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1. 发明申请

US20080081963A1 Methods and Apparatus for Profiling Cardiovascular Vulnerability to Mental Stress 审中-公开
标题翻译：心血管应力心血管易感性分析方法与装置
公开(公告)号：US20080081963A1
公开(公告)日：2008-04-03
申请号：US11863490
申请日：2007-09-28
申请人： Morteza Naghavi , Timothy J. O'Brien , Craig Jamieson , Mark C. Johnson , Haider A. Hassan
发明人： Morteza Naghavi , Timothy J. O'Brien , Craig Jamieson , Mark C. Johnson , Haider A. Hassan
IPC分类号： A61B5/00
CPC分类号： A61B5/026 , A61B5/01 , A61B5/02241 , A61B5/6806 , A61B5/6826 , A61B5/6838 , A61B5/7275
摘要： Methods and apparatus are provided for determining individual responses to induced and actual mental stress and for identifying individuals susceptible to detrimental effects of mental stress on the cardiovascular system. The subjects may be at risk for chronic effects of mental stress by virtue of synergistic effects of mental stress and cardiovascular (CV) disease risk factors) or may be at risk, or vulnerable to, acute effects of mental stress by virtue of synergistic effects of mental stress and underlying hidden coronary atherosclerosis. The invention further provides methods and apparatus for assessing vascular reactivity in individuals under ambulatory conditions and relating mental stress responses to vascular reactivity.
摘要翻译：提供了方法和装置，用于确定对诱导和实际精神压力的个人反应，并确定易受精神压力对心血管系统的不利影响的个体。由于精神压力和心血管疾病（CV）疾病风险因素的协同作用，受试者可能面临精神压力的慢性影响的风险，或者由于精神压力的协同效应而处于危险中或易受精神压力的急性影响精神压力和隐藏的冠状动脉粥样硬化。本发明还提供了用于评估在流动条件下个体的血管反应性并将精神压力反应与血管反应性相关联的方法和装置。

2. 发明申请

US20070225606A1 METHOD AND APPARATUS FOR COMPREHENSIVE ASSESSMENT OF VASCULAR HEALTH 审中-公开
标题翻译：方法和装置对血管健康的综合评估
公开(公告)号：US20070225606A1
公开(公告)日：2007-09-27
申请号：US11690122
申请日：2007-03-22
申请人： Morteza Naghavi , Timothy J. O'Brien , Craig Jamieson , Mark C. Johnson , Naser Ahmadi , Haider A. Hassan
发明人： Morteza Naghavi , Timothy J. O'Brien , Craig Jamieson , Mark C. Johnson , Naser Ahmadi , Haider A. Hassan
IPC分类号： A61B8/00
CPC分类号： A61B5/0285 , A61B5/015 , A61B5/02007 , A61B5/022 , A61B5/0261 , A61B8/06
摘要： Apparatus and methods for comprehensive assessment of vascular health is provided including functional status of the individual, risk factor assessment based on epidemiologic studies, and structural studies of the individual. Functional assessment in accordance with an embodiment of the invention includes generation of information on the status of three compartments: the microvasculature, the macrovasculature and the neurovasculature.
摘要翻译：提供血管健康综合评估的装置和方法，包括个体的功能状态，基于流行病学研究的风险因素评估和个体的结构研究。根据本发明的实施例的功能评估包括产生关于三个隔室的状态的信息：微血管系统，大血管系统和神经血管系统。

3. 发明申请

US20090177224A1 METHODS AND APPARATUS FOR BLOOD SAMPLING 审中-公开
标题翻译：血液采样方法和装置
公开(公告)号：US20090177224A1
公开(公告)日：2009-07-09
申请号：US12349068
申请日：2009-01-06
申请人： Morteza Naghavi , Albert Yen , Craig Jamieson , Haider A. Hassan , David Panthagani , Gary McQuilkin , Timothy J. O'Brien
发明人： Morteza Naghavi , Albert Yen , Craig Jamieson , Haider A. Hassan , David Panthagani , Gary McQuilkin , Timothy J. O'Brien
IPC分类号： A61B17/00 , A61B5/151 , A61F7/08
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150061 , A61B5/150068 , A61B5/150076 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150748 , A61B5/15109 , A61B5/1519 , A61B5/15194
摘要： Methods and apparatus for blood sampling from skin capillaries are provided. Blood extraction is improved by applying gradient pressure in a proximal to distal direction of an extremity. Blood is extracted and sampled from the skin capillaries with a blood sampling mechanism of at least a lancet and testing kit.
摘要翻译：提供了从皮肤毛细血管采血的方法和装置。通过在肢体的近端到远端方向施加梯度压力来提高血液提取。用至少一种刺血针和测试试剂盒的血液采样机构从皮肤毛细血管中提取和取样血液。

4. 发明授权

US10631771B2 Methods and apparatus for blood sampling 有权
公开(公告)号：US10631771B2
公开(公告)日：2020-04-28
申请号：US12349068
申请日：2009-01-06
申请人： Morteza Naghavi , Albert Andrew Yen , Haider Hassan , David Panthagani , Craig Jamieson , Gary L. McQuilkin , Timothy J O'Brien
发明人： Morteza Naghavi , Albert Andrew Yen , Haider Hassan , David Panthagani , Craig Jamieson , Gary L. McQuilkin , Timothy J O'Brien
IPC分类号： A61B5/15 , A61B5/157
CPC分类号： A61B5/157
摘要： Methods and apparatus for blood sampling from skin capillaries are provided. Blood extraction is improved by applying gradient pressure in a proximal to distal direction of an extremity. Blood is extracted and sampled from the skin capillaries with a blood sampling mechanism of at least a lancet and testing kit.

