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1. 发明授权

US06565784B1 Telecommunications cable composition process 有权
标题翻译：电信电缆组成过程
公开(公告)号：US06565784B1
公开(公告)日：2003-05-20
申请号：US09585698
申请日：2000-06-01
申请人： Mohamed Esseghir , Alex Kharazi , John Francis Wojdyla , Sean Gerard Duffy , Thomas Shiaw-Tong Lin
发明人： Mohamed Esseghir , Alex Kharazi , John Francis Wojdyla , Sean Gerard Duffy , Thomas Shiaw-Tong Lin
IPC分类号： B29C4700
CPC分类号： C08J3/201 , B29B7/007 , B29B7/88 , B29C47/0004 , B29C47/0016 , C08J2323/02 , H01B3/441
摘要： A process for the preparation of a composition useful in telecommunications jacketing comprising: (i) introducing a polyolefin into the first mixing zone of a melt/mixer having first and second mixing zones; (ii) introducing particulate carbon black per se or a premix of said carbon black and polyolefin into the first mixing zone, said carbon black being in an amount of about 2 to about 50 percent based on the weight of the polyolefin introduced into the first mixing zone; (iii) melting the polyolefin in the presence of the carbon black in the first mixing zone; (iv) mixing the carbon black and the molten polyolefin in the first mixing zone to provide a molten mixture; (v) passing the molten mixture from step (iv) into the second mixing zone; (vi) adding sufficient polyolefin to the molten mixture from step (v) to dilute the carbon black to a level of about 2 to about 3 percent by weight based on the weight of the total polyolefin in the melt/mixer; (vii) mixing the added polyolefin with the molten mixture in the second mixing zone to provide a molten mixture; (viii) about simultaneously with step (vii), venting the second mixing zone; (ix) recovering the mixture from step (vii); and (x) optionally, pelletizing the mixture from step (ix).
摘要翻译：一种制备用于电信护套的组合物的方法，包括：（i）将聚烯烃引入具有第一和第二混合区的熔体/混合器的第一混合区中;（ii）引入颗粒状炭黑本身或预混物所述炭黑和聚烯烃进入第一混合区，所述炭黑的量为引入第一混合区的聚烯烃的重量的约2-约50％;（iii）在（iv）将第一混合区中的炭黑和熔融聚烯烃混合以提供熔融混合物;（v）使来自步骤（iv）的熔融混合物进入第二混合区;（vi ）将足够的聚烯烃添加到来自步骤（v）的熔融混合物中以将炭黑稀释至基于熔体/混合器中总聚烯烃重量的约2至约3重量％的水平;（vii）将所加入的聚烯烃与（vii）大约与步骤（vii）同时排出第二混合区;（ix）回收步骤（vii）中的混合物;（vii）和（x）任选地，将步骤（ix）的混合物造粒。

2. 发明申请

US20080247263A1 Method to Increase Production Rate of a Continuous Mixer or Extruder 审中-公开
标题翻译：提高连续搅拌机或挤出机生产率的方法
公开(公告)号：US20080247263A1
公开(公告)日：2008-10-09
申请号：US12065025
申请日：2006-08-02
申请人： Mohamed Esseghir , Alex Kharazi , Anthony C. Neubauer , Albert A. Quaranta
发明人： Mohamed Esseghir , Alex Kharazi , Anthony C. Neubauer , Albert A. Quaranta
IPC分类号： B29C47/10
CPC分类号： B29C48/501 , B29C48/03 , B29C48/285 , B29C48/288 , B29C48/297
摘要： Compounding or extrusion rates can be increased by splitting the polymer solid feed. Melting of additional solid polymer is significantly assisted by excess enthalpy from incoming melt from a primary mixing stage. Depending on resin rheology and melting characteristics, rate increases were achieved of from up to about 55 to about 100% rate increase over the use of a single feed at the same rotor speed. The net result is a decrease in the overall SEI (specific energy input to the polymer) and thus melt temperatures.
摘要翻译：可以通过分离聚合物固体进料来增加复合或挤出速率。额外的固体聚合物的熔融显着地由来自主混合阶段的熔融物的过量焓辅助。根据树脂流变性和熔融特性，在相同转子速度下使用单一进料，实现了高达约55至约100％速率增加的速率增加。最终的结果是总体SEI（对聚合物的比能量输入）降低，从而降低熔融温度。

