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1. 发明授权

US08815924B2 Heterocyclic carbonyl compounds 有权
标题翻译：杂环羰基化合物
公开(公告)号：US08815924B2
公开(公告)日：2014-08-26
申请号：US11665854
申请日：2005-04-04
申请人： Dieter Dorsch , Rolf Gericke , Werner Mederski , Norbert Beier , Florian Lang
发明人： Dieter Dorsch , Rolf Gericke , Werner Mederski , Norbert Beier , Florian Lang
IPC分类号： A61K31/421 , A61K31/422 , A61K31/416 , A61K31/4178 , A61K31/341 , C07D413/00 , C07D413/02 , C07D233/54 , C07D231/56 , C07D307/34
CPC分类号： A61K31/421 , A61K31/341 , A61K31/416 , A61K31/4178 , A61K31/422 , C07D231/56 , C07D233/54 , C07D233/68 , C07D263/34 , C07D277/56 , C07D307/34 , C07D307/68 , C07D333/38 , C07D413/00 , C07D413/02
摘要： Novel heterocyclic compounds of the formula (I), in which R1, D, W, T and T′ have the meanings indicated in Claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.
摘要翻译：式（I）的新型杂环化合物，其中R1，D，W，T和T'具有权利要求1所示的含义，是SGK抑制剂，可用于治疗SGK诱导的疾病和病症，例如糖尿病，肥胖症，代谢综合征（血脂异常），全身和肺性高血压，心血管疾病和肾脏疾病，通常在任何类型的纤维和炎症过程中。

2. 发明授权

US08207210B2 Aminoindazolylurea derivatives 有权
标题翻译：氨基吲唑基脲衍生物
公开(公告)号：US08207210B2
公开(公告)日：2012-06-26
申请号：US12374100
申请日：2007-06-18
申请人： Markus Klein , Rolf Gericke , Norbert Beier , Florian Lang
发明人： Markus Klein , Rolf Gericke , Norbert Beier , Florian Lang
IPC分类号： A61K31/415 , C07D231/56
CPC分类号： C07D231/56
摘要： Novel aminoindazolylurea derivatives of the formula I (I), in which R1, R2, R3, R4, R5, X and Y have the meanings indicated in Claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.
摘要翻译：其中R 1，R 2，R 3，R 4，R 5，X和Y具有权利要求1所示含义的式I（I）的新型氨基吲唑基脲衍生物是SGK抑制剂，可用于治疗SGK诱导的疾病，通常在任何类型的纤维和炎症过程中，诸如糖尿病，肥胖，代谢综合征（血脂异常），全身和肺性高血压，心血管疾病和肾脏疾病的投诉。

3. 发明授权

US07850194B2 Footbed for gliding board binding 有权
标题翻译：脚踏板滑板固定
公开(公告)号：US07850194B2
公开(公告)日：2010-12-14
申请号：US12398949
申请日：2009-03-05
申请人： Kahlil Zaloom , Christopher C. Cunningham , Florian Lang , Matt Windt , Christopher M. Doyle , Richard William Wagner, Jr. , Ryan Larson , Gregory Aaron Dean , Greg Reagan
发明人： Kahlil Zaloom , Christopher C. Cunningham , Florian Lang , Matt Windt , Christopher M. Doyle , Richard William Wagner, Jr. , Ryan Larson , Gregory Aaron Dean , Greg Reagan
IPC分类号： A63C9/00
CPC分类号： A63C10/285 , A63C5/03 , A63C5/128 , A63C10/04 , A63C10/18 , A63C10/20 , A63C10/22 , A63C10/24 , A63C10/26
摘要： A method and apparatus for providing a gliding board binding, such as a snowboard binding. The binding may include an adjustment indicator that allows for determination of a longitudinal position of the base relative to a gliding board, heel-to-toe position of the base relative to a gliding board and/or an angular position of the base relative to a gliding board when the base is secured to the gliding board. The adjustment indicator may be included with a footbed that is removable from a binding base, e.g., that includes a foot engagement member to secure a rider's foot to the binding and board. A removable footbed may include a toe portion that is adjustable in position relative to a heel portion of the footbed. A gliding board may include a channel for mounting a binding that is arranged in the board core so that no portion of the board core is located on top or bottom sides of the channel, and instead so the top and bottom reinforcement layers are located above and below the channel.
摘要翻译：一种用于提供滑行板结合的方法和装置，例如滑雪板结合。装订可以包括调整指示器，其允许确定基座相对于滑板的纵向位置，基座相对于滑板的脚跟到脚趾位置和/或基座相对于滑动板的角位置当基座固定在滑板上时滑翔板。调节指示器可以包括可从装订基座移除的脚部，例如包括脚部接合构件以将骑手的脚固定到装订和板上。可移除的脚垫可以包括相对于脚踏板的跟部可调节的脚趾部分。滑板可以包括用于安装布置在板芯中的装订的通道，使得板芯的任何部分不位于通道的顶侧或底侧，而是顶部和底部加强层位于上方和在频道下方

