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1. 发明授权

US06818234B1 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 有权
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US06818234B1
公开(公告)日：2004-11-16
申请号：US10084575
申请日：2002-02-27
申请人： Muraleedharan G. Nair , Haibo Wang , David L. Dewitt , David W. Krempin , Dipak K. Mody , Yong Qian , David G. Groh , Audra J. Davies , Mary A. Murray , Robin Dykhouse , Marc Lemay
发明人： Muraleedharan G. Nair , Haibo Wang , David L. Dewitt , David W. Krempin , Dipak K. Mody , Yong Qian , David G. Groh , Audra J. Davies , Mary A. Murray , Robin Dykhouse , Marc Lemay
IPC分类号： A61K3578
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/29 , A61K36/35 , Y10S514/816 , A61K2300/00 , A23V2250/2104
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

2. 发明授权

US08337914B2 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 失效
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US08337914B2
公开(公告)日：2012-12-25
申请号：US10945609
申请日：2004-09-21
申请人： Muraleedharan G. Nair , David L. Dewitt , Haibo Wang , David W. Krempin , Dipak K. Mody , David G. Groh , Mary A. Murray , Marc Lemay , Yong Qian , Audra J. Davies , Robin Dykhouse
发明人： Muraleedharan G. Nair , David L. Dewitt , Haibo Wang , David W. Krempin , Dipak K. Mody , David G. Groh , Mary A. Murray , Marc Lemay , Yong Qian , Audra J. Davies , Robin Dykhouse
IPC分类号： A61K36/04 , A61K36/736 , A61K36/00
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/29 , A61K36/35 , A61K36/45 , A23V2250/2104 , A61K2300/00
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

3. 发明申请

US20050100622A1 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 失效
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US20050100622A1
公开(公告)日：2005-05-12
申请号：US10945609
申请日：2005-01-10
申请人： Muraleedharan Nair , David Dewitt , Haibo Wang , David Krempin , Dipak Mody , David Groh , Mary Murray , Marc Lemay , Yong Qian , Audra Davies , Robin Dykhouse
发明人： Muraleedharan Nair , David Dewitt , Haibo Wang , David Krempin , Dipak Mody , David Groh , Mary Murray , Marc Lemay , Yong Qian , Audra Davies , Robin Dykhouse
IPC分类号： A23L1/30 , A61K36/29 , A61K36/35 , A61K36/45 , A61K36/736 , A61K31/7048 , A61K31/353 , A61K35/78
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/29 , A61K36/35 , A61K36/45 , A23V2250/2104 , A61K2300/00
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

4. 发明申请

US20060024397A9 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 失效
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US20060024397A9
公开(公告)日：2006-02-02
申请号：US10945609
申请日：2004-09-21
申请人： Muraleedharan Nair , David Dewitt , Haibo Wang , David Krempin , Dipak Mody , David Groh , Mary Murray , Marc Lemay , Yong Qian , Audra Davies , Robin Dykhouse
发明人： Muraleedharan Nair , David Dewitt , Haibo Wang , David Krempin , Dipak Mody , David Groh , Mary Murray , Marc Lemay , Yong Qian , Audra Davies , Robin Dykhouse
IPC分类号： A61K31/7048 , A61K31/353 , A61K35/78
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/29 , A61K36/35 , A61K36/45 , A23V2250/2104 , A61K2300/00
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

5. 发明授权

US06429021B1 Antioxidant activity profile assay 失效
标题翻译：抗氧化活性谱测定
公开(公告)号：US06429021B1
公开(公告)日：2002-08-06
申请号：US09044573
申请日：1998-03-19
申请人： Yong Qian , Richard E. A. Leitz , David W. Krempin
发明人： Yong Qian , Richard E. A. Leitz , David W. Krempin
IPC分类号： G01N3090
CPC分类号： G01N33/50 , G01N2030/062 , Y10T436/20 , Y10T436/255
摘要： The present invention provides an assay for detecting the presence of an array or a profile of antioxidant activity in any sources or products. In particular, the invention provides a method in which a sample is extracted with a polar, a non-polar and a semi-polar solvent to obtain three extracts; the extracts are chromatographed to get a chemical profile; and the profile is analyzed to determine the presence of antioxidants by directly reacting to a free-radical.
摘要翻译：本发明提供了用于检测任何来源或产品中抗氧化活性的阵列或轮廓的存在的测定法。特别地，本发明提供一种方法，其中用极性，非极性和半极性溶剂萃取样品以获得三种提取物; 萃取液进行色谱分离，得到化学分布; 并分析轮廓以通过直接与自由基反应来确定抗氧化剂的存在。

