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1. 发明授权

US06230051B1 Device for enhancing transdermal agent delivery or sampling 失效
标题翻译：用于增强透皮药物递送或取样的装置
公开(公告)号：US06230051B1
公开(公告)日：2001-05-08
申请号：US08877153
申请日：1997-06-17
申请人： Michel J. N. Cormier , Avtar S. Nat , Armand P. Neukermans , Barry Block
发明人： Michel J. N. Cormier , Avtar S. Nat , Armand P. Neukermans , Barry Block
IPC分类号： A61N130
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150282 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15142 , A61B10/0045 , A61B17/205 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , A61N1/30 , A61N1/303
摘要： A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent. The microblades having a relatively sharp angled leading edge which transitions to a relatively gradually angled blade edge.
摘要翻译：一种经皮剂递送或取样装置，包括具有多个微刀片的片材，用于刺穿皮肤以增加药剂的经皮通量。微型刀片具有相对尖锐的前缘，其转变成相对逐渐倾斜的叶片边缘。

2. 发明授权

US07184826B2 Device and method for enhancing transdermal flux of agents being delivered or sampled 失效
标题翻译：用于增强递送或取样的试剂的经皮通量的装置和方法
公开(公告)号：US07184826B2
公开(公告)日：2007-02-27
申请号：US08877155
申请日：1997-06-17
申请人： Michel J. N. Cormier , Armand P. Neukermans , Barry Block , Felix T. Theeuwes , Alfred A. Amkraut
发明人： Michel J. N. Cormier , Armand P. Neukermans , Barry Block , Felix T. Theeuwes , Alfred A. Amkraut
IPC分类号： A61M1/30 , A61M31/00 , A61B5/00
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/150022 , A61B5/150099 , A61B5/150282 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15105 , A61B5/15113 , A61B5/15142 , A61B10/0045 , A61B17/205 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053 , A61N1/30 , A61N1/303
摘要： A percutaneous agent delivery or sampling device comprising a sheet having a plurality of microblades for piercing and anchoring to the skin for increasing transdermal flux of an agent and for improving the attachment of the device to the skin.
摘要翻译：一种经皮药剂递送或取样装置，其包括具有多个微刀片的片材，用于刺穿并锚定到皮肤上以增加药剂的经皮通量并改善装置与皮肤的连接。

3. 发明授权

US06918901B1 Device and method for enhancing transdermal agent flux 失效
标题翻译：增强透皮剂通量的装置和方法
公开(公告)号：US06918901B1
公开(公告)日：2005-07-19
申请号：US08988292
申请日：1997-12-10
申请人： Felix Theeuwes , Michel J. N. Cormier , Armand P. Neukermans
发明人： Felix Theeuwes , Michel J. N. Cormier , Armand P. Neukermans
IPC分类号： A61B17/20 , A61M37/00 , A61M31/00
CPC分类号： A61M37/0015 , A61B17/205 , A61M2037/0023 , A61M2037/0046
摘要： An agent delivery or sampling device (2) comprising a member (6) having a plurality of blades (4) for piercing the skin and a connecting medium (65) covering at least a part of the skin contacting side (48) of the member (6) for increasing transdermal flux of an agent.
摘要翻译：一种药剂输送或取样装置（2），包括具有用于刺穿皮肤的多个叶片（4）的构件（6）和覆盖该构件的皮肤接触侧（48）的至少一部分的连接介质（6）用于增加药剂的经皮通量。

4. 发明授权

US07087035B2 Device and method for enhancing skin piercing by microprotrusions 有权
公开(公告)号：US07087035B2
公开(公告)日：2006-08-08
申请号：US09733506
申请日：2000-12-08
申请人： Joseph C. Trautman , Michel J. N. Cormier , Kellee Eng , Wei-Qi Lin , Hyunok L. Kim , Sara L. Sendelbeck , Armand P. Neukermans , Bruce P. Edwards , Wai-Loong Lim , Andrew I. Poutiatine , J. Richard Gyory
发明人： Joseph C. Trautman , Michel J. N. Cormier , Kellee Eng , Wei-Qi Lin , Hyunok L. Kim , Sara L. Sendelbeck , Armand P. Neukermans , Bruce P. Edwards , Wai-Loong Lim , Andrew I. Poutiatine , J. Richard Gyory
IPC分类号： A61B17/20 , A61B17/22
CPC分类号： A61M37/0015 , A61B17/205 , A61M5/425 , A61M2037/0023 , A61M2037/0046
摘要： A device and method for enhancing skin piercing by microprotrusions involves pre-stretching the skin to enhance pathway formation when the microprotrusions are pressed into the skin. An expandable device includes skin engaging opposite ends that contact the skin surface so that when the device is expanded the skin is stretched. The skin is placed under a tension of about 0.01 to about 10 megapascals, preferably about 0.05 to 2 megapascals. The device has a plurality of microprotrusions which penetrate the skin while the skin is being stretched by the expanded device. Another stretching device employs suction for skin stretching.

