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1. 发明授权

US07414071B2 Methods of treatment with selective EP4 receptor agonists 失效
标题翻译：用选择性EP4受体激动剂治疗的方法
公开(公告)号：US07414071B2
公开(公告)日：2008-08-19
申请号：US10386307
申请日：2003-03-11
申请人： Kimberly O. Cameron , Bruce A. Lefker , Delvin R. Knight, Jr.
发明人： Kimberly O. Cameron , Bruce A. Lefker , Delvin R. Knight, Jr.
IPC分类号： A61K31/40 , A61K31/41 , A61K31/38
CPC分类号： C07D207/26 , A61K31/4015 , A61K31/4025 , A61K31/427 , C07D403/06 , C07D409/06 , C07D417/06
摘要： The present invention provides a method of treating hypertension, liver failure, loss of patency of ductus arteriosus, glaucoma or ocular hypertension in a patient, comprising administering to the patient a therapeutically effective amount of a selective EP4 receptor agonist of Formula I or a prodrug thereof, a pharmaceutically acceptable salt of the selective EP4 receptor agonist or prodrug or a stereoisomer or diastereomeric mixture of the EP4 receptor agonist, prodrug or salt, wherein the variables X, Z, Q, , and R2 are as defined in the specification.
摘要翻译：本发明提供一种治疗患者的高血压，肝功能衰竭，动脉导管动脉通畅，青光眼或高眼压的丧失的方法，包括向患者施用治疗有效量的选择性EP 4受体式I的激动剂或其前药，选择性EP 4受体激动剂的药学上可接受的盐或EP 4/4受体激动剂的前药或立体异构体或非对映体混合物，前药或盐，其中变量X，Z，Q，和R＆lt; 2＆gt;如说明书中所定义。

2. 发明授权

US06998423B2 Prevention of loss and restoration of bone mass by certain prostaglandin agonists 失效
公开(公告)号：US06998423B2
公开(公告)日：2006-02-14
申请号：US10652188
申请日：2003-08-29
申请人： Kimberly O. Cameron , Hua Z. Ke , Bruce A. Lefker , Robert L. Rosati , David D. Thompson
发明人： Kimberly O. Cameron , Hua Z. Ke , Bruce A. Lefker , Robert L. Rosati , David D. Thompson
IPC分类号： A61K31/18 , A61K31/38 , C07C303/00 , C07D333/12
CPC分类号： C07D207/263 , A61K45/06 , C07C235/34 , C07C311/04 , C07C311/06 , C07C323/49 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D213/42 , C07D215/18 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D271/12 , C07D277/28 , C07D277/56 , C07D307/24 , C07D307/52 , C07D307/68 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/38 , C07D409/12
摘要： Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.

3. 发明授权

US06747054B2 EP4 receptor selective agonists in the treatment of osteoporosis 失效
标题翻译： EP4受体选择性激动剂治疗骨质疏松症
公开(公告)号：US06747054B2
公开(公告)日：2004-06-08
申请号：US10326366
申请日：2002-12-20
申请人： Kimberly O. Cameron , Bruce A. Lefker
发明人： Kimberly O. Cameron , Bruce A. Lefker
IPC分类号： C07D40908
CPC分类号： C07D403/06 , C07D207/20 , C07D405/10 , C07D409/06 , C07D409/14 , C07D417/06
摘要： This invention is directed to EP4 receptor selective prostaglandin agonists of the Formula I, wherein R2, X, Z and Q are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds. This invention is also directed to methods of treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, bone fracture, osteotomy, bone loss associated with periodontitis, or prosthetic ingrowth in a mammal comprising administering those compounds.
摘要翻译：本发明涉及式I的EP4受体选择性前列腺素激动剂，其中R 2，X，Z和Q如说明书中所定义。本发明还涉及含有这些化合物的药物组合物。本发明还涉及治疗具有低骨量，特别是骨质疏松症，脆弱性，骨质疏松性骨折，骨缺损，儿童特发性骨丢失，牙槽骨丢失，下颌骨骨丢失，骨折，截骨术，骨丢失与哺乳动物中的牙周炎或假体向内生长相关，包括施用那些化合物。

