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1. 发明申请

US20090018211A1 Method for inhibiting of COX2 and inflammation with phenolic aldehydes 审中-公开
标题翻译：用酚醛抑制COX2和炎症的方法
公开(公告)号：US20090018211A1
公开(公告)日：2009-01-15
申请号：US11825748
申请日：2007-07-09
申请人： Muraleedharan G. Nair , Mulabagal Vanisree , Ruby L. Alexander-Lindo , David L. DeWitt
发明人： Muraleedharan G. Nair , Mulabagal Vanisree , Ruby L. Alexander-Lindo , David L. DeWitt
IPC分类号： A61K31/11 , A61P29/00
CPC分类号： A61K31/11
摘要： A method for inhibiting of COX2 and inflammation by administering a hydroxybenzaldehyde.
摘要翻译：通过施用羟基苯甲醛来抑制COX2和炎症的方法。

2. 发明授权

US08337914B2 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 失效
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US08337914B2
公开(公告)日：2012-12-25
申请号：US10945609
申请日：2004-09-21
申请人： Muraleedharan G. Nair , David L. Dewitt , Haibo Wang , David W. Krempin , Dipak K. Mody , David G. Groh , Mary A. Murray , Marc Lemay , Yong Qian , Audra J. Davies , Robin Dykhouse
发明人： Muraleedharan G. Nair , David L. Dewitt , Haibo Wang , David W. Krempin , Dipak K. Mody , David G. Groh , Mary A. Murray , Marc Lemay , Yong Qian , Audra J. Davies , Robin Dykhouse
IPC分类号： A61K36/04 , A61K36/736 , A61K36/00
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/29 , A61K36/35 , A61K36/45 , A23V2250/2104 , A61K2300/00
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

3. 发明授权

US06818234B1 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 有权
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US06818234B1
公开(公告)日：2004-11-16
申请号：US10084575
申请日：2002-02-27
申请人： Muraleedharan G. Nair , Haibo Wang , David L. Dewitt , David W. Krempin , Dipak K. Mody , Yong Qian , David G. Groh , Audra J. Davies , Mary A. Murray , Robin Dykhouse , Marc Lemay
发明人： Muraleedharan G. Nair , Haibo Wang , David L. Dewitt , David W. Krempin , Dipak K. Mody , Yong Qian , David G. Groh , Audra J. Davies , Mary A. Murray , Robin Dykhouse , Marc Lemay
IPC分类号： A61K3578
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/29 , A61K36/35 , Y10S514/816 , A61K2300/00 , A23V2250/2104
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

4. 发明申请

US20180192648A1 COMPOUNDS FOR INHIBITION OF FUNGAL MYCOTOXIN AND SPORULATION 审中-公开
公开(公告)号：US20180192648A1
公开(公告)日：2018-07-12
申请号：US15864696
申请日：2018-01-08
申请人： Gale M. Strasburg , Juma A. Mmongoyo , John E. Linz , Felicia Wu , Jovin K. Mugula , Amila A. Dissanayake , Chuan-Rui Zhang , Josephine M. Wee , Muraleedharan G. Nair , Devin M. Day
发明人： Gale M. Strasburg , Juma A. Mmongoyo , John E. Linz , Felicia Wu , Jovin K. Mugula , Amila A. Dissanayake , Chuan-Rui Zhang , Josephine M. Wee , Muraleedharan G. Nair , Devin M. Day
IPC分类号： A01N43/20 , A01N25/02
CPC分类号： A01N43/20 , A01N25/02
摘要： Compounds and compositions are described herein that inhibit the biosynthesis of mycotoxins and fungal sporulation. Such compounds and compositions are useful for inhibiting mold. Methods of using such compounds and compositions are also described herein that involve applying the compositions to plants, plant parts, structures, containers, and other surfaces.

