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1. 发明授权

US07635704B2 Stable crystal of 4-oxoquinoline compound 有权
标题翻译：稳定的4-氧代喹啉化合物
公开(公告)号：US07635704B2
公开(公告)日：2009-12-22
申请号：US11133471
申请日：2005-05-20
申请人： Motohide Satoh , Takahisa Motomura , Takashi Matsuda , Kentaro Kondo , Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
发明人： Motohide Satoh , Takahisa Motomura , Takashi Matsuda , Kentaro Kondo , Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
IPC分类号： A61K31/4704 , C07D215/36
CPC分类号： C07D215/56
摘要： Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2θ(°) as measured by X-ray powder diffractmetry.
摘要翻译：提供6-（3-氯-2-氟苄基）-1 - [（S）-1-羟甲基-2-甲基丙基] -7-甲氧基-4-氧代-1,4-二氢喹啉-3-酮的稳定结晶，羧酸（化合物A）。表示化合物A的晶体，其显示了通过X射线粉末衍射测量法测得的衍射角2θ（°）的特征衍射峰的特定X射线粉末衍射图。

2. 发明申请

US20060030710A1 Stable crystal of 4-oxoquinoline compound 有权
标题翻译：稳定的4-氧代喹啉化合物
公开(公告)号：US20060030710A1
公开(公告)日：2006-02-09
申请号：US11133471
申请日：2005-05-20
申请人： Motohide Satoh , Takahisa Motomura , Takashi Matsuda , Kentaro Kondo , Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
发明人： Motohide Satoh , Takahisa Motomura , Takashi Matsuda , Kentaro Kondo , Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
IPC分类号： C07D215/36 , A61K31/4704
CPC分类号： C07D215/56
摘要： Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2θ(°) as measured by X-ray powder diffractmetry.
摘要翻译：提供6-（3-氯-2-氟苄基）-1 - [（S）-1-羟基甲基-2-甲基丙基] -7-甲氧基-4-氧代-1,4-二氢喹啉-3-酮的稳定结晶，羧酸（化合物A）。表示化合物A的晶体，其显示了通过X射线粉末衍射测量法测得的衍射角2θ（°）的特征衍射峰的特定X射线粉末衍射图。

3. 发明授权

US08981103B2 Stable crystal of 4-oxoquinoline compound 有权
标题翻译：稳定的4-氧代喹啉化合物
公开(公告)号：US08981103B2
公开(公告)日：2015-03-17
申请号：US12538694
申请日：2009-08-10
申请人： Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
发明人： Koji Ando , Koji Matsuda , Shuji Miyake , Hideto Uehara
IPC分类号： C07D215/00 , C07D215/56
CPC分类号： C07D215/56
摘要： Provision of a stabilized crystal of 6-(3-chloro-2-fluorobenzyl)-1-[(S)-1-hydroxymethyl-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (compound A). A crystal of compound A, which shows a particular X-ray powder diffraction pattern of a characteristic diffraction peaks at diffraction angles 2θ(°) as measured by X-ray powder diffractometry.
摘要翻译：提供6-（3-氯-2-氟苄基）-1 - [（S）-1-羟甲基-2-甲基丙基] -7-甲氧基-4-氧代-1,4-二氢喹啉-3-酮的稳定结晶，羧酸（化合物A）。化合物A的晶体，其显示了通过X射线粉末衍射测量的衍射角2θ时的特征衍射峰的特定X射线粉末衍射图案（°）。

4. 发明授权

US08420821B2 Process for production of 4-oxoquinoline compound 有权
标题翻译： 4-氧代喹啉化合物的制备方法
公开(公告)号：US08420821B2
公开(公告)日：2013-04-16
申请号：US12281921
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
发明人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
IPC分类号： C07D215/233
CPC分类号： C07C229/30 , C07C65/21 , C07C69/716 , C07C229/34 , C07D215/233 , C07D215/56 , C07F7/1804 , Y02P20/55
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, for example, compounds represented by the formulas (6), (7-1), (7-2) and (8): wherein R is a fluorine atom or a methoxy group, R1 is a C1-C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物，其制备方法和使用该合成中间体的抗HIV药物的制备方法。具体地说，本发明提供例如由式（6），（7-1），（7-2）和（8）表示的化合物：其中R是氟原子或甲氧基，R1是C1 -C4烷基，R2为羟基保护基，X2为卤素原子，其制造方法以及使用该合成中间体的抗HIV剂的制造方法。