4. 发明授权

US06531485B2 Prostaglandin agonists 失效
标题翻译：前列腺素激动剂
公开(公告)号：US06531485B2
公开(公告)日：2003-03-11
申请号：US09446099
申请日：1999-12-16
申请人： Kimberly O. Cameron , Paul A. DaSilva-Jardine
发明人： Kimberly O. Cameron , Paul A. DaSilva-Jardine
IPC分类号： A61K315575
CPC分类号： C07D333/28 , C07C405/00 , C07D209/08 , C07D217/16 , C07D277/24 , C07D311/20 , C07D317/54
摘要： This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.
摘要翻译：本发明涉及前列腺素激动剂，使用这种前列腺素激动剂的方法，含有这种前列腺素激动剂的药物组合物和含有这种前列腺素激动剂的试剂盒。前列腺素激动剂可用于治疗包括骨质疏松症在内的骨疾病。

5. 发明授权

US06288120B1 Prevention of loss and restoration of bone mass by certain prostaglandin agonists 失效
标题翻译：预防某些前列腺素激动剂损失和恢复骨量
公开(公告)号：US06288120B1
公开(公告)日：2001-09-11
申请号：US09331081
申请日：1999-06-11
申请人： Kimberly O. Cameron , Hua Z. Ke , Bruce A. Lefker , Robert L. Rosati , David D. Thompson
发明人： Kimberly O. Cameron , Hua Z. Ke , Bruce A. Lefker , Robert L. Rosati , David D. Thompson
IPC分类号： A61K3116
CPC分类号： C07D207/263 , A61K45/06 , C07C235/34 , C07C311/04 , C07C311/06 , C07C323/49 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D213/42 , C07D215/18 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D271/12 , C07D277/28 , C07D277/56 , C07D307/24 , C07D307/52 , C07D307/68 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/38 , C07D409/12
摘要： Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits useful for the treatment of bone disorders including osteoporosis.
摘要翻译：式（I）的前列腺素激动剂，其中例如A是磺酰基或酰基，B是N或CH，M包含环，K和Q是连接基团，使用这种前列腺素激动剂的方法，含有这种前列腺素激动剂和用于治疗包括骨质疏松症在内的骨疾病的试剂盒。

6. 发明授权

US07053212B2 Acyclic amide and sulfonamide ligands for the estrogen receptor 失效
标题翻译：用于雌激素受体的非环酰胺和磺酰胺配体
公开(公告)号：US07053212B2
公开(公告)日：2006-05-30
申请号：US10666811
申请日：2003-09-17
申请人： Kimberly O. Cameron , Richard Chesworth
发明人： Kimberly O. Cameron , Richard Chesworth
IPC分类号： C07D279/12 , C07D295/12 , C07D413/12 , C07D211/18 , C07D207/04
CPC分类号： C07D249/08 , C07C233/60 , C07C311/21 , C07C311/29 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/08 , C07D207/16 , C07D211/14 , C07D211/42 , C07D211/46 , C07D213/38 , C07D213/40 , C07D215/20 , C07D215/36 , C07D217/02 , C07D231/12 , C07D233/56 , C07D261/10 , C07D295/088 , C07D295/135 , C07D295/185 , C07D307/12 , C07D333/34
摘要： The present invention provides estrogen receptor (ER) ligands of structural formula (I) the pharmaceutically acceptable salts, stereoisomers, and prodrugs thereof, and the pharmaceutically acceptable salts of the prodrugs, wherein R1, R2, R3, R4, R5, X, and Q are as defined herein. The invention further provides pharmaceutical compositions comprising the compounds of formula (I), and methods for treating or preventing diseases, disorders, conditions, or symptoms mediated by an ER which comprise administering to a mammalian subject in need of treatment therewith, an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof, or a pharmaceutically acceptable salt of the prodrug, or a pharmaceutical composition comprising a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer, or prodrug thereof, or a pharmaceutically acceptable salt of the prodrug. The invention further provides pharmaceutical compositions comprising combinations of the compounds of formula (I) and one or more of sodium fluoride, estrogen, a bone anabolic agent, a growth hormone or growth hormone secretagogue, a prostaglandin agonist/antagonist, and a parathyroid hormone, and methods of treating or preventing diseases, disorders, conditions, or symptoms mediated by an ER comprising the administration of an effective amount of such combination to a mammalian subject in need of treatment therewith.
摘要翻译：本发明提供结构式（I）的药学上可接受的盐，立体异构体和前药的雌激素受体（ER）配体和前药的药学上可接受的盐，其中R 1，R 2， R 3，R 3，R 4，R 5，X和Q如本文所定义。本发明还提供包含式（I）化合物的药物组合物，以及用于治疗或预防由ER介导的疾病，病症，病状或症状的方法，其包括向需要治疗的哺乳动物受试者施用有效量的式（I）化合物或其药学上可接受的盐，立体异构体或前药，或前药的药学上可接受的盐，或包含式（I）化合物或其药学上可接受的盐，立体异构体，或前药，或前药的药学上可接受的盐。本发明进一步提供包含式（I）化合物与一种或多种氟化钠，雌激素，骨合成代谢剂，生长激素或生长激素促分泌素，前列腺素激动剂/拮抗剂和甲状旁腺激素的组合的药物组合物，以及治疗或预防由ER介导的疾病，病症，病症或症状的方法，包括向需要治疗的哺乳动物受试者施用有效量的这种组合。

