHFR基因中单核苷酸多态性C677T和A1298C的基因型的方法。

3. 发明授权

US07919611B2 Nucleotide primer set and nucleotide probe for detecting genotype of N-acetyltransferase-2 (NAT2) 失效
标题翻译：用于检测N-乙酰转移酶-2（NAT2）基因型的核苷酸引物组和核苷酸探针
公开(公告)号：US07919611B2
公开(公告)日：2011-04-05
申请号：US12014592
申请日：2008-01-15
申请人： Naoko Nakamura , Keiko Ito , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko Nakamura , Keiko Ito , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： There is provided a nucleotide primer set for LAMP amplification, used for detecting genotypes of single-nucleotide polymorphisms G590A, G857A and T341C of a NAT2 gene. There is also provided a nucleotide probe for detection of an amplification product amplified with the primer set according to the present invention. There is also provided a method of detecting the genotypes of NAT2 gene single-nucleotide polymorphisms G590A, G857A and T341C by using the primer set according to the present invention.
摘要翻译：提供了LAMP扩增的核苷酸引物组，用于检测NAT2基因的单核苷酸多态性G590A，G857A和T341C的基因型。还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。还提供了通过使用本发明的引物组来检测NAT2基因单核苷酸多态性G590A，G857A和T341C的基因型的方法。

4. 发明申请

US20100003671A1 NUCLEOTIDE PRIMER SET AND NUCLEOTIDE PROBE FOR DETECTING GENOTYPE OF N-ACETYLTRANSFERASE-2 (NAT2) 失效
标题翻译：用于检测N-乙酰基转移酶-2（NAT2）基因组的核酸酶基因组和核酸探针
公开(公告)号：US20100003671A1
公开(公告)日：2010-01-07
申请号：US12014592
申请日：2008-01-15
申请人： Naoko Nakamura , Keiko Ito , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko Nakamura , Keiko Ito , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： There is provided a nucleotide primer set for LAMP amplification, used for detecting genotypes of single-nucleotide polymorphisms G590A, G857A and T341C of a NAT2 gene. There is also provided a nucleotide probe for detection of an amplification product amplified with the primer set according to the present invention. There is also provided a method of detecting the genotypes of NAT2 gene single-nucleotide polymorphisms G590A, G857A and T341C by using the primer set according to the present invention.
摘要翻译：提供了LAMP扩增的核苷酸引物组，用于检测NAT2基因的单核苷酸多态性G590A，G857A和T341C的基因型。还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。还提供了通过使用本发明的引物组来检测NAT2基因单核苷酸多态性G590A，G857A和T341C的基因型的方法。

5. 发明授权

US07728119B2 Nucleotide primer set and nucleotide probe for detecting genotype of methylene tetrahydrofolate reductase (MTHFR) 失效
标题翻译：用于检测亚甲基四氢叶酸还原酶（MTHFR）基因型的核苷酸引物组和核苷酸探针
公开(公告)号：US07728119B2
公开(公告)日：2010-06-01
申请号：US12015645
申请日：2008-01-17
申请人： Naoko Nakamura , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
发明人： Naoko Nakamura , Keiko Ito , Masayoshi Takahashi , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C07H21/02 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q2537/137 , C12Q2525/301
摘要： There is provided is a nucleotide primer set for LAMP amplification used for detecting genotypes of single-nucleotide polymorphisms C677T and A1298C of an MTHFR gene. There is also provided a nucleotide probe for detecting an amplification product amplified by the primer set according to the present invention. There is also provided a method of detecting the genotypes of the single-nucleotide polymorphisms C677T and A1298C in the MTHFR gene, by using the primer set according to the present invention.
摘要翻译：提供了用于检测MTHFR基因的单核苷酸多态性C677T和A1298C的基因型的LAMP扩增的核苷酸引物组。还提供了用于检测根据本发明的引物组扩增的扩增产物的核苷酸探针。还提供了通过使用根据本发明的引物组来检测MTHFR基因中单核苷酸多态性C677T和A1298C的基因型的方法。

