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    • 1. 发明授权
    • Use of polyethylene glycol to control the spray pattern of sprayable liquid abrasive cleansers
    • 使用聚乙二醇控制可喷涂液体磨料清洁剂的喷雾形式
    • US09546346B2
    • 2017-01-17
    • US13081758
    • 2011-04-07
    • Mick BjelopavlicJoan M. BergstromFelix Ayala-Fierro
    • Mick BjelopavlicJoan M. BergstromFelix Ayala-Fierro
    • C11D9/20C11D3/37C11D3/12
    • C11D3/3707C11D3/1233
    • Liquid abrasive cleanser compositions sprayable through conventional manual trigger sprayers comprise a polyalkylene glycol, a nonionic surfactant, a pH adjusting agent, an abrasive, and water, wherein sprayability is made possible by the addition of the polyalkylene glycol. The compositions that are sprayable and acceptable as hard surface cleaners comprise polyethylene glycol as the polyalkylene glycol. The addition of polyethylene glycol having molecular weight of from about 4,000 to about 1,000,000 dramatically increases the sprayer output volume of liquid abrasive compositions having greater than or equal to 10 wt. % calcium carbonate. Addition of polyethylene glycol of molecular weight of from about 4,000 to about 100,000 converts otherwise non-sprayable liquid abrasive compositions into reliably sprayable compositions. Addition of PEG having molecular weight from about 4,000 to about 100,000 also provides a method for controlling the spray pattern of sprayable liquid abrasive compositions, in particular a method for optimizing the diameter of a conical spray pattern produced from a manual trigger sprayer having a conical spray nozzle.
    • 可通过常规手动触发式喷雾器喷雾的液体磨料清洁剂组合物包括聚亚烷基二醇,非离子表面活性剂,pH调节剂,研磨剂和水,其中可通过加入聚亚烷基二醇进行喷涂。 作为硬表面清洁剂可喷涂和可接受的组合物包含聚乙二醇作为聚亚烷基二醇。 分子量为约4000至约1,000,000的聚乙二醇的加入显着增加了具有大于或等于10重量%的液体磨料组合物的喷雾器输出体积。 %碳酸钙。 加入分子量为约4000至约100,000的聚乙二醇将其它不可喷涂的液体磨料组合物转化为可靠地喷雾的组合物。 分子量为约4000至约100,000的PEG的添加还提供了一种用于控制可喷涂液体研磨剂组合物的喷雾图案的方法,特别是用于优化由具有锥形喷雾器的手动扳机喷雾器产生的锥形喷雾图案的直径的方法 喷嘴。
    • 2. 发明申请
    • USE OF POLYETHYLENE GLYCOL TO CONTROL THE SPRAY PATTERN OF SPRAYABLE LIQUID ABRASIVE CLEANSERS
    • 使用聚乙烯甘油控制可喷涂液体清洁剂的喷雾图案
    • US20120258904A1
    • 2012-10-11
    • US13081758
    • 2011-04-07
    • Mick BjelopavlicJoan M. BergstromFelix Ayala-Fierro
    • Mick BjelopavlicJoan M. BergstromFelix Ayala-Fierro
    • C11D3/60
    • C11D3/3707C11D3/1233
    • Liquid abrasive cleanser compositions sprayable through conventional manual trigger sprayers comprise a polyalkylene glycol, a nonionic surfactant, a pH adjusting agent, an abrasive, and water, wherein sprayability is made possible by the addition of the polyalkylene glycol. The compositions that are sprayable and acceptable as hard surface cleaners comprise polyethylene glycol as the polyalkylene glycol. The addition of polyethylene glycol having molecular weight of from about 4,000 to about 1,000,000 dramatically increases the sprayer output volume of liquid abrasive compositions having greater than or equal to 10 wt. % calcium carbonate. Addition of polyethylene glycol of molecular weight of from about 4,000 to about 100,000 converts otherwise non-sprayable liquid abrasive compositions into reliably sprayable compositions. Addition of PEG having molecular weight from about 4,000 to about 100,000 also provides a method for controlling the spray pattern of sprayable liquid abrasive compositions, in particular a method for optimizing the diameter of a conical spray pattern produced from a manual trigger sprayer having a conical spray nozzle.
    • 可通过常规手动触发式喷雾器喷雾的液体磨料清洁剂组合物包括聚亚烷基二醇,非离子表面活性剂,pH调节剂,研磨剂和水,其中可通过加入聚亚烷基二醇进行喷涂。 作为硬表面清洁剂可喷涂和可接受的组合物包含聚乙二醇作为聚亚烷基二醇。 分子量为约4000至约1,000,000的聚乙二醇的加入显着增加了具有大于或等于10重量%的液体磨料组合物的喷雾器输出体积。 %碳酸钙。 加入分子量为约4000至约100,000的聚乙二醇将其它不可喷涂的液体磨料组合物转化为可靠地喷雾的组合物。 分子量为约4000至约100,000的PEG的添加还提供了一种用于控制可喷涂液体研磨剂组合物的喷雾图案的方法,特别是用于优化由具有锥形喷雾器的手动扳机喷雾器产生的锥形喷雾图案的直径的方法 喷嘴。
    • 9. 发明授权
    • Hydrophilic pressure sensitive adhesive for topical administration of
hydrophobic drugs
    • 疏水性压敏胶粘剂用于静脉注射药物的局部给药
    • US5173302A
    • 1992-12-22
    • US590648
    • 1990-09-28
    • Carolann M. HolmbladJoan M. BergstromTerese A. Bartlett
    • Carolann M. HolmbladJoan M. BergstromTerese A. Bartlett
    • A61K9/70A61L15/44A61L15/58
    • A61K9/7061A61L15/58
    • Novel hydrogel formulations useful as adhesive reservoirs for topical or transdermal drugs employ as the polymer base a crosslinked polymer or copolymer of 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof. The gels are prepared from polymerizable compositions comprising:20%-50% of a monofunctional monomer component, at least 75% of said component comprising 2-acrylamido-2-methylpropane sulfonic acid or a salt thereof, the balance being selected from the group consisting of acrylic acid, water soluble acrylic functional monomers and vinyl pyrrolidone;30%-50% of a glycol component selected from the group consisting of compounds of the formulaHO--(C.sub.2 H.sub.4 O).sub.n --H,HO--(C.sub.3 H.sub.6 O).sub.m --H and mixtures thereof, where n is in the range of about 4 to about 16 and m is 1-4;between about 0.02% and about 0.20% of a crosslinking monomer;an amount of a free radical polymerization initiator effective for initiating polymerization of said monofunctional monomer and crosslinking monomer components; anda therapeutically effective amount of a topically or transdermally deliverable drug, at least about 60% of said drug being dissolved in the formulation.
    • 用作局部或透皮药物的粘合剂储存器的新型水凝胶制剂使用2-丙烯酰胺基-2-甲基丙磺酸或其盐的交联聚合物或共聚物作为聚合物基质。 凝胶由可聚合组合物制备,包括:20%-50%的单官能单体组分,至少75%的所述组分包含2-丙烯酰氨基-2-甲基丙磺酸或其盐,余量选自 的丙烯酸,水溶性丙烯酸官能单体和乙烯基吡咯烷酮; 30%-50%的选自式HO-(C 2 H 4 O)n H,HO-(C 3 H 6 O)m H的化合物及其混合物的二醇组分,其中n在约4至约16的范围内,m 是1-4; 约0.02%至约0.20%的交联单体; 一定量的自由基聚合引发剂,用于引发所述单官能单体和交联单体组分的聚合; 和治疗有效量的局部或透皮递送的药物,至少约60%的所述药物溶解在制剂中。