7. 发明授权

US06552067B2 EP4 receptor selective agonists in the treatment of osteoporosis 失效
标题翻译： EP4受体选择性激动剂治疗骨质疏松症
公开(公告)号：US06552067B2
公开(公告)日：2003-04-22
申请号：US09990556
申请日：2001-11-21
申请人： Kimberly O. Cameron , Bruce A. Lefker
发明人： Kimberly O. Cameron , Bruce A. Lefker
IPC分类号： C07D20704
CPC分类号： C07D403/06 , C07D207/20 , C07D405/10 , C07D409/06 , C07D409/14 , C07D417/06
摘要： This invention is directed to EP4 receptor selective prostaglandin agonists of the Formula I, wherein R2, X, Z and Q are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds. This invention is also directed to methods of treating conditions which present with low bone mass, particularly osteoporosis, frailty, an osteoporotic fracture, a bone defect, childhood idiopathic bone loss, alveolar bone loss, mandibular bone loss, bone fracture, osteotomy, bone loss associated with periodontitis, or prosthetic ingrowth in a mammal comprising administering those compounds.
摘要翻译：本发明涉及式I的EP4受体选择性前列腺素激动剂，其中R2，X，Z和Q如说明书中所定义。本发明还涉及含有这些化合物的药物组合物。本发明还涉及治疗具有低骨量，特别是骨质疏松症，脆弱性，骨质疏松性骨折，骨缺损，儿童特发性骨丢失，牙槽骨丢失，下颌骨骨丢失，骨折，截骨术，骨丢失与哺乳动物中的牙周炎或假体向内生长相关，包括施用那些化合物。

8. 发明授权

US06492412B2 Prevention of loss and restoration of bone mass by certain prostaglandin agonists 失效
公开(公告)号：US06492412B2
公开(公告)日：2002-12-10
申请号：US09897824
申请日：2001-06-29
申请人： Kimberly O. Cameron , Hua Z. Ke , Bruce A. Lefker , Robert L. Rosati , David D. Thompson
发明人： Kimberly O. Cameron , Hua Z. Ke , Bruce A. Lefker , Robert L. Rosati , David D. Thompson
IPC分类号： A61K3140
CPC分类号： C07D207/263 , A61K45/06 , C07C235/34 , C07C311/04 , C07C311/06 , C07C323/49 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D213/42 , C07D215/18 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D271/12 , C07D277/28 , C07D277/56 , C07D307/24 , C07D307/52 , C07D307/68 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/38 , C07D409/12
摘要： Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.

9. 发明授权

US06376502B1 Osteoporosis compounds 失效
标题翻译：骨质疏松症化合物
公开(公告)号：US06376502B1
公开(公告)日：2002-04-23
申请号：US09511128
申请日：2000-02-22
申请人： Kimberly O. Cameron , Bruce A. Lefker , Robert L. Rosati
发明人： Kimberly O. Cameron , Bruce A. Lefker , Robert L. Rosati
IPC分类号： C07D40112
CPC分类号： C07D213/70 , A61K45/06 , C07C311/06 , C07D277/56 , C07D307/68 , C07D333/40
摘要： This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders including osteoporosis.
摘要翻译：本发明涉及前列腺素激动剂，使用这种前列腺素激动剂的方法，含有这种前列腺素激动剂的药物组合物和含有这种前列腺素激动剂的试剂盒。前列腺素激动剂可用于治疗包括骨质疏松症在内的骨疾病。

10. 发明授权

US06344485B1 Method for treating glaucoma 失效
标题翻译：治疗青光眼的方法
公开(公告)号：US06344485B1
公开(公告)日：2002-02-05
申请号：US09335630
申请日：1999-06-18
申请人： Kimberly O. Cameron , Bruce A. Lefker
发明人： Kimberly O. Cameron , Bruce A. Lefker
IPC分类号： A61K3118
CPC分类号： A61K31/496 , A61K31/192 , A61K31/197 , A61K31/381 , A61K31/41 , Y10S514/912 , Y10S514/913
摘要： Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.
摘要翻译：使用前列腺素激动剂降低眼内压的方法，因此使用青光眼。

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