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1. 发明申请

US20120329074A1 MARKER FOR DETECTING GASTRIC CANCER AND METHOD FOR DETECTING GASTRIC CANCER 有权
标题翻译：用于检测胃癌的标记物和用于检测胃癌的方法
公开(公告)号：US20120329074A1
公开(公告)日：2012-12-27
申请号：US13582316
申请日：2011-03-03
申请人： Yoshinori Tanaka , Satoko Kanamori , Michimoto Kobayashi , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
发明人： Yoshinori Tanaka , Satoko Kanamori , Michimoto Kobayashi , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
IPC分类号： G01N33/574
CPC分类号： G01N33/57446 , G01N2333/4712
摘要： It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.
摘要翻译：目的在于提供一种检测对人体检测对象侵袭性低，检测灵敏度高，准确度高的胃癌的方法。本发明提供了一种方法，其包括在源自人类受检者的体液样品中体外测量COTL1蛋白，其变体和/或其片段的量，并检测影响测试的胃癌的存在或不存在基于该量的受试者，以及包含能够特异性结合蛋白质的抗体的胃癌诊断试剂盒。

2. 发明授权

US09127054B2 Immunoassay of cofilin 1 protein 有权
标题翻译： cofilin 1蛋白的免疫测定
公开(公告)号：US09127054B2
公开(公告)日：2015-09-08
申请号：US13992567
申请日：2011-12-05
申请人： Michimoto Kobayashi , Yoshinori Tanaka , Aiko Takayama , Satoko Kanamori , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
发明人： Michimoto Kobayashi , Yoshinori Tanaka , Aiko Takayama , Satoko Kanamori , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
IPC分类号： C07K16/18 , G01N33/577 , G01N33/574
CPC分类号： C07K16/18 , C07K2317/34 , G01N33/57446 , G01N33/577
摘要： An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.
摘要翻译：本发明的目的是实现特异性识别椰子蛋白1蛋白的抗体或其片段，以及检测和检测具有高检测性能的胃肠癌的方法，其包括使用抗体或免疫球蛋白进行免疫测定片段。使用两种或更多种类型的抗-cofilin1单克隆抗体或其片段特异性识别构成所述辅酶1蛋白的氨基酸序列中的不同肽区域的方法，对样品中的菲菲林1或其片段进行测定。

3. 发明申请

US20130011865A1 MARKER FOR DETECTING GASTRIC CANCER AND METHOD FOR DETECTING GASTRIC CANCER 审中-公开
标题翻译：用于检测胃癌的标记物和用于检测胃癌的方法
公开(公告)号：US20130011865A1
公开(公告)日：2013-01-10
申请号：US13582382
申请日：2011-03-03
申请人： Michimoto Kobayashi , Yoshinori Tanaka , Satoko Kanamori , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
发明人： Michimoto Kobayashi , Yoshinori Tanaka , Satoko Kanamori , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
IPC分类号： G01N33/574 , G01N21/64 , C07K16/18
CPC分类号： G01N33/57446 , C07K14/4702 , G01N33/57488
摘要： It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of Cofilin 1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.
摘要翻译：目的在于提供一种检测对人体检测对象侵袭性低，检测灵敏度高，准确度高的胃癌的方法。本发明提供了一种方法，其包括在体外测定源自人类受检者的体液样品中的Cofilin1蛋白，其变体和/或其片段的量，并检测是否存在影响基于该量的测试对象，以及包含能够特异性结合蛋白质的抗体的胃癌诊断试剂盒。

4. 发明授权

US09081013B2 Marker for detecting gastric cancer and method for detecting gastric cancer 有权
标题翻译：检测胃癌的标志物和检测胃癌的方法
公开(公告)号：US09081013B2
公开(公告)日：2015-07-14
申请号：US13582316
申请日：2011-03-03
申请人： Yoshinori Tanaka , Satoko Kanamori , Michimoto Kobayashi , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
发明人： Yoshinori Tanaka , Satoko Kanamori , Michimoto Kobayashi , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
IPC分类号： G01N33/53 , G01N33/574
CPC分类号： G01N33/57446 , G01N2333/4712
摘要： It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.
摘要翻译：目的在于提供一种检测对人体检测对象侵袭性低，检测灵敏度高，准确度高的胃癌的方法。本发明提供了一种方法，其包括在源自人类受检者的体液样品中体外测量COTL1蛋白，其变体和/或其片段的量，并检测影响测试的胃癌的存在或不存在基于该量的受试者，以及包含能够特异性结合蛋白质的抗体的胃癌诊断试剂盒。