4. 发明授权

US07762573B2 Footbed for gliding board binding 有权
公开(公告)号：US07762573B2
公开(公告)日：2010-07-27
申请号：US11825652
申请日：2007-07-06
申请人： Kahlil Zaloom , Christopher C. Cunningham , Florian Lang , Matt Windt , Christopher M. Doyle , Richard William Wagner, Jr. , Ryan Larson , Gregory Aaron Dean , Greg Reagan
发明人： Kahlil Zaloom , Christopher C. Cunningham , Florian Lang , Matt Windt , Christopher M. Doyle , Richard William Wagner, Jr. , Ryan Larson , Gregory Aaron Dean , Greg Reagan
IPC分类号： A63C9/00
CPC分类号： A63C10/285 , A63C5/03 , A63C5/128 , A63C10/04 , A63C10/18 , A63C10/20 , A63C10/22 , A63C10/24 , A63C10/26
摘要： A method and apparatus for providing a gliding board binding, such as a snowboard binding. The binding may include an adjustment indicator that allows for determination of a longitudinal position of the base relative to a gliding board, heel-to-toe position of the base relative to a gliding board and/or an angular position of the base relative to a gliding board when the base is secured to the gliding board. The adjustment indicator may be included with a footbed that is removable from a binding base, e.g., that includes a foot engagement member to secure a rider's foot to the binding and board. A removable footbed may include a toe portion that is adjustable in position relative to a heel portion of the footbed. A gliding board may include a channel for mounting a binding that is arranged in the board core so that no portion of the board core is located on top or bottom sides of the channel, and instead so the top and bottom reinforcement layers are located above and below the channel.

5. 发明授权

US07669880B2 Strap for snowboard boots or bindings 失效
公开(公告)号：US07669880B2
公开(公告)日：2010-03-02
申请号：US11215727
申请日：2005-08-29
申请人： Christopher Doyle , Ryan Larson , Gregory Dean , Florian Lang
发明人： Christopher Doyle , Ryan Larson , Gregory Dean , Florian Lang
IPC分类号： A63C9/18
CPC分类号： A43C11/146 , A63C10/06 , A63C10/24
摘要： A binding or boot strap is provided that allows a rider to easily, rapidly and/or effectively tighten and/or loosen the strap about his or her boot. The strap includes a boot-engaging strap portion that engages with an engagement strap coupleable to the boot, as may be the case with boots used for step-in bindings, or to the binding, as may be the case with strap-type bindings. An arrangement for facilitating tightening/loosening of the two strap pieces so that a rider can slip his or her foot into or out from the boot or fasten the boot to or loosen it from a snowboard binding is also provided. In one embodiment, this arrangement includes a tightening element, such as for example a cord, lace or strap, suitably coupled to one or both strap portions such that a rider can pull on the tightening element to move the strap pieces relative to each other and tighten the strap. The tightening arrangement may be configured with a mechanical advantage whereby the force applied to the tightening element results in a greater force applied to the strap. To take up any excess amount of tightening element after the strap has been tightened, a retraction device, such as a self-winding spool, may be utilized. To separate the strap from the boot or binding, a hook and catch arrangement may be employed.

