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1. 发明授权

US07521580B1 Non-cytotoxic synthetic analogues of (1E, 6E)-1, 7-Bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-Dione and therapeutic applications thereof in cystic fibrosis 有权
标题翻译：（1E，6E）-1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮的非细胞毒性合成类似物及其在囊性纤维化中的治疗应用
公开(公告)号：US07521580B1
公开(公告)日：2009-04-21
申请号：US12032955
申请日：2008-02-18
申请人： Muhammed Majeed , Rajinder Kumar Bammi , Natarajan Sankaran , Subbalakshmi Prakash , Kalyanam Nagabhushanam , Samuel Manoharan Thomas , Susmitha Anand , Geetha Kanhangad-Gangadharan
发明人： Muhammed Majeed , Rajinder Kumar Bammi , Natarajan Sankaran , Subbalakshmi Prakash , Kalyanam Nagabhushanam , Samuel Manoharan Thomas , Susmitha Anand , Geetha Kanhangad-Gangadharan
IPC分类号： C07C49/203 , C07C49/215 , A61K31/12
CPC分类号： C07C49/248 , A61K31/12 , C07C45/74
摘要： Disclosed are novel, synthetic analogues of (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione and the therapeutic applications for cystic fibrosis thereof in correcting altered CFTR trafficking and the associated impaired chloride (Cl−) ion transport. Introduction of branched-alkyl groups ortho to the phenolic groups gave rise to clinical compounds with vastly improved trafficking of delF508CFTR and with no cytotoxicity.
摘要翻译：公开了（1E，6E）-1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮的新型合成类似物，以及用于其改变的囊性纤维化的治疗应用 CFTR贩运和相关的氯化物（Cl - ）离子迁移。引入酚基团邻位的支链烷基产生临床化合物，其具有大大改善的delF508CFTR的运输并且没有细胞毒性。

2. 发明申请

US20100075360A1 UV BASED CELL VIABILITY AS AN INDICATOR OF SUN PROTECTION FACTOR AND METHODS OF MEASUREMENT THEREOF 审中-公开
标题翻译：作为太阳能保护因子指标的紫外线电池的可靠性及其测量方法
公开(公告)号：US20100075360A1
公开(公告)日：2010-03-25
申请号：US12234804
申请日：2008-09-22
申请人： Muhammed Majeed , Susmitha Anand , Geetha Kanhangad Gangadharan , Subbalakshmi Prakash
发明人： Muhammed Majeed , Susmitha Anand , Geetha Kanhangad Gangadharan , Subbalakshmi Prakash
IPC分类号： C12Q1/02
CPC分类号： G01N33/5008
摘要： Disclosed is a simple method of determining SPF based on the staining pattern of viable cells like mouse fibroblasts and human keratinocytes after exposure to ultraviolet radiations. The method provides results comparable to the standard methods of SPF measurement using human subjects.
摘要翻译：公开了一种基于在暴露于紫外线辐射后的活细胞如小鼠成纤维细胞和人角质形成细胞的染色模式来确定SPF的简单方法。该方法提供与使用人类受试者的SPF测量的标准方法相当的结果。

