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    • 6. 发明申请
    • Synthetic, bioabsorbable polymer materials and implants
    • 合成,生物可吸收的聚合物材料和植入物
    • US20070134292A1
    • 2007-06-14
    • US10565023
    • 2004-07-19
    • Esa SuokasNureddin AshammakhiPertti Tormala
    • Esa SuokasNureddin AshammakhiPertti Tormala
    • A61F2/00
    • A61F2/02A61F2210/0004A61F2250/0067A61L17/005A61L31/16A61L2300/00
    • The invention relates to synthetic, bioabsorbable polymer materials and implants, like fibres, sutures, meshes and other tissue management, wound closure or tissue engineering devices, which contain: a) a bioabsorbable polymeric matrix; b) antibiotic and/or anti-inflammatory agent particles or mixture thereof, dispersed in the matrix, and c) optionally an additive agent to facilitate device recognition and/or handling to facilitate the use and application of finalized product. In the matrix, cavities around the particles are induced by mechanical processing of the matrix phase. A preferred embodiment of the present invention is a device (suture) that provides a sustained release of antibiotic agent over several days to several weeks for the prevention or treatment of infection. The sutures may be effectively implanted into or in the vicinity of: 1) infected tissue, 2) potentially infected tissue, or in tissues where infection, should it occur, leads to disastrous consequences.
    • 本发明涉及合成的,生物可吸收的聚合物材料和植入物,如纤维,缝合线,网眼和其他组织管理,伤口闭合或组织工程装置,其包含:a)生物可吸收聚合物基质; b)分散在基质中的抗生素和/或抗炎剂颗粒或其混合物,以及c)任选的添加剂,以促进装置的识别和/或处理以促进最终产品的使用和应用。 在矩阵中,通过基体相的机械加工来诱导颗粒周围的空腔。 本发明的一个优选实施方案是一种装置(缝合线),其在几天至几周内提供抗生素剂的持续释放以预防或治疗感染。 缝合线可以有效地植入或附近:1)感染的组织,2)潜在的感染组织,或在感染发生的组织中会导致灾难性的后果。