5. 发明授权

US09295714B2 Apparatus and method for transdermal delivery of parathyroid hormone agents 有权
公开(公告)号：US09295714B2
公开(公告)日：2016-03-29
申请号：US12455830
申请日：2009-06-08
申请人： Mahmoud Ameri , Michel J. N. Cormier , Yuh-Fun Maa , Peter E. Daddona , Marika Kamberi
发明人： Mahmoud Ameri , Michel J. N. Cormier , Yuh-Fun Maa , Peter E. Daddona , Marika Kamberi
IPC分类号： A61K38/29 , C07K14/635 , A61M31/00 , A61M37/00 , A61K9/00 , A61K47/12 , A61K47/18 , A61K47/26
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.

6. 发明授权

US09056061B2 Transdermal nicotine salt delivery system 有权
标题翻译：透皮尼古丁盐输送系统
公开(公告)号：US09056061B2
公开(公告)日：2015-06-16
申请号：US11525977
申请日：2006-09-22
申请人： Robert M. Gale , Jay Audett , Rama V. Padmanabhan , Michel J. N. Cormier , Allison Luciano , Eric N. Silverberg , Paul B. Foreman
发明人： Robert M. Gale , Jay Audett , Rama V. Padmanabhan , Michel J. N. Cormier , Allison Luciano , Eric N. Silverberg , Paul B. Foreman
IPC分类号： A61K31/4439 , A61K9/70 , A61K31/56
CPC分类号： A61K9/7061 , A61K31/4439 , A61K31/56 , C09J7/255 , C09J7/385 , C09J133/06 , C09J2467/006
摘要： A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.
摘要翻译：向个体透皮的尼古丁盐输送系统。该系统具有高尼古丁盐负荷以实现治疗通量。溶解有高尼古丁盐的丙烯酸酯聚合物药物储库提供了所需的粘合特性和有效的经皮治疗性质。

7. 发明授权

US08663155B2 Transdermal drug delivery devices having coated microprotrusions 有权
标题翻译：透皮药物递送装置具有包被的微突起
公开(公告)号：US08663155B2
公开(公告)日：2014-03-04
申请号：US11347779
申请日：2006-02-02
申请人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona , Wei-Qi Lin
发明人： Michel J. N. Cormier , Wendy A. Young , Kofi Nyam , Peter E. Daddona , Wei-Qi Lin
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61K9/0021 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.
摘要翻译：提供了用于经皮透皮递送有效药理活性剂的装置（12）和方法。将试剂溶解在水中以形成具有适当粘度的水性涂料溶液，以涂覆极微小的皮肤刺穿元件（10）。使用已知的涂覆技术将涂布溶液施加到皮肤刺穿元件（10）上，然后干燥。将装置（12）施加到活动物（例如人）的皮肤上，导致微突起（10）刺穿角质层并将治疗有效剂量的药剂递送至动物。

8. 发明授权

US5995869A Reduction of skin sensitization in electrotransport drug delivery 失效
标题翻译：减少电转运药物中的皮肤过敏
公开(公告)号：US5995869A
公开(公告)日：1999-11-30
申请号：US872723
申请日：1997-06-11
申请人： Michel J. N. Cormier , James A. Matriano , Ronald P. Haak , Peter E. Daddona
发明人： Michel J. N. Cormier , James A. Matriano , Ronald P. Haak , Peter E. Daddona
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： A device and method are provided for reducing or preventing skin sensitization in electrotransport drug delivery. The method involves co-administration of a countersensitizing agent, comprising cis-urocanic acid or an analog thereof, with the drug delivered via electrotransport. Novel drug reservoirs and electrotransport drug delivery systems, formulated with a countersensitizing agent as described herein, are provided as well.
摘要翻译：提供了用于减少或预防电转运药物递送中的皮肤致敏的装置和方法。该方法包括将包含顺式尿刊或其类似物的致敏剂与经由电转运递送的药物共同给药。还提供了用本文所述的增敏剂配制的新型药物储库和电转运药物递送系统。

