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1. 发明授权

US5317029A Pharmaceutical composition of benzopyranes for the inhibition of bone resorption 失效
标题翻译：用于抑制骨吸收的苯并吡喃的药物组合物
公开(公告)号：US5317029A
公开(公告)日：1994-05-31
申请号：US990617
申请日：1992-12-14
申请人： Mizuho Inazu , Ryoichi Satoh , Tsutomu Inoue , Hiroshi Kitagawa , Masakazu Katoh , Heinrich Englert , Denis Carniato , Hans-Jochen Lang
发明人： Mizuho Inazu , Ryoichi Satoh , Tsutomu Inoue , Hiroshi Kitagawa , Masakazu Katoh , Heinrich Englert , Denis Carniato , Hans-Jochen Lang
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/4025 , A61K31/435 , A61K31/44 , A61K31/443 , A61P3/00 , A61P19/10 , A61P43/00 , C07D405/04 , A61K31/35 , A61K31/53
CPC分类号： A61K31/40 , A61K31/44
摘要： Pharmaceutical compositions for the inhibition of bone resorption comprising a pharmaceutical carrier and a therapeutically effective amount of a benzopyran derivative represented by the general formula (I) ##STR1## wherein the broken-lined bond denotes an optional double bond, R.sub.1 denotes a hydrogen atom or a hydroxyl group, R.sub.2 denotes a cyano group, a phenylsulfonyl group or a halogen-substituted methoxyl group, and R.sub.3 denotes a group having the formula ##STR2## Since they inhibit bone resorption, they are useful for the treatment and prevention of diseases associated with bone metabolism.
摘要翻译：用于抑制骨吸收的药物组合物，其包含药物载体和治疗有效量的由通式（I）表示的苯并吡喃衍生物，其中破碎的键表示任选的双键，R 1表示氢原子或羟基，R2表示氰基，苯基磺酰基或卤素取代的甲氧基，R3表示具有下式的基团：由于它们抑制骨吸收，因此它们可用于治疗和预防与骨代谢相关的疾病。

2. 发明授权

US5364868A Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them 失效
标题翻译：氨基取代的苯甲酰胍，其制备方法，它们作为药物的用途和含有它们的药物
公开(公告)号：US5364868A
公开(公告)日：1994-11-15
申请号：US16535
申请日：1993-02-11
申请人： Heinrich Englert , Dieter Mania , Hans-Jochen Lang , Wolfgang Scholz , Wolfgang Linz , Udo Albus
发明人： Heinrich Englert , Dieter Mania , Hans-Jochen Lang , Wolfgang Scholz , Wolfgang Linz , Udo Albus
IPC分类号： A61K31/155 , A61K31/165 , A61K31/445 , A61P1/16 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P35/00 , C07C279/22 , C07D213/65 , C07D295/14 , C07D295/155 , C07C279/10 , C07D207/06 , C07D211/28
CPC分类号： C07D295/155 , C07C279/22 , C07D213/65
摘要： Amino-substituted benzoylguanidines, process for their preparation, their use as a medicament and medicament containing themBenzoylguanidines of the formula I ##STR1## are described in which R(1) or R(2) is an amino group --NR(3)R(4), where R(3) and R(4) are H or (cyclo)alkyl or R(3) is phenyl-(CH.sub.2).sub.p -- where p=0, 1, 2, 3 or 4, or phenyl, or R(3) and R(4) can also together be a methylene chain, and in which the other substituent R(1) or R(2) in each case is H, F, Cl, alkyl, alkoxy, CF.sub.3, C.sub.m F.sub.2m+1 --CH.sub.2 --, benzyl or phenoxy, and their pharmaceutically tolerable salts.The compounds according to the invention have very good antiarrhythmic properties, as occur, for example, in the case of oxygen deficiency symptoms. The compounds are used as antiarrhythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment as well as for the treatment of angina pectoris, where they also preventively inhibit or greatly decrease the pathophysiological processes in the formation of ischemically induced damage, in particular in the production of ischemically induced cardiac arrhythmias.
摘要翻译：氨基取代的苯甲酰胍，其制备方法，它们作为药物的用途和含有它们的药物描述了其中R（1）或R（2）是氨基-NR（ 3）R（4）其中R（3）和R（4）是H或（环）烷基或R（3）是苯基 - （CH 2）p - ，其中p = 0,1,2,3或4，或苯基或R（3）和R（4）也可以一起为亚甲基链，其中每种情况下其它取代基R（1）或R（2）为H，F，Cl，烷基，烷氧基， CF3，CmF2m + 1-CH2-，苄基或苯氧基，及其药学上可耐受的盐。根据本发明的化合物具有非常好的抗心律失常性质，例如在缺氧症状的情况下发生。该化合物被用作具有用于梗塞预防和梗塞治疗的心脏保护组分以及用于治疗心绞痛的抗心律失常药物，其中它们也预防性地抑制或大大降低缺血诱导的损伤形成中的病理生理过程，特别是在产生缺血诱导的心律失常。

