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1. 发明授权

US5663560A Method and apparatus for mass analysis of solution sample 失效
标题翻译：溶液样品质量分析方法和装置
公开(公告)号：US5663560A
公开(公告)日：1997-09-02
申请号：US555192
申请日：1995-11-08
申请人： Minoru Sakairi , Tadao Mimura , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Minoru Sakairi , Tadao Mimura , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： H01J49/04 , H01J49/06 , H01J49/40
CPC分类号： H01J49/044 , H01J49/061
摘要： A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.
摘要翻译：将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。

2. 发明授权

US6005245A Method and apparatus for ionizing a sample under atmospheric pressure and selectively introducing ions into a mass analysis region 失效
标题翻译：用于在大气压下电离样品并选择性地将离子引入质量分析区域的方法和装置
公开(公告)号：US6005245A
公开(公告)日：1999-12-21
申请号：US919785
申请日：1997-08-29
申请人： Minoru Sakairi , Tadao Mimura , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Minoru Sakairi , Tadao Mimura , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： H01J49/04 , H01J49/06
CPC分类号： H01J49/061 , H01J49/044
摘要： A method in which cutting of small droplets, neutral particles or photons through to a slit provided between a differential pumping portion and a mass analysis portion is combined with slight deflection of ions just before introduction of the ions into the mass analysis portion so that noises are greatly reduced without reduction of signals to thereby improve the signal-to-noise ratio which is an index of detecting sensitivity or lower limit.
摘要翻译：将小液滴，中性粒子或光子穿过到设置在差分泵送部分和质量分析部分之间的狭缝的切割与在将离子引入质量分析部分之前的离子的轻微偏转相结合，使得噪声为大大降低了信号的降低，从而提高作为检测灵敏度或下限的指标的信噪比。

3. 发明授权

US6157030A Ion trap mass spectrometer 有权
标题翻译：离子阱质谱仪
公开(公告)号：US6157030A
公开(公告)日：2000-12-05
申请号：US143398
申请日：1998-08-28
申请人： Minoru Sakairi , Tadao Mimura , Toshihiro Ishizuka , Masaru Tomioka , Yasuaki Takada , Takayuki Nabeshima
发明人： Minoru Sakairi , Tadao Mimura , Toshihiro Ishizuka , Masaru Tomioka , Yasuaki Takada , Takayuki Nabeshima
IPC分类号： H01J49/42
CPC分类号： H01J49/424
摘要： Disclosed is an ion trap mass spectrometer improved to obtain a high sensitivity without the lowering of resolution. By fitting a mesh electrode to an aperture (an ion sampling aperture or an ion extracting aperture) made in endcap electrodes constituting an ion trap mass analysis region, a radio frequency electric field in the mass analysis region is not disturbed even if the diameter of the aperture is set to a large value to heighten ion transmission efficiency. By fitting a shield electrode for preventing collision of ions with an insulated ring constituting an outer wall of the mass analysis region, charging up of the insulated ring is prevented to improve stability of detection signals. Furthermore, by arranging a shield member for shielding stray charged particles detouring through the circumference of the mass analysis region to approach an ion detector, generation of noises based on these stray charged particles is prevented.
摘要翻译：公开了一种改进的离子阱质谱仪，可以在不降低分辨率的情况下获得高灵敏度。通过将网状电极装配到构成离子阱质量分析区域的端盖电极中的孔（离子取样孔或离子提取孔）上，即使直径为孔径被设定为大的值以提高离子传输效率。通过安装用于防止离子与构成质量分析区域的外壁的绝缘环碰撞的屏蔽电极，防止了绝缘环的充电以提高检测信号的稳定性。此外，通过设置用于屏蔽通过质量分析区域的圆周去除杂散带电粒子的屏蔽构件以接近离子检测器，防止了基于这些杂散带电粒子的噪声的产生。

4. 发明授权

US5825027A Mass spectrometer 失效
公开(公告)号：US5825027A
公开(公告)日：1998-10-20
申请号：US831486
申请日：1997-03-31
申请人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
发明人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
IPC分类号： G01N27/62 , H01J49/04 , H01J49/06 , H01J49/34 , H01J49/42
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region and a ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.