3. 发明申请

US20060122261A1 [METHOD OF PREPARING LABDANE DITERPENE COMPOSITION, PREFERABLY ISOFORSKOLIN AND DEACETYLFORSKOLIN FROM FORSKOLIN EXTRACT AND THEIR USE FOR PROMOTING LEAN BODY MASS AND OTHER APPLICATIONS] 审中-公开
标题翻译： [辛伐他汀组合物的制备方法，来自福柯林提取物的优选异冰片和脱乙酰壳多糖及其用于促进精神体质和其他应用的用途]
公开(公告)号：US20060122261A1
公开(公告)日：2006-06-08
申请号：US10707087
申请日：2003-11-20
申请人： Muhammed Majeed , Rajinder Kumar Bammi , Natarajan Sankaran , Rajendran Ramanujam , Satyan Kalkunte Seshadri , Subbalakshmi Prakash
发明人： Muhammed Majeed , Rajinder Kumar Bammi , Natarajan Sankaran , Rajendran Ramanujam , Satyan Kalkunte Seshadri , Subbalakshmi Prakash
IPC分类号： A61K31/353
CPC分类号： A61K31/353
摘要： The invention describes methods of preparation of isoforskolin extract, deacetylforskolin extract and related compounds from a natural source. Compositions and human and veterinary applications of such extracts in weight management through promoting lean body mass and in topical preparations for cellulite control, are also described. The compositions of the invention could be administered in a variety of dosage forms, including but not limited to ready-to-serve beverages, dry mixes for food products and beverages, oral preparations, injectables, emulsions, liniments or oils, to humans or animals.
摘要翻译：本发明描述了异佛尔酮蛋白提取物，脱乙酰福斯克林提取物以及天然来源的相关化合物的制备方法。还描述了通过促进瘦体重和用于脂肪团控制的局部制剂中的这些提取物在体重管理中的组合物和人和兽医学应用。本发明的组合物可以以各种剂型施用，包括但不限于即食服务饮料，食品和饮料的干混物，口服制剂，注射剂，乳剂，搽剂或油，用于人或动物。

4. 发明授权

US08383594B2 Peptides modified with triterpenoids and small organic molecules: synthesis and use in cosmeceuticals 有权
标题翻译：用三萜类化合物和小有机分子修饰的肽：合成和用于药妆品
公开(公告)号：US08383594B2
公开(公告)日：2013-02-26
申请号：US11835165
申请日：2007-08-07
申请人： Muhammed Majeed , Renukeshwar H Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
发明人： Muhammed Majeed , Renukeshwar H Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
IPC分类号： A61K38/08 , A61K8/64
CPC分类号： A61Q19/08 , A61K8/64 , A61Q19/00
摘要： The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.
摘要翻译：本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上表现出细小的表达线和皱纹。具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。

5. 发明授权

US08394852B2 Inotilone derivatives as coherent biological response modifier (cBMR) 有权
标题翻译：联酮衍生物作为相关生物反应调节剂（cBMR）
公开(公告)号：US08394852B2
公开(公告)日：2013-03-12
申请号：US12872675
申请日：2010-08-31
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Samuel Manoharan Thomas , Subbalakshmi Prakash
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Samuel Manoharan Thomas , Subbalakshmi Prakash
IPC分类号： A61K31/34
CPC分类号： C07D307/58 , A23L31/00 , A23L33/10 , A61K31/341
摘要： Optimal compositions of derivatives of 5-methyl-3(2H)-furanone compounds and phenylpropanoid polyketides related to inotilone, that exert biological response modification in health and disease, and their method of preparation, are disclosed. Methods of treating degenerative conditions stemming from over-expression of inducible nitric oxide synthase (iNOS) using these compositions are also disclosed.
摘要翻译：本发明公开了5-甲基-3（2H） - 呋喃酮化合物和苯丙素类聚酮化合物与艾吐子酮有关的衍生物的最佳组合物，其在健康和疾病中发挥生物反应修饰及其制备方法。还公开了使用这些组合物治疗由诱导型一氧化氮合酶（iNOS）过表达引起的退行性病症的方法。

6. 发明授权

US07253324B1 Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers 有权
标题翻译：通过相应的烷基醚脱烷基合成生物活性氧化化合物的方法
公开(公告)号：US07253324B1
公开(公告)日：2007-08-07
申请号：US11626225
申请日：2007-01-23
申请人： Muhammed Majeed , Samuel Manoharan Thomas , Kalyanam Nagabhushanam , Sivaprakash Kurumanghat Balakrishnan , Subbalakshmi Prakash
发明人： Muhammed Majeed , Samuel Manoharan Thomas , Kalyanam Nagabhushanam , Sivaprakash Kurumanghat Balakrishnan , Subbalakshmi Prakash
IPC分类号： C07C37/00
CPC分类号： C07C39/27 , C07C37/055 , C07C39/14 , C07C39/19 , C07C39/21 , C07C41/26 , C07C43/23 , C07C51/377 , C07C253/30 , C07C65/21 , C07C255/53 , C07C39/24
摘要： Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.
摘要翻译：通过用氯化铝/ N，N-二甲基苯胺络合物处理，烷氧基芳族化合物方便地脱苄基化成相应的酚类化合物。芳族聚O-脱甲基是本发明的独特特征。该方法适用于多酚如白藜芦醇，氧化藜芦醇，Gnetol的制造。

