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1. 发明授权

US06246459B1 Assembly including an active matrix liquid crystal display module and having plural environmental seals 失效
标题翻译：组件包括有源矩阵液晶显示模块并具有多个环境密封
公开(公告)号：US06246459B1
公开(公告)日：2001-06-12
申请号：US09095427
申请日：1998-06-10
申请人： Murthy Simhambhatla , David Barry , Nils Wydler
发明人： Murthy Simhambhatla , David Barry , Nils Wydler
IPC分类号： G02F11333
CPC分类号： G02F1/133385 , G02F1/133308
摘要： An active matrix liquid crystal display module (10) is contained in a base (20). Improved environmental sealing is provided by a primary seal (36) along the edge of the liquid crystal display module and a secondary seal (14a, 14b) at the base. The liquid crystal display module is affixed to a cover (12) which in turn is affixed to the base, such that the liquid crystal display module is suspended in a cavity (21) in the base, spaced apart from physical contact with the base. In this way, any thermomechanical stresses that may develop in the base are not transmitted to the liquid crystal display module. Thermal contact between the liquid crystal display module and the base is made via a thermally conductive material (19), to permit efficient heat dissipation.
摘要翻译：有源矩阵液晶显示模块（10）包含在基座（20）中。通过沿着液晶显示模块的边缘的主要密封件（36）和在底部的辅助密封件（14a，14b）提供改进的环境密封。液晶显示模块固定在盖子12上，盖子又固定在基座上，使得液晶显示模块悬挂在底座中的空腔（21）中，与基座的物理接触间隔开。以这种方式，在基底中可能产生的任何热机械应力都不会传递到液晶显示模块。通过导热材料（19）制造液晶显示模块和基座之间的热接触，以允许有效的散热。

2. 发明授权

US07326238B1 Method and apparatus for treating vulnerable plaque 有权
标题翻译：治疗易损斑块的方法和装置
公开(公告)号：US07326238B1
公开(公告)日：2008-02-05
申请号：US10262149
申请日：2002-09-30
申请人： Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
发明人： Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/22 , A61B2017/22077 , A61B2017/22082 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/075 , A61F2250/0067 , A61L27/3808 , A61L27/3843 , A61L31/16 , A61M25/0084 , A61M29/02 , A61M2025/0086
摘要： An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.
摘要翻译：一种治疗易损斑块的装置和方法。在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。可扩张管屏蔽易损斑块与体腔。

3. 发明申请

US20050222584A1 Device for treating vulnerable plaque 有权
标题翻译：治疗易损斑块的装置
公开(公告)号：US20050222584A1
公开(公告)日：2005-10-06
申请号：US11140240
申请日：2005-05-26
申请人： Deborah Kilpatrick , Robert Ainsworth , Murthy Simhambhatla , Jeong Lee
发明人： Deborah Kilpatrick , Robert Ainsworth , Murthy Simhambhatla , Jeong Lee
IPC分类号： A61F2/06 , A61F2/84 , A61F11/00 , A61M29/00
CPC分类号： A61F2/958 , A61B2017/22081
摘要： A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.
摘要翻译：一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。该过程在损伤或破裂部位产生ECM合成的显着增加。因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。本发明的方法特别可用于治疗纤维腺瘤型易损斑块。在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。在替代实施例中，使用直径限制装置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。

4. 发明授权

US08747385B2 Methods and compositions to treat myocardial conditions 失效
公开(公告)号：US08747385B2
公开(公告)日：2014-06-10
申请号：US13468956
申请日：2012-05-10
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

5. 发明申请

US20070190103A1 Implantable medical device with surface-eroding polyester drug delivery coating 有权
标题翻译：具有表面侵蚀聚酯药物输送涂层的植入式医疗器械
公开(公告)号：US20070190103A1
公开(公告)日：2007-08-16
申请号：US11351598
申请日：2006-02-10
申请人： Syed Hossainy , Stephen Pacetti , Murthy Simhambhatla
发明人： Syed Hossainy , Stephen Pacetti , Murthy Simhambhatla
IPC分类号： A61K31/4745 , A61K31/395
CPC分类号： A61L27/34 , A61K31/395 , A61K31/4745 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/606 , C08L67/04
摘要： The present invention relates to an implantable medical device comprising therapeutic agents coated on the device using polyesters for the drug reservoir layer that exhibit surface-eroding characteristics.
摘要翻译：本发明涉及可植入医疗装置，其包括使用展示表面侵蚀特征的药物储存层的聚酯涂覆在该装置上的治疗剂。

