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1. 发明授权

US5424444A Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(S)-pyrrolidinyl) isoxazoles 失效
标题翻译：制备对映体纯的3-甲基-5-（1-烷基-2（S） - 吡咯烷基）异恶唑的方法
公开(公告)号：US5424444A
公开(公告)日：1995-06-13
申请号：US234442
申请日：1994-04-28
申请人： Nan-Horng Lin , Yun He , Richard L. Elliott , Mukund S. Chorghade , Thomas K. J. Esch , Dieter O. Beer , Christian C. Witzig , Thomas C. Herzig , Steven J. Wittenberger , William H. Bunnelle , Bikshandar A. Narayanan , Pulla R. Singam , Alla V. Rama Rao
发明人： Nan-Horng Lin , Yun He , Richard L. Elliott , Mukund S. Chorghade , Thomas K. J. Esch , Dieter O. Beer , Christian C. Witzig , Thomas C. Herzig , Steven J. Wittenberger , William H. Bunnelle , Bikshandar A. Narayanan , Pulla R. Singam , Alla V. Rama Rao
IPC分类号： C07D413/04 , C07D261/08
CPC分类号： C07D413/04
摘要： A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
摘要翻译：以高产率制备对映异构纯的3-甲基-5-（1-（C 1 -C 3 - 烷基）-2-吡咯烷基）异恶唑的新方法，其中将受保护的吡咯烷或2-氧代 - 吡咯烷起始原料与合适的有机阴离子和所得的β-酮肟中间体被环化和脱水，以及可用于其制备的中间体。

2. 发明授权

US6001849A Furopyridine, thienopyridine pyrrolopyridine useful in controlling chemical synaptic transmission 失效
标题翻译：呋喃吡啶，噻吩并吡啶吡咯并吡啶可用于控制化学突触传播
公开(公告)号：US6001849A
公开(公告)日：1999-12-14
申请号：US834053
申请日：1997-04-11
申请人： Richard L. Elliott , Keith B. Ryther , Mark W. Holladay , James T. Wasicak , Jerome F. Daanen , Nan-Horng Lin , Michael J. Dart , Yun He , Yihong Li
发明人： Richard L. Elliott , Keith B. Ryther , Mark W. Holladay , James T. Wasicak , Jerome F. Daanen , Nan-Horng Lin , Michael J. Dart , Yun He , Yihong Li
IPC分类号： A61K31/00 , A61K31/435 , A61K31/4353 , A61K31/4355 , A61P9/00 , A61P25/00 , A61P25/30 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D495/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/4355 , C07D487/04 , C07D491/04 , C07D495/04
摘要： Novel heterocyclic ether compounds having the formula: ##STR1## wherein A, m, R, X, Y.sup.1, Y.sup.2 and Y.sup.3 are specifically defined, which are useful in selectively controlling chemical synaptic transmission; therapeutically-effective pharmaceutical compositions thereof; and use of said compositions to selectively control synaptic transmission in mammals.
摘要翻译：具有下式的新型杂环醚化合物：其中A，m，R，X，Y 1，Y 2和Y 3具体定义，其可用于选择性地控制化学突触传递; 其治疗有效的药物组合物; 以及使用所述组合物来选择性地控制哺乳动物中的突触传递。

3. 发明授权

US5914328A Heterocyclic ether compounds useful in controlling neurotransmitter release 失效
标题翻译：用于控制神经递质释放的杂环醚化合物
公开(公告)号：US5914328A
公开(公告)日：1999-06-22
申请号：US485537
申请日：1995-06-07
申请人： Nan-Horng Lin , Mark W. Holladay , Melwyn A. Abreo , David E. Gunn , Suzanne A. Lebold , Richard L. Elliott , Yun He
发明人： Nan-Horng Lin , Mark W. Holladay , Melwyn A. Abreo , David E. Gunn , Suzanne A. Lebold , Richard L. Elliott , Yun He
IPC分类号： C07D401/12 , C07D403/12 , C07D417/12 , A61K31/425 , A61K31/495 , A61K31/50 , A61K31/505
CPC分类号： C07D401/12 , C07D403/12 , C07D417/12
摘要： Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R.sup.1, R.sup.2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibiting neurotransmitter release; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to activate or inhibit neurotransmitter release in mammals.
摘要翻译：具有下式的新型杂环醚化合物：其中*，A，B，n，R 1，R 2和X具体定义，或其药学上可接受的盐或前药，其可用于选择性活化或抑制神经递质释放; 到这些化合物的治疗有效的药物组合物; 以及使用所述组合物来激活或抑制哺乳动物中的神经递质释放。

