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1. 发明申请

US20090053707A1 Methods for lightening skin and hair 审中-公开
标题翻译：减轻皮肤和头发的方法
公开(公告)号：US20090053707A1
公开(公告)日：2009-02-26
申请号：US11983207
申请日：2007-11-07
申请人： Mina Yaar , Hee-Young Park , Vladimir Botchkarev , Barbara A. Gilchrest
发明人： Mina Yaar , Hee-Young Park , Vladimir Botchkarev , Barbara A. Gilchrest
IPC分类号： C12Q1/68 , C12Q1/02 , C12Q1/48 , G01N33/573
CPC分类号： A61Q5/08 , A61K8/64 , A61K8/981 , A61K8/985 , A61Q19/02
摘要： Methods are described wherein the skin of a vertebrate, or the skin or hair of a mammal can be lightened by administration of an agent, e.g., protein, peptide, active fusion protein, active fragment, or molecular mimic, that binds to BMP-4 transmembrane receptors on melanocytes and decreases the level of melanin synthesis. Also described are methods to identify molecules that mimic the function of BMP-4 in causing a decrease in melanin in melanocytes.
摘要翻译：描述了其中脊椎动物的皮肤或哺乳动物的皮肤或毛发可以通过施用与BMP-4结合的试剂例如蛋白质，肽，活性融合蛋白，活性片段或分子模拟物而减轻的方法黑色素细胞上的跨膜受体并降低黑色素合成的水平。还描述了鉴定模仿BMP-4功能以引起黑素细胞中黑色素减少的分子的方法。

2. 发明申请

US20100286247A1 Methods of Protection from Oxidative Stress 审中-公开
标题翻译：保护氧化应激的方法
公开(公告)号：US20100286247A1
公开(公告)日：2010-11-11
申请号：US11909435
申请日：2006-04-04
申请人： Barbara A. Gilchrest , Mark S. Eller , Mina Yaar , Margaret S. Lee-Bellantoni
发明人： Barbara A. Gilchrest , Mark S. Eller , Mina Yaar , Margaret S. Lee-Bellantoni
IPC分类号： A61K31/7088 , A61P3/10 , A61P9/00 , A61P9/12 , A61P17/00 , A61P25/28 , A61P27/02
CPC分类号： C12N15/115
摘要： Alterations in the structure of telomeres lead to modulation in the redox state of the cell. Substances which mimic destabilized telomeres, such as t-oligos, have a protective effect on future exposure of a cell to oxidative stress.
摘要翻译：端粒结构的变化导致细胞氧化还原状态的调节。模拟不稳定端粒的物质，如t-oligos，对未来细胞暴露于氧化应激具有保护作用。

3. 发明授权

US5470577A Stimulation of tanning by DNA fragments or single-stranded DNA 失效
标题翻译：通过DNA片段或单链DNA刺激鞣制
公开(公告)号：US5470577A
公开(公告)日：1995-11-28
申请号：US88251
申请日：1993-07-07
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/60 , A61K45/06 , A61Q19/04 , A61K37/22 , A61K9/50
CPC分类号： A61Q19/04 , A61K31/70 , A61K31/7008 , A61K31/7048 , A61K45/06 , A61K8/606
摘要： A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.
摘要翻译：公开了一种增加哺乳动物皮肤色素沉着的方法，以及保护哺乳动物皮肤免受紫外线损害。还公开了增加哺乳动物细胞中色素沉积的方法，以及增强哺乳动物黑素细胞中黑色素产生的方法。另外公开了本发明方法中有用的制剂。所述方法包括在脂质体制剂或其它合适的载体中向表皮或细胞施用单链或双链或二者或脱氧核苷酸的混合物的DNA片段。该制剂包括DNA片段或脱氧核苷酸以及合适的递送载体，例如脂质体。

