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1. 发明申请

US20110171634A1 METHODS AND DEVICES FOR SINGLE-MOLECULE WHOLE GENOME ANALYSIS 有权
标题翻译：用于单分子全基因组分析的方法和设备
公开(公告)号：US20110171634A1
公开(公告)日：2011-07-14
申请号：US13001697
申请日：2009-06-30
申请人： Ming Xiao , Parikshit A. Deshpande , Han Cao , Michael Austin , Kandaswamy Vijayan , Alexey Y. Sharonov , Michael Boyce-Jacino
发明人： Ming Xiao , Parikshit A. Deshpande , Han Cao , Michael Austin , Kandaswamy Vijayan , Alexey Y. Sharonov , Michael Boyce-Jacino
IPC分类号： C12Q1/68 , C07H1/00 , G01N33/53 , C07K1/107 , C12N9/96 , G01N30/96 , B82Y15/00
CPC分类号： C12Q1/6818 , C12Q1/6806 , C12Q1/6825 , C12Q1/6869 , G06F19/18 , C12Q2565/629 , C12Q2565/1015 , C12Q2521/301 , C12Q2537/1376 , C12Q2561/109 , C12Q2565/1025 , C12Q2565/631
摘要： Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.
摘要翻译：提供单分子基因组分析的方法和装置。在一个实施方案中，所述方法需要处理双链核酸并表征所述核酸。这些方法在例如确定个体之间的结构变化和拷贝数变化方面是有用的。

2. 发明申请

US20110306504A1 POLYNUCLEOTIDE MAPPING AND SEQUENCING 有权
标题翻译：多核苷酸映射和测序
公开(公告)号：US20110306504A1
公开(公告)日：2011-12-15
申请号：US13129634
申请日：2009-11-18
申请人： Ming Xiao , Han Cao , Parikshit A. Deshpande , Michael Boyce-Jacino
发明人： Ming Xiao , Han Cao , Parikshit A. Deshpande , Michael Boyce-Jacino
IPC分类号： C40B20/08 , C40B40/06 , C12Q1/68 , G01N21/64
CPC分类号： C12Q1/6874 , C12Q1/68 , C12Q1/6806 , C12Q1/6869 , C12Q2565/133 , C12Q2565/1025 , C12Q2521/301 , C12Q2563/107 , C12Q2535/101
摘要： The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
摘要翻译：本发明提供获得关于生物聚合物样品的结构信息的方法。所述方法包括在一些情况下标记生物聚合物（例如DNA或RNA）的部分线性化生物聚合物，并确定标签之间的距离。然后，用户可以比较不同样品的标记间距离，以定性比较不同的样品，并测定给定的样品，用于在标签侧翼的区域中添加或缺失核苷酸。该方法还允许对生物聚合物进行测序。

3. 发明授权

US09181578B2 Polynucleotide mapping and sequencing 有权
标题翻译：多核苷酸定位和测序
公开(公告)号：US09181578B2
公开(公告)日：2015-11-10
申请号：US13129634
申请日：2009-11-18
申请人： Ming Xiao , Han Cao , Parikshit A. Deshpande , Michael Boyce-Jacino
发明人： Ming Xiao , Han Cao , Parikshit A. Deshpande , Michael Boyce-Jacino
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/68 , C12Q1/6806 , C12Q1/6869 , C12Q2565/133 , C12Q2565/1025 , C12Q2521/301 , C12Q2563/107 , C12Q2535/101
摘要： The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
摘要翻译：本发明提供获得关于生物聚合物样品的结构信息的方法。所述方法包括在一些情况下标记生物聚合物（例如DNA或RNA）的部分线性化生物聚合物，并确定标签之间的距离。然后，用户可以比较不同样品的标记间距离，以定性比较不同的样品，并测定给定的样品，用于在标签侧翼的区域中添加或缺失核苷酸。该方法还允许对生物聚合物进行测序。

