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1. 发明授权

US09125928B2 Agent for suppressing the formation of abnormal skin cells caused by exposure to light 有权
标题翻译：用于抑制由暴露于光引起的异常皮肤细胞形成的药剂
公开(公告)号：US09125928B2
公开(公告)日：2015-09-08
申请号：US13703671
申请日：2011-06-24
申请人： Mitsuaki Kawamura , Shigeo Shinohara , Fumiki Harano , Akihiro Aoki , Eri Ueno
发明人： Mitsuaki Kawamura , Shigeo Shinohara , Fumiki Harano , Akihiro Aoki , Eri Ueno
IPC分类号： A01N43/04 , A61K31/70 , A61K31/7076 , A61K9/00 , A61K47/10
CPC分类号： A61K31/7076 , A61K9/0014 , A61K47/10
摘要： An object of the present invention is to provide an agent for suppressing the formation of skin cells induced by exposure to light such as ultraviolet light. The object is achieved by using a purine nucleic acid for suppressing the formation of abnormal skin cells caused by exposure to light.
摘要翻译：本发明的目的是提供一种用于抑制由诸如紫外线的光照射而诱导的皮肤细胞形成的药剂。该目的通过使用嘌呤核酸来抑制由于暴露于光而引起的异常皮肤细胞的形成来实现。

2. 发明申请

US20130090301A1 AGENT FOR SUPPRESSING THE FORMATION OF ABNORMAL SKIN CELLS CAUSED BY EXPOSURE TO LIGHT 有权
标题翻译：用于抑制由于暴露于光而引起的异常皮肤细胞的形成的代理
公开(公告)号：US20130090301A1
公开(公告)日：2013-04-11
申请号：US13703671
申请日：2011-06-24
申请人： Mitsuaki Kawamura , Shigeo Shinohara , Fumiki Harano , Akihiro Aoki , Eri Ueno
发明人： Mitsuaki Kawamura , Shigeo Shinohara , Fumiki Harano , Akihiro Aoki , Eri Ueno
IPC分类号： A61K31/7076
CPC分类号： A61K31/7076 , A61K9/0014 , A61K47/10
摘要： An object of the present invention is to provide an agent for suppressing the formation of skin cells induced by exposure to light such as ultraviolet light. The object is achieved by using a purine nucleic acid for suppressing the formation of abnormal skin cells caused by exposure to light.
摘要翻译：本发明的目的是提供一种用于抑制由诸如紫外线的光照射而诱导的皮肤细胞形成的药剂。该目的通过使用嘌呤核酸来抑制由于暴露于光而引起的异常皮肤细胞的形成来实现。

3. 发明授权

US07994153B2 Chloasma amelioration composition and dullness amelioration composition 有权
标题翻译： Chloasma改善成分和暗淡改善组成
公开(公告)号：US07994153B2
公开(公告)日：2011-08-09
申请号：US10514833
申请日：2003-05-19
申请人： Hideo Tanaka , Masahiko Tanaka , Yasuo Furuta , Kosaburo Wakamatsu , Junko Kamimura , Fumiki Harano , Mitsuaki Kawamura , Shigekatsu Kawabata , Shigeo Shinohara , Noboru Yoshino
发明人： Hideo Tanaka , Masahiko Tanaka , Yasuo Furuta , Kosaburo Wakamatsu , Junko Kamimura , Fumiki Harano , Mitsuaki Kawamura , Shigekatsu Kawabata , Shigeo Shinohara , Noboru Yoshino
IPC分类号： A61K8/02 , A61K31/7076 , A61K31/708 , A61Q19/00
CPC分类号： A61Q19/04 , A61K8/606 , A61K31/00 , A61K31/52 , A61K31/7076 , A61Q19/00
摘要： The present invention provides a composition that can effectively improve melasma and a composition that can effectively reduce skin dullness.The composition for improving melasma comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent melasma improving effect due to the action of the purine nucleic acid-related substance contained. The composition for reducing skin dullness comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent effect of reducing skin dullness due to the action of the purine nucleic acid-related substance contained.
摘要翻译：本发明提供能够有效地改善黑斑和可以有效减少皮肤迟钝的组合物的组合物。用于改善黑斑病的组合物包含嘌呤核酸相关物质和药学上或化妆品上可接受的载体，并且由于所含的嘌呤核酸相关物质的作用，显示出优异的黑斑病改善效果。用于减少皮肤迟钝的组合物包含嘌呤核酸相关物质和药学上或化妆品上可接受的载体，并且显示出由于所含的嘌呤核酸相关物质的作用而减少皮肤迟钝的优异效果。