4. 发明授权

US6147056A Use of locally applied DNA fragments 失效
标题翻译：使用局部应用的DNA片段
公开(公告)号：US6147056A
公开(公告)日：2000-11-14
申请号：US48927
申请日：1998-03-26
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K9/127 , A61K31/70 , A61K48/00 , A61P39/00 , C07H21/04 , C12N20060101
CPC分类号： A61K31/711 , A61K31/7048 , A61K31/713
摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative or allergically mediated diseases of other epithelia and methods for reducing photoaging or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed.
摘要翻译：治疗或预防影响上皮细胞如银屑病，白癜风，特应性皮炎或过度增生或紫外线反应性皮肤病的过度增殖性疾病或癌前病症的方法，其他上皮细胞过度增殖或过敏介导的疾病及减少光老化或预防的方法反映或减少皮肤癌发展的可能性。

5. 发明授权

US07196055B2 Inhibition of apoptosis in keratinocytes by a ligand of p75 nerve growth factor receptor 失效
标题翻译：通过p75神经生长因子受体的配体抑制角质细胞凋亡
公开(公告)号：US07196055B2
公开(公告)日：2007-03-27
申请号：US09018194
申请日：1998-02-04
申请人： Barbara A. Gilchrest , Mina Yaar , Mark S. Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark S. Eller
IPC分类号： A61K38/00 , A61K38/16
CPC分类号： A61K8/64 , A61K31/713 , A61K38/12 , A61K38/185 , A61Q7/00 , C07K7/64 , C12N15/113 , C12N15/1138 , C12N2310/315
摘要： Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.
摘要翻译：公开了控制或操纵黑素细胞和角化细胞死亡的方法。特别地，公开了一种防止由于脊椎动物中的损伤引起的表皮黑素细胞细胞损失的方法。还公开了一种在脊椎动物中诱导毛发生长的方法，在脊椎动物中诱发毛发颜色的方法，在脊椎动物中诱导肤色的方法，治疗个体中的秃发的方法以及治疗斑秃的方法个人。

6. 发明授权

US07094766B1 Use of locally applied DNA fragments 失效
标题翻译：使用局部应用的DNA片段
公开(公告)号：US07094766B1
公开(公告)日：2006-08-22
申请号：US09540843
申请日：2000-03-31
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K31/70 , A01N43/04
CPC分类号： A61Q17/04 , A61K8/606 , A61K9/0014 , A61K31/70 , A61K2800/86 , A61Q19/08
摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative or allergically mediated diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed.
摘要翻译：治疗或预防影响上皮细胞如银屑病，白癜风，特应性皮炎或过度增生或紫外线反应性皮肤病的过度增殖性疾病或癌前病症的方法，其他上皮细胞的过度增生或过敏介导的疾病以及减少光老化或氧化的方法公开了压力或用于预防或减少皮肤癌发展的可能性。

7. 发明授权

US06242416B1 Inhibition of &bgr;-amyloid binding to the p75 nerve growth factor receptor 失效
标题翻译：抑制β-淀粉样蛋白结合p75神经生长因子受体
公开(公告)号：US06242416B1
公开(公告)日：2001-06-05
申请号：US09163095
申请日：1998-09-29
申请人： Barbara A. Gilchrest , Mina Yaar
发明人： Barbara A. Gilchrest , Mina Yaar
IPC分类号： A61K3800
CPC分类号： C07K5/0815 , A61K38/00 , C07K14/4711 , C07K14/48 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： Methods of inhibiting &bgr;-amyloid-mediated activation of the p75 nerve growth factor receptor of a cell that expresses the p75 nerve growth factor receptor are provided. Methods of inhibiting the binding of &bgr;-amyloid protein and &bgr;-amyloid peptides to the p75 nerve growth factor receptor, and methods of inhibiting &bgr;-amyloid-mediated apoptosis of neural crest-derived cells are provided. The methods comprise contacting the cell with a substance, comprising, for example, the amino acid sequence lysine-glycine-lysine (KGK) or lysine-glycine-alanine (KGA), wherein the substance binds to the p75 nerve growth factor receptor, resulting in the inhibition of &bgr;-amyloid protein or &bgr;-amyloid peptide binding to and/or activation of the p75 nerve growth factor receptor, or wherein the substance inhibits &bgr;-amyloid protein or &bgr;-amyloid peptide mediated apoptosis of the cell which expresses the p75 nerve growth factor receptor.
摘要翻译：提供了抑制β-淀粉样蛋白介导的表达p75神经生长因子受体的细胞的p75神经生长因子受体活化的方法。提供了抑制β-淀粉样蛋白和β-淀粉样肽与p75神经生长因子受体结合的方法，以及抑制β-淀粉样蛋白介导的神经嵴衍生细胞凋亡的方法。所述方法包括使细胞与包含例如氨基酸序列赖氨酸 - 甘氨酸 - 赖氨酸（KGK）或赖氨酸 - 甘氨酸 - 丙氨酸（KGA）的物质接触，其中所述物质与p75神经生长因子受体结合，得到在β-淀粉样蛋白或β-淀粉样肽与p75神经生长因子受体结合和/或活化的抑制中，或其中该物质抑制β-淀粉样蛋白或β-淀粉样肽介导的表达p75的细胞的凋亡神经生长因子受体。

