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1. 发明授权

US4954640A Alpha-methyl benzyl amine salt of indoline -2- carboxylic acid 失效
标题翻译：二氢吲哚-2-羧酸的α-甲基苄基胺盐
公开(公告)号：US4954640A
公开(公告)日：1990-09-04
申请号：US462797
申请日：1990-01-10
申请人： Michel Vincent , Jean Baliarda , Bernard Marchand , Georges Remond
发明人： Michel Vincent , Jean Baliarda , Bernard Marchand , Georges Remond
IPC分类号： C07B61/00 , C07C211/27 , C07D209/42 , C07K1/02 , C07K5/02 , C07K5/06
CPC分类号： C07K5/0222 , C07D209/42
摘要： Process for the industrial synthesis of (2S,3 7aS)-2-carboxyperhydroindole by reduction of 2-carboxindole or of one of its esters to (R,S)-2-carboxyindo or of one of its esters which, after saponification, converted into the acid, the S isomer cf (R,S)-2-carboxyindoline being obtained by precipitation from the mixture of the two (R) and (S) isomers, in the presence of (+) methylbenzylamine, (S)-2-carboxyindoline being in its turn subjected to catalytic hydrogenation to give (2S, 3aS,7aS)-2-carboxyperhydroindole, after separation of (2S,3aR,7aR) isomer by crystallization.Application to the synthesis of carboxyalkyl d peptides capable of being employed in therapeutics.

2. 发明授权

US4914214A Process for the industrial synthesis of perindopril 失效
标题翻译：培哚普利工业化合成方法
公开(公告)号：US4914214A
公开(公告)日：1990-04-03
申请号：US245446
申请日：1988-09-16
申请人： Michel Vincent , Jean Baliarda , Bernard Marchand , Georges Remond
发明人： Michel Vincent , Jean Baliarda , Bernard Marchand , Georges Remond
IPC分类号： C07D209/42 , A61K38/00 , B01J23/00 , B01J23/40 , B01J23/755 , C07B31/00 , C07B53/00 , C07B61/00 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/32 , C07C229/16 , C07K1/02 , C07K5/02 , C07K5/06 , C07K14/81
CPC分类号： C07K5/0222 , A61K38/00
摘要： Process for the industrial synthesis of perindopril, in which (2S,3aS,7aS)-2-carboxyperhydroindole is condensed with N-[(S)-1-carbethoxybutyl]-(S)-alanine after protection of the carboxyl group, the product resulting from the condensation being then subjected to deprotection of the carboxyl carried by the heterocyclic ring.The (2S,3aS,7aS)-2-carboxyperhydroindole and N-[(S)-1-carbethoxybutyl]-(S)-alanine are themselves obtained in excellent conditions from 2-carboxyindole and from L-alanine respectively, both available on an industrial scale.
摘要翻译：在保护羧基后，（2S，3aS，7aS）-2-羧基全氢吲哚与N - [（S）-1-乙酯基] - （S） - 丙氨酸缩合的培养基工业合成方法，产物由缩合得到的杂环进行羧基负载脱保护。（2S，3aS，7aS）-2-羧基全氢吲哚和N - [（S）-1-甲乙氧基丁基] - （S） - 丙氨酸本身分别在2-羧基吲哚和L-丙氨酸的良好条件下得到，工业规模。

3. 发明授权

US4902817A Process for the synthesis of alpha n alkylated amino acids and esters thereof, application to the synthesis of carboxyalkyl dipeptides 失效
标题翻译：用于合成αn烷基化氨基酸及其酯的方法，应用于羧基烷基二肽的合成
公开(公告)号：US4902817A
公开(公告)日：1990-02-20
申请号：US245353
申请日：1988-09-16
申请人： Michel Vincent , Jean Baliarda , Bernard Marchand , Georges Remond
发明人： Michel Vincent , Jean Baliarda , Bernard Marchand , Georges Remond
IPC分类号： C07D209/12 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/435 , A61K31/47 , A61K31/472 , A61P3/00 , A61P9/00 , A61P9/12 , B01J23/40 , B01J23/755 , C07B31/00 , C07B53/00 , C07B61/00 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/32 , C07C227/42 , C07C229/16 , C07D209/14 , C07D209/42 , C07D209/44 , C07D209/52 , C07D215/14 , C07D217/16 , C07D221/22 , C07D453/06 , C07K5/02
CPC分类号： C07K5/0222 , C07C227/32 , C07D209/42
摘要： Stereoselective process for the industrial synthesis of compounds of formula (I): ##STR1## where R.sub.1 is linear or branched lower alkyl with 1 to 6 carbon atoms,R.sub.2 is a linear or branched lower alkyl with 1 to 4 carbon atoms,employing inexpensive starting materials and obtaining optimum yields.Application to the synthesis of carboxyalkyl dipeptides.
摘要翻译：用于工业合成式（I）化合物的立体选择性方法：其中R 1是具有1至6个碳原子的直链或支链低级烷基，R 2是具有1至4个碳原子的直链或支链低级烷基，采用廉价的原料并获得最佳产率。应用于羧基烷基二肽的合成。

