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    • 4. 发明授权
    • Process for producting imidazo[1,2-b]pyridazine derivative
    • 制备咪唑并[1,2-b]哒嗪衍生物的方法
    • US07307165B2
    • 2007-12-11
    • US10522798
    • 2003-07-16
    • Takanori TabuchiTetsuhiro YamamotoTakeshi Kajiwara
    • Takanori TabuchiTetsuhiro YamamotoTakeshi Kajiwara
    • C07D487/04
    • C07D471/04A01N47/36C07D487/04C07D513/04
    • A process for easily and inexpensively producing an imidazo[1,2-b]pyridazin-3-ylsulfonamide derivative which has a substituent bonded to the 6-position carbon atom and is represented by the formula (II): (wherein R represents lower alkyl, lower cycloalkyl optionally substituted by lower alkyl, lower alkenyl, or lower alkynyl), the process comprising reacting an imidazo[1,2-b]pyridazine compound represented by the formula (I): (wherein X represents halogeno or lower alkyl optionally substituted by halogeno; Y represents hydrogen or SO2N═CH—NR1R2; and Z represents halogeno or OSO2R3) with an organometallic compound in the presence of a transition metal catalyst. The derivative is useful as an intermediate for herbicides.
    • 一种容易且廉价地制备具有与6位碳原子键合的取代基并由式(II)表示的咪唑并[1,2-b]哒嗪-3-基磺酰胺衍生物的方法:(其中R表示低级烷基 ,低级烷基,低级烯基或低级炔基取代的低级环烷基),该方法包括使由式(I)表示的咪唑并[1,2-b]哒嗪化合物:其中X表示任选取代的卤代或低级烷基 通过卤代; Y表示氢或SO 2 N-CH-NR 1 R 2,Z表示卤代或OSO 2, / SO 3 R 3)与有机金属化合物在过渡金属催化剂存在下反应。 该衍生物可用作除草剂的中间体。