6. 发明授权

US08383158B2 Methods and compositions to treat myocardial conditions 有权
标题翻译：治疗心肌病症的方法和组合物
公开(公告)号：US08383158B2
公开(公告)日：2013-02-26
申请号：US10414602
申请日：2003-04-15
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyez Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61K9/14
CPC分类号： A61N1/3625 , A61K9/0024 , A61K31/00 , A61K31/728 , A61K31/732 , A61K31/734 , A61K31/78 , A61K31/79 , A61K36/886 , A61K38/40 , A61K41/0042 , A61K45/06 , A61K47/02 , A61K47/34 , A61K47/60 , A61K47/62 , A61K49/0404 , A61L24/043 , A61L27/20 , A61L27/50 , A61L27/54 , A61L2430/20 , A61N1/36521 , A61K2300/00
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.
摘要翻译：用于治疗心肌梗塞的方法，装置，试剂盒和组合物。在一个实施例中，该方法包括防止脑室梗死区的重塑。在其它实施方案中，该方法包括引入结构上增强剂。在其它实施方案中，将药剂引入心室以增加心室的依从性。在替代实施例中，预防重塑包括防止心室梗塞区变薄。在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。在其它实施方案中，结构上增强剂可以伴随其它治疗剂。这些试剂可以包括但不限于前成纤维细胞和血管生成剂。

7. 发明申请

US20100144635A1 METHODS AND COMPOSITIONS TO TREAT MYOCARDIAL CONDITIONS 有权
标题翻译：治疗肌肉条件的方法和组合
公开(公告)号：US20100144635A1
公开(公告)日：2010-06-10
申请号：US12632612
申请日：2009-12-07
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M37/00 , A61M25/00 , A61K38/22 , A61K31/7088 , A61K47/34 , A61P9/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译：用于治疗心肌梗塞的方法，装置，试剂盒和组合物。在一个实施例中，该方法包括防止脑室梗死区的重塑。在其它实施方案中，该方法包括引入结构上增强剂。在其它实施方案中，将药剂引入心室以增加心室的依从性。在替代实施例中，预防重塑包括防止心室梗塞区变薄。在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。在其它实施方案中，结构上增强剂可以伴随其它治疗剂。这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

8. 发明申请

US20060135943A1 Method and apparatus for treating vulnerable plaque 审中-公开
公开(公告)号：US20060135943A1
公开(公告)日：2006-06-22
申请号：US11283032
申请日：2005-11-17
申请人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy
发明人： Evgenia Mandrusov , Deborah Kilpatrick , Murthy Simhambhatla , Syed Hossainy
IPC分类号： A61M31/00
CPC分类号： A61M25/0084 , A61B2017/22081 , A61M25/0026 , A61M25/1006 , A61M2025/0096
摘要： An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.

9. 发明授权

US08821473B2 Methods and compositions to treat myocardial conditions 有权
标题翻译：治疗心肌病症的方法和组合物
公开(公告)号：US08821473B2
公开(公告)日：2014-09-02
申请号：US12632612
申请日：2009-12-07
申请人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
发明人： Eugene T. Michal , Evgenia Mandrusov , Charles D. Claude , Ni Ding , Murthy Simhambhatla , Syed Faiyaz Ahmed Hossainy , Srinivasan Sridharan , Paul Consigny
IPC分类号： A61M31/00 , A61K31/7088 , A61K9/00
CPC分类号： A61K9/0019 , A61K9/0024 , A61K31/7088
摘要： Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.
摘要翻译：用于治疗心肌梗塞的方法，装置，试剂盒和组合物。在一个实施例中，该方法包括防止脑室梗死区的重塑。在其它实施方案中，该方法包括引入结构上增强剂。在其它实施方案中，将药剂引入心室以增加心室的依从性。在替代实施例中，预防重塑包括防止心室梗塞区变薄。在另一个实施方案中，预防梗塞区的重塑和变薄包括胶原蛋白的交联和预防胶原蛋白滑脱。在其它实施方案中，结构上增强剂可以伴随其它治疗剂。这些药剂可以包括但不限于前成纤维细胞和血管生成剂。

10. 发明授权

US08652194B1 Method and apparatus for treating vulnerable plaque 有权
标题翻译：治疗易损斑块的方法和装置
公开(公告)号：US08652194B1
公开(公告)日：2014-02-18
申请号：US11388899
申请日：2006-03-23
申请人： Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
发明人： Deborah Kilpatrick , Murthy Simhambhatla , Santosh Prabhu , Shawn Chin Quee
IPC分类号： A61F2/82
CPC分类号： A61F2/07 , A61B17/22 , A61B2017/22077 , A61B2017/22082 , A61F2/86 , A61F2/90 , A61F2/958 , A61F2002/075 , A61F2250/0067 , A61L27/3808 , A61L27/3843 , A61L31/16 , A61M25/0084 , A61M29/02 , A61M2025/0086
摘要： An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque. In an alternative embodiment, the apparatus has an expandable tube attached to the inner surface of a stent, and a layer of endothelial cells seeded on the inner surface of the expandable tube. The expandable tube shields a vulnerable plaque from a body lumen.
摘要翻译：一种治疗易损斑块的装置和方法。在一个实施方案中，该装置具有治疗闭塞性斑块的医疗装置，并且还适于释放生物活性剂以治疗位于封闭斑块下游的易损斑块。在替代实施例中，该装置具有连接到支架的内表面的可扩张管和接种在可扩张管的内表面上的内皮细胞层。可扩张管屏蔽易损斑块与体腔。

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