4. 发明授权

US4935525A Process for the industrial synthesis of (2S, 3aS, 7aS) 2-carboxy perhydroindole, application to the industrial synthesis of carboxyalkyl dipeptides 失效
标题翻译：（2S，3aS，7aS）2-羧基全氢吲哚的工业合成方法，用于工业合成羧基烷基二肽
公开(公告)号：US4935525A
公开(公告)日：1990-06-19
申请号：US245352
申请日：1988-09-16
申请人： Michel Vincent , Jean Baliarda , Bernard Marchand , Georges Remond
发明人： Michel Vincent , Jean Baliarda , Bernard Marchand , Georges Remond
IPC分类号： C07B61/00 , C07C211/27 , C07D209/42 , C07K1/02 , C07K5/02 , C07K5/06
CPC分类号： C07K5/0222 , C07D209/42
摘要： Process for the industrial synthesis of (2S, 3 7aS)-2-carboxyperhydroindole by reduction of 2-carbox indole or of one of its esters to (R,S)-2-carboxyindo or of one of its esters which, after saponification, converted into the acid, the S isomer cf (R,S)-2-carboxyindoline being obtained by precipitation from the mixture of the two (R) and (S) isomers, in the presence of (+) methylbenzylamine, (S)-2-carboxyindoline being in its turn subjected to catalytic hydrogenation to give (2S, 3aS,7aS)-2-carboxyperhydroindole, after separation of (2S,3aR,7aR) isomer by crystallization.Application to the synthesis of carboxyalkyl d peptides capable of being employed in therapeutics.
摘要翻译：通过将2-羧基吲哚或其一种酯还原成（R，S）-2-羧基吲哚或其酯之一来工业合成（2S，3α7S）-2-羧基全氢吲哚的方法，其在皂化后，（R）和（S）异构体的混合物中，通过在（+）甲基苄胺，（S） - （S） - 在（2S，3aR，7aR）异构体通过结晶分离之后，2-羧基二氢吲哚依次进行催化氢化，得到（2S，3aS，7aS）-2-羧基全氢吲哚。适用于能够用于治疗的羧烷基d肽的合成。

5. 发明授权

US06859437B2 Method and system for extending the reach of a data communication channel using a flow control interception device 有权
标题翻译：一种使用流量控制拦截装置扩展数据通信信道范围的方法和系统
公开(公告)号：US06859437B2
公开(公告)日：2005-02-22
申请号：US10379611
申请日：2003-03-05
申请人： Pierre Miller , Bernard Marchand , Marc W. Leclair
发明人： Pierre Miller , Bernard Marchand , Marc W. Leclair
IPC分类号： H04L12/56 , H04J12/28
CPC分类号： H04L47/29 , H04L47/10 , H04L47/26 , H04L47/30 , H04L47/39
摘要： A system and method for extending the reach of a data communication channel using flow control interception devices is described. The method decreases the latency-induced reduction in the data throughput and permits data transmission at subrates through the data communication channel. The method includes transmitting a data frame from a sending device. The data frame is transmitted through the data communication channel if a flow control signal is not asserted. The data frame is buffered if the flow control signal is asserted. The buffered data frame is transmitted through the data communication channel in response the flow control signal changing to an asserted state. The method also includes receiving the transmitted data frame from the data communication channel and transmitting the received data frame to a receiving device if the receiving device is available to process the data frame. If the receiving device is unavailable, the received data frame is buffered until the receiving device becomes available to process the buffered data frame.
摘要翻译：描述了使用流控制拦截设备来扩展数据通信信道的范围的系统和方法。该方法减少了延迟引起的数据吞吐量的降低，并允许通过数据通信信道在子速率上进行数据传输。该方法包括从发送设备发送数据帧。如果没有声明流量控制信号，则通过数据通信通道传输数据帧。如果流量控制信号被断言，则数据帧被缓冲。缓冲的数据帧通过数据通信信道传输，以响应流控制信号改变为断言状态。该方法还包括从数据通信信道接收发送的数据帧，并且如果接收设备可用于处理数据帧，则将接收的数据帧发送到接收设备。如果接收设备不可用，则缓冲接收到的数据帧，直到接收设备变得可用来处理缓冲的数据帧。

