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2. 发明申请

US20110208270A1 Swallowable Capsule and Method for Stimulating Incretin Production Within the Intestinal Tract 有权
标题翻译：吞咽胶囊和刺激肠道内营养素的方法
公开(公告)号：US20110208270A1
公开(公告)日：2011-08-25
申请号：US12849574
申请日：2010-08-03
申请人： Mir A. Imran , Mir Hashim , Emily Arnsdorf
发明人： Mir A. Imran , Mir Hashim , Emily Arnsdorf
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61K38/26 , A61N1/05 , A61N1/0507 , A61N1/0509 , A61N1/06 , A61N1/37217
摘要： Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.
摘要翻译：本发明的实施方案提供了用于刺激肠道中的L细胞以产生用于治疗包括糖尿病和肥胖的病症的肠溶素的装置和方法。许多实施方案提供了一种用于通过电刺激L细胞分泌胰岛素来刺激或以其它方式调节胰岛素的产生来治疗糖尿病的方法和装置。具体实施方案提供了一种吞咽胶囊，用于在胶囊移动通过管道时刺激肠道中的L细胞。胶囊可以包括用于向L-细胞提供电刺激的两个或更多个电极，用于为胶囊的一个或多个部件供电的电源，用于感测胶囊在肠道中的位置的传感器; 控制器和波形发生器，用于产生由电极发射的电信号，以刺激L细胞分泌胰岛素，例如GLP-1，以刺激胰岛素产生用于糖尿病状态的葡萄糖调节。

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