4. 发明授权

US5472958A 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function 失效
标题翻译： 2 - （（硝基）苯氧基甲基）杂环化合物，增强认知功能
公开(公告)号：US5472958A
公开(公告)日：1995-12-05
申请号：US297454
申请日：1994-08-29
申请人： David E. Gunn, Jr. , Richard L. Elliott , Nan-Horng Lin , Hana A. Kopecka , Mark W. Holladay
发明人： David E. Gunn, Jr. , Richard L. Elliott , Nan-Horng Lin , Hana A. Kopecka , Mark W. Holladay
IPC分类号： A61K31/40 , A61K31/33
CPC分类号： A61K31/40
摘要： Selective and potent cholinergic ligands selective for neuronal nicotinic cholinergic channel receptors, which ligands have the formula: ##STR1## as well as pharmaceutically-acceptable salts or prodrugs thereof, which are useful in the treatment of dementias, attentional hyperactivity disorder, or substance abuse withdrawal characterized by decreased cholinergic function, one of which is also an analgesic agent, and one of which is an agent useful for treating anxiety associated with cognitive impairment.
摘要翻译：对神经元烟碱性胆碱能通道受体有选择性和有效的胆碱能配体，其配体具有以下分子式：及其药学上可接受的盐或前药，其可用于治疗痴呆，注意性多动症或药物滥用戒断其特征在于胆碱能功能降低，其中之一也是止痛剂，其中之一是可用于治疗与认知障碍相关的焦虑的药剂。

5. 发明授权

US5578592A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US5578592A
公开(公告)日：1996-11-26
申请号：US302652
申请日：1994-09-06
申请人： George Burton , Richard L. Elliott
发明人： George Burton , Richard L. Elliott
IPC分类号： A61K31/00 , A61K31/545 , A61K31/546 , A61P31/00 , A61P31/04 , C07D501/00 , C07D501/04 , C07D501/62 , A61K31/39 , A61K31/54 , C07D513/14 , C07D513/22
CPC分类号： C07D501/00 , Y02P20/55
摘要： Compounds of formula (I) or salts thereof: wherein R.sup.1 is hydrogen, methoxy or formamido; R.sup.2 is an acyl group; CO.sub.2 R.sup.3 is a carboxy group or a carboxylate anion, or R.sup.3 is a readily removable carboxy protecting group or a pharmaceutically acceptable salt-forming group or in vivo hydrolysable ester group; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 independently represent hydrogen or a bond or a substituent group or may form a cyclic system. These compounds have antibacterial activity.
摘要翻译： PCT No.PCT / GB93 / 00457 Sec。 371日期：1994年9月6日 102（e）1994年9月6日PCT PCT 1993年3月4日PCT公布。公开号WO93 / 18044 （I）式（I）化合物或其盐：其中R1是氢，甲氧基或甲酰氨基; R2是酰基; CO 2 R 3是羧基或羧酸根阴离子，或者R3是容易除去的羧基保护基或药学上可接受的成盐基团或体内可水解的酯基; R4，R5，R6和R7独立地表示氢或键或取代基，或者可以形成环状体系。这些化合物具有抗菌活性。