5. 发明授权

US08383819B2 Method for producing 4-oxoquinoline compound 有权
标题翻译： 4-氧代喹啉化合物的制备方法
公开(公告)号：US08383819B2
公开(公告)日：2013-02-26
申请号：US12281889
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeji Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
发明人： Koji Matsuda , Koji Ando , Shigeji Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
IPC分类号： C07D215/00
CPC分类号： C07C229/30 , C07C43/215 , C07C57/72 , C07C57/76 , C07C61/40 , C07C67/333 , C07C67/343 , C07C69/708 , C07C69/716 , C07C69/738 , C07C69/92 , C07C69/94 , C07C229/34 , C07D215/56
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2′): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物及其制备方法，以及使用该合成中间体的抗HIV剂的制备方法。具体而言，例如，式（2'）表示的化合物或其盐，其中R为氟原子或甲氧基，R400为氢原子或C1-C4烷基，以及使用该合成中间体的抗HIV剂的制造方法。

6. 发明申请

US20090318702A1 PROCESS FOR PRODUCTION OF 4-OXOQUINOLINE COMPOUND 有权
标题翻译： 4-氧杂环戊烯化合物的生产方法
公开(公告)号：US20090318702A1
公开(公告)日：2009-12-24
申请号：US12281921
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
发明人： Koji Matsuda , Koji Ando , Shigeji Ohki , Takahiro Yamasaki , Jun-ichi Hoshi
IPC分类号： C07D215/233 , C07C229/34 , C07C69/612 , C07C49/303
CPC分类号： C07C229/30 , C07C65/21 , C07C69/716 , C07C229/34 , C07D215/233 , C07D215/56 , C07F7/1804 , Y02P20/55
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, the present invention provides, for example, compounds represented by the formulas (6), (7-1), (7-2) and (8): wherein R is a fluorine atom or a methoxy group, R1 is a C1-C4 alkyl group, R2 is a hydroxyl-protecting group, and X2 is a halogen atom, a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物，其制备方法和使用该合成中间体的抗HIV药物的制备方法。具体地说，本发明提供例如由式（6），（7-1），（7-2）和（8）表示的化合物：其中R是氟原子或甲氧基，R1是C1 -C4烷基，R2为羟基保护基，X2为卤素原子，其制造方法以及使用该合成中间体的抗HIV剂的制造方法。

7. 发明申请

US20090036684A1 METHOD FOR PRODUCING 4-OXOQUINOLINE COMPOUND 有权
标题翻译：生产4-氧杂环戊烯化合物的方法
公开(公告)号：US20090036684A1
公开(公告)日：2009-02-05
申请号：US12281889
申请日：2007-03-06
申请人： Koji Matsuda , Koji Ando , Shigeki Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
发明人： Koji Matsuda , Koji Ando , Shigeki Ohki , Jun-ichi Hoshi , Takahiro Yamasaki
IPC分类号： C07D215/00 , C07C69/76 , C07C65/00 , C07C49/105
CPC分类号： C07C229/30 , C07C43/215 , C07C57/72 , C07C57/76 , C07C61/40 , C07C67/333 , C07C67/343 , C07C69/708 , C07C69/716 , C07C69/738 , C07C69/92 , C07C69/94 , C07C229/34 , C07D215/56
摘要： The present invention provides a compound useful as a synthetic intermediate for an anti-HIV agent having an integrase inhibitory activity, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate. Specifically, for example, a compound represented by the formula (2′): wherein R is a fluorine atom or a methoxy group, and R400 is a hydrogen atom or a C1-C4 alkyl group, or a salt thereof, and a production method thereof, and a production method of an anti-HIV agent using the synthetic intermediate.
摘要翻译：本发明提供了可用作具有整合酶抑制活性的抗HIV剂的合成中间体的化合物及其制备方法，以及使用该合成中间体的抗HIV剂的制备方法。具体而言，例如，式（2'）表示的化合物或其盐，其中R为氟原子或甲氧基，R400为氢原子或C1-C4烷基，以及使用该合成中间体的抗HIV剂的制造方法。