6. 发明授权

US07619115B2 Ortho-substituted N'-benzylidene-(3-hydroxyphenyl)acethydrazides 失效
标题翻译：正 - 取代的N'-亚苄基 - （3-羟基苯基）乙酰肼
公开(公告)号：US07619115B2
公开(公告)日：2009-11-17
申请号：US11630827
申请日：2005-06-06
申请人： Rolf Gericke , Dieter Dorsch , Werner Mederski , Norbert Beier , Florian Lang
发明人： Rolf Gericke , Dieter Dorsch , Werner Mederski , Norbert Beier , Florian Lang
IPC分类号： C07C243/18 , A61K31/195
CPC分类号： C07C251/86 , C07D295/135
摘要： Novel ortho-substituted N′-benzylidene-(3-hydroxyphenyl)acetohydrazides of the formula (I), in which R1-R9 have the meanings indicated in claim 1, are SGK inhibitors and can be used for the treatment of SGK-induced diseases and conditions, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in fibroses and inflammatory processes of any type.
摘要翻译：式（I）的新型邻位取代的N'-亚苄基 - （3-羟基苯基）乙酰肼，其中R 1 -R 9具有权利要求1所示的含义，是SGK抑制剂，可用于治疗SGK诱发的疾病和诸如糖尿病，肥胖症，代谢综合征（血脂异常），全身和肺性高血压，心血管疾病和肾脏疾病之类的病症，通常在任何类型的纤维和炎症过程中。

7. 发明申请

US20090194972A1 FOOTBED FOR GLIDING BOARD BINDING 有权
标题翻译：冰盖板绑定
公开(公告)号：US20090194972A1
公开(公告)日：2009-08-06
申请号：US12398949
申请日：2009-03-05
申请人： Kahlil Zaloom , Christopher C. Cunningham , Florian Lang , Matt Windt , Christopher M. Doyle , Richard William Wagner, JR. , Ryan Larson , Gregory Aaron Dean , Greg Reagan
发明人： Kahlil Zaloom , Christopher C. Cunningham , Florian Lang , Matt Windt , Christopher M. Doyle , Richard William Wagner, JR. , Ryan Larson , Gregory Aaron Dean , Greg Reagan
IPC分类号： A63C9/00
CPC分类号： A63C10/285 , A63C5/03 , A63C5/128 , A63C10/04 , A63C10/18 , A63C10/20 , A63C10/22 , A63C10/24 , A63C10/26
摘要： A method and apparatus for providing a gliding board binding, such as a snowboard binding. The binding may include an adjustment indicator that allows for determination of a longitudinal position of the base relative to a gliding board, heel-to-toe position of the base relative to a gliding board and/or an angular position of the base relative to a gliding board when the base is secured to the gliding board. The adjustment indicator may be included with a footbed that is removable from a binding base, e.g., that includes a foot engagement member to secure a rider's foot to the binding and board. A removable footbed may include a toe portion that is adjustable in position relative to a heel portion of the footbed. A gliding board may include a channel for mounting a binding that is arranged in the board core so that no portion of the board core is located on top or bottom sides of the channel, and instead so the top and bottom reinforcement layers are located above and below the channel.
摘要翻译：一种用于提供滑行板结合的方法和装置，例如滑雪板结合。装订可以包括调整指示器，其允许确定基座相对于滑板的纵向位置，基座相对于滑板的脚跟到脚趾位置和/或基座相对于滑动板的角位置当基座固定在滑板上时滑翔板。调节指示器可以包括可从装订基座移除的脚部，例如包括脚部接合构件以将骑手的脚固定到装订和板上。可移除的脚垫可以包括相对于脚踏板的脚跟部分可调节的脚趾部分。滑动板可以包括用于安装布置在板芯中的装订的通道，使得板芯的任何部分不位于通道的顶侧或底侧，而是顶部和底部加强层位于上方和/ 在频道下方