4. 发明授权

US08628919B2 Methods and devices for single-molecule whole genome analysis 有权
标题翻译：单分子全基因组分析的方法和装置
公开(公告)号：US08628919B2
公开(公告)日：2014-01-14
申请号：US13001697
申请日：2009-06-30
申请人： Ming Xiao , Parikshit A. Deshpande , Han Cao , Michael Austin , Kandaswamy Vijayan , Alexey Y. Sharonov , Michael Boyce-Jacino
发明人： Ming Xiao , Parikshit A. Deshpande , Han Cao , Michael Austin , Kandaswamy Vijayan , Alexey Y. Sharonov , Michael Boyce-Jacino
IPC分类号： C12Q1/68 , C12M1/34 , C12M3/00 , C07H21/02
CPC分类号： C12Q1/6818 , C12Q1/6806 , C12Q1/6825 , C12Q1/6869 , G06F19/18 , C12Q2565/629 , C12Q2565/1015 , C12Q2521/301 , C12Q2537/1376 , C12Q2561/109 , C12Q2565/1025 , C12Q2565/631
摘要： Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.
摘要翻译：提供单分子基因组分析的方法和装置。在一个实施方案中，所述方法需要处理双链核酸并表征所述核酸。这些方法在例如确定个体之间的结构变化和拷贝数变化方面是有用的。

5. 发明申请

US20130240357A1 METHODS AND DEVICES FOR SINGLE-MOLECULE WHOLE GENOME ANALYSIS 有权
标题翻译：用于单分子全基因组分析的方法和设备
公开(公告)号：US20130240357A1
公开(公告)日：2013-09-19
申请号：US13765353
申请日：2013-02-12
申请人： Ming Xiao , Han Cao
发明人： Ming Xiao , Han Cao
IPC分类号： G06F19/18
CPC分类号： C12Q1/6818 , C12Q1/6806 , C12Q1/6825 , C12Q1/6869 , G06F19/18 , C12Q2565/629 , C12Q2565/1015 , C12Q2521/301 , C12Q2537/1376 , C12Q2561/109 , C12Q2565/1025 , C12Q2565/631
摘要： Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g. determining structural variations and copy number variations between individuals.
摘要翻译：提供单分子基因组分析的方法和装置。在一个实施方案中，所述方法需要处理双链核酸并表征所述核酸。这些方法在例如，确定个体之间的结构变化和复制数量变化。

6. 发明授权

US09758780B2 Whole genome mapping by DNA sequencing with linked-paired-end library 有权
公开(公告)号：US09758780B2
公开(公告)日：2017-09-12
申请号：US14728223
申请日：2015-06-02
申请人： Ming Xiao , Justin Sibert
发明人： Ming Xiao , Justin Sibert
IPC分类号： C12Q1/68 , C12N15/10 , C07H21/02 , G06F19/18
CPC分类号： C12N15/1068 , C12Q1/6806 , G06F19/18
摘要： The present invention relates to innovative means of generating sequence-linked DNA fragments and subsequent uses of such linked DNA fragments for de novo haplotype-resolved whole genome mapping and massively parallel sequencing. In various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme, or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments, and methods of de novo whole genome mapping. Thus, the methods of this invention allow establishing sequence contiguity across the whole genome, and achieving high-quality, low-cost de novo assembly of complex genomes.

7. 发明申请

US20150344873A1 Whole Genome Mapping by DNA Sequencing With Linked-Paired-End Library 有权
标题翻译：通过DNA测序的全基因组映射与链接配对文库
公开(公告)号：US20150344873A1
公开(公告)日：2015-12-03
申请号：US14728223
申请日：2015-06-02
申请人： Ming Xiao , Justin Sibert
发明人： Ming Xiao , Justin Sibert
IPC分类号： C12N15/10 , G06F19/18 , C12Q1/68
CPC分类号： C12N15/1068 , C12Q1/6806 , G06F19/18
摘要： The present invention relates to innovative means of generating sequence-linked DNA fragments and subsequent uses of such linked DNA fragments for de novo haplotype-resolved whole genome mapping and massively parallel sequencing. In various embodiments described herein, the methods of the invention relate to methods of generating paired-end nucleic acid fragment sharing common linker nucleic acid sequences using a nicking endonuclease, a T7 endonuclease, a restriction enzyme, or a transposase, methods of analyzing the nucleotides sequences from the linked-paired-end sequenced fragments, and methods of de novo whole genome mapping. Thus, the methods of this invention allow establishing sequence contiguity across the whole genome, and achieving high-quality, low-cost de novo assembly of complex genomes.
摘要翻译：本发明涉及产生序列连接的DNA片段的创新方法以及随后使用这种连接的DNA片段进行从头单体型解析的全基因组测绘和大规模并行测序。在本文描述的各种实施方案中，本发明的方法涉及使用切口内切核酸酶，T7内切核酸酶，限制酶或转座酶产生分支共同连接体核酸序列的配对末端核酸片段的方法，分析核苷酸的方法来自连锁配对末端测序片段的序列，以及从头整体基因组测绘的方法。因此，本发明的方法允许跨整个基因组建立序列连续性，并实现复杂基因组的高品质，低成本的从头装配。