5. 发明授权

US06180941B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06180941B2
公开(公告)日：2001-01-30
申请号：US09447578
申请日：1999-11-23
申请人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
发明人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and an ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译：一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分析分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置，意味着通过设置在电极中的孔进入真空区域，以及离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置的电极之间其中所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，并且注入离子阱质谱分析装置的离子降低。即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。

6. 发明授权

US5969351A Mass spectrometer 失效
标题翻译：质谱仪
公开(公告)号：US5969351A
公开(公告)日：1999-10-19
申请号：US796548
申请日：1997-02-06
申请人： Takayuki Nabeshima , Minoru Sakairi , Yasuaki Takada , Yukiko Hirabayashi , Hideaki Koizumi
发明人： Takayuki Nabeshima , Minoru Sakairi , Yasuaki Takada , Yukiko Hirabayashi , Hideaki Koizumi
IPC分类号： H01J49/04 , H01J49/28
CPC分类号： H01J49/168 , H01J49/0404 , H01J49/049 , G01N30/726
摘要： A semi-micro liquid chromatograph/mass spectrometer apparatus has an ion source. The space from the end portion of a flow passage of a liquid chromatograph shell to a vaporization portion is closed so as to prevent the inflow of a gas from outside the ion source into the space. Further, the nebulization and vaporization portions are joined together and heated by a common heater. Dilution of a sample to be analyzed is prevented, and high sensitivity detection becomes possible in a low velocity liquid chromatograph/mass spectrometer.
摘要翻译：半微量液相色谱仪/质谱仪装置具有离子源。从液相色谱仪壳体的流路端部到气化部分的空间被封闭，以防止从离子源外部的气体流入空间。此外，将雾化和蒸发部分接合在一起并通过公共加热器加热。防止要分析的样品的稀释，并且可以在低速液相色谱仪/质谱仪中进行高灵敏度检测。

7. 发明授权

US5898175A Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution 失效
标题翻译：用于分析溶液中所含化合物的质谱仪和质谱法
公开(公告)号：US5898175A
公开(公告)日：1999-04-27
申请号：US708415
申请日：1996-09-05
申请人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
发明人： Atsumu Hirabayashi , Yukiko Hirabayashi , Minoru Sakairi , Yasuaki Takada , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： G01N27/62 , G01N27/447 , G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/7266 , H01J49/0468 , H01J49/167
摘要： A mass spectrometer employing an ion source includes a capillary for spraying therethrough liquid into the atmospheres and an orifice through which a portion in the vicinity of a tip of the capillary is inserted, the orifice being designed in such a way that gases are caused to flow up to the tip of the capillary along a peripheral wall face of the capillary. The flow rate of gas in the vicinity of the tip of the capillary is about the sonic velocity, and a voltage is applied across the liquid flowing through the capillary and the orifice or an electrode arranged in the vicinity of the tip of the capillary.
摘要翻译：使用离子源的质谱仪包括用于将液体喷射到气氛中的毛细管和插入毛细管的尖端附近的部分的孔，孔被设计成使气体流动直到毛细管的尖端沿着毛细管的周壁面。毛细管尖端附近的气体的流速大约是声速，并且在流过毛细管的液体和布置在毛细管尖端附近的孔或电极之间施加电压。