9. 发明授权

US5629019A Formulations with hydrophobic permeation enhancers 失效
标题翻译：疏水渗透促进剂配方
公开(公告)号：US5629019A
公开(公告)日：1997-05-13
申请号：US064689
申请日：1993-05-20
申请人： Eun Soo Lee , Su Il Yum , Michel J. N. Cormier
发明人： Eun Soo Lee , Su Il Yum , Michel J. N. Cormier
IPC分类号： A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/28 , A61K47/36 , A61K9/06
CPC分类号： A61K47/26 , A61K47/12 , A61K47/14 , A61K47/186 , A61K47/20 , A61K47/28 , A61K47/36 , A61K9/0014 , Y10S514/944 , Y10S514/946 , Y10S514/951
摘要： This invention is directed to a novel formulation for effectively utilizing hydrophobic permeation enhancers for the increased permeability of active agents through the skin or mucosa along with reduction of the lag time between application of the active agent and attainment of a therapeutically effective agent flux, with little or no irritation to the host. The invention is directed to compositions containing a hydrophobic permeation enhancer, which permeation enhancer has been micronized and stabilized in an inert carrier such as water. These compositions can be combined with a biologically active agent to provide enhanced permeability of the active agent to the skin or mucosa.
摘要翻译：本发明涉及一种用于有效利用疏水性渗透增强剂以增加活性剂通过皮肤或粘膜的渗透性的新型制剂，同时减少施用活性剂之间的滞后时间并获得治疗有效的药剂通量或对主机没有刺激。本发明涉及含有疏水渗透增强剂的组合物，该渗透增强剂已经在惰性载体如水中微粉化并稳定。这些组合物可与生物活性剂组合以提供活性剂对皮肤或粘膜的增强的渗透性。

10. 发明授权

US5149539A Reduction or prevention of sensitization to drugs 失效
标题翻译：减少或预防对药物的敏感性
公开(公告)号：US5149539A
公开(公告)日：1992-09-22
申请号：US793936
申请日：1991-11-15
申请人： Philip W. Ledger , Michel J. N. Cormier , Alfred Amkraut
发明人： Philip W. Ledger , Michel J. N. Cormier , Alfred Amkraut
IPC分类号： A61K9/70 , A61K33/02
CPC分类号： A61K9/7023 , A61K33/02
摘要： The present invention is directed to a method of reducing or preventing skin sensitization by inhibiting the immunological processing of a sensitizing drug as an antigen. The drug is sensitizing to humans, i.e., the drug is susceptible to inducing skin or mucosa sensitization in a human when the drug is transdermally administered to the human at a therapeutically effective rate. Skin sensitization reduction or prevention is induced by coadministering to the skin or mucosa of the human:(a) a therapeutically effective amount of a sensitizing drug, at a therapeutically effective rate over a predetermined period of time; and(b) an antigen processing-inhibiting agent in an amount effective to inhibit the antigen processing of the drug.The system of the invention comprises a matrix adapted to be placed in sensitizing drug and antigen processing-inhibiting agent transmitting relation to the selected skin or mucosa site. The matrix contains sufficient amounts of the drug and the agent to continuously coadminister to the skin or mucosa site the drug, at a therapeutically effective rate and over a predetermined delivery period, and the antigen processing-inhibiting agent, at a rate and for a period of time sufficient to inhibit the processing of the drug as an antigen.
摘要翻译：本发明涉及通过抑制作为抗原的敏化药物的免疫处理来减少或预防皮肤致敏的方法。药物对人类敏感，即当药物以治疗有效的速率经皮给药时，药物易于引起人类皮肤或粘膜致敏。通过向人的皮肤或粘膜共同诱导皮肤致敏减少或预防：（a）治疗有效量的敏化药物，以预定时间段的治疗有效速率; 和（b）有效抑制药物抗原加工的抗原加工抑制剂。本发明的系统包括适于放置在致敏药物和抗原加工抑制剂中的基质，其与所选择的皮肤或粘膜部位传递关系。基质含有足够量的药物和药剂，以治疗有效速率和超过预定的递送期间，以一定的速率和一段时间连续地连续地附着到皮肤或粘膜部位，药物，抗原加工抑制剂的时间足以抑制作为抗原的药物的加工。

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