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1. 发明授权

US5470577A Stimulation of tanning by DNA fragments or single-stranded DNA 失效
标题翻译：通过DNA片段或单链DNA刺激鞣制
公开(公告)号：US5470577A
公开(公告)日：1995-11-28
申请号：US88251
申请日：1993-07-07
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/60 , A61K45/06 , A61Q19/04 , A61K37/22 , A61K9/50
CPC分类号： A61Q19/04 , A61K31/70 , A61K31/7008 , A61K31/7048 , A61K45/06 , A61K8/606
摘要： A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.
摘要翻译：公开了一种增加哺乳动物皮肤色素沉着的方法，以及保护哺乳动物皮肤免受紫外线损害。还公开了增加哺乳动物细胞中色素沉积的方法，以及增强哺乳动物黑素细胞中黑色素产生的方法。另外公开了本发明方法中有用的制剂。所述方法包括在脂质体制剂或其它合适的载体中向表皮或细胞施用单链或双链或二者或脱氧核苷酸的混合物的DNA片段。该制剂包括DNA片段或脱氧核苷酸以及合适的递送载体，例如脂质体。

2. 发明授权

US6147056A Use of locally applied DNA fragments 失效
标题翻译：使用局部应用的DNA片段
公开(公告)号：US6147056A
公开(公告)日：2000-11-14
申请号：US48927
申请日：1998-03-26
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K9/127 , A61K31/70 , A61K48/00 , A61P39/00 , C07H21/04 , C12N20060101
CPC分类号： A61K31/711 , A61K31/7048 , A61K31/713
摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative or allergically mediated diseases of other epithelia and methods for reducing photoaging or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed.
摘要翻译：治疗或预防影响上皮细胞如银屑病，白癜风，特应性皮炎或过度增生或紫外线反应性皮肤病的过度增殖性疾病或癌前病症的方法，其他上皮细胞过度增殖或过敏介导的疾病及减少光老化或预防的方法反映或减少皮肤癌发展的可能性。

3. 发明授权

US07094766B1 Use of locally applied DNA fragments 失效
标题翻译：使用局部应用的DNA片段
公开(公告)号：US07094766B1
公开(公告)日：2006-08-22
申请号：US09540843
申请日：2000-03-31
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K31/70 , A01N43/04
CPC分类号： A61Q17/04 , A61K8/606 , A61K9/0014 , A61K31/70 , A61K2800/86 , A61Q19/08
摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative or allergically mediated diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed.
摘要翻译：治疗或预防影响上皮细胞如银屑病，白癜风，特应性皮炎或过度增生或紫外线反应性皮肤病的过度增殖性疾病或癌前病症的方法，其他上皮细胞的过度增生或过敏介导的疾病以及减少光老化或氧化的方法公开了压力或用于预防或减少皮肤癌发展的可能性。

4. 发明授权

US6103689A Methods of inducing hair growth and coloration 失效
标题翻译：诱导毛发生长和着色的方法
公开(公告)号：US6103689A
公开(公告)日：2000-08-15
申请号：US298941
申请日：1994-08-31
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/64 , A61K38/18 , A61Q7/00 , A61K38/02 , A61K38/04
CPC分类号： A61K31/713 , A61K38/185 , A61K8/64 , A61Q7/00 , Y10S514/88
摘要： A method for maintaining hair growth and coloration in humans by using neurotrophin ligands to prevent p75 nerve growth factor (NGF) receptor mediated apoptosis in melanocytes and keratinocytes is described.
摘要翻译：描述了通过使用神经营养因子配体来保护人类毛发生长和着色以防止黑素细胞和角质形成细胞中p75神经生长因子（NGF）受体介导的细胞凋亡的方法。

5. 发明授权

US5955059A Use of locally applied DNA fragments 失效
标题翻译：使用局部应用的DNA片段
公开(公告)号：US5955059A
公开(公告)日：1999-09-21
申请号：US467012
申请日：1995-06-06
申请人： Barbara A. Gilchrest , Mark Eller , Mina Yaar
发明人： Barbara A. Gilchrest , Mark Eller , Mina Yaar
IPC分类号： C07H21/04 , A01N43/04 , A61K9/08 , A61K9/12 , A61K9/127 , A61K31/70 , A61K47/10 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/16 , A61P35/00 , C12N15/00 , A61K7/42
CPC分类号： A61K31/7048 , A61K31/711
摘要： Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-induced dermatoses, and methods for reducing photoaging or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed. The methods comprise administering to the cells of interest an effective amount of DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers. The DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers can be administered in an appropriate vehicle, such as a liposomal preparation or propylene glycol. Preparations useful in the present methods are additionally disclosed. The preparations comprise DNA fragments, either single- or double-stranded, or a mixture of both single- and double-stranded fragments, or deoxynucleotides, dinucleotides, or dinucleotide dimers, and an appropriate delivery vehicle, such as liposomes or propylene glycol.
摘要翻译：治疗或预防影响上皮细胞如银屑病，白癜风，特应性皮炎或过度增生性或UV诱导的皮肤病的过度增殖性疾病或癌前病症的方法，以及用于减少光老化或预防或降低可能性的方法公开了皮肤癌的发展。所述方法包括向感兴趣的细胞施用有效量的单链或双链的DNA片段，或单链和双链片段或脱氧核苷酸，二核苷酸或二核苷酸二聚体的混合物。 DNA片段，脱氧核苷酸，二核苷酸或二核苷酸二聚体可以在合适的载体如脂质体制剂或丙二醇中施用。另外公开了本发明方法中有用的制剂。制备物包括单链或双链的DNA片段，或单链和双链片段或脱氧核苷酸，二核苷酸或二核苷酸二聚体以及合适的递送载体如脂质体或丙二醇的混合物。

6. 发明授权

US5532001A Stimulation of tanning by DNA fragments or single-stranded DNA 失效
公开(公告)号：US5532001A
公开(公告)日：1996-07-02
申请号：US451317
申请日：1995-05-26
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/60 , A61K45/06 , A61Q19/04 , A61K9/127
CPC分类号： A61Q19/04 , A61K31/70 , A61K31/7008 , A61K31/7048 , A61K45/06 , A61K8/606
摘要： A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.