3. 发明授权

US09080184B2 Transgenic therapeutic stem cells and methods for their use and manufacture 有权
标题翻译：转基因治疗性干细胞及其使用和制造方法
公开(公告)号：US09080184B2
公开(公告)日：2015-07-14
申请号：US13776614
申请日：2013-02-25
申请人： Alex Kharazi , M G Muralidhar , Grigory Vertelov
发明人： Alex Kharazi , M G Muralidhar , Grigory Vertelov
IPC分类号： A61K48/00 , C12N15/63 , C07H21/04 , C12N15/85 , C12N5/16
CPC分类号： C12N15/85 , C07H21/04 , C12N5/0663 , C12N5/16 , C12N15/63 , C12N2510/00
摘要： The invention relates to transgenic stem cells for therapeutic use. Stem cells according to the invention comprise at least one therapeutic trans gene that is expressed when transplanted to a subject. Methods of use and manufacturing the transgenic stem cells of the invention are also contemplated, including the use of transiently transgenic G-CSF bone marrow stem cells for treating the penumbra of ischemic tissues such as central nervous system tissues.
摘要翻译：本发明涉及用于治疗用途的转基因干细胞。根据本发明的干细胞包含至少一种在移植到受试者时表达的治疗性转基因。还考虑使用和制造本发明的转基因干细胞的方法，包括使用瞬时转基因G-CSF骨髓干细胞来治疗缺血组织如半胱氨酸中枢神经系统组织的半暗带。

4. 发明授权

US06426026B1 Process for pelletizing ultra-high melt flow polymers 失效
标题翻译：造粒超高熔体流动聚合物的方法
公开(公告)号：US06426026B1
公开(公告)日：2002-07-30
申请号：US09473532
申请日：1999-12-28
申请人： Marios Avgousti , Edward Allen Leach , Alex Kharazi
发明人： Marios Avgousti , Edward Allen Leach , Alex Kharazi
IPC分类号： B29C4778
CPC分类号： B29B9/06 , B29C47/0011 , B29C47/822 , B29C47/8895 , B29C2035/1616 , B29K2023/06 , B29K2023/12
摘要： Disclosed is a process for pelletizing high melt flow crystalline polymers to produce crystalline pellet products. The process includes feeding a polyolefin granular or pelleted polymer into a melting/mixing mechanism to provide a molten polymer material. The molten polymer material is optionally passed through a melt pump and through a die to form a plurality of molten polymer strands. The plurality of molten polymer strands then are passed through or along a water trough declined with respect to the direction of the horizontal arrays where they are sprayed with cool liquid a plurality of times in such a manner that the sprayed cool liquid creates turbulent flow and disturbs a thin film of hot water and/or steam that forms around each molten polymer strand as it is cooled without undesirable axial acceleration of the polymer strands. Subjecting the molten polymer strands to such a cooling procedure produces cooled polymer strands, which then are fed to a cutting mechanism and cut into pellets. The process produces ultra high melt flow crystalline polymer pellets which are uniformly compounded.
摘要翻译：公开了一种用于造粒高熔体流动结晶聚合物以制备结晶颗粒产品的方法。该方法包括将聚烯烃颗粒状或颗粒状聚合物进料到熔融/混合机构中以提供熔融聚合物材料。熔融聚合物材料任选地通过熔体泵并通过模具以形成多个熔融聚合物股线。然后，多个熔融聚合物链通过或沿着水槽相对于水平阵列的方向下降，其中它们以冷液体喷射多次，使得喷射的冷液体产生湍流和干扰在每个熔融聚合物股线周围形成的热水和/或蒸汽的薄膜，因为它被冷却而不会有不希望的聚合物股线的轴向加速。使熔融的聚合物链条经受这种冷却程序产生冷却的聚合物股线，然后将其送入切割机构并切割成粒料。该方法产生均匀混合的超高熔体流动结晶聚合物颗粒。