8. 发明申请

US20090076091A1 INDAZOLE-HETEROARYL DERIVATIVES 有权
标题翻译：异吲哚衍生物
公开(公告)号：US20090076091A1
公开(公告)日：2009-03-19
申请号：US12278307
申请日：2007-01-10
申请人： Markus Klein , Rolf Gericke , Werner Mederski , Norbert Beier , Florian Lang
发明人： Markus Klein , Rolf Gericke , Werner Mederski , Norbert Beier , Florian Lang
IPC分类号： A61K31/4439 , C07D405/14
CPC分类号： C07D405/04 , C07D405/14 , C07D409/14
摘要： The invention relates to novel indazole derivatives as cited in claim 1, which are inhibitors of CHK1, CHK2 and SGK kinases and can be used to treat cancer and other diseases.
摘要翻译：本发明涉及权利要求1所述的新的吲唑衍生物，其是CHK1，CHK2和SGK激酶的抑制剂，可用于治疗癌症和其它疾病。

9. 发明申请

US20090036508A1 AMINO INDAZOLE DERIVATIVES 审中-公开
标题翻译：氨基吲哚衍生物
公开(公告)号：US20090036508A1
公开(公告)日：2009-02-05
申请号：US12278325
申请日：2007-01-10
申请人： Markus Klein , Rolf Gericke , Werner Mederski , Norbert Beier , Florian Lang
发明人： Markus Klein , Rolf Gericke , Werner Mederski , Norbert Beier , Florian Lang
IPC分类号： A61K31/416 , C07D231/56 , A61P35/04 , A61P3/10 , A61P9/00 , A61P13/12
CPC分类号： C07D405/04 , C07D409/04 , C07D409/14
摘要： Compounds of the formula I in which X, Y, R1, R2, R3 and R4 have the meanings indicated in claim 1, are inhibitors of CHK1 CHK2 and SGK kinases and can be employed, inter alia, for the treatment of cancer.
摘要翻译：其中X，Y，R 1，R 2，R 3和R 4具有权利要求1所示含义的式I化合物是CHK1 CHK2和SGK激酶的抑制剂，并且可以用于治疗癌症。

10. 发明申请

US20080262096A1 Squaric Acid Derivatives 审中-公开
标题翻译：方酸衍生物
公开(公告)号：US20080262096A1
公开(公告)日：2008-10-23
申请号：US11813475
申请日：2005-12-09
申请人： Werner Mederski , Rolf Gericke , Dieter Dorsch , Markus Klein , Norbert Beier , Florian Lang
发明人： Werner Mederski , Rolf Gericke , Dieter Dorsch , Markus Klein , Norbert Beier , Florian Lang
IPC分类号： A61K31/138 , C07C211/53 , A61P9/00 , A61P3/10 , A61P3/04
CPC分类号： C07C225/20 , C07C225/22 , C07C255/59 , C07C311/37 , C07C311/39 , C07C2601/02 , C07C2601/04
摘要： Novel squaric acid compounds of the formula (I), in which R, R1, R1′, R2 and X have the meanings indicated in Claim (1), are SGK inhibitors and can be used for the treatment of SGK-induced diseases and complaints, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, generally in fibroses and inflammatory processes of any type.
摘要翻译：式（I）的新型方酸化合物，其中R 1，R 1，R 1，R 2，R 2和X具有如下含义：权利要求（1）所述的是SGK抑制剂，可以用于治疗SGK诱发的疾病和投诉，例如糖尿病，肥胖症，代谢综合征（血脂异常），全身和肺性高血压，心血管疾病和肾脏疾病，通常在纤维和任何类型的炎症过程。

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