8. 发明授权

US06465779B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06465779B2
公开(公告)日：2002-10-15
申请号：US09968928
申请日：2001-10-03
申请人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
发明人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectroscopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region, and an ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译：一种质谱仪，其特征在于，包括：离子化装置，用于在大气压下对质谱进行质谱分析的样品化合物进行离子化;将含有所述样品化合物的溶液供给到所述电离装置的样品溶液供给装置，将由所述电离装置形成的离子供给将设置在电极中的孔设置在真空区域中，以及离子阱型质谱分析装置，用于对通过孔进入真空区域的离子进行质谱分析，其中离子减速电场形成装置设置在孔和设置有离子入口的电极，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，并且注入离子阱质谱分析装置的离子降低。即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。

9. 发明授权

US06316769B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06316769B2
公开(公告)日：2001-11-13
申请号：US09739217
申请日：2000-12-19
申请人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
发明人： Yasuaki Takada , Minoru Sakairi , Takayuki Nabeshima , Yukiko Hirabayashi , Hideaki Koizumi
IPC分类号： H01J4942
CPC分类号： H01J49/067 , H01J49/04
摘要： A mass spectrometer comprising an ionization means for ionizing sample compounds to be analyzed mass spectro-scopically in an atmospheric pressure, a sample solution supply means for supplying a solution containing the sample compounds to the ionization means, means for feeding the ions formed by the ionization means through an aperture disposed in an electrode into a vacuum region and a ion trap type mass spectroscopic means for mass spectroscopically analyzing ions entered through the aperture into the vacuum region, in which an ion decelerating electric field forming means is disposed between the electrode disposed with the aperture and an electrode disposed with an ion entrance opening for entering the ions into the ion trap type mass spectroscopic means for forming an electric field for decelerating the ions, and the ions injected to the ion trap mass spectroscopic means is lowered. This facilitates accumulation ions in the ion trap mass spectralyzing means even if a high drift voltage is used thereby enabling high sensitivity analysis for polar compounds such as peptides.
摘要翻译：一种质谱仪，其特征在于，包括：离子化装置，用于将大气压力分散分析的样品化合物离子化;将含有样品化合物的溶液供给到电离装置的样品溶液供给装置，意味着通过设置在电极中的孔进入真空区域和离子阱型质谱分析装置，用于质谱分析通过孔进入真空区域的离子，其中离子减速电场形成装置设置在设置有所述孔和电极设置有离子入口，用于将离子进入离子阱型质谱分析装置，用于形成用于使离子减速的电场，以及注入离子阱质谱分析装置的离子。即使使用高漂移电压，这也有助于离子阱质谱分析手段中的积聚离子，从而能够对极性化合物如肽进行高灵敏度分析。

10. 发明授权

US06252225B1 Mass spectrometry of solution and apparatus therefor 有权
标题翻译：溶液质谱仪及其设备
公开(公告)号：US06252225B1
公开(公告)日：2001-06-26
申请号：US09492352
申请日：2000-01-27
申请人： Yasuaki Takada , Minoru Sakairi , Atsumu Hirabayashi , Takayuki Nabeshima , Hideaki Koizumi
发明人： Yasuaki Takada , Minoru Sakairi , Atsumu Hirabayashi , Takayuki Nabeshima , Hideaki Koizumi
IPC分类号： H01J4910
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/168
摘要： A mass spectrometer including a sprayer for spraying a sample solution, a needle electrode for ionizing the sample contained in the sample solution, an aperture for introducing the ions of the sample into a lower pressure region having a pressure lower than the pressure of a region in which the needle electrode is disposed, and a mass spectrometric apparatus for analyzing the ions introduced from the aperture. A direction of a spray caused by the sprayer is almost perpendicular to a center axis of the aperture and a tip of the needle is disposed facing to an electrode having the aperture.
摘要翻译：一种质谱仪，包括用于喷射样品溶液的喷雾器，用于使包含在样品溶液中的样品电离的针状电极，用于将样品的离子引入低于区域压力的低压区域的孔设置针状电极的质谱仪和用于分析从孔径引入的离子的质谱仪。由喷雾器引起的喷雾方向几乎垂直于孔的中心轴线，并且针的尖端面向具有孔的电极设置。

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