8. 发明授权

US08680632B2 Magnetoresistive element and magnetic memory 有权
标题翻译：磁阻元件和磁记忆体
公开(公告)号：US08680632B2
公开(公告)日：2014-03-25
申请号：US13310154
申请日：2011-12-02
申请人： Tadaomi Daibou , Junichi Ito , Tadashi Kai , Minoru Amano , Hiroaki Yoda , Terunobu Miyazaki , Shigemi Mizukami , Koji Ando , Kay Yakushiji , Shinji Yuasa , Hitoshi Kubota , Akio Fukushima , Taro Nagahama , Takahide Kubota
发明人： Tadaomi Daibou , Junichi Ito , Tadashi Kai , Minoru Amano , Hiroaki Yoda , Terunobu Miyazaki , Shigemi Mizukami , Koji Ando , Kay Yakushiji , Shinji Yuasa , Hitoshi Kubota , Akio Fukushima , Taro Nagahama , Takahide Kubota
IPC分类号： H01L29/82 , G11C11/00
CPC分类号： H01L43/10 , H01L23/528 , H01L27/222 , H01L27/226 , H01L43/02 , H01L43/08 , H01L2924/0002 , H01L2924/00
摘要： A magnetoresistive element according to an embodiment includes: a base layer; a first magnetic layer formed on the base layer, and including a first magnetic film having an axis of easy magnetization in a direction perpendicular to a film plane, the first magnetic film including MnxGa100-x (45≦x
摘要翻译：根据实施例的磁阻元件包括：基底层; 第一磁性层，其形成在所述基底层上，并且包括在垂直于膜平面的方向上具有容易磁化的轴的第一磁性膜，所述第一磁性膜包括Mn x Ga 100-x（45≤n1E; x <64原子％）; 形成在第一磁性层上的第一非磁性层; 以及形成在所述第一非磁性层上的第二磁性层，并且包括在垂直于膜平面的方向上具有容易磁化的轴的第二磁性膜，所述第二磁性膜包括MnyGa100-y（45＆lt; IL1; y <64原子％），。第一和第二磁性层包括彼此不同的Mn组成比，第一磁性层的磁化方向可以通过第一非磁性层在第一磁性层和第二磁性层之间流动的电流而改变。

9. 发明授权

US08521795B2 Random number generating device 有权
标题翻译：随机数生成装置
公开(公告)号：US08521795B2
公开(公告)日：2013-08-27
申请号：US12452012
申请日：2008-03-24
申请人： Akio Fukushima , Hitoshi Kubota , Kay Yakushiji , Shinji Yuasa , Koji Ando
发明人： Akio Fukushima , Hitoshi Kubota , Kay Yakushiji , Shinji Yuasa , Koji Ando
IPC分类号： G06F7/58
CPC分类号： G06F7/588
摘要： A random number generating device is constructed such that it has improved random number generation rate and allows for construction of compact circuit with ease.The random number generating device includes a magnetoresistive element that has three layers consisting of a magnetization free layer, an interlayer, and a magnetization fixed layer, and has at least two resistance values depending on arrangement of magnetization in the magnetization free layer and the magnetization fixed layer, wherein the magnetoresistive element is subjected to be applied with a magnetization current so that the inversion probability of the magnetization free layer assumes a value between 0 and 1, through which the resistance value of the magnetoresistive element is extracted as random numbers.
摘要翻译：构造随机数生成装置，使其具有改善的随机数生成速率并且容易地构造紧凑电路。该随机数生成装置包括具有由磁化自由层，中间层和磁化固定层构成的三层的磁致电阻元件，并且具有取决于磁化自由层的磁化排列和磁化固定的至少两个电阻值层，其中磁阻元件经受施加磁化电流，使得磁化自由层的反转概率为0和1之间的值，磁阻元件的电阻值通过该值提取为随机数。

10. 发明授权

US07936631B2 Non-volatile memory element and method of operation therefor 有权
标题翻译：非易失性存储元件及其操作方法
公开(公告)号：US07936631B2
公开(公告)日：2011-05-03
申请号：US12318823
申请日：2009-01-09
申请人： Vadym Zayets , Koji Ando
发明人： Vadym Zayets , Koji Ando
IPC分类号： G11C13/04
CPC分类号： H01L29/66984 , G11C11/161 , G11C11/1659 , G11C11/1673 , G11C11/1675 , G11C13/06 , H01L29/868
摘要： A very small magnetic tunnel junction is formed on a semiconductor p-i-n diode. Spin-polarized current which is generated by circular polarized light or elliptically-polarized light, is injected into a free layer of the magnetic tunnel junction so that magnetization direction (two opposite directions) in the free layer is changed based on the information, whereby information is stored in the memory element.
摘要翻译：在半导体p-i-n二极管上形成非常小的磁性隧道结。由圆偏振光或椭圆偏振光产生的自旋极化电流被注入到磁性隧道结的自由层中，使得自由层中的磁化方向（两个相反的方向）基于信息而改变，由此信息存储在存储元件中。

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