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    • 2. 发明授权
    • Parametric speech synthesis method and system
    • 参数语音合成方法和系统
    • US08977551B2
    • 2015-03-10
    • US13640562
    • 2011-10-27
    • Fengliang WuZhenhua Wu
    • Fengliang WuZhenhua Wu
    • G10L13/00G10L13/08G10L21/00G10L15/00H04M1/64G10L15/22
    • G10L13/08G10L2015/227
    • The present invention provides a parametric speech synthesis method and a parametric speech synthesis system. The method comprises sequentially processing each frame of speech of each phone in a phone sequence of an input text as follows: for a current phone, extracting a corresponding statistic model from a statistic model library and using model parameters of the statistic model that correspond to the current frame of the current phone as rough values of currently predicted speech parameters; according to the rough values and information about a predetermined number of speech frames occurring before the current time point, obtaining smoothed values of the currently predicted speech parameters; according to global mean values and global standard deviation ratios of the speech parameters obtained through statistics, performing global optimization on the smoothed values of the speech parameters to generate necessary speech parameters; and synthesizing the generated speech parameters to obtain a frame of speech synthesized for the current frame of the current phone. With this solution, the capacity of an RAM needed by speech synthesis will not increase with the length of the synthesized speech, and the time length of the synthesized speech is no longer limited by the RAM.
    • 本发明提供一种参数语音合成方法和参数语音合成系统。 该方法包括以如下方式在输入文本的电话序列中顺序处理每个电话的每个帧:对于当前电话,从统计模型库中提取相应的统计模型,并使用对应于该统计模型的统计模型的模型参数 当前手机的当前帧作为当前预测的语音参数的粗略值; 根据关于在当前时间点之前发生的预定数量的语音帧的粗略值和信息,获得当前预测的语音参数的平滑值; 根据通过统计获得的语音参数的全局平均值和全局标准偏差比,对语音参数的平滑值执行全局优化以产生必要的语音参数; 以及合成所生成的语音参数以获得为当前电话的当前帧合成的语音帧。 利用该解决方案,语音合成所需的RAM的容量不会随着合成语音的长度而增加,并且合成语音的时间长度不再受RAM限制。
    • 3. 发明授权
    • Bus traffic profiling
    • 巴士流量剖析
    • US08572295B1
    • 2013-10-29
    • US12033677
    • 2008-02-19
    • Wenwei CaiZhenhua Wu
    • Wenwei CaiZhenhua Wu
    • G06F3/00G06F9/44
    • G06F11/3027G06F3/00G06F9/44G06F11/3013G06F11/349G06F2201/81G06F2201/86
    • Methods and systems for analyzing bus traffic in a target device, such as a system on-a-chip (SOC) comprises capturing a processor event and generating an interrupt based on a threshold associated with the processor event. Based on at least the interrupt, a instruction pointer associated with the processor event that generated the interrupt is identified. An instruction analyzer identifies a memory address of the instruction associated with the processor event that generated the interrupt. At least the processor event and a associated instruction information are collected by a sample collector and transferred to a host for performance profiling.
    • 用于分析目标设备(诸如片上系统(SOC))中的总线流量的方法和系统包括捕获处理器事件并基于与处理器事件相关联的阈值生成中断。 基于至少该中断,识别与产生中断的处理器事件相关联的指令指针。 指令分析器识别与产生中断的处理器事件相关联的指令的存储器地址。 至少处理器事件和关联的指令信息由样本收集器收集并传送到主机以进行性能分析。
    • 4. 发明申请
    • PARAMETRIC SPEECH SYNTHESIS METHOD AND SYSTEM
    • 参数语音合成方法与系统
    • US20130066631A1
    • 2013-03-14
    • US13640562
    • 2011-10-27
    • Fengliang WuZhenhua Wu
    • Fengliang WuZhenhua Wu
    • G10L13/00
    • G10L13/08G10L2015/227
    • The present invention provides a parametric speech synthesis method and a parametric speech synthesis system. The method comprises sequentially processing each frame of speech of each phone in a phone sequence of an input text as follows: for a current phone, extracting a corresponding statistic model from a statistic model library and using model parameters of the statistic model that correspond to the current frame of the current phone as rough values of currently predicted speech parameters; according to the rough values and information about a predetermined number of speech frames occurring before the current time point, obtaining smoothed values of the currently predicted speech parameters; according to global mean values and global standard deviation ratios of the speech parameters obtained through statistics, performing global optimization on the smoothed values of the speech parameters to generate necessary speech parameters; and synthesizing the generated speech parameters to obtain a frame of speech synthesized for the current frame of the current phone. With this solution, the capacity of an RAM needed by speech synthesis will not increase with the length of the synthesized speech, and the time length of the synthesized speech is no longer limited by the RAM.