6. 发明申请

US20100248210A1 Nucleic acid primer set for detection of drug-resistant strain of hepatitis B virus, assay kit, and method of detecting drug-resistant strain of hepatitis B virus 审中-公开
标题翻译：用于检测乙型肝炎病毒耐药菌株的核酸引物组，测定试剂盒和检测乙型肝炎病毒耐药菌株的方法
公开(公告)号：US20100248210A1
公开(公告)日：2010-09-30
申请号：US12382733
申请日：2009-03-23
申请人： Masayoshi Takahashi , Michie Hashimoto , Keiko Ito , Keiko Kizu , Shunji Mishiro , Kazuaki Takahashi , Kazunori Miyazaki , Koji Hashimoto , Nobuhiro Gemma
发明人： Masayoshi Takahashi , Michie Hashimoto , Keiko Ito , Keiko Kizu , Shunji Mishiro , Kazuaki Takahashi , Kazunori Miyazaki , Koji Hashimoto , Nobuhiro Gemma
IPC分类号： C12Q1/70
CPC分类号： C12Q1/706
摘要： The invention provides a method of detecting a drug-resistant strain of hepatitis B virus, including amplifying a hepatitis B virus nucleic acid in a sample solution by LAMP with a primer set to yield an amplification product, and hybridizing the amplification product with a probe containing a polynucleotide derived from a drug-resistant strain and/or a probe containing a polynucleotide derived from a drug-nonresistant strain, to detect a drug-resistant strain of hepatitis B virus.
摘要翻译：本发明提供一种检测乙型肝炎病毒的耐药性菌株的方法，包括通过具有引物组的LAMP扩增样品溶液中的乙型肝炎病毒核酸以产生扩增产物，并将扩增产物与含有衍生自耐药菌株的多核苷酸和/或含有衍生自药物不耐药菌株的多核苷酸的探针，以检测乙型肝炎病毒的耐药菌株。

7. 发明申请

US20090035750A1 METHOD OF DETECTING HUMAN PAPILLOMA VIRUS BY USING NUCLEIC ACID AMPLIFICATION METHOD AND NUCLEIC ACID CHAIN-IMMOBILIZED CARRIER 有权
标题翻译：通过使用核酸扩增方法和核酸链固定载体检测人乳头瘤病毒的方法
公开(公告)号：US20090035750A1
公开(公告)日：2009-02-05
申请号：US12134420
申请日：2008-06-06
申请人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
发明人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
IPC分类号： C12Q1/70 , C07H21/00
CPC分类号： C12Q1/708
摘要： Provided is a nucleic acid primer for LAMP amplification for use in the detection of human papilloma virus and identification of its genotype. The present invention also provides a method of detecting human papilloma virus and identifying its genotype, includes a step of amplifying the nucleic acid chains in a sample in LAMP reaction by using multiple primers including at least one primer selected from the nucleic acid primers according to the present invention and a step of detecting presence of amplified products after the amplification reaction and identifying their genotypes.
摘要翻译：提供了用于LAMP扩增的核酸引物，用于检测人乳头瘤病毒并鉴定其基因型。本发明还提供了一种检测人乳头状瘤病毒并鉴定其基因型的方法，包括通过使用包含至少一种引物的多个引物来扩增LAMP反应中的核酸链的步骤，该引物选自根据本发明的核酸引物本发明和扩增反应后检测扩增产物的存在并鉴定其基因型的步骤。

8. 发明授权

US07910719B2 Method of detecting human papilloma virus by using nucleic acid amplification method and nucleic acid chain-immobilized carrier 有权
标题翻译：用核酸扩增法和核酸链固定化载体检测人乳头状瘤病毒的方法
公开(公告)号：US07910719B2
公开(公告)日：2011-03-22
申请号：US12134420
申请日：2008-06-06
申请人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
发明人： Koji Hashimoto , Keiko Ito , Naoko Nakamura , Hideki Horiuchi , Michie Hashimoto , Osamu Sato
IPC分类号： C07H21/04 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/708
摘要： Provided is a nucleic acid primer for LAMP amplification for use in the detection of human papilloma virus and identification of its genotype. The present invention also provides a method of detecting human papilloma virus and identifying its genotype, includes a step of amplifying the nucleic acid chains in a sample in LAMP reaction by using multiple primers including at least one primer selected from the nucleic acid primers according to the present invention and a step of detecting presence of amplified products after the amplification reaction and identifying their genotypes.
摘要翻译：提供了用于LAMP扩增的核酸引物，用于检测人乳头瘤病毒并鉴定其基因型。本发明还提供了一种检测人乳头状瘤病毒并鉴定其基因型的方法，包括通过使用包含至少一种引物的多个引物来扩增LAMP反应中的核酸链的步骤，该引物选自根据本发明的核酸引物本发明和扩增反应后检测扩增产物的存在并鉴定其基因型的步骤。

