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1. 发明申请

US20110251212A1 PIPERAZINE DERIVATIVES 审中-公开
标题翻译：哌嗪衍生物
公开(公告)号：US20110251212A1
公开(公告)日：2011-10-13
申请号：US12674275
申请日：2008-08-19
申请人： Moriyasu Masui , Minoru Tomida , Naotake Kobayashi , Kousuke Anan , Aya Tazawa , Kayoko Hata
发明人： Moriyasu Masui , Minoru Tomida , Naotake Kobayashi , Kousuke Anan , Aya Tazawa , Kayoko Hata
IPC分类号： A61K31/496 , C07D401/12 , C07D413/14 , C07D487/08 , A61P25/00 , C07D403/12 , A61P9/10 , A61P25/28 , A61P25/26 , A61P25/32 , C07D413/12 , A61K31/422
CPC分类号： C07D209/34 , C07D215/22 , C07D235/26 , C07D263/58 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D487/08 , C07D498/04
摘要： A compound which specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist is provided.It has been found out that a piperazine derivative represented by the formula (I) binds specifically to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist.A compound represented by: wherein R1 is each independently C1-C3 alkyl or the like, m is an integer of 0 to 4, X is —N(R4)—C(═O)—C(═O)—, —N(R4)—(CR5R6)p—C(═O)—, —N(R4)—C(═O)—(CR7R8)q— or —C(═O)—N(R4)—(CR7R8)q—, p and q are each independently an integer of 1 to 3, R4, R5, R6, R7 and R8 are each independently a hydrogen atom or lower alkyl, A1 is benzoxazolinone or the like, and A2 is optionally substituted phenyl or the like, or a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：提供了特异性结合NR1 / NR2B的受体并用作NR2B受体拮抗剂的化合物。已经发现，由式（I）表示的哌嗪衍生物与NR1 / NR2B的受体特异性结合，用作NR2B受体拮抗剂。由下式表示的化合物：其中R 1各自独立地为C 1 -C 3烷基等，m为0〜4的整数，X为-N（R 4）-C（= O）-C（= O） - ， - N （R4） - （CR5R6）p-C（= O） - ， - N（R4）-C（= O） - （CR7R8）q-或-C（= O）-N（R4） - （CR7R8）q - ，p和q各自独立地为1〜3的整数，R4，R5，R6，R7和R8各自独立地为氢原子或低级烷基，A1为苯并恶唑啉酮等，A2为任选取代的苯基等，或其药学上可接受的盐或溶剂合物。

2. 发明授权

US08546380B2 Aminodihydrothiazine derivatives 有权
标题翻译：氨基二氢噻嗪衍生物
公开(公告)号：US08546380B2
公开(公告)日：2013-10-01
申请号：US13243971
申请日：2011-09-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
IPC分类号： C07D279/00 , C07D265/00 , A61K31/535 , A61K31/541
CPC分类号： C07D417/14 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/554 , C07D239/14 , C07D239/24 , C07D239/42 , C07D265/08 , C07D277/18 , C07D279/06 , C07D279/08 , C07D279/12 , C07D281/02 , C07D405/04 , C07D405/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04
摘要： A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group; E is lower alkylene; X is S; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; or its pharmaceutically acceptable salt thereof.
摘要翻译：一种具有BACE1抑制活性的组合物，其含有式（I）表示的化合物：其中环A为任选取代的杂环基; E为低级亚烷基; X是S; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素或羟基等; n和m各自独立地为0〜3的整数， n + m为0〜3的整数， R5是氢原子或取代的低级烷基; 或其药学上可接受的盐。

3. 发明授权

US4158725A Method of manufacturing an adhesive 失效
标题翻译：制造粘合剂的方法
公开(公告)号：US4158725A
公开(公告)日：1979-06-19
申请号：US872108
申请日：1978-01-25
申请人： Makoto Nishimura , Keiichi Naito , Yoshio Fujiwara , Naotake Kobayashi
发明人： Makoto Nishimura , Keiichi Naito , Yoshio Fujiwara , Naotake Kobayashi
IPC分类号： C08F8/00 , C08F8/30 , C09J133/04 , C09J133/06 , C09J157/00 , C08F8/32
CPC分类号： C09J133/068 , C09J157/00
摘要： A method for the manufacture of an adhesive suitable for use with polyvinylfluoride sheets which includes the steps of copolymerizing a vinyl compound and a vinyl compound having an epoxy group and then treating the copolymer thus produced with aqueous ammonia to aminate the epoxy group.
摘要翻译：一种适用于聚氟乙烯片材的粘合剂的制造方法，包括使乙烯基化合物和具有环氧基的乙烯基化合物进行共聚，然后用氨水处理由此制备的共聚物以氨基化环氧基的步骤。