    • 本发明提供一种参数语音合成方法和参数语音合成系统。 该方法包括以如下方式在输入文本的电话序列中顺序处理每个电话的每个帧:对于当前电话,从统计模型库中提取相应的统计模型,并使用对应于该统计模型的统计模型的模型参数 当前手机的当前帧作为当前预测的语音参数的粗略值; 根据关于在当前时间点之前发生的预定数量的语音帧的粗略值和信息,获得当前预测的语音参数的平滑值; 根据通过统计获得的语音参数的全局平均值和全局标准偏差比,对语音参数的平滑值进行全局优化以产生必要的语音参数; 以及合成所生成的语音参数以获得为当前电话的当前帧合成的语音帧。 利用该解决方案,语音合成所需的RAM的容量不会随着合成语音的长度而增加,并且合成语音的时间长度不再受RAM限制。
    • 5. 发明申请
    • Role of gax in alzheimer neurovascular dysfunction
    • gax在阿尔茨海默病神经血管功能障碍中的作用
    • US20090181911A1
    • 2009-07-16
    • US11988999
    • 2006-08-03
    • Benslav V. ZlokovicZhenhua WuRashid Deane
    • Benslav V. ZlokovicZhenhua WuRashid Deane
    • A61K31/7088C12N15/87C12Q1/68C12N15/86C12N15/88
    • A61K48/005A61K48/0075
    • Neurovascular disorder critically contributes to the development and pathogenesis of Alzheimer's disease (AD). Transcriptional profiling of human brain endothelial cells (BEC) defines a subset of age-independent genes significantly altered in AD including the homebox gene GAX whose expression controls vascular phenotype and is low in AD. By using viral-mediated GAX gene silencing and transfer, restoring GAX expression in AD BEC is angio-genic, transcriptionally suppresses the AFX1 forkhead transcription factor-mediated apoptosis, and increases the levels of a major amyloid β-peptide (Aβ) clearance receptor, the low density lipoprotein receptor-related protein 1 (LRP-1) at the blood-brain barrier. In a mouse model of Alzheimer's disease, deletion of the Gax gene results in reductions in brain capillary density and the resting cerebral blood flow, loss of angiogenic brain response to hypoxia, and an impaired Aβ brain efflux caused by reduced LRP-1 levels. The link of GAX gene to AD neurovascular dysfunction provides new mechanistic and therapeutic insights into AD.
    • 神经血管疾病对阿尔茨海默病(AD)的发展和发病有重要的意义。 人类脑内皮细胞(BEC)的转录谱描述了AD中显着改变的年龄无关基因亚型,包括其表达控制血管表型且AD低的家箱基因GAX。 通过使用病毒介导的GAX基因沉默和转移,在AD BEC中恢复GAX表达是血管生成的,转录抑制AFX1叉头转录因子介导的凋亡,并且增加主要淀粉样蛋白β肽(Abeta)清除受体的水平, 低密度脂蛋白受体相关蛋白1(LRP-1)在血脑屏障。 在阿尔茨海默氏病的小鼠模型中,Gax基因的缺失导致脑毛细血管密度降低,静息脑血流量减少,血管发生脑对缺氧的反应减少,以及由降低的LRP-1水平引起的受损的Aβ脑流出。 GAX基因与AD神经血管功能障碍的联系为AD提供了新的机制和治疗见解。