3. 发明授权

US5591754A Benzoylguanidines, pharmaceutical composition containing them and treatment of arrthythmias therewith 失效
标题翻译：苯甲酰胍，含有它们的药物组合物和治疗心律失常
公开(公告)号：US5591754A
公开(公告)日：1997-01-07
申请号：US437552
申请日：1995-05-05
申请人： Hans-Jochen Lang , Andreas Weichert , Heinz-Werner Kleemann , Heinrich Englert , Wolfgang Scholz , Udo Albus
发明人： Hans-Jochen Lang , Andreas Weichert , Heinz-Werner Kleemann , Heinrich Englert , Wolfgang Scholz , Udo Albus
IPC分类号： A61K31/00 , A61K31/155 , A61K31/445 , A61P1/16 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P35/00 , C07C311/16 , C07C311/21 , C07C311/29 , C07C317/24 , C07C317/44 , C07C317/46 , C07C317/48 , C07C323/22 , C07C323/65 , C07D211/14 , C07D211/70 , C07D295/14 , C07D295/155 , A61K31/165 , C07D211/28
CPC分类号： C07D295/155 , A61K31/155 , C07C311/16 , C07C311/29 , C07C317/44 , C07C317/46 , C07C317/48 , C07C323/65 , C07D211/70 , C07C2101/08 , C07C2101/14
摘要： Benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them.The invention relates to benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is R(3)-S(O).sub.n -- or R(4)R(5)N--O.sub.2 S-- and the other substituent R(1) or R(2) in each case is H, OH, F, Cl, Br, I, alkyl, alkoxy, benzyloxy or phenoxy, R(3)-S(O).sub.n or R(4)R(5)N-- or 3,4-dehydropiperidine and R(3) is alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(4) and R(5) are alkyl or phenylalkyl or phenyl,and in which R (4) and R (5) can also together be a C.sub.4 -C.sub.7 -chain, and in which R(4) and R(5), together with the nitrogen atom to which they are bonded, can be a dihydroindole, tetrahydroquinoline or tetrahydroisoquinoline system,and where n is zero, 1 or 2 and their pharmaceutically tolerable salts are excellent antiarrhythmics.
摘要翻译：苯甲酰胍，其制备方法，它们作为药物的用途和含有它们的药物。本发明涉及式I的苯甲酰胍，其中R（1）或R（2）是R（3）-S（O）n - 或R（4）R（5）N-O 2 S- R（3）-S（O）n或R（4）其中R（1）或R（2）各自为H，OH，F，Cl，Br，I，烷基，烷氧基， R（5）N-或3,4-脱水哌啶，R（3）为烷基，环烷基，环戊基甲基，环己基甲基或苯基，R（4）和R（5）为烷基或苯基烷基或苯基，其中R ）和R（5）也可以一起是C 4 -C 7链，其中R（4）和R（5）与它们所键合的氮原子一起可以是二氢吲哚，四氢喹啉或四氢异喹啉体系，并且其中n为0,1或2及其药学上可耐受的盐是优异的抗心律失常药物。