5. 发明申请

US20130288277A1 IMMUNOASSAY OF COFILIN 1 PROTEIN 有权
标题翻译： COFILIN 1蛋白免疫
公开(公告)号：US20130288277A1
公开(公告)日：2013-10-31
申请号：US13992567
申请日：2011-12-05
申请人： Michimoto Kobayashi , Yoshinori Tanaka , Aiko Takayama , Satoko Kanamori , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
发明人： Michimoto Kobayashi , Yoshinori Tanaka , Aiko Takayama , Satoko Kanamori , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
IPC分类号： C07K16/18 , G01N33/577
CPC分类号： C07K16/18 , C07K2317/34 , G01N33/57446 , G01N33/577
摘要： An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.
摘要翻译：本发明的目的是实现特异性识别椰子蛋白1蛋白的抗体或其片段，以及检测和检测具有高检测性能的胃肠癌的方法，其包括使用抗体或免疫球蛋白进行免疫测定片段。使用两种或更多种类型的抗-cofilin1单克隆抗体或其片段特异性识别构成所述辅酶1蛋白的氨基酸序列中的不同肽区域的方法，对样品中的菲菲林1或其片段进行测定。

6. 发明申请

US20140363825A1 MARKER FOR DETECTING COLORECTAL CANCER OR ESOPHAGEAL CANCER AND METHOD FOR EXAMINING SUCH CANCER 审中-公开
标题翻译：用于检测彩色癌或食道癌的标记和检查此类癌症的方法
公开(公告)号：US20140363825A1
公开(公告)日：2014-12-11
申请号：US14241656
申请日：2012-08-28
申请人： Michimoto Kobayashi , Yoshinori Tanaka , Aiko Takayama , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
发明人： Michimoto Kobayashi , Yoshinori Tanaka , Aiko Takayama , Giman Jung , Yoshiharu Sakai , Hiroshi Okabe
IPC分类号： G01N33/574
CPC分类号： G01N33/57496 , C07K16/18 , C07K16/3046 , G01N33/57419
摘要： This invention relates to a method for detecting or examining a cancer selected from colorectal cancer and esophageal cancer with high detection sensitivity and accuracy and with less invasiveness to a subject. Specifically, it relates to a method for examining a cancer comprising measuring in vitro a COTL1 protein in a body fluid sample from a subject and evaluating whether or not the subject suffers from the cancer based on the measured amount of the COTL1 protein. It further relates to a kit for diagnosis of a cancer selected from colorectal cancer and esophageal cancer comprising an antibody or a fragment thereof capable of specifically binding to the protein.
摘要翻译：本发明涉及一种用于检测或检查选自结肠直肠癌和食管癌的癌症的方法，其具有高检测灵敏度和准确性并且对受试者的侵袭性较小。具体地，本发明涉及一种用于检查癌症的方法，其包括在体外测量来自受试者的体液样品中的COTL1蛋白质，并基于所测量的COTL1蛋白质评估受试者是否患有癌症。它还涉及用于诊断选自结肠直肠癌和食管癌的癌症的试剂盒，其包含能够特异性结合蛋白质的抗体或其片段。

7. 发明授权

US09645011B2 Optical device having polarizer and non-active retarders for spectroscopic polarimetry 有权
公开(公告)号：US09645011B2
公开(公告)日：2017-05-09
申请号：US12965165
申请日：2010-12-10
申请人： Hiroshi Okabe , Kenichi Matoba , Kazuhiko Oka
发明人： Hiroshi Okabe , Kenichi Matoba , Kazuhiko Oka
IPC分类号： G01J4/04 , G01J3/447
CPC分类号： G01J4/04 , G01J3/447
摘要： In the channeled spectroscopic polarimetry, a measurement error of a parameter showing a spectropolarization characteristic of a sample is effectively removed, the error being generated by various variations in retardation of a retarder depending upon the state of the sample. With attention being focused that the retardation of the retarder may be kept constant by stabilization of an incident direction of light that transmits through the retarder, the retarder was arranged on the light source side with respect to the sample so as to effectively remove an influence relative to a measurement error, such as variations in direction of a light ray due to the sample.

8. 发明授权

US08072289B2 Composite right/left (CRLH) couplers 有权
标题翻译：复合右/左（CRLH）耦合器
公开(公告)号：US08072289B2
公开(公告)日：2011-12-06
申请号：US12122311
申请日：2008-05-16
申请人： Tatsuo Itoh , Christophe Caloz , I-Hsiang Lin , Hiroshi Okabe
发明人： Tatsuo Itoh , Christophe Caloz , I-Hsiang Lin , Hiroshi Okabe
IPC分类号： H01P5/12 , H01P5/22
CPC分类号： H01P5/227
摘要： High-frequency couplers and coupling techniques are described utilizing artificial composite right/left-handed transmission line (CRLH-TL). Three specific forms of couplers are described; (1) a coupled-line backward coupler is described with arbitrary tight/loose coupling and broad bandwidth; (2) a compact enhanced-bandwidth hybrid ring coupler is described with increased bandwidth and decreased size; and (3) a dual-band branch-line coupler that is not limited to a harmonic relation between the bands. These variations are preferably implemented in a microstrip fabrication process and may use lumped-element components. The couplers and coupling techniques are directed at increasing the utility while decreasing the size of high-frequency couplers, and are suitable for use with separate coupler or couplers integrated within integrated devices.
摘要翻译：利用人造复合右/左传输线（CRLH-TL）描述高频耦合器和耦合技术。描述了三种具体形式的耦合器; （1）耦合线反向耦合器被描述为具有任意的紧/松耦合和宽带宽; （2）以增加的带宽和减小的尺寸描述紧凑的增强带宽混合环耦合器; 和（3）双频分支线耦合器，不限于频带之间的谐波关系。这些变化优选地在微带制造过程中实现，并且可以使用集总元件部件。耦合器和耦合技术旨在增加效用，同时降低高频耦合器的尺寸，并且适用于集成在集成器件内的单独的耦合器或耦合器。

