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1. 发明申请

US20110217377A1 Long Circulating Nanoparticles for Sustained Release of Therapeutic Agents 审中-公开
标题翻译：用于持续释放治疗剂的长循环纳米颗粒
公开(公告)号：US20110217377A1
公开(公告)日：2011-09-08
申请号：US13108361
申请日：2011-05-16
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
IPC分类号： A61K9/14 , A61K31/337 , A61K31/436 , A61K31/519 , A61K31/437 , A61P35/00 , B82Y5/00
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
摘要翻译：本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。

2. 发明申请

US20100104645A1 METHODS FOR THE PREPARATION OF TARGETING AGENT FUNCTIONALIZED DIBLOCK COPOLYMERS FOR USE IN FABRICATION OF THERAPEUTIC TARGETED NANOPARTICLES 审中-公开
标题翻译：制备用于制备治疗性靶向纳米颗粒的靶向功能性二嵌段共聚物的方法
公开(公告)号：US20100104645A1
公开(公告)日：2010-04-29
申请号：US12485818
申请日：2009-06-16
申请人： Mir M. Ali , Jeff Hrkach , Stephen E. Zale
发明人： Mir M. Ali , Jeff Hrkach , Stephen E. Zale
IPC分类号： A61K9/14 , A61P35/00
CPC分类号： A61K47/34 , A61K9/5153 , A61K47/60 , A61K47/6911
摘要： This application provides methods of making nanoparticles using pre-functionalized poly(ethylene glycol) (also referred to as PEG) as a macroinitiator for the synthesis of diblock copolymers. These diblock copolymers comprise a poly(ethylene glycol) block bearing a targeting agent at its terminus and a second biocompatible and biodegradable hydrophobic polymer block (e.g. a poly(ester)). The poly(ethylene glycol) is hetero-bifunctional with a targeting moiety (agent) covalently bound to its α terminus and a polymerization initiating functional group (e.g., a hydroxyl group) present on its ω terminus. Ring opening polymerization yields the desired poly(ester)-poly(ethylene glycol)-targeting agent polymer that is used to impart targeting capability to therapeutic nanoparticles. This “polymerization from” approach typically employs precursors of the targeting agent wherein the reactivity of functional groups of the targeting agent is masked using protecting groups. Also described is a “coupling to” that utilized the poly(ethylene glycol)-targeting agent conjugate where the targeting agent remains in its native un-protected form. This method uses “orthogonal” chemistry that exhibit no cross reactivity towards functional groups typically found within targeting agents of interest. Nanoparticles produced according to the disclosed methods as well as their use in the treatment of various diseases are also provided.
摘要翻译：本申请提供了使用预官能化聚（乙二醇）（也称为PEG）作为二嵌段共聚物合成的大分子引发剂制备纳米颗粒的方法。这些二嵌段共聚物包含在其末端具有靶向剂的聚（乙二醇）嵌段和第二生物相容性和可生物降解的疏水性聚合物嵌段（例如聚（酯））。聚（乙二醇）与其α末端共价结合的靶向部分（试剂）和其ω末端存在的聚合起始官能团（例如羟基）是异双官能的。开环聚合产生用于赋予治疗性纳米颗粒靶向能力的所需聚（酯） - 聚（乙二醇） - 靶向剂聚合物。这种“聚合”方法通常使用靶向剂的前体，其中靶向剂的官能团的反应性使用保护基掩蔽。还描述了使用聚（乙二醇） - 靶向剂缀合物的“偶联”，其中靶向剂保持其天然未保护形式。该方法使用对正常感兴趣的靶向剂中通常发现的官能团没有交叉反应性的“正交”化学。还提供了根据所公开的方法制备的纳米颗粒及其在治疗各种疾病中的用途。

3. 发明授权

US09308179B2 Long circulating nanoparticles for sustained release of therapeutic agents 有权
公开(公告)号：US09308179B2
公开(公告)日：2016-04-12
申请号：US13556647
申请日：2012-07-24
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/51 , A61K47/34 , B82Y5/00 , A61K9/00 , A61K47/48
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.

4. 发明申请

US20100216804A1 Long Circulating Nanoparticles for Sustained Release of Therapeutic Agents 审中-公开
标题翻译：用于持续释放治疗剂的长循环纳米颗粒
公开(公告)号：US20100216804A1
公开(公告)日：2010-08-26
申请号：US12638297
申请日：2009-12-15
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright , Susan Low
IPC分类号： A61K9/14 , A61K31/337 , A61K31/4745 , A61K31/519 , A61K31/436 , A61P35/00
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
摘要翻译：本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。

5. 发明申请

US20130034608A1 Long Circulating Nanoparticles for Sustained Release of Therapeutic Agents 有权
标题翻译：用于持续释放治疗剂的长循环纳米颗粒
公开(公告)号：US20130034608A1
公开(公告)日：2013-02-07
申请号：US13556647
申请日：2012-07-24
申请人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
发明人： Stephen E. Zale , Greg Troiano , Mir M. Ali , Jeff Hrkach , James Wright
IPC分类号： A61K9/14 , A61K31/337 , A61P35/00 , B82Y5/00
CPC分类号： A61K9/5153 , A61K9/0019 , A61K9/1641 , A61K31/337 , A61K31/436 , A61K31/475 , A61K31/519 , A61K47/542 , A61K47/593 , A61K47/60 , A61K47/6925 , A61K47/6937 , B82Y5/00
摘要： The present disclosure is directed in part to a biocompatible nanoparticle composition comprising a plurality of non-colloidal long circulating nanoparticles, each comprising a α-hydroxy polyester-co-polyether and a therapeutic agent, wherein such disclosed compositions provide a therapeutic effect for at least 12 hours.
摘要翻译：本公开部分地涉及生物相容性纳米颗粒组合物，其包含多个非胶体长循环纳米颗粒，每个非胶体长循环纳米颗粒包含α-羟基聚酯 - 共聚醚和治疗剂，其中所述公开的组合物至少提供治疗效果 12小时。