4. 发明授权

US5416094A Antiarrhythmic and cardioprotective substituted -1(2H)isoquinolines, medicament containing them, and their use for combating heart failures 失效
标题翻译：抗心律失常和心脏保护性取代的-1（2H）异喹啉，含有它们的药物及其对抗心力衰竭的用途
公开(公告)号：US5416094A
公开(公告)日：1995-05-16
申请号：US126200
申请日：1993-09-24
申请人： Bansi Lal , Ramesh Gidwani , Ramanujam Rajagopalan , Radha Panicker , Chinnakulandai Sankar , Hans-Jochen Lang , Heinrich Englert , Wolfgang Scholz
发明人： Bansi Lal , Ramesh Gidwani , Ramanujam Rajagopalan , Radha Panicker , Chinnakulandai Sankar , Hans-Jochen Lang , Heinrich Englert , Wolfgang Scholz
IPC分类号： A61K31/47 , A61K31/472 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , C07D217/26 , C07D401/04 , C07D401/12 , C07D413/04 , C07D413/12 , C07D217/12
CPC分类号： C07D401/04 , C07D217/26 , C07D413/04
摘要： Described are guanidinocarbonyl isoquinolines of the formula I, ##STR1## wherein R(1) is hydrogen, (amino) (cyclo) (aryl)alk(en)yl (heteroaryl); R(2) is hydrogen, halogen, alkyl, or aryl; G is a radical of the formula VII: ##STR2## X(2), X(3) and X(4) are hydrogen, halogen, nitro, amino, alkyl, sulfonamide, (mono) (di) (lower alkyl) (amino), benzyloxy, hydroxy; X(1) hydrogen, oxygen, sulfur and NR(7)R(8), and their pharmaceutically acceptable salts; described is also a process for their preparation, their use as medicaments, and medicaments containing them for treating congestive heart failure, and arrhythmic conditions as well as cardioprotective agents in mammals.
摘要翻译：描述了式I，其中R（1）是氢，（氨基）（环）（芳基）烷基（烯）基（杂芳基））的胍基羰基异喹啉。 R（2）是氢，卤素，烷基或芳基; G是式VII的基团：X（2），X（3）和X（4）是氢，卤素，硝基，氨基，烷基，磺酰胺，（单）（二）（低级烷基）（氨基），苄氧基，羟基; X（1）氢，氧，硫和NR（7）R（8）及其药学上可接受的盐; 也描述了它们的制备方法，它们作为药物的用途，以及含有它们用于治疗充血性心力衰竭的药物，以及心律失常病症以及哺乳动物的心脏保护剂。

5. 发明授权

US5516805A 3,5-substituted aminobenzoylguanidines, their use as a medicament or diagnostic and medicament containing them 失效
标题翻译： 3,5-取代的氨基苯甲酰基胍，它们用作药物或诊断剂以及含有它们的药物
公开(公告)号：US5516805A
公开(公告)日：1996-05-14
申请号：US450225
申请日：1995-05-25
申请人： Hans-Jochen Lang , Heinrich Englert , Andreas Weichert , Heinz-Werner Kleemann , Wolfgang Scholz , Udo Albus
发明人： Hans-Jochen Lang , Heinrich Englert , Andreas Weichert , Heinz-Werner Kleemann , Wolfgang Scholz , Udo Albus
IPC分类号： A61K31/165 , A61K31/155 , A61K49/00 , A61P1/04 , A61P9/00 , A61P9/10 , A61P35/00 , A61P43/00 , C07C279/22 , C07C311/16
CPC分类号： C07C279/22
摘要： 3,5-Substituted aminobenzoylguanidines, process for their preparation, their use as a medicament or diagnostic and medicament containing themThere are described benzoylguanidines of the formula I ##STR1## where one of the substituents R(1), R(2), R(3) or R(4) is: an amino group ##STR2## where R(5), R(6)=inter alia, H or alkyl, or alternatively R(5) and R(6), together with the nitrogen atom, are a 5-7-membered ring, and the other substituents R(1), R(2), R(3) and R(4) in each case are: H, Hal, CN, CF.sub.3, NO.sub.2, CF.sub.3 --O--, C.sub.m F.sub.2m+1 --CH.sub.2 --O--, R(11)--C.sub.q H.sub.2q --X.sub.p --, X=O or NR(12), R(11)=H, (cyclo)alkyl, phenyl, and where R(1) and R(4) are not simultaneously hydrogen.The compounds I have very good antiarrhythmic and cardio-protective properties, but no undesired salidiuretic properties. They additionally exhibit protective properties against is chemically induced damage in vivo and in vitro in different organs and gastroprotective properties as a result of inhibition of gastric acid secretion. Moreover, they are distinguished by inhibitory action on the proliferation of cells.
摘要翻译： 3,5-取代的氨基苯甲酰胍，其制备方法，它们作为药物或诊断剂的用途和含有它们的药物描述了式I（I）的苯甲酰胍，其中取代基R（1），R（2 ），R（3）或R（4）是：氨基，其中R（5），R（6）=特别是H或烷基，或者R（5）和R（6）与氮原子一起为5-7元环，其他取代基R（1），R（2），R（3）和R（4）分别为：H，Hal，CN，CF 3， NO2，CF3-O-，CmF2m + 1-CH2-O-，R（11）-CqH2q-Xp-，X = O或NR（12），R（11）= H，（环）烷基，苯基和其中R（1）和R（4）不同时为氢。化合物I具有非常好的抗心律失常和心脏保护作用，但没有不希望的耐盐性。它们另外表现出防止由于抑制胃酸分泌而导致的体内和体外在不同器官和胃保护性质中的化学诱导的损伤的保护性。此外，它们通过对细胞增殖的抑制作用来区分。