7. 发明申请

US20110091398A1 OLEANOYL PEPTIDE COMPOSITION AND A METHOD OF TREATING SKIN AGING 有权
标题翻译： OLEANOYL PEPTIDE COMPOSITION和一种治疗皮肤老化的方法
公开(公告)号：US20110091398A1
公开(公告)日：2011-04-21
申请号：US12979667
申请日：2010-12-28
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
IPC分类号： A61K8/64 , C07K7/06 , A61K8/97 , A61Q19/08 , A61Q17/04 , A61Q19/02
CPC分类号： A61K8/64 , A61K2800/57 , A61K2800/78 , A61Q19/00 , A61Q19/007 , A61Q19/04 , A61Q19/08 , C07K7/06
摘要： The present invention relates to a composition containing peptide of SEQ ID No. 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.
摘要翻译：本发明涉及与齐墩果酸连接的含有SEQ ID No.1的肽的组合物和治疗皮肤老化的方法。该组合物有效地减少由于氧化，胶原蛋白不足和丝氨酸蛋白酶如弹性蛋白酶和胶原酶的过度活动导致皮肤皱纹，细纹，减少皮肤厚度，色素沉着过度，眼睛黑眼圈和过早老化等现象。

8. 发明授权

US08987212B2 Oleanoyl peptide composition and method of treating skin aging 有权
标题翻译：油酰基肽组合物和治疗皮肤老化的方法
公开(公告)号：US08987212B2
公开(公告)日：2015-03-24
申请号：US12979667
申请日：2010-12-28
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
IPC分类号： A61K38/08 , A61K8/64 , A61Q19/00 , A61Q19/08 , C07K7/06
CPC分类号： A61K8/64 , A61K2800/57 , A61K2800/78 , A61Q19/00 , A61Q19/007 , A61Q19/04 , A61Q19/08 , C07K7/06
摘要： The present invention relates to a composition containing peptide of SEQ ID NO: 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.
摘要翻译：本发明涉及与齐墩果酸连接的含有SEQ ID NO：1的肽的组合物和治疗皮肤老化的方法。该组合物有效地减少由于氧化，胶原蛋白不足和丝氨酸蛋白酶如弹性蛋白酶和胶原酶的过度活动导致皮肤皱纹，细纹，减少皮肤厚度，色素沉着过度，眼睛黑眼圈和过早老化等现象。

9. 发明申请

US20140206842A1 Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceutical 审中-公开
标题翻译：用三萜类化合物和小有机分子修饰的肽：合成和用于药妆
公开(公告)号：US20140206842A1
公开(公告)日：2014-07-24
申请号：US13746633
申请日：2013-01-22
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
IPC分类号： C07K1/107
CPC分类号： C07K1/1077 , C07K7/06
摘要： The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the Synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.
摘要翻译：本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上出现细小的表达线和皱纹。具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。

10. 发明申请

US20100034758A1 Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceuticals 有权
标题翻译：用三萜类化合物和小有机分子修饰的肽：在化妆品中的合成和应用
公开(公告)号：US20100034758A1
公开(公告)日：2010-02-11
申请号：US11835165
申请日：2007-08-07
申请人： Muhammed Majeed , Renukeshwar H. Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
发明人： Muhammed Majeed , Renukeshwar H. Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
IPC分类号： A61K8/64 , A61Q17/04 , A61Q19/00 , C07K1/00 , C07K7/06
CPC分类号： A61Q19/08 , A61K8/64 , A61Q19/00
摘要： The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.
摘要翻译：本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上表现出细小的表达线和皱纹。具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。

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