6. 发明申请

US20120140790A1 Therapeutic Polymeric Nanoparticle Compositions with High Glass Transition Termperature or High Molecular Weight Copolymers 有权
标题翻译：具有高玻璃化转变温度或高分子量共聚物的聚合物纳米粒子组合物
公开(公告)号：US20120140790A1
公开(公告)日：2012-06-07
申请号：US13372036
申请日：2012-02-13
申请人： Mir M. Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Tina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh C. Campbell
发明人： Mir M. Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Tina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh C. Campbell
IPC分类号： G01N25/20 , G01K17/00
CPC分类号： G01N25/4866 , A61K9/0019 , A61K9/146 , A61K9/5153 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
摘要： The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译：本公开部分涉及包含具有某些玻璃化转变温度的聚合物纳米颗粒的药物组合物。本发明的其它方面包括制备这种纳米颗粒的方法。

7. 发明申请

US20110294717A1 Therapeutic Polymeric Nanoparticle Compositions with High Glass Transition Temperature or High Molecular Weight Copolymers 有权
标题翻译：具有高玻璃化转变温度或高分子量共聚物的聚合物纳米粒子组合物
公开(公告)号：US20110294717A1
公开(公告)日：2011-12-01
申请号：US12968625
申请日：2010-12-15
申请人： Mir M. Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Tina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh C. Campbell
发明人： Mir M. Ali , Abhimanyu Sabnis , David Dewitt , Greg Troiano , James Wright , Maria Figueiredo , Michael Figa , Tina Van Geen Hoven , Young-Ho Song , Jason Auer , Tarikh C. Campbell
IPC分类号： A61K47/34 , A61K31/69 , A61K38/02 , A61K31/439 , A61K31/436 , A61K31/427 , A61K31/573 , A61K31/58 , A61P35/00 , A61P11/06 , A61P19/02 , A61P17/00 , A61P1/00 , A61P1/04 , A61P25/28 , A61K31/337
CPC分类号： G01N25/4866 , A61K9/0019 , A61K9/146 , A61K9/5153 , A61K31/00 , A61K31/337 , A61K31/427 , A61K31/436 , A61K31/475 , A61K31/573 , A61K31/58 , A61K31/585 , A61K31/69 , A61K47/34
摘要： The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.
摘要翻译：本公开部分涉及包含具有某些玻璃化转变温度的聚合物纳米颗粒的药物组合物。本发明的其它方面包括制备这种纳米颗粒的方法。

8. 发明授权

US06763324B1 Integrated engineering analysis process with solution feedback 有权
标题翻译：集成工程分析流程与解决方案反馈
公开(公告)号：US06763324B1
公开(公告)日：2004-07-13
申请号：US09534677
申请日：2000-03-24
申请人： Robert N. Pittman , Scott J. Dennison , Kenneth E. Seitzer , John D. Bibler , Stephen P. Schrantz , John C. Blanton , Mir M. Ali , Robert J. Maffeo , James C. Dudley , David M. Johnson
发明人： Robert N. Pittman , Scott J. Dennison , Kenneth E. Seitzer , John D. Bibler , Stephen P. Schrantz , John C. Blanton , Mir M. Ali , Robert J. Maffeo , James C. Dudley , David M. Johnson
IPC分类号： G06F1710
CPC分类号： G05B17/02 , F05B2230/00 , F05B2260/20 , F05B2270/303 , G05B19/0426 , G05B2219/23292 , G05B2219/23293 , Y02T50/675
摘要： An integrated engineering analysis system that determines at least one final output value in response to at least one initial input value. A first subprocesses provides at least one output value in response to the initial input value. A plurality of subprocesses provide a plurality of output values in response to the output values of the first subprocess. The plurality of output values and the output value of the first subprocess are inputted into at least one of the plurality of subprocesses. A command code executes each of the plurality of subprocesses in response to the output values and determines which one of the plurality of subprocesses to run and a final subprocess provides a final output. The final output is the result of a plurality of calculations executed by the plurality of subprocesses and the command code compares the final output with the initial input.
摘要翻译：综合工程分析系统，其响应于至少一个初始输入值确定至少一个最终输出值。第一子处理器响应于初始输入值提供至少一个输出值。多个子处理器响应于第一子过程的输出值提供多个输出值。将多个输出值和第一子过程的输出值输入到多个子处理中的至少一个。命令代码响应于输出值执行多个子处理中的每一个，并且确定要运行的多个子处理中的哪个子进程和最后的子进程提供最终的输出。最终输出是由多个子处理执行的多个计算的结果，并且命令代码将最终输出与初始输入进行比较。

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