6. 发明授权

US5373024A 3,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament of diagnostic and medicament containing them 失效
标题翻译： 3,5-取代的苯甲酰胍，其制备方法，它们作为含有它们的诊断药物和药物的用途
公开(公告)号：US5373024A
公开(公告)日：1994-12-13
申请号：US15926
申请日：1993-02-10
申请人： Florian Lang , Hans-Jochen Lang , Dieter Mania , Andreas Weichert , Wolfgang Scholz , Udo Albus , Heinrich Englert
发明人： Florian Lang , Hans-Jochen Lang , Dieter Mania , Andreas Weichert , Wolfgang Scholz , Udo Albus , Heinrich Englert
IPC分类号： A61K31/155 , A61K31/18 , A61K31/275 , A61P1/16 , A61P3/08 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P35/00 , A61P35/04 , C07C217/44 , C07C311/16 , C07C311/37 , C07C311/39 , C07C311/47 , C07C317/42 , C07C317/44 , C07C323/65 , C07C279/22
CPC分类号： C07C217/44 , C07C311/16 , Y10S514/821
摘要： Benzoylguanidines of the formula I ##STR1## are described where R(1) is R(4)--SO.sub.m or R(5)R(6)N--SO.sub.z --, where R(4) and R(5) are alk(en)yl or --C.sub.n H.sub.2n --R(7), and where R(7) is a cycloalkyl or phenyl, where R(5) also has the meaning of H, and R(6) is H or C.sub.1 -C.sub.4 -alkyl, R(2) is hydrogen, halogen, alkyl, O--(CH.sub.2).sub.m C.sub.p F.sub.2p+1, --X--R(10), where X is O, S or NR(11), R(10) is H, (cyclo)alkyl(methyl) or --C.sub.n H.sub.2n --R(12) where R(12) is phenyl, and R(3) is defined, inter alia, as R(1), and their pharmaceutically tolerable salts.The compounds I are obtained by reaction of compounds of the formula II ##STR2## with guanidine, in which L is a leaving group which can be easily nucleophilically substituted.Compounds I are outstandingly suitable as antiarrythmic pharmaceuticals having a cardioprotective component for infarct prophylaxis and infarct treatment and for the treatment of angina pectoris, where they also preventively inhibit or greatly reduce the pathophysiological processes during the formation of ischemically induced damage. They are moreover distinguished by strong inhibitory action on the proliferation of cells. They can therefore be used as antiatherosclerotics, agents against late-onset diabetic complications, cancers, and fibrotic diseases such as pulmonary fibrosis, fibrosis of the liver or fibrosis of the kidneys.They are effective inhibitors of the cellular sodium/proton antiporter (Na.sup.+ /H.sup.+ exchanger).
摘要翻译：其中R（1）为R（4）-SOm或R（5）R（6）N-SOz-，其中R（4）和R（5）为烷基（烯）或-C n H 2n-R（7），其中R（7）为环烷基或苯基，其中R（5）也为H，R（6）为H或C 1 -C 4 - 烷基，R（2）为氢，卤素，烷基，O-（CH2）mCpF2p + 1，-XR（10）其中X为O，S或NR（11），R（10）为H，（环）烷基（甲基）或-CnH2n-R（12）其中R（12）为苯基，R（3）特别定义为R（1）及其药学上可耐受的盐。化合物I通过式II化合物（II）与胍反应而获得，其中L是可容易地亲核取代的离去基团。化合物I非常适合作为具有用于梗死预防和梗塞治疗的心脏保护组分和用于治疗心绞痛的抗焦虑药物，其中它们还预防性地抑制或大大降低在缺血诱导的损伤形成期间的病理生理过程。此外，它们通过对细胞增殖的强抑制作用而不同。因此，它们可以用作抗动脉粥样硬化，抗晚发性糖尿病并发症，癌症和纤维化疾病如肺纤维化，肝纤维化或肾纤维化的药物。它们是细胞钠/质子反转录酶（Na + / H +交换剂）的有效抑制剂。