6. 发明授权

US09072735B2 Proteinases destroy cancer tumor's solid structure and kill cancer cells locally 有权
标题翻译：蛋白酶破坏癌症肿瘤的固体结构并杀死癌细胞
公开(公告)号：US09072735B2
公开(公告)日：2015-07-07
申请号：US12900812
申请日：2010-10-08
申请人： Yong Qian
发明人： Yong Qian
IPC分类号： A61K38/48 , A61P35/00 , C12N9/50
CPC分类号： A61K38/48 , A61K38/482 , A61K2300/00
摘要： A proteinase therapy has been invented to eliminate solid tumors by destroying tumors' solid structure and killing cancer cells by cleaving vital extracellular matrix proteins C-terminally, N-terminally or both with cell membrane intact and limited adverse effects. The micro-scale intratumoral proteinase K therapy is tumor specific but not cancer type specific. Proteinase K therapy can be operated on multiple tumors on multiple occasions, if necessary. It may be employed to eliminate any solid tumor to prolong a cancer patient's life span.
摘要翻译：已经发明了一种蛋白酶治疗方法，通过破坏肿瘤的固体结构，通过切除细胞外基质蛋白C末端，N末端或两者与细胞膜完整和有限的不良反应来破坏肿瘤细胞，来消除实体瘤。微量肿瘤内蛋白酶K治疗是肿瘤特异性但不是癌症类型特异性。如果需要，蛋白酶K治疗可以在多种肿瘤上进行操作。可用于消除任何实体肿瘤以延长癌症患者的寿命。

7. 发明申请

US20170258883A1 Protease-engineered Cancer Cell Spheres as an Immunotherapy to Treat Cancer and non-Cancer Diseases 审中-公开
公开(公告)号：US20170258883A1
公开(公告)日：2017-09-14
申请号：US15599479
申请日：2017-05-19
申请人： Yong Qian
发明人： Yong Qian
IPC分类号： A61K39/00 , A61K45/06 , A61K39/39 , A61K38/17
CPC分类号： A61K39/0011 , A61K38/1709 , A61K45/06 , A61K2039/5152 , A61K2300/00
摘要： Disclosed is a method of making a proteinase-engineered cancer vaccine or cancer-cell-derived spheres for treating a cancer patient, especially for cancer patients at advanced/metastatic stage. The cancer vaccine comprises dead cancer-cell-derived spheres with unbroken plasma membrane wherein the extracellular proteins and extracellular portion of membrane proteins are cleaved by proteinase digestion. The cancer vaccine may be derived from cancer cell lines or patients' cancer cells or derivatives. Also disclosed is a method of treating a cancer patient by administrating an effective amount of the cancer vaccine or cancer-cell-derived spheres to the patient. The present invention further provides a method of treating multiple diseases in addition to cancers by the cancer-cell-derived spheres, and obtaining cancer-specific immune components from blood of individuals treated with the cancer-cell-derived spheres.

8. 发明授权

US09669082B2 Proteinase-engineered cancer vaccine induces immune responses to prevent cancer and to systemically kill cancer cells 有权
公开(公告)号：US09669082B2
公开(公告)日：2017-06-06
申请号：US14594166
申请日：2015-01-11
申请人： Yong Qian
发明人： Yong Qian
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/5152
摘要： The present invention provides a method of making a proteinase-engineered cancer vaccine for treating a cancer patient, especially for cancer patient at advanced/metastatic stage. The cancer vaccine comprises dead cancer cells with unbroken plasma membrane wherein the extracellular proteins and extracellular portion of membrane proteins are cleaved by proteinase digestion. The cancer vaccine may be derived from cancer cell lines or patients' cancer cells. The present invention provides a method of treating a cancer patient by administrating an effective amount of the cancer vaccine to the patient. In a clinical trial with 35 cancer patients, the cancer vaccine therapy brings cancer-free lives (no detectable tumor, micro tumor or cancer cells after treatments of customized cancer vaccines) back to 40% of these patients. The present invention further provides a method of obtaining cancer-specific immune components from blood of individuals treated with the cancer vaccine.