4. 发明授权

US06506903B1 Process for producing 4-thiazolylmethyl derivative 失效
标题翻译： 4-噻唑基甲基衍生物的制备方法
公开(公告)号：US06506903B1
公开(公告)日：2003-01-14
申请号：US09622441
申请日：2000-08-17
申请人： Masaaki Uenaka , Masahiko Nagai , Naotake Kobayashi
发明人： Masaaki Uenaka , Masahiko Nagai , Naotake Kobayashi
IPC分类号： C07D27722
CPC分类号： C07D277/22 , A61K38/00 , C07D277/30 , C07D277/32 , C07K5/06139
摘要： A process for the production of 4-thiazolylmethyl derivatives are provided. A process for the production of the compound represented by the formula (I): wherein R1 is hydrogen or halogen and Hal is halogen, which comprises reacting 4-methylthiazole with N-halosuccinimide in a solvent in the presence of a radical initiator.
摘要翻译：提供了制备4-噻唑基甲基衍生物的方法。制备由式（I）表示的化合物的方法：其中R1是氢或卤素，Hal是卤素，其包括在自由基引发剂存在下，在溶剂中使4-甲基噻唑与N-卤代琥珀酰亚胺反应。

5. 发明授权

US4977136A Cover film for hard copy printing paper 失效
标题翻译：复印纸盖纸
公开(公告)号：US4977136A
公开(公告)日：1990-12-11
申请号：US406196
申请日：1989-10-04
申请人： Yoshio Fujiwara , Naotake Kobayashi , Satoru Shinohara , Tetsuya Abe
发明人： Yoshio Fujiwara , Naotake Kobayashi , Satoru Shinohara , Tetsuya Abe
IPC分类号： B41M5/382 , B41M7/00
CPC分类号： B41M7/0027 , Y10S428/913 , Y10S428/914 , Y10T428/24868 , Y10T428/31533 , Y10T428/31739 , Y10T428/31743 , Y10T428/31786 , Y10T428/31797 , Y10T428/31855
摘要： The present invention relates to a cover film for hard copy printing paper which can easily form a colorless and transparent protecting layer on the surface of, for example, a printing paper on which a color picture image is printed. The cover film for hard copy printing paper is such one that the cover film for hard copy printing paper is formed on the surface of a hard copy printing paper on which the printing is carried out by the sublimation transfer method and the cover film is designed to include at least one layer the glass transition temperature of which is selected to be higher than 40.degree. C. and whose water absorbing ratio (ASTM D570) is selected to be lower than 2%, whereby even under high temperature and high humidity, the bad influence exerted by the movement of a dye can be removed.
摘要翻译：本发明涉及一种用于硬拷贝打印纸的覆盖膜，其能够容易地在其上印刷彩色图像的打印纸的表面上形成无色透明的保护层。用于硬拷贝打印纸的覆盖膜是这样一种用于硬拷贝打印纸的覆盖膜形成在通过升华转印方法进行打印的硬拷贝打印纸的表面上，并且覆盖膜设计成包括玻璃化转变温度选择为高于40℃的至少一层，其吸水率（ASTM D570）选择为低于2％，由此即使在高温高湿下也不好可以去除染料运动所产生的影响。