7. 发明授权

US06820663B2 Tool for machining workpieces of wood, plastic material or the like 失效
标题翻译：用于加工木材，塑料材料等的工件的工具
公开(公告)号：US06820663B2
公开(公告)日：2004-11-23
申请号：US10143167
申请日：2002-05-10
申请人： Heinrich Englert , Albrecht Dawidziak , Josef Ballweg , Bernd Martin
发明人： Heinrich Englert , Albrecht Dawidziak , Josef Ballweg , Bernd Martin
IPC分类号： B27C900
CPC分类号： B27C1/08 , B27G13/007
摘要： A tool for machining workpieces of wood, plastic material, or the like has at least one plane head provided with cutting knives and having a first end and a second end. A first surface milling cutter is arranged on the first end of the plane head. At least one second surface milling cutter is connected to the plane head and is adjustable relative to the first surface milling cutter. The plane head has at least one axial guide for the second surface milling cutter. The axial guide is a fitting groove provided in the mantle surface of the plane head. The second surface milling cutter has a feather key engaging the fitting groove.
摘要翻译：用于加工木材，塑料材料等的工件的工具具有至少一个平面头，该平面头设置有切割刀并且具有第一端和第二端。第一表面铣刀布置在平面头的第一端上。至少一个第二表面铣刀连接到平面头部并且可相对于第一表面铣刀进行调节。平面头具有用于第二表面铣刀的至少一个轴向引导件。轴向引导件是设置在平面头的外套表面中的配合槽。第二表面铣刀具有接合配合槽的羽毛键。

8. 发明授权

US06561239B2 Machine for machining workpieces of wood, plastic and the like, in particular, a molding machine, and a method for adjusting such a machine 失效
标题翻译：用于加工木材，塑料等的工件的机器，特别是成型机，以及用于调节这种机器的方法
公开(公告)号：US06561239B2
公开(公告)日：2003-05-13
申请号：US09794893
申请日：2001-02-26
申请人： Heinrich Englert
发明人： Heinrich Englert
IPC分类号： B23Q1500
CPC分类号： G05B19/4093 , B23Q17/12 , B27C5/02 , G05B2219/31304 , G05B2219/45229 , G05B2219/49302 , G05B2219/50299 , Y02P90/10 , Y02P90/265 , Y10T409/30728
摘要： A machine for machining workpieces of wood and plastic has a transport path for transporting workpieces through the machine. One or more driven spindles having a tool for machining the workpieces transported through the machine are provided. An adjustable element that is adjustable relative to the tool is provided. At least one data storage is provided for storing data at least of the tool wherein the data are used to determine a position of the adjustable element relative to the tool and are retrievable. In the method for adjusting the machine, characteristic data of the tool are measured and stored in the data storage. The characteristic data are supplied to a control unit. In the control unit positioning data for the adjustable element are calculated based on the characteristic data and then made available for processing the workpieces.
摘要翻译：用于加工木材和塑料工件的机器具有用于通过机器输送工件的输送路径。提供了一个或多个从动轴，其具有用于加工通过机器传送的工件的工具。提供了相对于工具可调节的可调元件。提供至少一个数据存储器用于存储至少该工具的数据，其中数据用于确定可调节元件相对于工具的位置并且是可检索的。在调整机器的方法中，测量工具的特征数据并将其存储在数据存储器中。特征数据被提供给控制单元。在控制单元中，基于特征数据计算可调元件的定位数据，然后使其可用于处理工件。