5. 发明授权

US5981775A Process for the preparation of isoflavones 有权
标题翻译：异黄酮制备方法
公开(公告)号：US5981775A
公开(公告)日：1999-11-09
申请号：US154230
申请日：1998-09-16
申请人： Balasubramanian Sreenivasan , Muraleedharan G. Nair
发明人： Balasubramanian Sreenivasan , Muraleedharan G. Nair
IPC分类号： C07D311/36 , C07D311/04
CPC分类号： C07D311/36
摘要： A process for the preparation of an isoflavone from a 2'-hydroxydeoxybenzoin(I) is described. The process uses prepared N,N'-dimethyl(chloromethylene) ammonium chloride as a reactant with (I) in borontrifluoride etherate or other Lewis acid as a solvent. The isoflavones are known biologically active compounds.
摘要翻译：描述了从2'-羟基脱氧苯偶姻（I）制备异黄酮的方法。该方法使用制备的N，N'-二甲基（氯亚甲基）氯化铵作为反应物与（I）在三氟化硼醚合物或其它路易斯酸作为溶剂中。异黄酮是已知的生物活性化合物。

6. 发明授权

US5009698A Method for stimulating plant growth using synthetically produced 9-beta-1(+) adenosine 失效
标题翻译：使用合成产生的9-β-1（+）腺苷刺激植物生长的方法
公开(公告)号：US5009698A
公开(公告)日：1991-04-23
申请号：US345217
申请日：1989-04-28
申请人： Stanley K. Ries , Violet F. Wert , Muraleedharan G. Nair
发明人： Stanley K. Ries , Violet F. Wert , Muraleedharan G. Nair
IPC分类号： A01N43/90
CPC分类号： A01N43/90
摘要： A method for stimulating plant growth using synthetically produced 9-beta-L(+) adenosine is described. The method uses the synthetically produced compound instead of a naturally occurring material which occurs in only minute amounts and is difficult to isolate.
摘要翻译：描述了使用合成产生的9-β-L（+）腺苷刺激植物生长的方法。该方法使用合成产生的化合物代替仅以微量发生且难以分离的天然存在的材料。

7. 发明授权

US07341747B2 Carrier-free composition for the treatment of onychomycosis 有权
标题翻译：用于治疗甲真菌病的无载体组合物
公开(公告)号：US07341747B2
公开(公告)日：2008-03-11
申请号：US10949681
申请日：2004-09-24
申请人： Muraleedharan G. Nair
发明人： Muraleedharan G. Nair
IPC分类号： A61K36/00 , A61K36/53
CPC分类号： A61K31/05 , A61K31/045 , A61K31/125 , A61K36/61 , A61K2300/00
摘要： A composition for the treatment of onychomycosis (fungal nail disease) is described. The composition consists essentially of thymol, camphor, menthol and Eucalyptus citridiora as a colorless liquid oil without any carrier or solvent for these ingredients.
摘要翻译：描述了用于治疗甲真菌病（真菌性指甲疾病）的组合物。该组合物基本上由麝香草酚，樟脑，薄荷醇和柠檬酸桉树作为无色液体油组成，没有任何载体或溶剂用于这些成分。

8. 发明授权

US07195784B2 Cyclooxygenase-2 inhibitory withanolide compositions and method 失效
公开(公告)号：US07195784B2
公开(公告)日：2007-03-27
申请号：US10294106
申请日：2002-11-14
申请人： Muraleedharan G. Nair , Bolleddula Jayaprakasam
发明人： Muraleedharan G. Nair , Bolleddula Jayaprakasam
IPC分类号： A01N65/00
CPC分类号： A61K36/81 , A61K31/351 , A61K31/366 , A61K2300/00
摘要： Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.