6. 发明授权

US4735847A Electrically conductive adhesive sheet, circuit board and electrical connection structure using the same 失效
标题翻译：导电胶片，电路板和电气连接结构使用相同
公开(公告)号：US4735847A
公开(公告)日：1988-04-05
申请号：US61608
申请日：1987-06-22
申请人： Yoshio Fujiwara , Naotake Kobayashi , Yuichi Matsubara , Hisashi Ando , Hidehiro Numao , Kazuaki Suzuki
发明人： Yoshio Fujiwara , Naotake Kobayashi , Yuichi Matsubara , Hisashi Ando , Hidehiro Numao , Kazuaki Suzuki
IPC分类号： H01R4/04 , H05K1/18 , H05K3/32 , H05K3/36 , B32B15/00 , B32B3/00
CPC分类号： H05K3/323 , H01R4/04 , H01L2224/16 , H01L2224/293 , H01L2224/45144 , H01L2224/83192 , H01L2924/01014 , H01L2924/01021 , H01L2924/01057 , H01L2924/01063 , H01L2924/01066 , H01L2924/01067 , H01L2924/01068 , H01L2924/01078 , H01L2924/01079 , H01L2924/09701 , H01R12/51 , H01R12/52 , H01R12/59 , H01R12/62 , H05K1/181 , H05K2201/0129 , H05K2201/10689 , H05K2201/10719 , H05K2201/10977 , H05K2203/0425 , H05K2203/1311 , H05K3/361 , Y10S428/901 , Y10T428/24917 , Y10T428/256 , Y10T428/2857
摘要： An electrically conductive adhesive sheet is disclosed which has an electrically conducting property across a thickness thereof and an electrically insulating property along a sheet surface direction. The electrically conductive adhesive sheet comprises an electrically insulating adhesive material and electrically conductive metal powder uniformly dispersed therein. The metal powder has a melting point lower than a certain working temperature, and is flattened by application of pressure between a pair of conductors between which the adhesive sheet is provided. The adhesive material is molten at the certain working temperature and is flown by application of pressure. The adhesive sheet is useful to electrically connect a pair of circuit boards each having a plurality of conductor patterns thereon by bonding corresponding ones through the metal powder as molten, while keeping the neighboring patterns insulated. The circuit board is mechanically integrated simultaneously by the adhesive sheet. The circuit board and the connection structure using such an adhesive sheet as above are also disclosed.
摘要翻译：公开了一种导电粘合片，其具有贯穿其厚度的导电性和沿着片材表面方向的电绝缘性。导电粘合片包括电绝缘粘合剂材料和均匀分散在其中的导电金属粉末。金属粉末的熔点低于一定的工作温度，并且在设置有粘合片的一对导体之间施加压力而变平。粘合剂材料在一定的工作温度下熔融并通过施加压力而流动。粘合片用于通过将相应的电路板通过熔融的金属粉末粘合在一起而将其上具有多个导体图案的一对电路板电连接，同时保持相邻图案绝缘。电路板通过粘合片同时机械地集成。还公开了使用这种粘合片的电路板和连接结构。

7. 发明授权

US4599259A Cover film for sublimation transfer type hard copy 失效
标题翻译：用于升华转印型硬拷贝的覆膜
公开(公告)号：US4599259A
公开(公告)日：1986-07-08
申请号：US624683
申请日：1984-06-22
申请人： Naotake Kobayashi , Tetsuya Abe , Satoru Shinohara , Yoshio Fujiwara
发明人： Naotake Kobayashi , Tetsuya Abe , Satoru Shinohara , Yoshio Fujiwara
IPC分类号： B41M7/00 , B41M5/26
CPC分类号： B41M7/0054 , Y10S428/913 , Y10S428/914 , Y10T428/24851 , Y10T428/24868 , Y10T428/24876 , Y10T428/24901 , Y10T428/265 , Y10T428/31511 , Y10T428/31739 , Y10T428/31783 , Y10T428/31786 , Y10T428/3179 , Y10T428/31906 , Y10T428/31935 , Y10T428/31986
摘要： A cover film for a sublimation transfer type hard copy of the present invention is a cover film which is melt bonded by heat on the surface of a hard copy printing paper in which a picture image is formed on the surface thereof by selectively transferring a sublimation dye. The cover film includes a resinous layer containing a metal compound selected from Al, Mg, Ca and Sn. This cover film is capable of producing magenta color of high color saturation by arbitrarily controlling the coloring of reddish dye to be shifted to the blue side and can also protect the surface of the printing paper.Furthermore, the present invention relates to a cover film which is melt bonded by heat on the surface of a hard copy printing paper in which a picture image is formed on the surface thereof by selectively transferring a sublimation dye. This cover film includes a layer mainly formed of a phosphor whitener and a resin to increase a whiteness degree of a portion which is not colored so that a picture image is made clear and which can prevent the color of dye from being faded.
摘要翻译： PCT No.PCT / JP83 / 00374 Sec。 371日期1984年6月22日第 102（e）日期1984年6月22日PCT提交1983年10月25日PCT公布。出版物WO84 / 01745 日本公报1984年5月10日。本发明的升华转印型硬拷贝用覆盖膜是在其表面形成有图像的硬拷贝印刷纸的表面上通过热熔融粘结的覆盖膜通过选择性地转移升华染料。覆盖膜包括含有选自Al，Mg，Ca和Sn的金属化合物的树脂层。该覆盖膜能够通过任意地控制偏移到蓝色侧的红色染料的着色而产生高色饱和度的品红色，并且还可以保护打印纸的表面。此外，本发明涉及一种通过加热熔融粘结在其上通过选择性转移升华染料而在其表面上形成图像的硬拷贝印刷纸的表面覆盖膜。该覆盖膜包括主要由荧光增白剂和树脂形成的层，以增加未着色的部分的白度，使得图像图像清晰，并且可以防止染料的颜色褪色。