4. 发明申请

US20050220827A1 Chloasma amelioration composition and dullness amelioration composition 有权
标题翻译： Chloasma改善成分和暗淡改善组成
公开(公告)号：US20050220827A1
公开(公告)日：2005-10-06
申请号：US10514833
申请日：2003-05-19
申请人： Hideo Tanaka , Masahiko Tanaka , Yasuo Furuta , Kosaburo Wakamatsu , Junko Kamimura , Fumiki Harano , Mitsuaki Kawamura , Shigekatsu Kawabata , Shigeo Shinohara , Noboru Yoshino
发明人： Hideo Tanaka , Masahiko Tanaka , Yasuo Furuta , Kosaburo Wakamatsu , Junko Kamimura , Fumiki Harano , Mitsuaki Kawamura , Shigekatsu Kawabata , Shigeo Shinohara , Noboru Yoshino
IPC分类号： A61K8/60 , A61K31/00 , A61K31/7076 , A61P17/00 , A61Q19/00 , A61Q19/04 , A61K7/00
CPC分类号： A61Q19/04 , A61K8/606 , A61K31/00 , A61K31/52 , A61K31/7076 , A61Q19/00
摘要： The present invention provides a composition that can effectively improve melasma and a composition that can effectively reduce skin dullness. The composition for improving melasma comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent melasma improving effect due to the action of the purine nucleic acid-related substance contained. The composition for reducing skin dullness comprises a purine nucleic acid-related substance and a pharmaceutically or cosmetically acceptable carrier, and exhibits an excellent effect of reducing skin dullness due to the action of the purine nucleic acid-related substance contained.
摘要翻译：本发明提供能够有效地改善黑斑和可以有效减少皮肤迟钝的组合物的组合物。用于改善黑斑病的组合物包含嘌呤核酸相关物质和药学上或化妆品上可接受的载体，并且由于所含的嘌呤核酸相关物质的作用，显示出优异的黑斑病改善效果。用于减少皮肤迟钝的组合物包含嘌呤核酸相关物质和药学上或化妆品上可接受的载体，并且显示出由于所含的嘌呤核酸相关物质的作用而减少皮肤迟钝的优异效果。

5. 发明授权

US07794739B2 Nucleic acid based composition for cell proliferation 有权
标题翻译：用于细胞增殖的基于核酸的组合物
公开(公告)号：US07794739B2
公开(公告)日：2010-09-14
申请号：US10510738
申请日：2003-04-03
申请人： Mitsuaki Kawamura , Shigeo Shinohara
发明人： Mitsuaki Kawamura , Shigeo Shinohara
IPC分类号： A61K8/00 , A61K8/02 , A61K31/70
CPC分类号： A61Q19/08 , A61K8/606 , A61K9/0014 , A61K9/08 , A61K31/7072 , A61K31/7076 , A61K45/06 , A61K47/10 , A61K2800/59 , A61Q3/00 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61K2300/00
摘要： A method for effectively exerting a cell proliferation promoting effect of a purine nucleic acid-related substance, and a composition for cell proliferation containing a purine nucleic acid-related substance and a pyrimidine nucleic acid-related substance. Also a method for potentiating the cell proliferation promoting effect of the purine nucleic acid-related substance by using the purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance and a method for promoting cell proliferation, where the method includes the step of applying the purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance to the skin or mucosa.
摘要翻译：用于有效发挥嘌呤核酸相关物质的细胞增殖促进作用的方法，以及含有嘌呤核酸相关物质和嘧啶核酸相关物质的细胞增殖组合物。还有一种通过使用嘌呤核酸相关物质与嘧啶核酸相关物质组合来增强嘌呤核酸相关物质的细胞增殖促进作用的方法和促进细胞增殖的方法，其中该方法包括将嘌呤核酸相关物质与嘧啶核酸相关物质组合应用于皮肤或粘膜的步骤。