8. 发明授权

US6103689A Methods of inducing hair growth and coloration 失效
标题翻译：诱导毛发生长和着色的方法
公开(公告)号：US6103689A
公开(公告)日：2000-08-15
申请号：US298941
申请日：1994-08-31
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/64 , A61K38/18 , A61Q7/00 , A61K38/02 , A61K38/04
CPC分类号： A61K31/713 , A61K38/185 , A61K8/64 , A61Q7/00 , Y10S514/88
摘要： A method for maintaining hair growth and coloration in humans by using neurotrophin ligands to prevent p75 nerve growth factor (NGF) receptor mediated apoptosis in melanocytes and keratinocytes is described.
摘要翻译：描述了通过使用神经营养因子配体来保护人类毛发生长和着色以防止黑素细胞和角质形成细胞中p75神经生长因子（NGF）受体介导的细胞凋亡的方法。

9. 发明授权

US5955059A Use of locally applied DNA fragments 失效
标题翻译：使用局部应用的DNA片段
公开(公告)号：US5955059A
公开(公告)日：1999-09-21
申请号：US467012
申请日：1995-06-06
申请人： Barbara A. Gilchrest , Mark Eller , Mina Yaar
发明人： Barbara A. Gilchrest , Mark Eller , Mina Yaar
IPC分类号： C07H21/04 , A01N43/04 , A61K9/08 , A61K9/12 , A61K9/127 , A61K31/70 , A61K47/10 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/16 , A61P35/00 , C12N15/00 , A61K7/42
CPC分类号： A61K31/7048 , A61K31/711
摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-induced dermatoses, and methods for reducing photoaging or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed. The methods comprise administering to the cells of interest an effective amount of DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers. The DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers can be administered in an appropriate vehicle, such as a liposomal preparation or propylene glycol. Preparations useful in the present methods are additionally disclosed. The preparations comprise DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers, and an appropriate delivery vehicle, such as liposomes or propylene glycol.
摘要翻译：治疗或预防影响上皮细胞如银屑病，白癜风，特应性皮炎或过度增生性或UV诱导的皮肤病的过度增殖性疾病或癌前病症的方法，以及用于减少光老化或预防或降低可能性的方法公开了皮肤癌的发展。所述方法包括向感兴趣的细胞施用有效量的单链或双链的DNA片段，或单链和双链片段或脱氧核苷酸，二核苷酸或二核苷酸二聚体的混合物。 DNA片段，脱氧核苷酸，二核苷酸或二核苷酸二聚体可以在合适的载体如脂质体制剂或丙二醇中施用。另外公开了本发明方法中有用的制剂。制备物包括单链或双链的DNA片段，或单链和双链片段或脱氧核苷酸，二核苷酸或二核苷酸二聚体以及合适的递送载体如脂质体或丙二醇的混合物。

10. 发明授权

US5532001A Stimulation of tanning by DNA fragments or single-stranded DNA 失效
公开(公告)号：US5532001A
公开(公告)日：1996-07-02
申请号：US451317
申请日：1995-05-26
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/60 , A61K45/06 , A61Q19/04 , A61K9/127
CPC分类号： A61Q19/04 , A61K31/70 , A61K31/7008 , A61K31/7048 , A61K45/06 , A61K8/606
摘要： A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.

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