5. 发明授权

US06565779B1 Cable semiconducting shield compositions 失效
标题翻译：电缆半导体屏蔽组合物
公开(公告)号：US06565779B1
公开(公告)日：2003-05-20
申请号：US09052429
申请日：1998-03-31
申请人： Alex Kharazi
发明人： Alex Kharazi
IPC分类号： B29C4700
CPC分类号： H01B1/24 , C08K3/04
摘要： A process for the preparation of a semiconducting shield composition comprising: (i) introducing an elastomer into a melt/mixer having a melting zone and a mixing zone; (ii) introducing particulate conductive carbon black into the melt/mixer in an amount of about 10 to about 25 percent by weight based on the weight of the resin; (iii) melting the elastomer in the melting zone; (iv) mixing the carbon black and the molten elastomer in the mixing zone; (v) optionally, pelletizing the mixture of carbon black and elastomer; (vi) recycling the mixture of carbon black and elastomer from step (iv) or the pellets from step (v) to a melt/mixer; (vii) introducing additional particulate semiconductive carbon black into the melt/mixer in an amount sufficient to provide a total amount of carbon black in the range of about 25 to about 50 percent by weight based on the weight of the resin; (viii) melting and mixing the mixture from step (vii); and (ix) pelletizing or extruding the mixture from step (viii).
摘要翻译：一种制备半导体屏蔽组合物的方法，包括：（i）将弹性体引入具有熔融区和混合区的熔体/混合器中;（ii）将颗粒状导电炭黑引入熔体/混合器中，其量约为 10重量％至约25重量％;（iii）在熔融区熔融弹性体;（iv）在混合区中混合炭黑和熔融弹性体;（v）任选地，将混合物造粒的炭黑和弹性体;（vi）将来自步骤（iv）的炭黑和弹性体的混合物或步骤（v）的颗粒再循环到熔体/混合器中;（vii）将另外的颗粒半导体炭黑引入熔体/混合器其量足以提供基于树脂重量的约25至约50重量％范围内的炭黑的总量;（viii）熔融并混合来自步骤（vii）的混合物; 和（ix）从步骤（viii）造粒或挤出混合物。

6. 发明授权

US07674456B2 Breast cancer cell lines and uses thereof 有权
标题翻译：乳腺癌细胞系及其用途
公开(公告)号：US07674456B2
公开(公告)日：2010-03-09
申请号：US10868094
申请日：2004-06-14
申请人： Charles Wiseman , Alex Kharazi
发明人： Charles Wiseman , Alex Kharazi
IPC分类号： A61K35/12
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要： The invention provides, in part, novel SV-BR cancer cell lines. The invention provides a novel cell line SV-BR-1 deposited under ATCC PTA-1712 and SV-BR-1-GM cells deposited under ATCC PTA-1713. The invention further relates to therapeutic and non-therapeutic uses of the novel cell lines. Therapeutic uses include the use of SV-BR cell lines as cancer vaccines, and in particular, or the treatment of cancer.
摘要翻译：本发明部分地提供新型SV-BR癌细胞系。本发明提供了保藏在ATCC PTA-1713和保藏在ATCC PTA-1713下的SV-BR-1-GM细胞的新型细胞系SV-BR-1。本发明还涉及新型细胞系的治疗和非治疗用途。治疗用途包括使用SV-BR细胞系作为癌症疫苗，特别是或治疗癌症。

7. 发明申请

US20050276822A1 Novel breast cancer cell lines and uses thereof 有权
标题翻译：新型乳腺癌细胞系及其用途
公开(公告)号：US20050276822A1
公开(公告)日：2005-12-15
申请号：US10868094
申请日：2004-06-14
申请人： Charles Wiseman , Alex Kharazi
发明人： Charles Wiseman , Alex Kharazi
IPC分类号： A61K39/00 , A61P35/00 , C12N5/08
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要： The invention provides, in part, novel SV-BR cancer cell lines. The invention provides a novel cell line SV-BR-1 deposited under ATCC ______, and SV-BR-1-GM cells deposited under ATCC ______. The invention further relates to therapeutic and non-therapeutic uses of the novel cell lines. Therapeutic uses include the use of SV-BR cell lines as cancer vaccines, and in particular, or the treatment of cancer.
摘要翻译：本发明部分地提供新型SV-BR癌细胞系。本发明提供了保藏在ATCC ______下的新型细胞系SV-BR-1和保藏于ATCC ______下的SV-BR-1-GM细胞。本发明还涉及新型细胞系的治疗和非治疗用途。治疗用途包括使用SV-BR细胞系作为癌症疫苗，特别是或治疗癌症。