8. 发明授权

US08653067B2 Pharmaceutical composition for treating Alzheimer's disease 有权
标题翻译：用于治疗阿尔茨海默病的药物组合物
公开(公告)号：US08653067B2
公开(公告)日：2014-02-18
申请号：US12597470
申请日：2008-04-23
申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Gaku Sakaguchi , Akira Kato , Akihiro Hori , Hidekazu Haraguchi , Ken Yasui
发明人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Gaku Sakaguchi , Akira Kato , Akihiro Hori , Hidekazu Haraguchi , Ken Yasui
IPC分类号： A61K31/554 , A61K31/541 , A61K31/426 , A61K31/506 , C07D417/02 , C07D279/06 , C07D277/18 , C07D239/02
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/1623 , A61K9/2018 , A61K31/426 , A61K31/506 , A61K31/535 , A61K31/54 , A61K31/541 , A61K31/554 , C07D239/14 , C07D265/08 , C07D277/18 , C07D279/06 , C07D281/02 , C07D285/36 , C07D295/155 , C07D295/192 , C07D405/04 , C07D417/04 , C07D417/10 , C07D417/12 , A61K2300/00
摘要： A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要翻译：一种用于治疗含有由通式（I）表示的化合物的阿尔茨海默病的药物组合物; 其中环A是任选取代的碳环基团或任选取代的杂环基团; E为低级亚烷基等; X是S，O或NR1; R1是氢原子或低级烷基; R2a，R2b，R3a，R3b，R4a和R4b各自独立地为氢原子，卤素，羟基等; n和m各自独立地为0〜3的整数， n + m为1〜3的整数， R5为氢原子，任意取代的低级烷基等; 其药学上可接受的盐或其溶剂合物作为活性成分。

9. 发明授权

US4666320A Ink ribbon for sublimation transfer type hard copy 失效
标题翻译：墨带用于升华转印型硬拷贝
公开(公告)号：US4666320A
公开(公告)日：1987-05-19
申请号：US749624
申请日：1985-06-17
申请人： Naotake Kobayashi , Tetsuya Abe , Shinohara Satoru , Yoshio Fujiwara
发明人： Naotake Kobayashi , Tetsuya Abe , Shinohara Satoru , Yoshio Fujiwara
IPC分类号： B41M5/44 , B41J31/05
CPC分类号： B41M5/44
摘要： The present invention relates to an ink ribbon for sublimation transfer type hard copy which is used to produce as a hard copy a still picture image such as a picture image taken by a video camera, a television picture image and so on. The ink ribbon for sublimation transfer type hard copy of this invention comprises a heat-resistant plastic film base or a plastic film base having formed thereon a heat-resistant treating layer and coating layer of sublimation dye formed on the plastic film base. According to this ink ribbon for sublimation transfer type hard copy, it is possible to protect the film base from being shrunk and producing a bubble spot therein due to heat generated upon transfer, etc. Accordingly, a quality of a transferred picture image can be improved.

10. 发明授权

US4651645A Sublimation ink ribbon 失效
标题翻译：升华色带
公开(公告)号：US4651645A
公开(公告)日：1987-03-24
申请号：US711464
申请日：1985-02-26
申请人： Naotake Kobayashi , Tetsuya Abe , Satoru Shinohara , Yoshio Fujiwara
发明人： Naotake Kobayashi , Tetsuya Abe , Satoru Shinohara , Yoshio Fujiwara
IPC分类号： B41M5/382 , B41J31/00 , B41M5/26 , B41M5/392 , B41M5/395
CPC分类号： B41M5/395 , B41M5/26 , Y10S428/913 , Y10S428/914 , Y10T428/273
摘要： The present invention relates to a sublimation ink ribbon capable of printing on a printing paper a still picture image of various kinds of picture images such as a picture image shot by a video camera, a television picture image and the like. At least the surface of its sublimation ink layer is made of a layer containing a sublimation dye whose solubility relative to methyl ethyl ketone is not higher than 2.5g/100 ml or a layer in which a sublimation dye having a solubility higher than 2.5g/100 ml is mixed such that a ratio (P/B) of a weight P of the sublimation dye relative to a weight B of a binder is not higher than 0.5. Thus, it is possible to reduce the under layer soil characteristics.
摘要翻译： PCT No.PCT / JP84 / 00329 Sec。 371日期1985年2月26日第 102（e）1985年2月26日PCT PCT。1984年6月26日PCT公布。公开号WO85 / 00322 日本1985年1月31日。本发明涉及一种升华色带，其能够在打印纸上打印各种图像图像的静止图像图像，例如由摄像机拍摄的图像图像，电视图像图像和喜欢。至少其升华油墨层的表面由含有相对于甲基乙基酮的溶解度不高于2.5g / 100ml的升华染料的层构成，或者其中溶解度高于2.5g / 100ml的升华染料的层，将100ml混合，使得升华染料的重量P相对于粘合剂的重量B的比率（P / B）不高于0.5。因此，可以减少下层土壤特性。

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