6. 发明授权

US06438106B1 Inter-class schedulers utilizing statistical priority guaranteed queuing and generic cell-rate algorithm priority guaranteed queuing 有权
标题翻译：利用统计优先级保证队列和通用小区速率算法优先级保证排队的类间调度器
公开(公告)号：US06438106B1
公开(公告)日：2002-08-20
申请号：US09218510
申请日：1998-12-22
申请人： John Pillar , Bernard Marchand , Bernard St-Denis
发明人： John Pillar , Bernard Marchand , Bernard St-Denis
IPC分类号： H04L1226
CPC分类号： H04L12/5602 , H04L2012/5636 , H04L2012/5651 , H04L2012/5667 , H04L2012/5679 , H04L2012/5682 , H04Q11/0478
摘要： Inter-class schedulers for digital link systems provide high efficiency utilization of limited bandwidth by employing queuing techniques referred to as Statistical Priority Guarantee Queuing (SPGQ) and Generic Cell-Rate Algorithm Priority Guarantee Queuing (GCRA-PGQ). SPGQ “elevates” the priority of otherwise low-priority classes under prescribed circumstances in accordance with a statistical process. The SPGQ scheduler determines whether a number within a range produced by a uniform random number generator lies within a sub-range proportional to the programmed statistical guarantee for a given class. If the number lies within the sub-range associated with a given class, then the priority of that class is elevated to a higher priority when both are eligible to transmit. The GCRA-PGQ scheduler operates as a strict priority mechanism until a class requires bandwidth in excess of a GCRA “window” or threshold for that class. When that occurs, the service priority of that class is temporarily lowered.
摘要翻译：用于数字链路系统的类间调度器通过采用称为统计优先级保证排队（SPGQ）和通用小区速率算法优先级保证队列（GCRA-PGQ）的排队技术来提供有限带宽的高效率利用。按照统计过程，SPGQ根据规定的情况“提高”优先级低优先级的优先级。 SPGQ调度器确定由均匀随机数发生器产生的范围内的数字是否在与给定类的编程统计保证成比例的子范围内。如果数字在与给定类相关联的子范围内，则当两者都有资格传输时，该类的优先级被提升到更高的优先级。 GCRA-PGQ调度器作为严格的优先级机制运行，直到类需要超过该类的GCRA“窗口”或阈值的带宽。发生这种情况时，该类的服务优先级暂时降低。

7. 发明授权

US09680605B2 Method of offloading cyclic redundancy check on portions of a packet 有权
公开(公告)号：US09680605B2
公开(公告)日：2017-06-13
申请号：US14713632
申请日：2015-05-15
申请人： Eric Englert , Bernard Marchand , John F. Pillar
发明人： Eric Englert , Bernard Marchand , John F. Pillar
IPC分类号： H03M13/00 , H04L1/00
CPC分类号： H04L1/0061
摘要： A method and apparatus are provided for computing a CRC value for a data stream packet with a modified portion and an unmodified portion extending a distance to the end of the data stream packet by computing a first CRC value from the unmodified portion, computing a second CRC value from the modified portion, adjusting the second CRC value based on a shift length equal to the distance of the unmodified portion to compute a perspective shifted second CRC value by using a fixed number of distance lookup table operations, and generating an updated CRC value from the first CRC value and perspective shifted second CRC value, thereby avoiding recalculating a complete CRC value based on an entirety of the data stream packet.