7. 发明授权

US06867179B1 Methods of inducing hair growth and coloration 失效
标题翻译：诱导毛发生长和着色的方法
公开(公告)号：US06867179B1
公开(公告)日：2005-03-15
申请号：US09632748
申请日：2000-08-04
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/64 , A61K38/00 , A61K38/12 , A61K38/18 , A61Q7/00 , C07K7/64 , C12N15/113 , A61K38/08 , A61K38/17
CPC分类号： A61K31/713 , A61K8/64 , A61K38/12 , A61K38/185 , A61Q7/00 , C07K7/64 , C12N15/113 , C12N15/1138 , C12N2310/315
摘要： Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.
摘要翻译：公开了控制或操纵黑素细胞和角化细胞死亡的方法。特别地，公开了一种防止由于脊椎动物中的损伤引起的表皮黑素细胞细胞损失的方法。还公开了一种在脊椎动物中诱导毛发生长的方法，在脊椎动物中诱发毛发颜色的方法，在脊椎动物中诱导肤色的方法，治疗个体中秃发的方法以及治疗斑秃的方法个人。

8. 发明授权

US5643556A Stimulation of tanning by DNA fragments or single-stranded DNA 失效
标题翻译：通过DNA片段或单链DNA刺激鞣制
公开(公告)号：US5643556A
公开(公告)日：1997-07-01
申请号：US493251
申请日：1995-06-06
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/60 , A61K45/06 , A61Q19/04 , A61K48/00 , A61K7/42 , A61K47/30
CPC分类号： A61Q19/04 , A61K31/70 , A61K31/7008 , A61K31/7048 , A61K45/06 , A61K8/606
摘要： A method of stimulating pigment production in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of stimulating pigment production in mammalian cells, a method of stimulating melanogenesis in mammalian melanocytes, and a culture medium for stimulating melanin production. Preparations useful in the present methods are additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, dinucleotides, or dinucleotide dimers, in an appropriate vehicle, such as a liposomal preparation or propylene glycol. The preparations include DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers and an appropriate delivery vehicle, such as liposomes or a propylene glycol. The DNA fragments, deoxynucleotides, or dinucleotides used in the methods or in the preparations can be ultraviolet-irradiated. The preparations are sunlight-independent tanning or melanogenesis-stimulating agent.
摘要翻译：公开了刺激哺乳动物皮肤中颜料产生的方法，以及保护哺乳动物皮肤免受紫外线损害。还公开了刺激哺乳动物细胞中颜料产生的方法，刺激哺乳动物黑素细胞中黑素生成的方法，以及用于刺激黑色素生成的培养基。另外公开了本发明方法中有用的制剂。所述方法包括向合适的载体（例如脂质体制剂或丙二醇）向表皮或细胞施用单链或双链或二者或脱氧核苷酸二核苷酸或二核苷酸二聚体的DNA片段。制备物包括DNA片段，脱氧核苷酸，二核苷酸或二核苷酸二聚体和合适的递送载体，例如脂质体或丙二醇。在方法或制剂中使用的DNA片段，脱氧核苷酸或二核苷酸可以被紫外线照射。制剂是无阳光独立的鞣制或黑素生成刺激剂。

9. 发明授权

US5580547A Stimulation of tanning by DNA fragments or single-stranded DNA 失效
公开(公告)号：US5580547A
公开(公告)日：1996-12-03
申请号：US463425
申请日：1995-05-26
申请人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
发明人： Barbara A. Gilchrest , Mina Yaar , Mark Eller
IPC分类号： A61K8/60 , A61K45/06 , A61Q19/04 , A61K37/22 , A61K9/50
CPC分类号： A61Q19/04 , A61K31/70 , A61K31/7008 , A61K31/7048 , A61K45/06 , A61K8/606
摘要： A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.

10. 发明申请

US20100286247A1 Methods of Protection from Oxidative Stress 审中-公开
标题翻译：保护氧化应激的方法
公开(公告)号：US20100286247A1
公开(公告)日：2010-11-11
申请号：US11909435
申请日：2006-04-04
申请人： Barbara A. Gilchrest , Mark S. Eller , Mina Yaar , Margaret S. Lee-Bellantoni
发明人： Barbara A. Gilchrest , Mark S. Eller , Mina Yaar , Margaret S. Lee-Bellantoni
IPC分类号： A61K31/7088 , A61P3/10 , A61P9/00 , A61P9/12 , A61P17/00 , A61P25/28 , A61P27/02
CPC分类号： C12N15/115
摘要： Alterations in the structure of telomeres lead to modulation in the redox state of the cell. Substances which mimic destabilized telomeres, such as t-oligos, have a protective effect on future exposure of a cell to oxidative stress.
摘要翻译：端粒结构的变化导致细胞氧化还原状态的调节。模拟不稳定端粒的物质，如t-oligos，对未来细胞暴露于氧化应激具有保护作用。

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