6. 发明授权

US4827051A Pesticides 失效
标题翻译：农药
公开(公告)号：US4827051A
公开(公告)日：1989-05-02
申请号：US37344
申请日：1987-04-13
申请人： Michael Elliott , Norman; F. Janes , Richard L. Elliott
发明人： Michael Elliott , Norman; F. Janes , Richard L. Elliott
IPC分类号： A01N53/00 , C07C17/16 , C07C22/04 , C07C29/14 , C07C33/48 , C07C45/59 , C07C47/55 , C07C33/46 , C07C21/24
CPC分类号： C07C255/00 , A01N53/00 , C07C17/16 , C07C22/04 , C07C29/14 , C07C33/483 , C07C45/59 , C07C47/55
摘要： Pesticidal compounds have the formula: ##STR1## wherein D represents hydrogen or a cyano groupX represents chlorine or bromineA represents an alkyl groupn is 0 or an integer of 1-4 andRCOO is the residue of an acid RCOOH whose .alpha.-cyano-3-phenoxybenzyl ester has pesticidal properties. They are prepared by esterification methods.
摘要翻译：杀虫化合物具有下式：其中D表示氢或氰基X表示氯或溴A表示烷基，n表示0或1-4的整数，RCOO表示酸性RCOOH的残基，氰基-3-苯氧基苄基酯具有杀虫性。它们通过酯化方法制备。

7. 发明授权

US4661489A Benzazepines, and their use as anthelminthics 失效
标题翻译：苯扎西平，以及它们作为抗凝药物的用途
公开(公告)号：US4661489A
公开(公告)日：1987-04-28
申请号：US630524
申请日：1984-07-13
申请人： Roderick J. Dorgan , Richard L. Elliott
发明人： Roderick J. Dorgan , Richard L. Elliott
IPC分类号： C07D241/08 , C07D487/04 , C07D498/04 , A61K31/55 , C07D223/00 , C07D267/08
CPC分类号： C07D487/04 , C07D241/08
摘要： A compound of formula (I): ##STR1## in which R is optionally substituted phenyl; C.sub.3-8 cycloalkyl; C.sub.5-8 cycloalkenyl; C.sub.1-8 alkyl which may be straight or branched; C.sub.2-8 alkenyl which may be straight or branched; 5- or 6- membered heterocyclyl; or optionally substituted phenyl C.sub.1-4 alkyl, each of Y and Z, which may be the same or different, is oxygen or sulphur; and X is --CH.sub.2 -- or oxygen, a process for the preparation of such compounds and their use in human and veterinary medicine.
摘要翻译：式（I）的化合物：其中R是任选取代的苯基; C3-8环烷基; C5-8环烯基; 可以是直链或支链的C 1-8烷基; 可以是直链或支链的C 2-8烯基; 5-或6-元杂环基; 或任选取代的苯基C 1-4烷基，Y和Z各自可以相同或不同，是氧或硫; 并且X是-CH 2 - 或氧，一种制备这些化合物的方法及其在人和兽医学中的应用。

8. 发明授权

US4614798A Process for the production of xylazine 失效
标题翻译：生产赛拉嗪的方法
公开(公告)号：US4614798A
公开(公告)日：1986-09-30
申请号：US721362
申请日：1985-04-09
申请人： Richard L. Elliott , Paul H. Ruehle
发明人： Richard L. Elliott , Paul H. Ruehle
IPC分类号： C07D279/06 , C07D279/04 , C07C161/02
CPC分类号： C07D279/06
摘要： In the preparation of 2,6-dimethylphenylisothiocyanate by reacting N-(2,6-dimethylphenyl)acetamide with sodium hydride in an organic solvent to form the corresponding anion of said amide, then reacting carbon disulfide with said anion to form said 2,6-dimethylphenylisothiocyanate, unexpectedly high yields are obtained by using as the organic solvent tetrahydrofuran or a mixture of N,N-dimethylacetamide and toluene. 2,6-Dimethylphenylisothiocyanate is an intermediate in the preparation of xylazine useful, for instance, as a sedative, an analgesic and muscle relaxant.
摘要翻译：在2,6-二甲基苯基异硫氰酸酯的制备中，通过N-（2,6-二甲基苯基）乙酰胺与氢化钠在有机溶剂中反应形成所述酰胺的相应阴离子，然后使二硫化碳与所述阴离子反应形成所述2,6 二甲基苯基异硫氰酸酯，通过使用四氢呋喃或N，N-二甲基乙酰胺和甲苯的混合物作为有机溶剂，可以获得出乎意料的高产率。 2,6-二甲基苯基异硫氰酸酯是用于制备西拉嗪的中间体，例如可用作镇静剂，止痛剂和肌肉松弛剂。