9. 发明申请

US20080233634A1 NUCLEIC ACID DETECTION DEVICE 审中-公开
标题翻译：核酸检测装置
公开(公告)号：US20080233634A1
公开(公告)日：2008-09-25
申请号：US12048690
申请日：2008-03-14
申请人： Jun OKADA , Sadato Hongo , Keiko Ito , Kenji Ooki , Nobuhiro Gemma
发明人： Jun OKADA , Sadato Hongo , Keiko Ito , Kenji Ooki , Nobuhiro Gemma
IPC分类号： C12M1/00
CPC分类号： G01N35/085
摘要： A nucleic acid detection device is provided with a closed channel formed of a first channel portion, through which a washing reagent storage section for storing a washing reagent for washing a detection section for nucleic acid detection communicates with the detection section, and a second channel portion through which a pretreatment section for nucleic acid treatment communicates with the detection section. The closed channel is connected with a gas inlet/outlet path for communication with the outside. The gas inlet/outlet path is blocked by a sealing mechanism before nucleic acid detection. In storing a pretreatment reagent and the washing reagent frozen, the gas inlet/outlet path is kept open and connected to the channel. Thus, there is provided a nucleic acid detection device having a structure for preventing leakage of nucleic acid samples to the outside and which can be stored for a long period of time with the reagents therein.
摘要翻译：核酸检测装置设置有由第一通道部分形成的封闭通道，用于存储用于清洗用于核酸检测的检测部分的洗涤剂的洗涤剂存储部分与检测部分通信，第二通道部分用于核酸处理的预处理部分与检测部分通信。封闭通道与用于与外部连通的气体入口/出口路径连接。在核酸检测之前，气体入口/出口路径被密封机构堵塞。在储存预处理试剂和洗涤剂冻结时，气体入口/出口路径保持打开并连接到通道。因此，提供了一种核酸检测装置，其具有防止核酸样品向外部泄漏的结构，并且可以用其中的试剂长时间储存。

10. 发明授权

US07951541B2 Assay kit for use in method of detecting a target nucleic acid 有权
标题翻译：用于检测靶核酸的方法的测定试剂盒
公开(公告)号：US07951541B2
公开(公告)日：2011-05-31
申请号：US12851675
申请日：2010-08-06
申请人： Naoko Nakamura , Keiko Ito
发明人： Naoko Nakamura , Keiko Ito
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6844 , C12Q2525/161 , C12Q2525/301 , C12Q2531/101
摘要： Kits for use in a method of detecting an amplification product by hybridizing it with a probe, the amplification product is amplified from a target nucleic acid with the primers, including placing F3, F2 and F1 regions in this order from a 5′ terminal side and B3c, B2c and B1c regions in this order from a 3′ terminal side, and additionally an FP region in the region from the F2 to F1 regions and/or a BPc region in the region from the B2c to B1c regions in the target nucleic acid, determining the respective regions in such a manner that the FP and F2 regions and/or the BPc and B2c regions have an unoverlapping region of at least 10 bases or more and overlapping regions of 10 bases or less, and designing the primers according to the regions.
摘要翻译：用于通过与探针杂交来检测扩增产物的方法的试剂盒，使用引物从靶核酸扩增扩增产物，包括从5'末端侧依次放置F3，F2和F1区， B3c，B2c和B1c区域，另外在靶核酸中的从B2c到B1c区域的F2到F1区和/或BPc区的区域中的FP区域以这样的方式确定各个区域，使得FP和F2区域和/或BPc和B2c区域具有至少10个碱基以上的重叠区域和10个碱基以下的重叠区域，并且根据地区。

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