6. 发明授权

US07557093B2 Composition for promoting collagen production 有权
标题翻译：用于促进胶原蛋白生产的组合物
公开(公告)号：US07557093B2
公开(公告)日：2009-07-07
申请号：US10574696
申请日：2004-10-08
申请人： Shigeo Shinohara , Mitsuaki Kawamura
发明人： Shigeo Shinohara , Mitsuaki Kawamura
IPC分类号： A61K31/70 , A01N43/04
CPC分类号： A61K8/606 , A61K31/7064 , A61Q3/00 , A61Q5/006 , A61Q7/00 , A61Q19/00 , A61Q19/08
摘要： The invention provides a composition for promoting collagen production, and more specifically, provides a composition capable of promoting collagen production in human dermis. Further, the invention provides a method for promoting collagen production. The invention provides a composition for promoting collagen production containing a purine nucleic acid-related substance as an active ingredient as well as a composition for promoting collagen production containing a purine nucleic acid-related substance and a pyrimidine nucleic acid-related substance. The method for promoting collagen production of the invention comprises applying a purine nucleic acid-related substance alone or in combination with a pyrimidine nucleic acid-related substance to the skin.
摘要翻译：本发明提供了用于促进胶原蛋白生产的组合物，更具体地，提供了能够促进人真皮中的胶原产生的组合物。此外，本发明提供了促进胶原产生的方法。本发明提供了用于促进含有嘌呤核酸相关物质作为活性成分的胶原蛋白生产的组合物，以及用于促进含有嘌呤核酸相关物质和嘧啶核酸相关物质的胶原产生的组合物。用于促进本发明的胶原产生的方法包括将嘌呤核酸相关物质单独或与嘧啶核酸相关物质组合施用于皮肤。

7. 发明申请

US20070135374A1 Composition for promoting collagen production 有权
标题翻译：用于促进胶原蛋白生产的组合物
公开(公告)号：US20070135374A1
公开(公告)日：2007-06-14
申请号：US10574696
申请日：2004-10-08
申请人： Shigeo Shinohara , Mitsuaki Kawamura
发明人： Shigeo Shinohara , Mitsuaki Kawamura
IPC分类号： A61K31/7076 , A61K31/7072
CPC分类号： A61K8/606 , A61K31/7064 , A61Q3/00 , A61Q5/006 , A61Q7/00 , A61Q19/00 , A61Q19/08
摘要： The invention provides a composition for promoting collagen production, and more specifically, provides a composition capable of promoting collagen production in human dermis. Further, the invention provides a method for promoting collagen production. The invention provides a composition for promoting collagen production containing a purine nucleic acid-related substance as an active ingredient as well as a composition for promoting collagen production containing a purine nucleic acid-related substance and a pyrimidine nucleic acid-related substance. The method for promoting collagen production of the invention comprises applying a purine nucleic acid-related substance alone or in combination with a pyrimidine nucleic acid-related substance to the skin.
摘要翻译：本发明提供了用于促进胶原蛋白生产的组合物，更具体地，提供了能够促进人真皮中的胶原产生的组合物。此外，本发明提供了促进胶原产生的方法。本发明提供了用于促进含有嘌呤核酸相关物质作为活性成分的胶原蛋白生产的组合物，以及用于促进含有嘌呤核酸相关物质和嘧啶核酸相关物质的胶原产生的组合物。用于促进本发明的胶原产生的方法包括将嘌呤核酸相关物质单独或与嘧啶核酸相关物质组合施用于皮肤。

8. 发明申请

US20050222076A1 Composition for cell proliferation 有权
标题翻译：细胞增殖的组成
公开(公告)号：US20050222076A1
公开(公告)日：2005-10-06
申请号：US10510738
申请日：2003-04-03
申请人： Mitsuaki Kawamura , Shigeo Shinohara
发明人： Mitsuaki Kawamura , Shigeo Shinohara
IPC分类号： A61K8/60 , A61K31/7072 , A61K31/7076 , A61K45/06 , A61P17/02 , A61P43/00 , A61Q3/00 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K7/06 , A61K7/11 , A61K31/675
CPC分类号： A61Q19/08 , A61K8/606 , A61K9/0014 , A61K9/08 , A61K31/7072 , A61K31/7076 , A61K45/06 , A61K47/10 , A61K2800/59 , A61Q3/00 , A61Q7/00 , A61Q19/00 , A61Q19/02 , A61K2300/00
摘要： The present invention provides a method for effectively exerting a cell proliferation promoting effect of a purine nucleic acid-related substance. The present invention provides a composition for cell proliferation containing a purine nucleic acid-related substance and a pyrimidine nucleic acid-related substance. Further, the present invention provides a method for potentiating the cell proliferation promoting effect of the purine nucleic acid-related substance by using the purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance. Still further, the present invention provides a method for promoting cell proliferation, where the method comprising applying purine nucleic acid-related substance in combination with the pyrimidine nucleic acid-related substance to the skin or mucosa.
摘要翻译：本发明提供了有效发挥嘌呤核酸相关物质的细胞增殖促进作用的方法。本发明提供了含有嘌呤核酸相关物质和嘧啶核酸相关物质的细胞增殖组合物。此外，本发明提供了通过使用嘌呤核酸相关物质与嘧啶核酸相关物质组合来增强嘌呤核酸相关物质的细胞增殖促进作用的方法。此外，本发明提供一种促进细胞增殖的方法，其中所述方法包括将嘌呤核酸相关物质与嘧啶核酸相关物质组合应用于皮肤或粘膜。

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