8. 发明授权

US06625120B1 Method and apparatus for auto detection of AAL5 type frames for VCC and VPC switches 有权
标题翻译：用于自动检测VCC和VPC交换机的AAL5型帧的方法和装置
公开(公告)号：US06625120B1
公开(公告)日：2003-09-23
申请号：US09300790
申请日：1999-04-28
申请人： John Frank Pillar , Bernard St-Denis , Bernard Marchand
发明人： John Frank Pillar , Bernard St-Denis , Bernard Marchand
IPC分类号： H04L100
CPC分类号： H04Q11/0478 , H04L2012/5648 , H04L2012/5658
摘要： In Asynchronous Transfer Mode (ATM) communications networks, certain congestion control features, such as Partial Packet Discard (PPD) and Early Packet Discard (EPD), operate on ATM cells that have been segmented from ATM Adaptation Layer #5 (AAL5) frames (packets). AAL5 frames are automatically detected by observing transitions of an indicator in the ATM cell header unique to AAL5 traffic. Automatic detection of AAL5 traffic allows enablement of packet-aware cell discarding techniques such as PPD and EPD on a Virtual Channel Connection (VCC) basis, whether in a switch for a VCC or for a Virtual Path Connection (VPC) to which the VCC belongs.
摘要翻译：在异步传输模式（ATM）通信网络中，诸如部分分组丢弃（PPD）和早期分组丢弃（EPD）的某些拥塞控制特征对已经从ATM适配层＃5（AAL5）帧分段的ATM信元数据包）。通过观察AAL5业务独有的ATM信元头中的指示符的转换，自动检测AAL5帧。自动检测AAL5流量允许在虚拟通道连接（VCC）的基础上启用分组感知单元丢弃技术，如PPD和EPD，无论是在VCC的交换机还是VCC所属的虚拟路径连接（VPC）。

9. 发明授权

US06331970B1 Dynamic generic cell rate algorithm for policing ABR traffic 有权
标题翻译：用于监管ABR流量的动态通用信元速率算法
公开(公告)号：US06331970B1
公开(公告)日：2001-12-18
申请号：US09220857
申请日：1998-12-28
申请人： Benjamin B. Nieh , John F. Pillar , Jacob Guttman , Bernard Marchand , Sameh Rabie
发明人： Benjamin B. Nieh , John F. Pillar , Jacob Guttman , Bernard Marchand , Sameh Rabie
IPC分类号： H04L1256
CPC分类号： H04L12/5601 , H04L2012/5629 , H04L2012/5635 , H04L2012/5636
摘要： In an ATM communication system, a source transmitting in accordance with an Available Bit Rate service category must be policed to ensure that the cells are transmitted at a rate within the cell rate specified by the network at any given time. The usage parameter control system can only store a limited number of pending cell transmission rates to be enforced, and must make approximations by discarding certain stored pending cell transmission rates in order to make room for new cell transmission rates. This invention is directed towards a method for selecting which stored cell rates to discard that allows less cheating room in the cell rate enforcement than does the prior art, and that does not over-police.
摘要翻译：在ATM通信系统中，必须对根据可用比特率服务类别进行发送的源进行监管，以确保以任何给定时间由网络指定的小区速率内的小区发送小区。使用参数控制系统只能存储要强制执行的有限数量待决小区传输速率，并且必须通过丢弃某些存储的待决小区传输速率来进行近似，以便为新的小区传输速率腾出空间。本发明涉及一种用于选择哪些存储的信元速率丢弃的方法，其允许比现有技术更少的小区欺骗室，并且不会过警。

10. 发明授权

US4703057A Beta-blocking thiochroman derivatives, compositions and method of use therefor 失效
标题翻译： β-阻断二氢苯并噻喃衍生物，组合物及其用途
公开(公告)号：US4703057A
公开(公告)日：1987-10-27
申请号：US913351
申请日：1986-09-30
申请人： Bernard Marchand , Yves M. Gargouil
发明人： Bernard Marchand , Yves M. Gargouil
IPC分类号： A61K31/38 , A61K31/382 , A61P9/00 , A61P9/12 , C07D335/06
CPC分类号： C07D335/06
摘要： The invention relates to 1-tert.-butylamino-3-(4-hydroxy-8-thiochromanyloxy)-2-propanol.
摘要翻译：本发明涉及1-叔丁基氨基-3-（4-羟基-8-硫基苯并二氢吡喃氧基）-2-丙醇。

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