9. 发明授权

US06335467B1 Substituted benzenesulfonylureas and thioureas-process for their preparation and their use as pharmaceuticals 有权
标题翻译：取代苯磺酰脲和硫脲制备方法及其作为药物的用途
公开(公告)号：US06335467B1
公开(公告)日：2002-01-01
申请号：US09490078
申请日：2000-01-24
申请人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gögelein , Joachim Kaiser , Wolfgang Linz , David Wettlauper
发明人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gögelein , Joachim Kaiser , Wolfgang Linz , David Wettlauper
IPC分类号： C07C31116
CPC分类号： C07C311/46 , C07C311/58 , C07C335/42 , Y10S514/821
摘要： Benzenesulfonylureas and -thioureas of the formula I where R(1) in N or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(oxy)yl, E is O or S, Y is —[CR(3)2]n—, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO2 or alk(yl)oxy, are described. The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
摘要翻译：苯基磺酰脲和硫脲，其中R（1）在N或（氟）甲基中，R（2）是H，Hal或（氟）（巯基）烷（氧）），E是O或S，Y是 - [CR（3）2] n-，其中R（3）= H或烷基，n = 1-4，X为H，Hal或烷基，Z为Hal，NO 2或烷基（yl）化合物I用于治疗心律紊乱和预防心律失常引起的心源性猝死，因此可用作抗心律失常药物。它们特别适用于心律失常是冠状血管狭窄（如心绞痛或急性心肌梗死）的结果的情况。

10. 发明授权

US5698596A Substituted benzenesulfonylureas and thioureas process for their preparation and their use as pharmaceuticals 失效
标题翻译：取代苯磺酰脲和硫脲的制备方法及其作为药物的用途
公开(公告)号：US5698596A
公开(公告)日：1997-12-16
申请号：US707103
申请日：1996-09-03
申请人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
发明人： Heinrich Englert , Dieter Mania , Jens Hartung , Heinz Gogelein , Joachim Kaiser , Wolfgang Linz , David Wettlaufer
IPC分类号： A61K31/18 , A61K31/64 , A61P9/00 , A61P9/04 , A61P9/10 , C07C303/40 , C07C311/46 , C07C311/58 , C07C323/67 , C07C335/42 , A61K31/17
CPC分类号： C07C311/46 , C07C311/58 , C07C335/42 , Y10S514/821
摘要： Substituted benzenesulfonylureas and -thioureas--processes for their preparation and their use as pharmaceuticals Benzenesulfonylureas and -thioureas of the formula I ##STR1## where R(1) is H or (fluoro)methyl, R(2) is H, Hal or (fluoro)(mercapto)alk(oxy)yl, E is O or S; Y is --�CR(3).sub.2 !.sub.n --, where R(3)=H or alkyl and n=1-4, X is H, Hal or alkyl and Z is Hal, NO.sub.2 or alk(yl)oxy, are described. The compounds I are used for treatment of disturbances in cardiac rhythm and prevention of sudden cardiac death caused by arrhythmia, and can therefore be used as antiarrhythmics. They are particularly suitable for those cases where arrhythmias are a consequence of a narrowing of a coronary vessel, such as angina pectoris or acute cardiac infarction.
摘要翻译：取代的苯磺酰脲和硫脲 - 其制备方法及其作为药物的用途式I的苯磺酰脲和硫脲其中R（1）为H或（氟）甲基，R（2）为H，Hal或（氟）（巯基）烷（氧）基，E是O或S; Y是 - [CR（3）2] n - ，其中R（3）= H或烷基，n = 1-4，X是H，Hal或烷基，Z是Hal，NO 2或烷基（yl）描述。化合物I用于治疗心律紊乱和预防心律失常引起的心源性猝死，因此可用作抗心律失常药物。它们特别适用于心律失常是冠状血管狭窄（如心绞痛或急性心肌梗死）的结果的情况。

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