9. 发明申请

US20100230789A1 SEMICONDUCTOR DEVICE AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：半导体器件及其制造方法
公开(公告)号：US20100230789A1
公开(公告)日：2010-09-16
申请号：US12724268
申请日：2010-03-15
申请人： Chiko Yorita , Yuji Shirai , Hirokazu Nakajima , Hiroshi Ozaku , Tomonori Tanoue , Hiroshi Okabe , Tsutomu Hara
发明人： Chiko Yorita , Yuji Shirai , Hirokazu Nakajima , Hiroshi Ozaku , Tomonori Tanoue , Hiroshi Okabe , Tsutomu Hara
IPC分类号： H01L23/552 , H01L21/78 , H01L21/56
CPC分类号： H01L23/66 , H01L23/3121 , H01L23/3677 , H01L23/49838 , H01L23/50 , H01L23/5383 , H01L23/552 , H01L24/45 , H01L24/48 , H01L24/97 , H01L2223/6644 , H01L2224/32225 , H01L2224/45144 , H01L2224/45147 , H01L2224/48091 , H01L2224/48227 , H01L2224/73265 , H01L2224/97 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01012 , H01L2924/01013 , H01L2924/01015 , H01L2924/01019 , H01L2924/01023 , H01L2924/01029 , H01L2924/0103 , H01L2924/01033 , H01L2924/01042 , H01L2924/01046 , H01L2924/01047 , H01L2924/01061 , H01L2924/01074 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/10253 , H01L2924/12041 , H01L2924/1305 , H01L2924/1306 , H01L2924/14 , H01L2924/15311 , H01L2924/181 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H01L2924/19105 , H01L2924/30105 , H01L2924/30107 , H01L2924/3011 , H01L2924/3025 , H05K1/0218 , H05K3/0052 , H05K3/284 , H05K9/0084 , H05K2201/09036 , H05K2201/0909 , H01L2224/85 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： A technology is provided which allows a reduction in the size of a semiconductor device without degrading an electromagnetic shielding effect and reliability against reflow heating. After a plurality of components are mounted over a component mounting surface of a module substrate, a resin is formed so as to cover the mounted components. Further, over surfaces (upper and side surfaces) of the resin, a shield layer including a laminated film of a Cu plating film and an Ni plating film is formed. In the shield layer, a plurality of microchannel cracks are formed randomly along grain boundaries and in a net-like configuration without being coupled to each other in a straight line, and form a plurality of paths extending from the resin to a surface of the shield layer by the microchannel cracks.
摘要翻译：提供了一种技术，其允许减小半导体器件的尺寸而不降低电磁屏蔽效应和不受回流加热的可靠性。在将多个部件安装在模块基板的部件安装表面上之后，形成树脂以覆盖安装的部件。此外，树脂的表面（上表面和侧表面）上形成包括Cu镀膜和Ni镀膜的层叠膜的屏蔽层。在屏蔽层中，沿着晶界和网状构造随机地形成多个微通道裂纹，而不以直线彼此连接，并且形成从树脂延伸到屏蔽层表面的多个路径层由微通道裂缝。

10. 发明授权

US07782451B2 Device for and method of inspecting surface condition having different curvatures 有权
标题翻译：检查具有不同曲率的表面状况的装置和方法
公开(公告)号：US07782451B2
公开(公告)日：2010-08-24
申请号：US11707293
申请日：2007-02-14
申请人： Toshihiko Matsumoto , Hiroshi Okabe , Takashi Kinoshita , Yoshihiro Kanetani
发明人： Toshihiko Matsumoto , Hiroshi Okabe , Takashi Kinoshita , Yoshihiro Kanetani
IPC分类号： G01N21/00
CPC分类号： G01N21/9515 , G01N21/8851
摘要： A target surface of a target object including portions having different curvatures is inspected by using an illuminating device and a camera that are fixed, a supporting device for supporting the target object such that its position and orientation are variable. The position and orientation of the target object are controlled as its image is obtained for a plurality of times. The position and orientation of the target object are controlled such that the image of any point on the target surface will be included in at least one of the images obtained by the camera.
摘要翻译：通过使用固定的照明装置和照相机来检查包括具有不同曲率的部分的目标对象的目标表面，用于支撑目标对象的支撑装置，使得其位置和取向是可变的。控制目标对象的位置和方向，因为其图像获得多次。控制目标对象的位置和方向，使得目标表面上的任何点的图像将包含在由照相机获得的至少一幅图像中。

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