5. 发明授权

US08551008B2 Method and apparatus for determining vascular health conditions 失效
标题翻译：用于确定血管健康状况的方法和装置
公开(公告)号：US08551008B2
公开(公告)日：2013-10-08
申请号：US11871901
申请日：2007-10-12
申请人： Morteza Naghavi , Nachiket Kharalkar , Timothy J. O'Brien
发明人： Morteza Naghavi , Nachiket Kharalkar , Timothy J. O'Brien
IPC分类号： A61B5/02
CPC分类号： A61B5/01 , A61B5/0008 , A61B5/02007 , A61B5/02416 , A61B5/1455 , A61B5/4035 , A61B8/08 , A61B8/488 , A61B2560/0242
摘要： The present invention relates to assessing and measuring vascular and endothelial function. A vasostimulant is provided to a patient to stimulate hemodynamic activity in a selected extremity and vascular function is assessed by monitoring a change in a blood flow, skin temperature and/or blood oxygen content at the selected extremity and assessing the patient's vascular function based upon the monitoring.
摘要翻译：本发明涉及评估和测量血管和内皮功能。向患者提供血管兴奋剂以在所选择的末端刺激血液动力学活性，并且通过监测所选末端的血流量，皮肤温度和/或血氧含量的变化来评估血管功能，并且基于所述血液功能评估患者的血管功能监控。

6. 发明申请

US20080255471A1 METHOD AND APPARATUS FOR DETERMINING VASCULAR HEALTH CONDITIONS 失效
标题翻译：用于确定血管健康状况的方法和装置
公开(公告)号：US20080255471A1
公开(公告)日：2008-10-16
申请号：US11871901
申请日：2007-10-12
申请人： Morteza Naghavi , Nachiket Kharalkar , Timothy J. O'Brien
发明人： Morteza Naghavi , Nachiket Kharalkar , Timothy J. O'Brien
IPC分类号： A61B5/02 , A61B5/01
CPC分类号： A61B5/01 , A61B5/0008 , A61B5/02007 , A61B5/02416 , A61B5/1455 , A61B5/4035 , A61B8/08 , A61B8/488 , A61B2560/0242
摘要： The present invention relates to assessing and measuring vascular and endothelial function. A vasostimulant is provided to a patient to stimulate hemodynamic activity in a selected extremity and vascular function is assessed by monitoring a change in a blood flow, skin temperature and/or blood oxygen content at the selected extremity and assessing the patient's vascular function based upon the monitoring.
摘要翻译：本发明涉及评估和测量血管和内皮功能。向患者提供血管兴奋剂以在所选择的末端刺激血液动力学活性，并且通过监测所选末端的血流量，皮肤温度和/或血氧含量的变化来评估血管功能，并且基于所述血液功能评估患者的血管功能监控。

7. 发明申请

US20070173727A1 Method and apparatus for isolating the vascular component in digital temerature monitoring 审中-公开
标题翻译：在数字温度监测中隔离血管成分的方法和装置
公开(公告)号：US20070173727A1
公开(公告)日：2007-07-26
申请号：US11504225
申请日：2006-08-14
申请人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
发明人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/6826 , A61B5/01 , A61B5/4035 , A61B5/6806 , A61B5/6838
摘要： Methods and apparatus are provided for identifying and minimizing neurovascular contributions to determinations of endothelial function, including by digital temperature monitoring such that an accurate status of vascular reactivity can be obtained. Methods are also provided for identifying individuals having increased sympathetic nervous system activity impacting peripheral vascular function as well as for determining a status of diabetic foot.
摘要翻译：提供了方法和装置，用于识别和最小化对内皮功能测定的神经血管贡献，包括通过数字温度监测，从而可以获得血管反应性的准确状态。还提供了用于鉴定具有影响外周血管功能的增加的交感神经系统活性以及用于确定糖尿病足的状态的个体的方法。