8. 发明授权

US07771944B2 Methods for determining genetic haplotypes and DNA mapping 有权
标题翻译：确定遗传单倍体和DNA作图的方法
公开(公告)号：US07771944B2
公开(公告)日：2010-08-10
申请号：US11957216
申请日：2007-12-14
申请人： Ming Xiao , Pui-Yan Kwok , Paul Selvin , Mathew Gordon
发明人： Ming Xiao , Pui-Yan Kwok , Paul Selvin , Mathew Gordon
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/686 , C12Q1/6874 , C12Q2525/125 , C12Q2521/319 , C12Q2565/601 , C12Q2537/143
摘要： Improved methods of genetic haplotyping and DNA sequencing and mapping, including methods for making amplified ssDNA, methods for allele determination, and a DNA barcoding strategy based on direct imaging of individual DNA molecules and localization of multiple sequence motifs or polymorphic sites on a single DNA molecule.
摘要翻译：遗传单倍型和DNA测序和绘图的改进方法，包括制备扩增的ssDNA的方法，等位基因测定的方法和基于单个DNA分子的直接成像和多个序列基序或多态位点在单个DNA分子上的定位的DNA条形码策略。

9. 发明授权

US06323944B1 Compact spectrofluorometer 有权
标题翻译：紧凑型荧光分光光度计
公开(公告)号：US06323944B1
公开(公告)日：2001-11-27
申请号：US09443392
申请日：1999-11-19
申请人： Ming Xiao
发明人： Ming Xiao
IPC分类号： G01N2164
CPC分类号： G01J3/4406 , G01J3/02 , G01J3/0256 , G01J3/26 , G01J3/2803 , G01J2003/1213 , G01N21/645
摘要： Spectrofluorometer employing a pair of linear variable spectral filters to produce a three dimensional data output is disclosed. A collimated white light source is used that first passes through a first linear variable spectral filter, then through a sample where fluorescence occurs, then the resultant light passes through a second linear variable spectral light filter that is oriented at ninety degrees from the first filter. The light is then detected by a CCD sensor for conversion into data. This arrangement provides a very simple, rugged and compact instrument that can be used almost anywhere, such as at the scene of a contamination accident.
摘要翻译：公开了使用一对线性可变光谱滤波器产生三维数据输出的分光荧光计。使用准直的白光源，其首先通过第一线性可变光谱滤光器，然后通过荧光发生的样品，然后所得光通过从第一滤光器定向成90度的第二线性可变光谱滤光器。然后由CCD传感器检测光转换成数据。这种安排提供了一种非常简单，坚固耐用的紧凑型仪器，可以在几乎任何地方使用，例如在污染事故现场。

10. 发明申请

US20220352390A1 POWER SCHOTTKY BARRIER DIODES WITH HIGH BREAKDOWN VOLTAGE AND LOW LEAKAGE CURRENT 有权
公开(公告)号：US20220352390A1
公开(公告)日：2022-11-03
申请号：US17244394
申请日：2021-04-29
申请人： Yuhao ZHANG , Ming Xiao
发明人： Yuhao ZHANG , Ming Xiao
IPC分类号： H01L29/872 , H01L29/20 , H01L29/205 , H01L29/06 , H01L29/417 , H01L29/66
摘要： This disclosure provides a diode including a semiconductor region having at least one two-dimensional carrier channel of a first conductivity type. The diode also includes a plurality of sidewalls exposed in the semiconductor region defining at least one trench extending through the at least one two-dimensional carrier channel and a material of a second conductivity type, the second conductivity type being the other of the n-type and the p-type conductivity, disposed on the plurality of sidewalls and in contact with the at least one two-dimensional carrier channel. The diode also includes an anode material in contact with at least a portion of the semiconductor region and in contact with at least a portion of the material of the second conductivity type, and a cathode material in contact with the at least one two-dimensional carrier channel.

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