8. 发明授权

US06359077B1 Process for producing high melt flow polymers 失效
标题翻译：生产高熔体流动聚合物的方法
公开(公告)号：US06359077B1
公开(公告)日：2002-03-19
申请号：US09537850
申请日：2000-03-29
申请人： Marios Avgousti , Alex Kharazi
发明人： Marios Avgousti , Alex Kharazi
IPC分类号： C08F800
CPC分类号： C08J3/203 , C08F8/50 , C08F110/06 , C08F2810/10 , C08J2323/02 , C08F2500/12
摘要： Disclosed is a process making polyolefin pellet products that contain at least one unreacted free radical generator which, when heated, undergo chemical degradation producing a low viscosity polymer. The process includes contacting the polyolefin pellet with the at least one free radical generator to coat the pellet, and contacting the coated pellets and at least one unreacted free radical generator at an elevated temperature and for a period of time sufficient for the free radical initiator to soak into the interior of the pellets. The process of the invention enables the production of polyolefin pellets having any desired amount of free radical generator and therefore, production of a desired viscosity, and improves the processability of the polyolefin pellet at customer fabrication facilities to thereby provide superior quality final articles.
摘要翻译：公开了一种制造含有至少一种未反应的自由基发生剂的聚烯烃颗粒产品的方法，当加热时，其经历化学降解，产生低粘度聚合物。该方法包括使聚烯烃颗粒与至少一种自由基发生剂接触以包覆颗粒，并使涂覆的颗粒和至少一种未反应的自由基发生剂在升高的温度下接触，并使自由基引发剂足够的时间浸泡在颗粒的内部。本发明的方法能够生产具有任何所需量的自由基发生剂的聚烯烃颗粒，因此产生所需的粘度，并提高客户制造设备处的聚烯烃颗粒的加工性，从而提供优质的最终制品。

9. 发明授权

US5972267A Process for the production of a thermosetting composition 失效
标题翻译：制备热固性组合物的方法
公开(公告)号：US5972267A
公开(公告)日：1999-10-26
申请号：US50566
申请日：1998-03-30
申请人： Alex Kharazi , Neil William Dunchus
发明人： Alex Kharazi , Neil William Dunchus
IPC分类号： C08J3/20 , H01B3/30 , B29C71/02
CPC分类号： H01B3/30 , C08J3/201 , C08J3/203
摘要： A process comprising the following steps: (a) maintaining the process in an essentially oxygen-free state; (b) introducing a first polymer directly from the polymerization reactor in which it was prepared, in molten form, into a mixer/compounder; (c) reducing any higher pressure accompanying the first polymer from the polymerization reactor to the mixer/compounder to a pressure in the range of about 0 to about 5 barg; (d) adding additives selected from the group consisting of antioxidants, second polymers, other polymer enhancing additives, and mixtures thereof to the mixer/compounder, and mixing same with the molten first polymer; (e) passing the molten mixture from step (d) through one or more screens, each having a maximum opening size of about 25 microns; (f) pelletizing the mixture from step (e); (g) introducing the pellets into a spraying chamber, the interior of said chamber being operated in a static condition; (h) spraying the pellets in the chamber with a crosslinking formulation including an organic peroxide and, optionally, a scorch retarder and/or a cure booster to coat the pellets; and (i) annealing the coated pellets to impregnate the pellets with the crosslinking formulation.
摘要翻译：一种方法，包括以下步骤：（a）将该过程保持在基本上无氧状态; （b）将来自其制备的聚合反应器中的第一种聚合物以熔融形式引入混合器/混合器中; （c）将伴随第一聚合物的任何更高的压力从聚合反应器降低至混合器/混合器至约0至约5巴的压力; （d）向混合器/混合机中加入选自抗氧化剂，第二聚合物，其它聚合物增强添加剂及其混合物的添加剂，并将其与熔融的第一聚合物混合; （e）使来自步骤（d）的熔融混合物通过一个或多个筛网，每个筛网具有约25微米的最大开口尺寸; （f）将来自步骤（e）的混合物造粒; （g）将颗粒引入喷雾室中，所述室的内部处于静态状态; （h）用包含有机过氧化物和任选的防焦化剂和/或固化促进剂的交联配制剂将颗粒喷雾在室中以涂覆颗粒; 和（i）对涂覆的颗粒进行退火以用交联制剂浸渍颗粒。

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