8. 发明申请

US20080027330A1 RISK ASSESSMENT METHOD FOR ACUTE CARDIOVASCULAR EVENTS 审中-公开
标题翻译：急性心血管事件风险评估方法
公开(公告)号：US20080027330A1
公开(公告)日：2008-01-31
申请号：US11749105
申请日：2007-05-15
申请人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson , Naser Ahmadi , Haider Hassan
发明人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson , Naser Ahmadi , Haider Hassan
IPC分类号： A61B5/02
CPC分类号： A61B5/0402 , A61B5/02 , A61B8/06
摘要： Methods and apparatus are provided for assessing the risk of an acute cardiovascular event that includes providing an endothelial or vascular function test to identify higher risk from lower risk individuals in a population of symptomatic individuals presenting with chest pain that have inconclusive results in ECG and cardiovascular marker tests, such as a tropinin test, and are administered for triage in hospital and additional tests such as ECG exercise and nuclear stress tests. The invention further provides methods and apparatus for assessing the vascular status and response of patients in clinical trials for cardiovascular therapies.
摘要翻译：提供了用于评估急性心血管事件风险的方法和装置，其包括提供内皮或血管功能测试，以鉴定呈现胸痛的症状性个体群体中较低风险个体的高风险，其具有心电图和心血管标志物不确定的结果测试，如托特罗测试，并在医院进行分诊并进行额外的测试，如心电图运动和核压力测试。本发明还提供了用于评估患者在心血管疗法临床试验中的血管状态和反应的方法和装置。

9. 发明申请

US20070225614A1 METHOD AND APPARATUS FOR DETERMINING VASCULAR HEALTH CONDITIONS 审中-公开
标题翻译：用于确定血管健康状况的方法和装置
公开(公告)号：US20070225614A1
公开(公告)日：2007-09-27
申请号：US11563676
申请日：2006-11-27
申请人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
发明人： Morteza Naghavi , Timothy O'Brien , Craig Jamieson , Mark Johnson
IPC分类号： A61B5/01 , A61B5/00
CPC分类号： A61B5/01 , A61B5/0008 , A61B5/02007 , A61B5/02416 , A61B5/1455 , A61B5/4035 , A61B8/08 , A61B8/488 , A61B2560/0242
摘要： The present invention provides methods and apparatus for assessing a patient's vascular health including endothelial function by monitoring changes in hemodynamic parameters responsive to the introduction of a vasostimulant. The invention provides a thermal energy measurement apparatus including a thermal energy sensor adapted to measure temperature of a body part while not substantially changing the temperature of the body part, and a display or recorder coupled to the thermal energy sensor, wherein the thermal energy sensor measures the temperature of the body part before and subsequent to the provision of a vasostimulant, and the display or recorder reports the temperature of the body part prior to the provision of the stimulant and the temperature of the body part after provision of the stimulant. Also provides are methods and apparatus providing for a second thermal energy sensor on a corresponding contralateral site to the site subject to the vasostimulant and simultaneously monitoring and recording of temperature of the contralateral site as a measure of neurovascular status and microvascular reactivity.
摘要翻译：本发明提供了通过监测血管动力学参数的变化来响应于引入血管兴奋剂来评估患者血管健康（包括内皮功能）的方法和装置。本发明提供了一种热能测量装置，其包括适于测量身体部位的温度而不显着改变身体部位的温度的热能传感器，以及耦合到热能传感器的显示器或记录器，其中热能传感器测量在提供血管增生剂之前和之后的身体部位的温度，并且显示器或记录器在提供兴奋剂之前报告在提供兴奋剂之前身体部位的温度和身体部位的温度。还提供了将方法和装置提供给对应于血管增生物的部位的相应对侧部位上的第二热能传感器，同时监测和记录对侧部位的温度，作为神经血管状态和微血管反应性的量度。

10. 发明申请

US20100081941A1 CARDIOVASCULAR HEALTH STATION METHODS AND APPARATUS 审中-公开
标题翻译：心血管健康站方法和装置
公开(公告)号：US20100081941A1
公开(公告)日：2010-04-01
申请号：US11963681
申请日：2007-12-21
申请人： Morteza Naghavi , Robin Antony Owen , Albert Andrew Yen , Craig Jamieson , Haider Hassan , David Panthagani , Gary L. McQuilkin , Timothy O'Brien
发明人： Morteza Naghavi , Robin Antony Owen , Albert Andrew Yen , Craig Jamieson , Haider Hassan , David Panthagani , Gary L. McQuilkin , Timothy O'Brien
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/0066 , A61B5/015 , A61B5/02007 , A61B5/0261 , A61B5/0285 , A61B8/06
摘要： Methods and apparatus for improving measurements of cardiovascular health status in a given individual are provided. The comprehensive assessment of cardiovascular health includes at least two components: risk factor assessment based on epidemiologic studies and functional status of the individual. Structural studies of the individual can also be included in the comprehensive assessment of cardiovascular health. The invention aims to improve detection, treatment, devices, and administration of cardiovascular risk assessment.
摘要翻译：提供了用于改善给定个体心血管健康状况测量的方法和装置。心血管健康综合评估至少包括两个部分：基于流行病学研究的风险因素评估和个体功能状态。个人的结构研究也可以纳入心血管健康综合评估。本发明旨在改善心血管风险评估的检测，治疗，设备和管理。

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