9. 发明申请

US20150132285A1 Proteinase-engineered Cancer Vaccine Induces Immune Responses to Prevent Cancer and to Systemically Kill Cancer Cells 审中-公开
标题翻译：蛋白酶工程化的癌症疫苗诱导免疫应答来预防癌症并系统地杀死癌细胞
公开(公告)号：US20150132285A1
公开(公告)日：2015-05-14
申请号：US14594166
申请日：2015-01-11
申请人： Yong Qian
发明人： Yong Qian
IPC分类号： A61K39/00 , C07K16/18
CPC分类号： A61K39/0011 , A61K2039/5152
摘要： The present invention provides a method of making a proteinase-engineered cancer vaccine for treating a cancer patient, especially for cancer patient at advanced/metastatic stage. The cancer vaccine comprises dead cancer cells with unbroken plasma membrane wherein the extracellular proteins and extracellular portion of membrane proteins are cleaved by proteinase digestion. The cancer vaccine may be derived from cancer cell lines or patients' cancer cells. The present invention provides a method of treating a cancer patient by administrating an effective amount of the cancer vaccine to the patient. In a clinical trial with 35 cancer patients, the cancer vaccine therapy brings cancer-free lives (no detectable tumor, micro tumor or cancer cells after treatment) back to 40% of these patients. The cancer vaccine therapy for the first time brings the promise of cure to this deadly disease. The present invention further provides a method of obtaining cancer-specific immune components from blood of individuals treated with the cancer vaccine.
摘要翻译：本发明提供了一种制备用于治疗癌症患者的蛋白酶工程化癌症疫苗的方法，特别是对于晚期/转移期的癌症患者。癌症疫苗包括具有不间断质膜的死亡癌细胞，其中细胞外蛋白质和膜蛋白质的细胞外部分被蛋白酶消化切割。癌症疫苗可以衍生自癌细胞系或患者的癌细胞。本发明提供了通过向患者施用有效量的癌症疫苗来治疗癌症患者的方法。在35名癌症患者的临床试验中，癌症疫苗治疗将无癌生命（治疗后无可检测的肿瘤，微型肿瘤或癌细胞）带回到这些患者的40％。癌症疫苗治疗第一次带来了治愈这种致命疾病的希望。本发明还提供从用癌症疫苗治疗的个体的血液中获得癌症特异性免疫成分的方法。

10. 发明申请

US20140201275A1 SYSTEM AND METHOD FOR MANAGING A CONVERSATION FOR A MEETING SESSION IN A NETWORK ENVIRONMENT 审中-公开
标题翻译：用于管理网络环境中的会议会话的系统和方法
公开(公告)号：US20140201275A1
公开(公告)日：2014-07-17
申请号：US13742943
申请日：2013-01-16
申请人： Haihua Huang , Yong Qian , Yaqing Zhang , Kejun Xia
发明人： Haihua Huang , Yong Qian , Yaqing Zhang , Kejun Xia
IPC分类号： H04L29/06
CPC分类号： H04L65/403 , H04L65/1083 , H04L67/14 , H04L67/36
摘要： An example method is provided and includes receiving conversation precondition information associated with a meeting session in a network environment, determining, after a beginning of the meeting session, conversation precondition status information of at least one collaboration criteria indicated by the conversation precondition information, and causing a meeting client program to provide a representation of the conversation precondition status information.
摘要翻译：提供了一种示例性方法，并且包括在网络环境中接收与会议会话相关联的对话前提条件信息，在会议会话开始之后，确定由对话前提条件信息指示的至少一个协作标准的会话基准状态信息，并且引起会议客户端程序，用于提供会话前提条件状态信息的表示。

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