9. 发明授权

US06875746B1 Anticancer anthraquinones and method of use thereof 失效
标题翻译：抗癌蒽醌类及其使用方法
公开(公告)号：US06875746B1
公开(公告)日：2005-04-05
申请号：US10355483
申请日：2003-01-31
申请人： Muraleedharan G. Nair , Robert H. Cichewicz , Navindra P. Seeram , Yanjun Zhang
发明人： Muraleedharan G. Nair , Robert H. Cichewicz , Navindra P. Seeram , Yanjun Zhang
IPC分类号： C07H15/244 , A61K31/122 , A61K31/21 , A61K31/70 , A61K31/704 , A61P33/10 , A61P33/12 , C07C50/34 , C07C50/38 , C07C66/02 , C07C69/157 , A01N43/04 , A01N37/00
CPC分类号： A61K31/70 , A61K31/21 , C07C50/38 , Y02A50/423
摘要： Anthraquinones are described which have anticancer or antitumor activity and which are useful for inhibiting cancer cells and cells comprising tumors in vitro or in vivo. Preferably, the anthraquinones have the chemical formula: wherein R1 is selected from the group consisting of hydrogen, alkyl, and substituted alkyl; R2 is a group containing 1-12 carbons selected from the group consisting of alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate and combinations thereof; and R3 is a group containing 1 to 12 carbons selected from the group consisting of methyl, alkyl, substituted alkyl, aldehyde, hydroxy, hydroxymethyl, acid group, carbohydrate, and combinations thereof. The preferred anthraquinones are 1-hydroxy-2-acetyl-3,6-methyl anthraquinone, 2-acetyl-3,6-methyl anthraquinone monoacetate, 1-hydroxy-2-acetyl-3,7-methyl anthraquinone, 2-acetyl-3,7-methyl anthraquinone monoacetate, 1,2,8-trihydroxy-3-methyl anthraquinone, 1,8-dihydroxy-2-O-β-D-glucopyranoside anthraquinone, 1,2,8-trihydroxy-3-hydroxymethyl anthraquinone, and 1,8-dihydroxy-3-carboxy anthraquinone.
摘要翻译：描述了具有抗癌或抗肿瘤活性的蒽醌，其可用于在体外或体内抑制癌细胞和包含肿瘤的细胞。优选地，蒽醌具有以下化学式：其中R 1选自氢，烷基和取代的烷基; R2是含有选自烷基，取代的烷基，醛，羟基，羟甲基，酸基，碳水化合物及其组合的1-12个碳的基团; 并且R 3是选自甲基，烷基，取代的烷基，醛，羟基，羟甲基，酸基，碳水化合物及其组合中的1至12个碳的基团。优选的蒽醌是1-羟基-2-乙酰基-3,6-甲基蒽醌，2-乙酰基-3,6-甲基蒽醌单乙酸酯，1-羟基-2-乙酰基-3,7-甲基蒽醌，2-乙酰基 - 3,7-甲基蒽醌单乙酸酯，1,2,8-三羟基-3-甲基蒽醌，1,8-二羟基-2-O-β-D-吡喃葡萄糖苷蒽醌，1,2,8-三羟基-3-羟甲基蒽醌，和1,8-二羟基-3-羧基蒽醌。

10. 发明授权

US5478736A Process for the isolation and purification of taxol and taxanes from Taxus using methanol or acetone 失效
标题翻译：使用甲醇或丙酮分离和纯化紫杉醇和紫杉烷的方法
公开(公告)号：US5478736A
公开(公告)日：1995-12-26
申请号：US297005
申请日：1994-08-26
申请人： Muraleedharan G. Nair
发明人： Muraleedharan G. Nair
IPC分类号： C07D305/14 , C12P15/00 , C12P17/02 , C12N5/04
CPC分类号： C07D305/14 , C12P15/00 , C12P17/02
摘要： A process for the separation of taxanes, particularly taxol, cephalomannine, baccatin III and deacetylbaccatin III, from ornamental yew tissue is described. The process involves a specific solvent mixture of water and 50 to 95 percent by volume methanol, ethanol or acetone and treatment of the resulting extract using activated carbon, preferably charcoal. The taxanes are preferably separated from the crude extract by a normal phase chromatographic step which preferably is through vacuum and then medium pressure column chromatographic separation, using inexpensive silica gel as an absorbent. The silica gel is regenerated by heating in a furnace above about 500.degree. C. to remove adsorbed organic materials.
摘要翻译：描述了从装饰性紫杉组织中分离紫杉烷类，特别是紫杉醇，头孢麻黄碱，浆果赤霉素III和脱乙酰基浆果赤霉素III的方法。该方法包括水和50至95％（体积）甲醇，乙醇或丙酮的特定溶剂混合物，并使用活性炭（优选木炭）处理所得萃取物。紫杉烷优选通过正相色谱步骤从粗提取物中分离，其优选通过真空，然后使用廉价的硅胶作为吸收剂进行中压柱色谱分离。通过在高于约500℃的炉中加热来再生硅胶以除去吸附的有机材料。

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