9. 发明授权

US07358242B2 Tetraazabenzo[e]azulene derivatives and analogs thereof 失效
标题翻译：四氮杂苯并[e]薁衍生物及其类似物
公开(公告)号：US07358242B2
公开(公告)日：2008-04-15
申请号：US11780988
申请日：2007-07-20
申请人： Richard L. Elliott , Kimberly O. Cameron , Marlys Hammond
发明人： Richard L. Elliott , Kimberly O. Cameron , Marlys Hammond
IPC分类号： A61P3/10
CPC分类号： C07D487/14 , C07D243/24 , C07D471/14 , C07D487/04
摘要： This invention relates to CCK-A agonists of Formula (I) wherein R1-R4, A, B, X, D, E and G are as defined in the specification, as well as, among other things, pharmaceutical compositions containing the compounds and methods of use of the compounds and compositions. The compounds are useful in treating diabetes.
摘要翻译：本发明涉及式（I）的CCK-A激动剂，其中R 1，R 4，A，B，X，D，E和G如规格，以及其中包含含有化合物的药物组合物和使用化合物和组合物的方法。该化合物可用于治疗糖尿病。

10. 发明授权

US07294570B2 Contact integration method 有权
标题翻译：联系方式
公开(公告)号：US07294570B2
公开(公告)日：2007-11-13
申请号：US10812117
申请日：2004-03-29
申请人： Richard L. Elliott , Guy F. Hudson
发明人： Richard L. Elliott , Guy F. Hudson
IPC分类号： H01L21/44
CPC分类号： H01L21/7684 , H01L21/76838 , H01L21/76877 , H01L21/76886 , H01L23/485 , H01L2924/0002 , H01L2924/00
摘要： A method of making a contact plug and a metallization line structure is disclosed in which a substrate is provided with at least one contact hole within an insulation layer situated on a semiconductor substrate of a semiconductor wafer. A first metal layer is deposited upon the semiconductor wafer within the contact hole. A planarizing step isolates the first metal layer within the insulation layer in the form of a contact plug within the contact hole. A second metal layer is then deposited upon the semiconductor wafer over and upon the contact plug. Metallization lines are patterned and etched from the second metal layer. The contact hole may also be lined with a refractory metal nitride layer, with a refractory metal silicide interface being formed at the bottom of the contact hole as an interface between the contact plug and a silicon layer on the semiconductor substrate. Article qualities are achieved by the inventive method, including reduced interfacial resistance and its consequent faster signal speed for the structure, reduced metal creep where additional selected alloys are allowed to diffuse a selected quantity of preferred alloying elements from the first metal layer to the second metal layer, improved depth-of-focus requirements for patterning metallization lines, and resistance of electromigration in aluminum metallization lines.
摘要翻译：公开了一种制造接触插塞和金属化线结构的方法，其中衬底在位于半导体晶片的半导体衬底上的绝缘层内设置有至少一个接触孔。第一金属层沉积在接触孔内的半导体晶片上。平面化步骤将绝缘层内的第一金属层以接触孔中的接触塞的形式隔离。然后将第二金属层沉积在半导体晶片上并在接触插塞上。金属化线从第二金属层图案化并蚀刻。接触孔也可以衬有难熔金属氮化物层，难熔金属硅化物界面形成在接触孔的底部，作为接触插塞和半导体衬底上的硅层之间的界面。通过本发明的方法实现制品品质，包括降低的界面阻力及其结构的更快的信号速度，减少的金属蠕变，其中允许附加的选定合金将选定数量的优选的合金元素从第一金属层扩散到第二金属层，改善图案化金属化线的聚焦深度要求以及铝金属化线中电迁移的阻力。

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